CN109957554A - 工程化转氨酶多肽及其应用 - Google Patents

工程化转氨酶多肽及其应用 Download PDF

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CN109957554A
CN109957554A CN201711430922.6A CN201711430922A CN109957554A CN 109957554 A CN109957554 A CN 109957554A CN 201711430922 A CN201711430922 A CN 201711430922A CN 109957554 A CN109957554 A CN 109957554A
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陈海滨
黄勇开
王娟娟
蔡宝琴
尚传洋
马克·博科拉
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Ningbo Mei Sai Biotechnology Co Ltd
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Abstract

本公开内容提供了可用于在工业相关条件下不对称合成手性胺化合物的工程化转氨酶的氨基酸序列、制备方法及其反应工艺。本公开内容还提供了编码工程化转氨酶多肽的多核苷酸序列、能够表达工程化转氨酶多肽的重组工程菌和使用工程化转氨酶多肽生产手性胺化合物的方法。与其他制备方法相比，本发明提供的工程化转氨酶多肽的活性和稳定性更好，且克服了产物对酶的抑制，单位活性更高，具有很好的工业应用前景。

Description

工程化转氨酶多肽及其应用
技术领域
本发明属于生物工程技术领域，具体涉及一种工程化转氨酶多肽及其应用。
背景技术
手性胺类化合物是一类非常重要的化合物，在精细化学、制药、保健、农业及材料行业有非常广泛的用途。特别是在制药业，手性胺常被作为中间体用于制备多种药物，如头孢菌素、神经类药物、心血管药物、抗高血压药物、抗感染药物及疫苗等的合成都是以手性胺作为中间体，抗糖尿病的口服药Januvia的主要成分西他列汀是R-型胺。传统的化学制备手性胺化合物的工艺中，通常涉及到在极端条件下(高温、高压等等)的反应，同时为了得到手性纯度高的产品，需要繁琐的拆分或重结晶步骤，往往产生大量的废水和废渣，成本高，污染大。这就催促人们寻找一种高效制备手性胺的方法，而转氨酶的出现使研究者看到了曙光。转氨酶以其高选择性、高转化率及温和的反应条件受到了业界的青睐。转氨酶，也称为氨基转移酶，其能够催化氨基供体上的氨基转移到前手性的受体酮，得到手性胺产物和副产物酮(图1)，反应过程需要磷酸吡哆醛(pyridoxal phosphate，PLP)的参与。
虽然转氨酶在合成手性胺化合物上有非常好的应用前景，但从自然界发现的野生型的转氨酶应用在工业产品的合成上时，往往活性不高，或稳定性不足，或立体选择性不足，或无法接受期望的底物，或有底物和/或产物抑制，很难直接应用于工业生产(Fei Guoand Per Berglund，Transaminase biocatalysis:optimization and application，GreenChemistry， 2017,19,333-360)。近年来，随着蛋白质工程技术的兴起，可以通过定向进化技术对转氨酶的性能加以改进，使其满足特定手性胺化合物合成的工艺要求。本发明以一个野生型的转氨酶为起点，经过基因工程改造以及基于对R-(+)-α-苯乙胺(简称为R-苯乙胺)的筛选，开发出了一系列高活性、高稳定性、高立体选择性、或更广底物范围的工程化转氨酶多肽。
α-苯乙胺(α-Phenylethylamine)是一种重要的化工中间体原料，它的衍生物在医药、化工、乳化剂以及染料等行业有着非常广泛的用途。它的光学对映体可以用来拆分某些酸、醇、酯等，同时也可以作为合成某些手性物质的助剂或原料。因此，对苯乙胺的合成进行研究有着非常重要的意义。苯乙胺的制备包括天然提取，外消旋体拆分等方法方法。其中从天然产物中直接提取具有生物活性的手性化合物是最基本的方法，但其天然原料有限成本较高。当前应用的最为普遍的方法是对消旋体进行拆分，这种方法的理论产率最高为50％。与化学合成的方法相比较，利用转氨酶催化技术合成不仅可以得到较高产量和光学纯度，而且反应条件温和，成本较低，对环境污染影响较小。
发明内容
本发明提供了一种立体选择性高、催化活性高、稳定性好的工程化转氨酶多肽，能够不对称地合成手性胺类化合物，特别是不对称地合成R-(+)-α-苯乙胺。还提供了工程化转氨酶多肽的基因，含有该基因的重组表达载体，工程菌株及其高效制备方法，以及使用工程化多肽不对称合成手性胺类化合物的反应工艺。
本发明的第一方面提供了一种改进的工程化转氨酶多肽。这种工程化多肽是由一种野生型的转氨酶经过人为的定向进化过程的改造，发生一定数量的氨基酸残基置换、插入或缺失等突变而来。野生型的转氨酶源自于Aspergillus fumigatus，其序列如SEQ IDNo：2所示。该野生型的转氨酶的活性较低，稳定性较差，同时苯乙胺对该酶的活性有抑制。经过发明人检测，使用SEQ ID No：2的转氨酶进行图2所示的反应时，苯乙酮的载量为2g/L、转氨酶的载量为10g/L的条件下(0.5M异丙胺，0.1mM PLP，10％(v/v)甲醇，pH9.0，30℃)，反应进行6小时后就不再有更多的R-苯乙胺生成，且转化率≤15％。同时，R-苯乙胺对该野生型的转氨酶有非常强的抑制作用，如果在反应中存在≥0.5g/L的R-苯乙胺，SEQ ID No：2的转氨酶几乎不能将苯乙酮转化为R-苯乙胺。
本发明提供的改进的工程化转氨酶多肽与SEQ ID NO：2对应的野生型的转氨酶相比，具有更高的活性和/或稳定性，能够以极高的立体选择性不对称地制备手性胺类化合物，特别是更高效地催化苯乙酮转化为R-苯乙胺(图1)；或者在高浓度R-苯乙胺存在的情况想下，本发明提供的改进的工程化转氨酶多肽仍然能够不被抑制地催化苯乙酮转化为R-苯乙胺。这些改进的转氨酶多肽可包括在对应以下的残基位置与SEQ ID NO：2序列相比的一个或多个残基差异的氨基酸序列：X3，X4，X9，X18，X19，X31，X36，X40，X41，X47，X50，X53，X54， X56，X59，X60，X61，X62，X72，X78，X86，X98，X101，X113，X114，X115，X116，X122， X123，X124，X125，X126，X127，X128，X129，X130，X141，X143，X148，X153，X155，X156， X159，X162，X167，X173，X174，X175，X181，X182，X186，X187，X188，X190，X191，X194， X199，X209，X214，X219，X226，X235，X240，X243，X244，X252，X253，X262，X266，X271， X272，X273，X275，X278，X281，X287，X291，X302，X307，X312，X323。改进的转氨酶多肽包括包含以下特征至少之一的氨基酸序列：S3T，M4I，S9A，L18H，L18I，E19T，E19A，Y31W， L36F，S40Y，S40T，D41E，L47P，G50A，H53T，H53P，H53A，H53R，H53G，H53N，H53S，H53F， H53L，S54A，L56A，L56V，L56S，D59S，D59T，V60T，I61F，S62R，S62H，S62N，S62A，D72G，I78L，R86C，N98K，A101V，A101H，F113M，F113W，V114G，E115K，E115H，E115Y，E115F， V116I，L122T，T123S，T123I，G124S，V125D，V125N，R126Q，R126N，R126D，R126W，R126G， R126H，G127F，G127K，G127S，G127P，S128R，S128N，K129N，K129Q，P130Q，P130E，P130A， L141Q，L141T，L143S，L143R，V148L，N153D，N153K，L155S，L155I，L155R，H156L，H156I， H156R，E159S，I162V，R167V，A173D，F174S，F174I，D175Y，D175G，L181Y，L181F，Q182M， L186F，T187I，T187N，T187R，K188R，L190M，F191V，M194K，M194L，M194R，M194E，M194N， M194V，M194D，M194I，M194G，T199K，T199Q，T199E，N209H，S214C，S214P，V219I，V219L， I226L，R235E，K240D，K240S，K240Q，I243F，D244E，D252P，I253V，Q262T，Q262A，Q262F， S266A，M271C，C272T，T273S，A275G，I278V，I281V，Q287K，D291G，W302M，E307N，P312A， P312N，G323D；或同时在这些差异的基础上，包含1、2、3、4、5、6、7、8、9、10、11、 12、13、14、15、16、18、20、21、22、23、24、25或更多个氨基酸残基的插入或缺失。
