WO2018086556A8 - 捕捉或分离白血球的聚合物、装置、其制造方法及其应用 - Google Patents

捕捉或分离白血球的聚合物、装置、其制造方法及其应用 Download PDF

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Publication number
WO2018086556A8
WO2018086556A8 PCT/CN2017/110177 CN2017110177W WO2018086556A8 WO 2018086556 A8 WO2018086556 A8 WO 2018086556A8 CN 2017110177 W CN2017110177 W CN 2017110177W WO 2018086556 A8 WO2018086556 A8 WO 2018086556A8
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WIPO (PCT)
Prior art keywords
polymer
capturing
manufacturing
hydroxyl
leucocytes
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PCT/CN2017/110177
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English (en)
French (fr)
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WO2018086556A1 (zh
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张雍
叶至诚
杨承臻
鍾政峯
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普瑞博生技股份有限公司
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Application filed by 普瑞博生技股份有限公司 filed Critical 普瑞博生技股份有限公司
Priority to CN201780069531.8A priority Critical patent/CN109963600B/zh
Priority to EP17868975.8A priority patent/EP3539581A4/en
Priority to US16/348,325 priority patent/US11833289B2/en
Publication of WO2018086556A1 publication Critical patent/WO2018086556A1/zh
Publication of WO2018086556A8 publication Critical patent/WO2018086556A8/zh

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/36—Amides or imides
    • C08F222/38—Amides
    • C08F222/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/02—Loose filtering material, e.g. loose fibres
    • B01D39/06—Inorganic material, e.g. asbestos fibres, glass beads or fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C08J7/16—Chemical modification with polymerisable compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0407—Additives and treatments of the filtering material comprising particulate additives, e.g. adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0471—Surface coating material
    • B01D2239/0478—Surface coating material on a layer of the filter
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/24—Homopolymers or copolymers of amides or imides
    • C08J2333/26—Homopolymers or copolymers of acrylamide or methacrylamide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • External Artificial Organs (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

一种聚合物，用于捕捉或分离白血球。聚合物是以含酰胺基及羟基的单体进行聚合反应制备而得。此含酰胺基及羟基的单体具有式(1)的结构。在式(1)中，R 1是独立选自由氢、甲基、乙基、羟基、C1至C12长碳链其中任一及苯环所组成的群组，R 2是独立选自由氢、甲基、乙基、C1至C6长碳链其中任一、氨基及苯环所组成的群组，以及n为1至5的整数。
PCT/CN2017/110177 2016-11-09 2017-11-09 捕捉或分离白血球的聚合物、装置、其制造方法及其应用 WO2018086556A1 (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201780069531.8A CN109963600B (zh) 2016-11-09 2017-11-09 捕捉或分离白血球的聚合物、装置、其制造方法及其应用
EP17868975.8A EP3539581A4 (en) 2016-11-09 2017-11-09 POLYMER AND DEVICE FOR DETECTING OR SEPARATING LEUKOCYTES, PRODUCTION METHOD AND USE THEREOF
US16/348,325 US11833289B2 (en) 2016-11-09 2017-11-09 Polymer and device for capturing or separating leucocytes, manufacturing method and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662419600P 2016-11-09 2016-11-09
US62/419,600 2016-11-09

Publications (2)

Publication Number Publication Date
WO2018086556A1 WO2018086556A1 (zh) 2018-05-17
WO2018086556A8 true WO2018086556A8 (zh) 2023-03-30

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PCT/CN2017/110177 WO2018086556A1 (zh) 2016-11-09 2017-11-09 捕捉或分离白血球的聚合物、装置、其制造方法及其应用

Country Status (5)

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US (1) US11833289B2 (zh)
EP (1) EP3539581A4 (zh)
CN (1) CN109963600B (zh)
TW (1) TWI661864B (zh)
WO (1) WO2018086556A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230002416A (ko) 2020-03-27 2023-01-05 마이크론브레인 메디컬 씨오., 엘티디. 생물학적 샘플에서 미생물을 농축 및 검출하기 위한 방법 및 장치
CN113769120A (zh) * 2021-09-18 2021-12-10 北京脑陆科技有限公司 双层导电水凝胶的制备方法
TWI808510B (zh) * 2021-10-15 2023-07-11 中原大學 抗生物惰性效能衰變之雙離子型材料、薄膜及其應用

Family Cites Families (11)

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JPS60262805A (ja) * 1984-06-08 1985-12-26 Mitsubishi Rayon Co Ltd ポリｎ−（２−ヒドロキシエチル）メタクリルアミド又はアクリルアミド
JPS6168454A (ja) * 1984-09-11 1986-04-08 Mitsubishi Rayon Co Ltd Ｎ−２−ヒドロキシエチルアクリルアミドもしくはｎ−２−ヒドロキシエチルメタクリルアミドの製造方法
US5407581A (en) 1992-03-17 1995-04-18 Asahi Medical Co., Ltd. Filter medium having a limited surface negative charge for treating a blood material
DE60231659D1 (de) * 2001-07-31 2009-04-30 Asahi Kasei Kuraray Medical Co Leukozytenfilter mit polymerbeschichtung
US7897708B2 (en) * 2007-07-31 2011-03-01 Celanese International Corp. Self-crosslinking dispersions utilizing acrylamide/N-alkylolacrylamide crosslinking mixture with C2-C10 alkylol
EP2415490B1 (en) * 2009-03-30 2018-06-20 Terumo Kabushiki Kaisha Surface-treating agent, filtering material for filter, and blood treatment filter
TWI410269B (zh) * 2010-09-16 2013-10-01 私立中原大學 白血球過濾材料及其過濾方法
TWI481442B (zh) * 2013-11-14 2015-04-21 中原大學 雙離子電荷偏差型血球篩選用材料
WO2015088019A1 (ja) * 2013-12-13 2015-06-18 旭化成メディカル株式会社 白血球除去フィルター材、及び白血球を除去する方法
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US9522971B2 (en) * 2014-12-31 2016-12-20 Chung Yuan Christian University Amine modifying material and application thereof

Also Published As

Publication number Publication date
EP3539581A1 (en) 2019-09-18
US20190359752A1 (en) 2019-11-28
CN109963600B (zh) 2023-01-06
WO2018086556A1 (zh) 2018-05-17
CN109963600A (zh) 2019-07-02
EP3539581A4 (en) 2020-07-01
US11833289B2 (en) 2023-12-05
TWI661864B (zh) 2019-06-11
TW201817492A (zh) 2018-05-16

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