CN109963600A - 捕捉或分离白血球的聚合物、装置、其制造方法及其应用 - Google Patents

捕捉或分离白血球的聚合物、装置、其制造方法及其应用 Download PDF

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CN109963600A
CN109963600A CN201780069531.8A CN201780069531A CN109963600A CN 109963600 A CN109963600 A CN 109963600A CN 201780069531 A CN201780069531 A CN 201780069531A CN 109963600 A CN109963600 A CN 109963600A
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polymer
monomer
amide
hydroxyl
substrate
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CN109963600B (zh
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张雍
叶至诚
杨承臻
鍾政峯
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Puriblood Medical Co ltd
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    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/36—Amides or imides
    • C08F222/38—Amides
    • C08F222/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01D39/00—Filtering material for liquid or gaseous fluids
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    • B01D39/06—Inorganic material, e.g. asbestos fibres, glass beads or fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
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    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
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    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C08J7/16—Chemical modification with polymerisable compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0407—Additives and treatments of the filtering material comprising particulate additives, e.g. adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0471—Surface coating material
    • B01D2239/0478—Surface coating material on a layer of the filter
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/24—Homopolymers or copolymers of amides or imides
    • C08J2333/26—Homopolymers or copolymers of acrylamide or methacrylamide

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  • Health & Medical Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

本发明是关于一种聚合物，用于捕捉或分离白血球。聚合物是以含酰胺基及羟基的单体进行聚合反应制备而得。此含酰胺基及羟基的单体具有式(1)的结构：在式(1)中，R1是独立选自由氢、甲基、乙基、羟基、C1至C12长碳链其中任一及苯环所组成的群组，R2是独立选自由氢、甲基、乙基、C1至C6长碳链其中任一、氨基及苯环所组成的群组，以及n为1至5的整数。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201780069531.8A 2016-11-09 2017-11-09 捕捉或分离白血球的聚合物、装置、其制造方法及其应用 Active CN109963600B (zh)

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US201662419600P 2016-11-09 2016-11-09
US62/419,600 2016-11-09
PCT/CN2017/110177 WO2018086556A1 (zh) 2016-11-09 2017-11-09 捕捉或分离白血球的聚合物、装置、其制造方法及其应用

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EP (1) EP3539581A4 (zh)
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN113769120A (zh) * 2021-09-18 2021-12-10 北京脑陆科技有限公司 双层导电水凝胶的制备方法

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CA3171415A1 (en) * 2020-03-27 2021-09-16 Yung Chang Method and device for enriching and detecting microorganisms in biological samples
TWI808510B (zh) * 2021-10-15 2023-07-11 中原大學 抗生物惰性效能衰變之雙離子型材料、薄膜及其應用
EP4445905A1 (en) * 2023-04-14 2024-10-16 Santxa Research S.L.U. Plasma enriched in platelets and plasma molecules

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CN1545526A (zh) * 2001-07-31 2004-11-10 ��ҽѧ��ʽ���� 涂覆除白细胞的过滤器原材料用聚合物以及过滤器材料
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JPS6168454A (ja) 1984-09-11 1986-04-08 Mitsubishi Rayon Co Ltd Ｎ−２−ヒドロキシエチルアクリルアミドもしくはｎ−２−ヒドロキシエチルメタクリルアミドの製造方法
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CN1545526A (zh) * 2001-07-31 2004-11-10 ��ҽѧ��ʽ���� 涂覆除白细胞的过滤器原材料用聚合物以及过滤器材料
CN102292115A (zh) * 2009-03-30 2011-12-21 泰尔茂株式会社 表面处理剂及过滤器用过滤材料以及血液处理过滤器
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CN104623978A (zh) * 2013-11-14 2015-05-20 中原大学 双离子电荷偏差型血球筛选用材料及从血液样品中移除白血球的方法
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113769120A (zh) * 2021-09-18 2021-12-10 北京脑陆科技有限公司 双层导电水凝胶的制备方法

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TWI661864B (zh) 2019-06-11
WO2018086556A1 (zh) 2018-05-17
EP3539581A1 (en) 2019-09-18
US11833289B2 (en) 2023-12-05
CN109963600B (zh) 2023-01-06
WO2018086556A8 (zh) 2023-03-30
US20190359752A1 (en) 2019-11-28
EP3539581A4 (en) 2020-07-01
TW201817492A (zh) 2018-05-16

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