更具体的，在一些实施方案中，在SEQ ID NO：2基础上改进的工程化转氨酶多肽包括对应SEQ ID No：4、6、8、10、12、14、16、18、20、22、24、26、28、30、32、34、36、38、 40、42、44、46、48、50、52、54、56、58、60、62、64、66、68、70、72、74、76、78、 80、82、84、86、88、90、92、94、96、98、100、102、104、106、108、110、112、114、 116、118、120、122、124、126、128、130、132、134、136、138、140、142、144、146、 148、150、152、154、156、158、160、162、164、166、168、170、172、174、176、178、 180、182、184、186、188、190、192、194、196、198、200、202、204、206、208、210、 212、214、216、218、220、222、224、226、228、230、232、234、236、238、240、242、 244、246、248、250、252、254、256、258、260、262、264、266、268、270、272、274、 276、278、280、282、284、286、288、290、292、294、296、298、300、302、304、306、 308、310、312、314、316、318、320、322、324、326、328、330、332、334、336、338、 340、342、344、346、348、350、352、354、356、358、360、362、364、366、368、370、 372、374、376、378、380、382、384、386、388、390、392、394、396、398、400所示氨基酸序列组成的多肽。
在一些实施方案中，改进的工程化转氨酶多肽包括与SEQ ID No：4、6、8、10、12、14、 16、18、20、22、24、26、28、30、32、34、36、38、40、42、44、46、48、50、52、54、 56、58、60、62、64、66、68、70、72、74、76、78、80、82、84、86、88、90、92、94、 96、98、100、102、104、106、108、110、112、114、116、118、120、122、124、126、128、 130、132、134、136、138、140、142、144、146、148、150、152、154、156、158、160、162、164、166、168、170、172、174、176、178、180、182、184、186、188、190、192、 194、196、198、200、202、204、206、208、210、212、214、216、218、220、222、224、 226、228、230、232、234、236、238、240、242、244、246、248、250、252、254、256、 258、260、262、264、266、268、270、272、274、276、278、280、282、284、286、288、 290、292、294、296、298、300、302、304、306、308、310、312、314、316、318、320、 322、324、326、328、330、332、334、336、338、340、342、344、346、348、350、352、 354、356、358、360、362、364、366、368、370、372、374、376、378、380、382、384、 386、388、390、392、394、396、398、400的参考序列至少80％、85％、86％、87％、88％、 89％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更多序列同一性的氨基酸序列。
两条氨基酸序列或两条核苷酸序列之间的同一性均可通过本领域常用的算法得到，可采用NCBI Blastp和Blastn软件根据默认参数计算得到，也可采用采用Clustal W算法(Nucleic Acid Research,22(22):4673-4680,1994)。比如用采用Clustal W算法，SEQID NO：2 与SEQ ID NO：374的氨基酸序列同一性为92.6％。
在另一方面，本发明提供了编码工程化转氨酶多肽的多核苷酸序列。在一些实施方案中，多核苷酸可以是具有用于表达工程化转氨酶多肽的一种或多种控制序列的表达载体的部分。在一些实施方案中，多核苷酸可包括对应SEQ ID No：3、5、7、9、11、13、15、17、19、21、 23、25、27、29、31、33、35、37、39、41、43、45、47、49、51、53、55、57、59、61、 63、65、67、69、71、73、75、77、79、81、83、85、87、89、91、93、95、97、99、101、 103、105、107、109、111、113、115、117、119、121、123、125、127、129、131、133、 135、137、139、141、143、145、147、149、151、153、155、157、159、161、163、165、 167、169、171、173、175、177、179、181、183、185、187、189、191、193、195、197、 199、201、203、205、207、209、211、213、215、217、219、221、223、225、227、229、 231、233、235、237、239、241、243、245、247、249、251、253、255、257、259、261、 263、265、267、269、271、273、275、277、279、281、283、285、287、289、291、293、 295、297、299、301、303、305、307、309、311、313、315、317、319、321、323、325、 327、329、331、333、335、337、339、341、343、345、347、349、351、353、355、357、 359、361、363、365、367、369、371、373、375、377、379、381、383、385、387、389、 391、393、395、397、399所示序列的多核苷酸序列。
如本领域技术人员所知，由于核苷酸密码子的简并性，编码SEQ ID No：4、6、8、10、12、14、16、18、20、22、24、26、28、30、32、34、36、38、40、42、44、46、48、50、 52、54、56、58、60、62、64、66、68、70、72、74、76、78、80、82、84、86、88、90、 92、94、96、98、100、102、104、106、108、110、112、114、116、118、120、122、124、 126、128、130、132、134、136、138、140、142、144、146、148、150、152、154、156、 158、160、162、164、166、168、170、172、174、176、178、180、182、184、186、188、 190、192、194、196、198、200、202、204、206、208、210、212、214、216、218、220、222、224、226、228、230、232、234、236、238、240、242、244、246、248、250、252、 254、256、258、260、262、264、266、268、270、272、274、276、278、280、282、284、 286、288、290、292、294、296、298、300、302、304、306、308、310、312、314、316、 318、320、322、324、326、328、330、332、334、336、338、340、342、344、346、348、 350、352、354、356、358、360、362、364、366、368、370、372、374、376、378、380、 382、384、386、388、390、392、394、396、398、400的氨基酸序列的多核苷酸序列不仅仅局限于SEQ ID No：3、5、7、9、11、13、15、17、19、21、23、25、27、29、31、33、35、37、39、41、43、45、47、49、51、53、55、57、59、61、63、65、67、69、71、73、75、 77、79、81、83、85、87、89、91、93、95、97、99、101、103、105、107、109、111、113、 115、117、119、121、123、125、127、129、131、133、135、137、139、141、143、145、 147、149、151、153、155、157、159、161、163、165、167、169、171、173、175、177、 179、181、183、185、187、189、191、193、195、197、199、201、203、205、207、209、 211、213、215、217、219、221、223、225、227、229、231、233、235、237、239、241、 243、245、247、249、251、253、255、257、259、261、263、265、267、269、271、273、 275、277、279、281、283、285、287、289、291、293、295、297、299、301、303、305、 307、309、311、313、315、317、319、321、323、325、327、329、331、333、335、337、 339、341、343、345、347、349、351、353、355、357、359、361、363、365、367、369、 371、373、375、377、379、381、383、385、387、389、391、393、395、397、399。本发明的转氨酶基因的核酸序列也可以是编码序列表中SEQ IDNo：4、6、8、10、12、14、16、18、 20、22、24、26、28、30、32、34、36、38、40、42、44、46、48、50、52、54、56、58、 60、62、64、66、68、70、72、74、76、78、80、82、84、86、88、90、92、94、96、98、 100、102、104、106、108、110、112、114、116、118、120、122、124、126、128、130、 132、134、136、138、140、142、144、146、148、150、152、154、156、158、160、162、 164、166、168、170、172、174、176、178、180、182、184、186、188、190、192、194、196、198、200、202、204、206、208、210、212、214、216、218、220、222、224、226、 228、230、232、234、236、238、240、242、244、246、248、250、252、254、256、258、 260、262、264、266、268、270、272、274、276、278、280、282、284、286、288、290、292、294、296、298、300、302、304、306、308、310、312、314、316、318、320、322、 324、326、328、330、332、334、336、338、340、342、344、346、348、350、352、354、 356、358、360、362、364、366、368、370、372、374、376、378、380、382、384、386、 388、390、392、394、396、398、400所示氨基酸序列的其他任何核酸序列。
在另一方面，本公开内容提供包含编码工程化转氨酶的多核苷酸或能够表达工程化转氨酶的表达载体和宿主细胞。在一些实施方案中，宿主细胞可以是细菌宿主细胞，比如大肠杆菌。宿主细胞可用于表达和分离本文所述的工程化转氨酶，或可选地直接用于反应转化底物为产物。
在一些实施方案中，以完整细胞、粗提取物、分离的多肽或纯化的多肽形式的工程化转氨酶可单独使用，或以固定化形式(比如固定在树脂上)使用。
本公开内容还提供了使用本文公开的工程化转氨酶多肽将结构式(II)所示的酮底物转化为结构式(I)所示的手性胺化合物的方法：
所述结构式(I)的胺产物在标为*的手性中心具有所示的立体化学构型；所示结构式(I) 的胺产物与相应的对映异构体相比过量，其中
R1是任选地取代的芳基或杂芳基，或是任选地取代的C1-C8烃基，也可以是
R2是任选地取代的C1-C6烃基、卤素(如-F、-Cl、-Br和-I)、-NO2、-NO、-SO2R’或-SOR’、 -S R’、-N R’R’、-O R’、-CO2R’或-COR’、-C(O)NR’、-SO2NH2或-SO NH2、-CN、CF3；
其中每个R’独立地选自-H或(C1-C4)烃基，所述方法包括在适于转化酮底物为胺产物的反应条件下，将结构式(II)的酮底物和氨基供体与转氨酶多肽接触，其中所述转氨酶多肽是本文所述的工程化转氨酶多肽。在一些实施方案中，所述工程化转氨酶多肽与SEQID NO：2具有至少80％、85％、86％、87％、88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更高的序列同一性并能够以与SEQ ID NO：2相比更高的转化率将结构式(II)的酮底物转化为结构式(I)的胺产物。
在一些实施方案中，结构式(I)的胺产物以至少60％、65％、70％、75％、80％、85％、90％、 91％、92％、93％、94％、95％、96％、97％、98％或99％或更大的对映体过量产生。
在该方法的一些实施方案中，结构式(I)的胺产物是：
其中R3是C1-C4烃基、-H、卤素(如-F、-Cl、-Br和-I)、-NO2、-NO、-SO2R’或-SOR’、 -SR’、-N R’R’、-O R’、-CO2R’或-COR’、-C(O)NR’、-SO2NH2或-SO NH2、-CN、CF3，其中每个R’独立地选自-H或(C1-C4)烃基；
R3也可以是R2如上定义，且结构式(II)的酮底物是：
在一些实施方案中，R3在苯基环的对位。在一些实施方案中，R3在苯基环的间位。在一些实施方案中，R3在苯基环的邻位。在一些实施方案中，R3同时在苯基环的对位和间位。在一些实施方案中，R3同时在苯基环的对位和邻位。在一些实施方案中，R3同时在苯基环的间位和邻位。
在该方法的一些实施方案中，结构式(I)的胺产物是：
其中R4是如以上定义的R3，R3和R2如上定义，且结构式(II)的酮底物是：
在一些实施方案中，R3在苯基环的间位。在一些实施方案中，R3在苯基环的邻位。
在一些实施方案中，改进的工程化转氨酶多肽可以用在制备对映体过量的式A2化合物R- 苯乙胺的方法中：
在这些实施方案中，所述方法包括在适于转化式A1化合物为式A2化合物的反应条件下，在适当的有机溶剂中，在氨基供体存在下，将结构式A1化合物苯乙胺：
与本文公开的改进的工程化转氨酶多肽接触的步骤。
在以上方法的一些实施方案中，式(I)化合物或式A2化合物以至少60％，65％，70％，75％， 80％，85％，90％、91％、92％、93％、94％、95％、96％、97％、98％或99％或更大的对映体过量产生。
用于该方法的工程化的转氨酶多肽的具体实施方案在详述中进一步提供。可用在以上方法中的改进的工程化转氨酶多肽可包括选自对应SEQ ID NO：4、6、8、10、12、14、16、18、 20、22、24、26、28、30、32、34、36、38、40、42、44、46、48、50、52、54、56、58、 60、62、64、66、68、70、72、74、76、78、80、82、84、86、88、90、92、94、96、98、 100、102、104、106、108、110、112、114、116、118、120、122、124、126、128、130、 132、134、136、138、140、142、144、146、148、150、152、154、156、158、160、162、 164、166、168、170、172、174、176、178、180、182、184、186、188、190、192、194、196、198、200、202、204、206、208、210、212、214、216、218、220、222、224、226、228、230、232、234、236、238、240、242、244、246、248、250、252、254、256、258、 260、262、264、266、268、270、272、274、276、278、280、282、284、286、288、290、 292、294、296、298、300、302、304、306、308、310、312、314、316、318、320、322、 324、326、328、330、332、334、336、338、340、342、344、346、348、350、352、354、 356、358、360、362、364、366、368、370、372、374、376、378、380、382、384、386、 388、390、392、394、396、398、400的氨基酸序列。
如本文公开的使用工程化多肽用于制备式(I)化合物或式A2化合物的方法中的任一种可在一系列合适的反应条件下被执行，所述一系列合适的反应条件包括但不限于氨基供体、pH、温度、缓冲液、溶剂系统、底物载量、多肽载量、辅因子载量、压力和反应时间的范围。例如，在一些实施方案中，制备式(I)化合物或式A2化合物可被执行，其中合适的反应条件包括：(a)约1g/L至200g/L底物化合物(II)或A1的底物载量；(b)约0.1g/L至50g/L工程化多肽；(c)约10g/L至300g/L的氨基供体载量；(d)约0.1mM至5mM的PLP辅因子浓度；(e)约0％(v/v) 至约60％(v/v)的有机溶剂，这里所述的有机溶剂包括但不限于二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、甲基叔丁基醚(MTBE)、乙酸异丙酯、甲醇、乙醇或丙醇；(f)约7.0至约11.0 的pH；和(g)约10℃至60℃的温度。
2详述
2.1定义
关于本公开内容，除非另外明确定义，否则本文说明书中使用的技术术语和科学术语具有本领域普通技术人员通常理解的含义。
“蛋白”、“多肽”和“肽”在本文可互换使用，表示由酰胺键共价连接的至少两个氨基酸的聚合物，而不论长度或翻译后修饰(如，糖基化、磷酸化、脂质化、豆蔻酰化、泛素化等等)。该定义包括D-氨基酸和L-氨基酸、以及D-氨基酸和L-氨基酸的混合物。
“工程化转氨酶”、“工程化转氨酶多肽”、“改进的转氨酶多肽”和“工程化多肽”在本文可互换使用。
“菌体”或“湿菌体”指表达了多肽或工程化多肽的宿主细胞，包括实施例2和实施例6 所示的制备过程所得到的湿菌体。
“多核苷酸”和“核酸”在本文可互换使用。
如本文使用的“辅因子”指在催化反应中与酶联合起作用的非蛋白化合物。如本文使用的，“辅因子”意图包括维生素B6家族化合物PLP、PN、PL、PM、PNP和PMP，其有时也被称作辅酶。
“磷酸吡哆醛”、“PLP”、“吡哆醛5’-磷酸”、“PYP”和“P5P”在本文可互换地使用，来指在转氨酶反应中用作辅因子的化合物。
“编码序列”指编码蛋白的氨基酸序列的核酸部分(例如，基因)。
“天然存在的”或“野生型”是指在自然界发现的形式。例如，天然存在的或野生型的多肽或多核苷酸序列是存在于生物体中、可分离自自然界中的来源且未通过人工操作有意地修饰的序列。
“重组的”或“工程化的”或“非天然存在的”当用于指例如细胞、核酸或多肽时，是指如下材料或与该材料的天然形式或固有形式相对应的材料：所述材料以自然界中不会存在的方式被改变，或与其相同但是从合成材料和/或通过使用重组技术操作而产生或获取。
“序列同一性”和“同源性”在本文可互换地用于指多核苷酸之间或多肽之间的对比(“序列同一性”和“同源性”通常以百分比的形式来表示)，且通过在比较窗口上比较两个最佳对齐的序列来确定，其中多核苷酸或多肽序列在比较窗口中的部分与参照序列相比可包括添加或缺失(即，空位)，用于两个序列的最佳对齐。百分比可以通过如下计算：确定两个序列中出现相同的核酸碱基或氨基酸残基的位置数目以产生匹配位置的数目，将匹配位置的数目除以比较窗口中位置总数并将结果乘以100以得到序列同一性百分比。可选地，该百分比可通过以下计算：确定相同核酸碱基或氨基酸残基在两个序列中都存在的位置数或核酸碱基或氨基酸残基与空位对齐的位置数以得到匹配位置数，将该匹配位置数除以比较窗口中的位置总数，并将结果乘以100以得到序列同一性的百分比。本领域技术人员将认识到，存在许多可用于比对两个序列的建立的算法。用于比较的序列最佳比对可例如通过Smith和Waterman， 1981，Adv.Appl.Math.2:482的局部同源性算法、通过Needleman和Wunsch，1970， J.Mol.Biol.48:443的同源性比对算法，通过Pearson和Lipman,1988,Proc.Natl.Acad.Sci.USA85:2444的相似性搜索方法，通过这些算法的计算机实现(GCGWisconsin 软件包中的GAP、BESTFIT、FASTA或TFASTA)或通过直观检查(一般参见，Current Protocols in Molecular Biology,F.M.Ausubel等编著，Current Protocols,Greene Publishing Associates Inc.和John Wiley&Sons,Inc.之间的合资企业,(1995年增刊)(Ausubel))。适宜于确定序列同一性和序列相似性百分比的算法的实例是BLAST和BLAST2.0算法，它们分别描述于Altschul等人，1990，J.Mol.Biol.215:403-410和Altschul等,1977,Nucleic Acids Res.3389-3402中。用于执行BLAST分析的软件是通过美国国家生物技术信息中心(National Center for Biotechnology Information)网站公开可用的。该算法包括首先通过鉴定查询序列中长度W的短字来鉴定高评分序列对(HSP)，所述短字与数据库序列中相同长度的字比对时匹配或满足一些正值的阀值得分T。T被称作邻近字评分阈值(Altschul等，如上述)。这些初始相邻字匹配(word hit)充当用于启始搜索的种子来寻找包含它们的更长的HSP。然后字匹配沿着每个序列在两个方向延伸到累积比对得分不能够增加的程度。对于核苷酸序列，累积得分使用参数M(对于匹配残基对的奖励得分；永远＞0)和N(对于错配残基的惩罚得分；永远＜0)计算。对于氨基酸序列，得分矩阵被用于计算累计得分。当以下情况时，每个方向中的字匹配字串的延伸被终止：累积比对得分从其最大达到值下降了量X；由于累积一个或多个负得分残基比对，累积得分达到0或以下；或到达任一序列末端。BLAST算法参数W、T和X决定比对的灵敏度和速度。BLASTN程序(用于核苷酸序列)使用字长(W)11、期望值(E)10、M＝5、 N＝-4以及两链的比较作为默认值。对于氨基酸序列，BLASTP程序使用以下作为缺省值：字长 (W)为3，期望值(E)为10和BLOSUM62得分矩阵(见Henikoff和Henikoff,1989,Proc Natl Acad Sci USA89：10915)。序列比对和序列同一性％的示例性确定可使用GCG Wisconsin软件包 (Accelrys,Madison WI)中的BESTFIT或GAP程序，使用所提供的缺省参数。
“参考序列”是指用作序列比较的基础的限定序列。参考序列可以是较大序列的子集，例如，全长基因或多肽序列的片段。一般而言，参考序列为至少20个核苷酸或氨基酸残基长，至少25个残基长，至少50个残基长，或者核酸或多肽的全长。因为两种多核苷酸或多肽可以各自(1)包括在两种序列之间相似的序列(即，完整序列的一部分)，且(2)可以进一步包括在两种序列之间不同的序列，两种(或更多)多核苷酸或多肽之间的序列比较通常通过在“比较窗口”内比较两种多核苷酸或多肽的序列来进行以鉴定和比较序列相似性的局部区域。在一些实施方案中，“参照序列”不意为限于野生型序列，且可包括工程化或改变的序列。例如，“在对应于X40的残基处具有苏氨酸的基于SEQ ID NO:2的参考序列”指其中在SEQ ID NO:2 中的X40处相应的残基(是丝氨酸)已经改变成苏氨酸的参考序列。
“比较窗口”指至少约20个相邻核苷酸位置或者氨基酸残基的概念性片段，其中序列可以与至少20个相邻核苷酸或氨基酸的参考序列相比较，并且其中比较窗口中的序列的部分可以包括与参考序列(其不包括添加或缺失)相比20％或更少的添加或缺失(即，空位)，用于两序列的最佳比对。比较窗口可以长于20个相邻残基，并且包括任选地30、40、50、100或更长的窗口。
在用于指定的氨基酸或多核苷酸序列的编号的情况下，"相应于"、"参考于"或"相对于" 指当指定的氨基酸或多核苷酸序列与参考序列相比较时指定的参考序列残基的编号。换言之，给定序列的残基编号或残基位置是根据参考序列指定的，而不是给定氨基酸或多核苷酸序列内的残基的实际数字位置指定的。例如，可以将给定的氨基酸序列诸如工程化转氨酶的氨基酸序列与参考序列进行比对，这是通过引入空位以优化这两条序列之间的残基匹配而实现的。在这些情况下，虽然存在空位，但是给定氨基酸或多核苷酸序列中的残基编号相对于已与其比对的参考序列制定。
“氨基酸差异”或“残基差异”指在多肽序列的一个位置处氨基酸残基相对于参考序列中相应位置处的氨基酸残基的差异。本文中氨基酸差异的位置一般被称为“Xn”，其中n指残基差异基于其的参考序列中的相应位置。例如，“与SEQ ID NO:2相比在位置X40处的残基差异”指在相应于SEQ ID NO:2的位置40的多肽位置处的氨基酸残基的差异。因此，如果SEQ ID NO:2的参考多肽在位置40处具有丝氨酸，那么“与SEQ ID NO:2相比在位置X40处的残基差异”是指在相应于SEQ ID NO:2的位置40的多肽位置处除了丝氨酸之外的任何残基的氨基酸取代。在本文的大多数实例中，在一个位置处的特定氨基酸残基差异表示为“XnY”，其中“Xn”指如以上描述的对应位置，并且“Y”为在工程化多肽中发现的氨基酸的一字母标识符(即，与参考多肽中的不同的残基)。在一些实例中(例如，在表1中)，本公开内容还提供由常规符号“AnB”表示的特定氨基酸差异，其中A为参考序列中的残基的一字母标识符，“n”为在参考序列中的残基位置的编号，并且B为工程化多肽的序列中残基取代的单字母标识符。在一些实例中，本公开内容的多肽可包含相对于参考序列的一个或更多个氨基酸残基差异，其通过相对于参考序列存在残基差异处的特定位置的列表表示。在一些实施方案中，当多于一个氨基酸可被用于多肽的特定残基位置时，可使用的多个氨基酸残基通过“/”分隔开(例如，X40T/ X39Y)。
“缺失”指通过从参考多肽去除一个或更多个氨基酸而对多肽的修饰。缺失可以包括除去1个或多个、2个或多个氨基酸，5个或多个氨基酸，10个或多个氨基酸，15个或多个氨基酸，或20个或多个氨基酸，多达组成参照酶的氨基酸总数的10％，或多达组成参照酶的氨基酸总数的20％，同时保留工程化转氨酶的酶活性和/或保留工程化转氨酶的改进的性质。缺失可以涉及多肽的内部部分和/或末端部分。在各种实施方案中，缺失可以包括连续的区段或者可以是不连续的。
"插入"指通过从参考多肽添加一个或多个氨基酸的多肽的修饰。在一些实施方案中，改进的工程化转氨酶包括一个或更多个氨基酸插入天然存在的转氨酶多肽，以及一个或更多个氨基酸插入其他改进的转氨酶多肽。可在多肽的内部部分插入，或插入到羧基或氨基末端。如本文所用的，插入包括本领域中已知的融合蛋白。插入可以是氨基酸的连续区段，或者被在天然存在的多肽中一个或更多个氨基酸分隔。
如本文所用的"片段"指具有氨基末端和/或羧基末端缺失、但是其中保留的氨基酸序列与序列中相应的位置相同的多肽。片段可以为至少10个氨基酸长、至少20个氨基酸长，至少50 个氨基酸长或更长，以及高达全长转氨酶多肽的70％、80％、90％、95％、98％和99％。
“分离的多肽”是指如下多肽：所述多肽基本上与其天然伴随的其他物质例如蛋白、脂质和多核苷酸分离。该术语包括已从其天然存在的环境或表达系统(例如，宿主细胞或体外合成中)移去或纯化的多肽。改进的转氨酶多肽可以存在于细胞内、存在于细胞培养基中或者以各种形式制备，诸如裂解物或分离的制备物。像这样，在一些实施方案中，改进的转氨酶多肽可以是分离的多肽。
“手性中心”是指连接四个不同基团的碳原子。
“立体选择性”(stereoselectivity)指在化学或酶促反应中一种立体异构体相对于另一种或多种异构体的优先形成。立体选择性可以是部分的，其中一种立体异构体的形成优于另一种异构体；或可以是完全的，其中仅形成一种立体异构体。当立体异构体是对映异构体时(enantiomers)，立体选择性被称为对映异构体选择性(enantioselectivity)，一种对映异构体在两种对映异构体的混合物之中的过量分数(通常被报告为百分比)通常被可选地报告为“对映异构体过量”(enantiomeric excess，简称为ee)。当立体异构体是非对映异构体时(diastereoisomers)，立体选择性被称为非对映异构体选择性(diastereoselectivity)，即一种非对映异构体在两种非对映异构体的混合物之中的过量分数(通常被报告为百分比)，通常被可选地报告为“非对映异构体过量”(diastereoisomeric excess，简称为de)。在本领域内该分数(典型地为百分比)通常可选择地报道为根据下式从中计算的对映异构体过量 (enantiomeric excess，即ee)：[主要对映异构体浓度–次要对映异构体浓度]/[主要对映异构体浓度+次要对映异构体浓度]。
“立体异构体”、“立体异构形式”和类似表述在本文可互换使用，是指分子差异仅在其原子在空间中的方位不同所造成的所有异构体。其包括对映异构体和具有多于一个手性中心、且彼此不是镜像的化合物的异构体(即“非对映异构体”)。
“改进的酶性质”指与参考转氨酶相比显示任何酶性质的改进的转氨酶多肽，所述参考转氨酶诸如野生型转氨酶或另一种改进的工程化转氨酶。期望改进的酶性质包括，但不限于，酶活性(其可以底物的转化百分比的方式被表示)、热稳定性、溶剂稳定性、pH活性特征、辅因子需求、对抑制物的耐受性(例如，底物或产物抑制)、立体特异性和立体选择性。
“转化”指底物向相应的产物的酶转化。“转化百分比”或“转化率”是指在指定条件下在一段时间内被转化为产物的底物的百分比。因此，转氨酶多肽的“酶活性”或“活性”可以被表示为底物向产物的“转化百分比”。
“热稳定的”指与野生型酶相比转氨酶多肽在暴露于升高的温度(例如30-60℃)持续一段时间(例如0.5-24小时)之后维持相似活性(例如多于50％)。
“溶剂稳定的”指与野生型酶相比转氨酶多肽在暴露于不同浓度(例如5-99％)的溶剂 (乙醇、异丙醇、二甲基亚砜(DMSO)、四氢呋喃、2-甲基四氢呋喃、丙酮、甲苯、乙酸丁酯、甲基叔丁基醚等)持续一段时间(例如0.5-24小时)之后维持相似的活性(多于例如50％至 80％)。
“合适的反应条件”指生物催化反应溶液中的那些条件(例如，酶载量、底物载量、辅因子载量、温度、pH、缓冲液、共溶剂等的范围)，在该条件下本公开内容的转氨酶多肽能将底物转化成期望的产物化合物。示例性“合适的反应条件”被提供于本公开内容并通过实施例例证。
“氨基供体”是指能够被转氨酶接受的、可以供应氨基的化合物，典型的氨基供体包括丙氨酸等氨基酸，或异丙胺等胺类化合物。
“烃基”是指直链或支链的烃基团。符号“C”后出现下标的数字规定了特定基团可包含的碳原子数。例如，“C1-C8”是指具有1至8个碳原子的直链或支链烃基基团。烃基基团可任选第被一个或多个取代基基团取代。“芳基”是指6至约20个碳原子的单价芳香族烃基。“杂芳基”和“杂芳族”是指其中母体芳环系统的一个或多个碳原子被杂原子(O，N或S)代替的芳基基团。“取代的”当用于修饰指定基团或自由基时，是指指定基团或自由基的一个或多个氢原子各自彼此独立地本文所用的“化合物”是指伴随本文公开的化合物标明的结构式和/ 或化学名涵盖的任何化合物。化合物可以其化学结构和/或化学名标明。当化学结构与化学名冲突时，化学结构决定化合物的身份。除非另外具体地描述或指出，否则本文描述的化学结构涵盖所描述化合物的所有可能异构体形式。
被相同或不同的取代基代替。“取代的烃基、芳基或杂芳基”指其中一个或多个氢原子用另一取代基代替的烃基、芳基或杂芳基基团。“任选”或“任选地”是指所描述的事件或情况可能发生或不发生；例如“任选地取代的芳基”是指可能被取代或可能未被取代的芳基基团，这一描述包括取代的芳基基团和未取代的芳基基团二者。
2.2改进的工程化转氨酶
以下表1举例说明本发明所开发的工程化转氨酶多肽。每一行给出一个具体的工程化转氨酶多肽的核苷酸序列编号和氨基酸序列编号，以及与SEQ ID No:2相比较的残基差异。每个举例的工程化转氨酶多肽的催化性能(在反应中的整体表现，综合了活性、稳定性、选择性以及克服产物抑制的性能)以“+”表示，具体的含义见表2。
表1
表2
表1所列的氨基酸序列(即SEQ ID NO:2-396的偶数序列标识符)都含有323个氨基酸残基。SEQ ID NO:398和SEQ ID NO:400所示氨基酸序列，与SEQ ID No:2相比较有不同数目的氨基酸残基的缺失和置换，SEQ ID NO:398和SEQ ID NO:400所示工程化转氨酶多肽在表2 (+++++)所示的反应条件下，表现出比SEQ ID No:2的转化率高至少500倍的催化性能。表2 所述酶粉，含有等量的工程化转氨酶多肽。
2.3可用于制备工程化转氨酶多肽的多核苷酸、控制序列、表达载体和宿主细胞
在另一方面，本公开内容提供了编码本文描述的具有转氨酶活性的工程化多肽的多核苷酸。多核苷酸可与控制基因表达的一种或多种异源调控序列可操作地连接以产生能够表达多肽的重组多核苷酸。包含编码工程化的转氨酶的异源多核苷酸的表达构建体可被引入合适的宿主细胞以表达相应的工程化转氨酶多肽。
如对本领域技术人员明显的是，蛋白序列的可得性和相应于多种氨基酸的密码子的知识提供能够编码目标蛋白序列的所有多核苷酸的说明。其中相同氨基酸由可选择的或同义密码子编码的遗传密码的简并性允许产生极大数目的核酸，所有这些核酸编码本文公开的改进的转氨酶多肽。因此，确定特定的氨基酸序列后，本领域的技术人员可以以不改变蛋白质的氨基酸序列的方式通过仅仅修饰一个或多个密码子的序列来产生任何数目的不同的核酸。在这点上，本公开内容特别地构思了可通过基于可能的密码子选取而选择组合来制备的多核苷酸的各个和每个可能的改变，并且对于本文公开的任何多肽，包括在表1中提供的示例性工程化多肽的氨基酸序列，以及在通过引用并入本文的序列表中作为SEQ IDNO:4-400的偶数序列标识符的序列公开的任何多肽，所有这些改变被认为特别地公开。
在多种实施方案中，密码子被优选地选择以适应在其中产生蛋白的宿主细胞。例如，用于细菌的优选密码子用于表达细菌中的基因；用于酵母中的优选密码子用于在酵母中表达；且用于哺乳动物的优选密码子用于在哺乳动物细胞中表达。
在一些实施方案中，所述多核苷酸编码包含与选自SEQ ID NO:4-400的偶数序列标识符的参考序列至少约80％、85％、86％、87％、88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更多序列同一性的氨基酸序列的转氨酶多肽，其中所述多肽具有转氨酶活性以及本文描述的改进的特性中的一种或更多种，例如以与SEQ ID NO:2的多肽相比增加的活性将化合物A1转化成产物化合物A2的能力。
在一些实施方案中，所述多核苷酸编码工程化转氨酶多肽，所述工程化转氨酶多肽包含与SEQ ID NO:2相比具有以上描述的同一性百分比并且具有选自的一个或更多个氨基酸残基差异的氨基酸序列。在一些实施方案中，本公开内容提供了具有转氨酶活性的工程化多肽，所述工程化多肽包含与SEQ ID NO:2的参考序列具有至少80％的序列同一性以及具有选自以下位置的残基差异的组合：X3，X4，X9，X18，X19，X31，X36，X40，X41，X47，X50，X53，X54， X56，X59，X60，X61，X62，X72，X78，X86，X98，X101，X113，X114，X115，X116，X122，X123，X124，X125，X126，X127，X128，X129，X130，X141，X143，X148，X153，X155，X156， X159，X162，X167，X173，X174，X175，X181，X182，X186，X187，X188，X190，X191，X194， X199，X209，X214，X219，X226，X235，X240，X243，X244，X252，X253，X262，X266，X271， X272，X273，X275，X278，X281，X287，X291，X302，X307，X312，X323。
在一些实施方案中，编码工程化转氨酶多肽的多核苷酸包含选自SEQ ID NO:3-399的奇数序列标识符的序列。
在一些实施方案中，所述多核苷酸编码本文所述的多肽，但是在核苷酸水平上与编码工程化转氨酶的参考多核苷酸具有约50％、55％、60％、65％、70％、75％、80％、85％、86％、 87％、88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％或99％或更高的序列同一性。在一些实施方案中，参考多核苷酸序列选自具有SEQ ID NO:3-399的奇数序列标识符的序列。
编码工程化转氨酶多肽的分离的多核苷酸可以多种方法被操作以提供多肽的表达，所述方法包括通过密码子优化来进一步改变序列以改进表达、在合适的有或无另外的控制序列的表达元件中插入、和转化入适于表达并产生多肽的宿主细胞。
取决于表达载体，在分离的多核苷酸插入载体之前对分离的多核苷酸的操作可以是期望的或必需的。利用重组DNA方法修饰多核苷酸和核酸序列的技术在本领域中是公知的。在以下中提供了指导：Sambrook等人,2001,MolecuLar Cloning:A LaboratoryManual,第三版,Cold Spring Harbor Laboratory Press；和Current Protocols inMolecuLar Biology,Ausubel.F. 编著,GreenePub.Associates,1998,2010年更新。
在另一个方面，本公开还涉及重组表达载体，根据它们将被导入的宿主的类型，其包括编码工程化转氨酶多肽或其变体的多核苷酸，和一个或多个表达调节区，诸如启动子和终止子、复制起点等等。可选地，本公开内容的核酸序列可以通过使核酸序列或包括该序列的核酸构建体插入到适当的表达载体中来表达。在产生表达载体时，编码序列位于载体中以使编码序列被可操作地连接于用于表达的合适的控制序列上。
重组表达载体可为任何载体(例如，质粒或病毒)，其可方便地应用于重组DNA步骤中并且可带来多核苷酸序列的表达。载体的选择通常将取决于载体与待引入载体的宿主细胞的相容性。载体可以是线性或闭合环状的质粒。表达载体可以是自主复制的载体，即作为染色体外的实体而存在的载体，它的复制独立于染色体的复制，如质粒、染色体外的元件、微小染色体、或人工染色体。载体可以包含用于保证自我复制的任何工具。可选地，载体可以是在被引入到宿主细胞中时整合到基因组中并且与其所整合到的染色体一起复制的载体。而且，可以使用单一载体或质粒或者一起包含待引入到宿主细胞基因组中的总DNA的两种或多种载体或质粒。
对本公开内容的实施方案有用的很多表达载体是商业上可得的。示例性表达载体可通过将编码改进的转氨酶多肽的多核苷酸可操作地连接到质粒pACYC-Duet-1(Novagen)中来制备。
在另一方面，本公开内容提供包含编码本公开内容的改进的转氨酶多肽的多核苷酸的宿主细胞，所述多核苷酸被可操作地连接至在宿主细胞中用于转氨酶的表达的一个或更多个控制序列。用于表达由本公开内容的表达载体编码的多肽的宿主细胞在本领域是公知的，并且包括但不局限于诸如大肠杆菌、节杆菌属种KNK168、链霉菌属和鼠伤寒沙门氏菌(Salmonella typhimurium)细胞的细菌细胞；诸如酵母细胞(例如，酿酒酵母或巴斯德毕赤氏酵母(Pichia pastoris))的真菌细胞；诸如果蝇S2以及灰翅夜蛾(Spodoptera)Sf9细胞的昆虫细胞；诸如 CHO、COS、BHK、293和Bowes黑色素瘤细胞的动物细胞；以及植物细胞。示例性的宿主细胞为大肠杆菌BL21(DE3)。上述宿主细胞可以是野生型的，也可以是经过基因组编辑的工程细胞，比如把宿主细胞基因组中所携带的野生型的转氨酶基因敲除。上述宿主细胞的合适的培养基以及生长条件在本领域内是公知的。
用于表达转氨酶的多核苷酸可通过本领域已知的多种方法被引入至细胞。技术包括，除了其他以外，电穿孔、生物颗粒轰击法、脂质体介导的转染、氯化钙转染和原生质体融合。将多核苷酸引入细胞的不同方法对于本领域技术人员是明显的。
2.4产生工程化转氨酶多肽的方法
通过将编码转氨酶的多核苷酸经历诱变和/或定向进化方法，可以获得工程化转氨酶。示例性的定向进化技术可见《Biocatalysis for the Pharmaceutical Industry:Discovery, Development,and Manufacturing》(2009John Wiley&Sons Asia(Pte)Ltd.ISBN: 978-0-470-82314-9)。
当工程化多肽的序列为已知时，编码酶的多核苷酸可根据已知的合成方法通过标准的固相方法制备。在一些实施方案中，多达约100个碱基的片段可单独地合成，然后连接(例如，通过酶促或化学的连接方法或聚合酶介导的方法)以形成任何需要的连续序列。例如，本公开内容的多核苷酸和寡核苷酸可通过化学合成制备，使用，例如，描述于Beaucage等人,1981, TetLett22：1859-69的经典的亚磷酰胺方法，或描述于Matthes等人,1984,EMBOJ.3:801-05 的方法，例如，如在自动化合成方法中典型地实践的。根据亚磷酰胺方法，寡核苷酸在例如，在自动化DNA合成仪中合成、纯化、退火、连接以及克隆至合适的载体中。另外，基本上任何核酸可从多种商业来源的任一个获得。
在一些实施方案中，本公开内容还提供了用于制备或制作工程化转氨酶多肽的方法，其中该方法包括在适于表达多肽的培养条件下培养能够表达编码工程化多肽的多核苷酸的宿主细胞。在一些实施方案中，制备多肽的方法还包括分离多肽。工程化多肽可在合适的细胞中表达，并利用所熟知的用于蛋白纯化的技术中的任何一种或更多种从宿主细胞和/或培养基分离(或回收)，所述用于蛋白纯化的技术包括，除了其他以外，溶菌酶处理、超声、过滤、盐析、超速离心和色谱。
2.5利用工程化转氨酶的方法以及用其制备的化合物
在另一方面，本文所述的改进的工程化转氨酶多肽，在氨基供体存在下，可将前手性的受体酮化合物转化为手性胺化合物。本公开内容还提供了使用本文公开的工程化转氨酶多肽制备广泛范围的化合物(I)或其结构类似物的方法。在一些实施方案中，工程化转氨酶多肽可用在制备结构式(I)的化合物的方法中：
所述结构式(I)的胺产物在标为*的手性中心具有所示的立体化学构型；所示结构式(I) 的胺产物与相应的对映异构体相比过量，其中
R1是任选地取代的芳基或杂芳基，或是任选地取代的C1-C8烃基；，也可以是
R2是任选地取代的C1-C6烃基、卤素(如-F、-Cl、-Br和-I)、-NO2、-NO、-SO2R’或-SOR’、 -S R’、-N R’R’、-O R’、-CO2R’或-COR’、-C(O)NR’、-SO2NH2或-SO NH2、-CN、CF3；
其中每个R’独立地选自-H或(C1-C4)烃基，所述方法包括在适于转化酮底物为胺产物的反应条件下，将结构式(II)的酮底物：
和氨基供体与转氨酶多肽接触，其中所述转氨酶多肽是本文所述的工程化转氨酶多肽。在一些实施方案中，所述工程化转氨酶多肽与SEQ ID NO：2具有至少80％、85％、86％、87％、 88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更高的序列同一性并能够以与SEQ ID NO：2相比更高的转化率将结构式(II)所示的化合物转化为结构式(I)所示的化合物。
在一些实施方案中，结构式(I)的手性胺产物以至少60％、65％、70％、75％、80％、85％、 90％、91％、92％、93％、94％、95％、96％、97％、98％或99％或更大的对映体过量产生。
如上所述，可用于本公开内容的方法中的转氨酶多肽可按照其转化苯乙酮为R-苯乙胺的能力来表征。因此，在本文公开的方法的任何实施方案中，可进行该方法，其中转氨酶多肽能够以与SEQ ID NO：2相比更高的催化性能将苯乙酮转化为R-苯乙胺，并与SEQ IDNO：2具有至少80％、85％、86％、87％、88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更大的氨基酸序列同一性。
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R3是C1-C4烃基、-H、卤素(如-F、-Cl、-Br和-I)、-NO2、-NO、-SO2R’或-SOR’、 -SR’、-N R’R’、-O R’、-CO2R’或-COR’、-C(O)NR’、-SO2NH2或-SO NH2、-CN、CF3，其中每个R’独立地选自-H或(C1-C4)烃基；
R3也可以是R2如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R4是如以上定义的R3，R3和R2如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R3如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R3如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R3如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R3如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R3如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R3如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R2和R3如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
其中R2如上定义，且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在该方法的一些实施方案中，结构式(I)的手性胺产物是：
且结构式(II)的酮底物是：
在一些实施方案中，在上述方法中产生的结构式(I)的胺产物以至少70％、75％、80％、 85％、90％、91％、92％、93％、94％、95％、96％、97％、98％或99％或更大的对映体过量产生。
在一些实施方案中，改进的工程化转氨酶多肽可以用在制备对映体过量的式A2化合物R- 苯乙胺的方法中：
在这些实施方案中，所述方法包括在合适的反应条件下，在氨基供体存在下，将结构式 A1所示化合物：
与本文公开的改进的工程化转氨酶多肽接触的步骤。
在以上方法的一些实施方案中，式(I)化合物或式A2化合物以至少70％，75％，80％，85％，90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更大对映体过量产生。
用于该方法的工程化的转氨酶多肽的具体实施方案在详述中进一步提供。可用在以上方法中的改进的工程化转氨酶多肽可包括选自对应SEQ ID NO：4、6、8、10、12、14、16、18、 20、22、24、26、28、30、32、34、36、38、40、42、44、46、48、50、52、54、56、58、60、62、64、66、68、70、72、74、76、78、80、82、84、86、88、90、92、94、96、98、 100、102、104、106、108、110、112、114、116、118、120、122、124、126、128、130、 132、134、136、138、140、142、144、146、148、150、152、154、156、158、160、162、 164、166、168、170、172、174、176、178、180、182、184、186、188、190、192、194、196、198、200、202、204、206、208、210、212、214、216、218、220、222、224、226、228、230、232、234、236、238、240、242、244、246、248、250、252、254、256、258、 260、262、264、266、268、270、272、274、276、278、280、282、284、286、288、290、 292、294、296、298、300、302、304、306、308、310、312、314、316、318、320、322、 324、326、328、330、332、334、336、338、340、342、344、346、348、350、352、354、 356、358、360、362、364、366、368、370、372、374、376、378、380、382、384、386、 388、390、392、394、396、398、400的氨基酸序列。
如本文描述并在实施例中例证的，本公开内容构思了可在本文的方法中使用的合适的反应条件的范围，包括但不限于pH、温度、缓冲液、溶剂系统、底物载量、多肽载量和反应时间的范围。用于执行使用本文描述的工程化的转氨酶多肽将底物化合物生物催化地转化成产物化合物的方法的另外的合适的反应条件可容易地通过常规实验优化，所述常规实验包括但不限于在浓度、pH、温度、溶剂条件的实验反应条件下使工程化转氨酶多肽与底物化合物接触，并检测产物化合物，例如，利用在本文提供的实施例中描述的方法。
如以上描述的，用于本公开内容的方法的具有转氨酶活性的工程化多肽通常包含与选自 SEQ ID NO:4-400的偶数序列的任一个的参考氨基酸序列具有至少80％、85％、86％、87％、 88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％或99％序列同一性的氨基酸序列。
考虑到例如期望的产物化合物的量、底物浓度对酶活性的影响、反应条件下酶的稳定性、和底物到产物的转化百分比，反应混合物中的底物化合物可以变化。在所述方法的一些实施方案中，合适的反应条件包括至少约0.5g/L、至少约1g/L、至少约5g/L、至少约10g/L、至少约15g/L、至少约20g/L、至少约30g/L、至少约50g/L、至少约75g/L、至少约100g/L、至少约150g/L、至少约200g/L、至少约250g/L、至少约300g/L、至少约350g/L、至少约400g/L或甚至更大的底物(II)或底物A1的载量。虽然本文提供的底物载量的值是基于化合物(II)或 A1的分子量，但是还预期，也可在方法中使用相等的摩尔量的化合物(II)或A1的多种水合物和盐。
在本文描述的方法中，工程化转氨酶多肽催化酮底物与氨基供体形成手性胺产物。在一些实施方案中，反应条件中的氨基供体包括选自丙氨酸、异丙胺(也称为2-氨基丙烷)、苯丙氨酸、谷氨酰胺、亮氨酸或3-氨基丁酸等任何合适的氨基酸，或包括选自甲基苄胺等任何合适的手性胺或非手性胺；所述氨基供体也可以以盐的形式(比如丙氨酸盐酸盐、丙氨酸醋酸盐、异丙胺盐酸盐、异丙胺醋酸盐等)应用于实施方案中。在一些实施方案中，氨基供体是异丙胺。在一些实施方案中，合适的反应条件包括以至少约1倍于底物(II)摩尔载量的载量存在的氨基供体，特别是异丙胺。在一些实施方案中，异丙胺以0.1M至约4.0M的载量存在。
如图1或图2所示，转氨酶催化反应是可逆的，在一些实施方案中，本发明所公开的工程化转氨酶多肽也可以将式(I)或式A2的手性胺化合物分别转化为化合物(II)或A1。
在反应的实施方案中，反应条件可包括合适的pH。如以上所述，期望的pH或期望的pH范围可通过使用酸或碱、合适的缓冲剂、或缓冲和添加酸或碱的组合来保持。反应混合物的pH 可在反应过程之前和/或期间控制。在一些实施方案中，合适的反应条件包括约7至约11的溶液pH。在一些实施方案中，反应条件包括约7、7.5、8、8.5、9、9.5、10、10.5或11的溶液pH。
在本文的方法的实施方案中，例如考虑到在较高的温度下在反应速率上的增加、对于足够久的反应持续时间的酶的活性，合适的温度可被用于反应条件。相应地，在一些实施方案中，合适的反应条件包括约10℃至约60℃、约25℃至约50℃、约25℃至约40℃、或约25℃至约30℃的温度。在一些实施方案中，合适的反应温度包括约25℃、30℃、35℃、40℃、45℃、 50℃、55℃或60℃的温度。在一些实施方案中，酶促反应期间的温度可以贯穿反应过程保持在一定温度。在一些实施方案中，酶促反应期间的温度可以在反应过程期间调整为温度曲线。
使用工程化转氨酶的方法通常在水或溶剂中进行。合适的溶剂包括水性缓冲溶液、有机溶剂和/或共溶剂系统，共溶剂系统通常包括水性溶剂和有机溶剂。水性溶液(水或水性共溶剂系统)可为pH-缓冲的或非缓冲的。在一些实施方案中，使用工程化转氨酶多肽的方法通常地于包含以下的水性共溶剂系统中进行：有机溶剂(例如，甲醇、乙醇、丙醇、异丙醇(IPA))、二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、乙酸异丙酯、乙酸乙酯、乙酸丁酯、1-辛醇、庚烷、辛烷、甲基叔-丁基醚(MTBE)、甲苯等)、离子液体(例如，四氟硼酸1-乙基4-甲基咪唑、四氟硼酸1-丁基-3-甲基咪唑、六氟磷酸1-丁基-3-甲基咪唑等)。水性共溶剂系统中的有机溶剂组分可与水性组分混溶，提供单一的液相，或可与水性组分部分混溶或不混溶，提供双液相。转氨反应过程中产生的二氧化碳有可能造成泡沫的形成，可以适当添加消泡剂。示例性的水性共溶剂系统包含水和一种或多种有机溶剂。通常，选择水性共溶剂系统的有机溶剂组分以便其不会完全使转氨酶失活。通过用候选溶剂系统中的感兴趣的确定的底物并利用诸如本文描述的酶活性测定而测量特定的工程化的转氨酶的酶活性，合适的共溶剂系统可被容易地鉴定。在方法的一些实施方案中，合适的反应条件包括水性共溶剂，所述水性共溶剂包含约1％至约100％(v/v)、约1％至约60％(v/v)、约2％至约60％(v/v)、约5％至约60％ (v/v)、约10％至约60％(v/v)、约10％至约50％(v/v)或约10％至约40％(v/v)的浓度的DMSO。在方法的一些实施方案中，合适的反应条件包括含有至少约1％、5％、10％、15％、20％、 25％、30％、35％、40％、45％、50％、55％或60％(v/v)的浓度的DMSO的水性共溶剂。
合适的反应条件可包括提供将底物化合物生物催化转化成其相应的产物化合物的反应参数的组合。相应地，在方法的一些实施方案中，反应参数的组合包括：(a)约10g/L至200g/L 底物A1的载量；(b)约1g/L至50g/L的工程化多肽浓度；(c)约7.0至11.0的pH；和(d)约10℃至60℃的温度。
在一些实施方案中，上述方法包括，在约1M至约2M的异丙胺存在下，在约10％至约40％的DMSO、约30℃至约50℃的温度和pH7.0至10.0的反应条件下，将≥10g/L的酮底物与≥5g/L的本文所述工程化转氨酶多肽接触，在24小时内至少70％、80％、90％或更多的酮底物被转化为手性胺产物，且手性胺产物以至少60％，65％，70％，75％，80％，85％，90％、91％、92％、93％、 94％、95％、96％、97％、98％、99％或更大对映体过量产生。在一些实施方案中，能够进行商务反应的转氨酶多肽包括对应SEQ ID NO：4、6、8、10、12、14、16、18、20、22、24、 26、28、30、32、34、36、38、40、42、44、46、48、50、52、54、56、58、60、62、64、 66、68、70、72、74、76、78、80、82、84、86、88、90、92、94、96、98、100、102、104、 106、108、110、112、114、116、118、120、122、124、126、128、130、132、134、136、 138、140、142、144、146、148、150、152、154、156、158、160、162、164、166、168、 170、172、174、176、178、180、182、184、186、188、190、192、194、196、198、200、 202、204、206、208、210、212、214、216、218、220、222、224、226、228、230、232、 234、236、238、240、242、244、246、248、250、252、254、256、258、260、262、264、266、268、270、272、274、276、278、280、282、284、286、288、290、292、294、296、 298、300、302、304、306、308、310、312、314、316、318、320、322、324、326、328、 330、332、334、336、338、340、342、344、346、348、350、352、354、356、358、360、 362、364、366、368、370、372、374、376、378、380、382、384、386、388、390、392、 394、396、398、400的氨基酸序列。
示例性反应条件包括在表2以及实施例7中提供的测定条件。
在进行本文描述的转氨反应时，工程化的转氨酶多肽可以部分地纯化的或纯化的酶、用编码酶的基因转化的完整细胞、和/或此类细胞的细胞提取物和/或裂解物的形式加入至反应混合物中。用编码工程化的转氨酶的基因转化的完整细胞，或其细胞提取物、其裂解物，以及分离的酶可以多种不同的形式使用，包括固体(例如，冻干的、喷雾干燥的等)或半固体(例如，湿菌体等粗糊状物)。细胞提取物或细胞裂解物可通过沉淀(例如，硫酸铵、聚乙烯亚胺、热处理或类似处理)部分纯化，之后在冻干前进行除盐程序(例如，超滤、透析及类似程序)。任何酶制品可通过使用已知的交联剂诸如，例如戊二醛交联或固定到固相材料(例如树脂)而被稳定化。
在本文描述的转氨反应的一些实施方案中，反应在本文描述的合适的反应条件下进行，其中工程化转氨酶多肽被固定至固体支持物上。可用于固定进行转氨反应的工程化转氨酶的固体支持物包括但不限于微球或树脂，所述微球或树脂包含具有环氧官能团的聚甲基丙烯酸酯、具有氨基环氧官能团的聚甲基丙烯酸酯、具有十八烷基官能团的苯乙烯/DVB共聚物或具有十八烷基官能团的聚甲基丙烯酸酯。示例性固体支持物包括但不限于壳聚糖珠、EupergitC 和SEPABEAD(Mitsubishi)，包括以下不同类型的SEPABEAD：EC-EP、EC-HFA/S、EXA252、EXE119 和EXE120。
在一些实施方案中，其中工程化多肽可以分泌多肽的形式被表达，含有该分泌多肽的培养基可被用于本文的方法中。
在一些实施方案中，固体反应物(例如，酶、盐等)可以各种不同的形式提供给反应，包括粉末(例如，冻干的、喷雾干燥的等)、溶液、乳液、悬浮液等。反应物可使用为本领域普通技术人员共知的方法和仪器容易地冻干或喷雾干燥。例如，蛋白质溶液可以小量冷冻于 -80℃，然后加入至预冷却的冻干室内，之后应用真空。
在一些实施方案中，加入反应物的顺序并不关键。反应物可同时一起加入至溶剂中(例如，单相溶剂、双相水性共溶剂体系等)，或者可选择地，一些反应物可分别地加入，以及一些在不同的时间点一起加入。例如，转氨酶和转氨酶底物可首先加入溶剂中。然后可加入并混合有机相。可选择地，转氨酶底物可在添加至水相之前在有机相中预混合。
本公开内容的不同的特征和实施方案示例于以下代表性的实施例中，其意图是例证性的而不是限制性的。
附图说明
图1转氨酶催化反应。
图2苯乙酮转化为R-(+)-α-苯乙胺的转氨酶催化反应。
具体实施方式
下面用实施例来进一步说明本发明，但本发明并不受其限制。下列实施例中未注明具体条件的实验方法，通常按照常规条件，或按照制造厂商所建议的条件。
实施例1：基因克隆和表达载体的构建
源自于Aspergillus fumigatus的野生型的转氨酶的氨基酸序列，可从NCBI上检索得到，然后通过本领域的常见技术将其对应的核酸合成出来并克隆到表达载体pACYC-Duet-1上。将重组表达质粒转化到E.coil BL21(DE3)的感受态细胞中，转化条件42℃，热击90秒，转化液涂布到含有氯霉素的LB平板上，37℃倒置培养过夜，即获得重组转化体。
实施例2：转氨酶多肽的摇瓶表达
将实施例1所得的重组E.coli BL21(DE3)转化体，接种至装有50mL含氯霉素的LB培养基 (蛋白胨10g/L，酵母浸出粉5g/L，氯化钠10g/L，pH值7.0±0.2,25℃)的250mL锥形瓶中，置于30℃，250rpm摇床振荡培养过夜。当培养液的OD600达到2时，按5％(v/v)的接种量接入装有250mL TB培养基(胰蛋白胨12g/L，酵母浸出粉24g/L，磷酸氢二钠9.4g/L，磷酸氢二钾 2.2g/L，pH值7.2±0.2,30℃)的1000mL锥形瓶中，加入终浓度为6g/L乳糖作为诱导剂，放置于30℃，250rpm摇床振摇培养。30℃诱导20h后，将培养液离心，收集细胞，并用PBS缓冲液 (pH7.4)洗涤两次，离心弃上清得湿菌体，将所得的湿菌体放置于-20℃冰箱中待用。如需酶液，将所得湿菌体加入50mL的PBS缓冲液(pH7.4)中，回溶细胞，将回溶液放于冰浴中，用超声破碎5min(5s/s，50％功率)，使用Thermo Multifuge X3R离心机在4℃以8000rpm离心10min来澄清所得的破碎液。澄清上清液分配到浅容器中，在-20℃冷冻并使用冻干机冻干成酶粉。所得转氨酶酶粉在-20℃冻存。
实施例3：转氨酶突变文库的构建
这里所用到的都是商业试剂，较佳地选用Quikchange试剂盒(供应商：Agilent)。突变引物的序列设计按照试剂盒的说明进行。现以单个残基位置的饱和突变文库的构建为例说明。 PCR体系为：5xBuffer 10uL，10mM dNTP 1uL，质粒DNA模板1uL(50ng/uL),上下游引物各取 0.75uL(10uM)，高保真酶0.5uL,ddH2O 36uL。PCR引物在突变位置的密码子为NNK。
PCR扩增步骤为：(1)98℃，预变性3min；(2)98℃，变性10s；(3)72℃退火和延伸3min；步骤(2)～(3)重复25次；(5)72℃继续延伸10min，冷却至4℃。在PCR产物中加入2uLDpnI， 37℃过夜酶切消除质粒模板。酶切后的PCR产物按转化E.coli BL21(DE3)感受态细胞，涂布到含氯霉素的LB平板上即得目标残基位置的饱和突变文库。
实施例4：转氨酶突变文库的高通量筛选
对转氨酶突变文库的表达，按照摇瓶制备方式，同比例缩小至96孔板进行培养得到培养液，具体操作方案如下。从LB琼脂平板中挑取突变酶库的单克隆，接种至200μL/孔LB培养基的96孔平底浅板中(含氯霉素)，置于180rpm、30℃、80％湿度的摇床过夜培养18～20h。 OD 600达到2.0左右，此时取20μL菌液接种到400μL/孔TB培养基的96孔深孔板中(含氯霉素)，置于250rpm、30℃、80％湿度摇床继续培养。当培养液的OD 600达到0.6～0.8时，加入终浓度为1mM的IPTG作为诱导剂，置于摇床30℃过夜诱导18～20h。最后拿出深孔板4000rpm离心10min去除培养基，制作成96孔板湿菌体放置于-20℃冰柜待用。
针对催化苯乙酮到R-苯乙胺的突变酶库的筛选反应方案如下：
从-20℃冰箱中取出含湿菌体的96孔板，用分液器加200μL/孔化学破碎液，封膜后置于平板振荡器上700rpm破碎1h，4000rpm离心10min备用。配制反应混合母液0.4mM PLP、6M IPM、0.1M TEOA滴加盐酸调节pH至9.0(25℃)，用移液工作站取50μL/孔于96深孔板中使反应终浓度为0.1mM PLP、1.5M IPM；配置苯乙酮母液溶于甲醇中，取50μL/孔至深孔板中使苯乙酮终浓度为50g/L，甲醇25％；取离心后的酶液上清100μL/孔加入到96深孔板中，反应总体积为200μL。用铝膜热封96孔板，放置于摇床30℃、200rpm反应20h后加 400μL ACN，平板振荡器800rpm灭活1h，取样进行HPLC分析检测转化率情况。
实施例5：HPLC分析方法
针对R-苯乙胺的高通量筛选分析方法：分析柱LP-C18 150*4.6mm，流动相为0.4％高氯酸水溶液(pH1.5):乙腈＝55：45，流速为2.2mL/min，柱温为40℃，检测波长为220nm，分析时间为2.5min，苯乙酮的保留时间为2.34min，R-苯乙胺的保留时间为0.97min。
R-苯乙胺的手性分析方法：分析柱CROWNPAK CR-I(+)150*4.6mm，流动相为0.8％高氯酸水溶液(pH1):乙腈＝70：30，流速为0.5mL/min，柱温为30℃.检测波长为210nm，分析时间为10min，苯乙酮的保留时间为4.53min，R-苯乙胺的保留时间为5.82min，S-苯乙胺的保留时间为8.62min。
实施例6：发酵及后处理
将包含带有目标工程化转氨酶多肽表达质粒的大肠杆菌BL21(DE3)的单个菌落接种到含 30μg/mL氯霉素的50mL LB肉汤(5.0g/L Yeast Extract LP0021、10g/L TryptoneLP0042、 10g/L氯化钠)中，在30℃摇床中250rpm摇动培养16h，当培养液的OD600是3.5至4.5时，从摇床中取出培养液，立即用于接种发酵罐。
将含有0.4L生长培养基的1.0L发酵罐在121℃高压蒸汽灭菌锅灭菌30min。向发酵罐接种上述摇瓶中的培养液。以夹套控制发酵罐温度保持在37℃，以200-800rpm的速度搅动，以0.4-0.8L/min向发酵容器供应空气以保持溶解氧水平为30％或更大。通过加入25-28％v/v 氢氧化铵保持培养液的pH在7.0。菌的生长通过流加含500g/L食用葡萄糖右旋糖一水合物、 12g/L氯化铵和5g/L硫酸镁七水合物的补料溶液来维持。当培养液达到OD600为25±5后，将培养液温度下降并维持在30℃，通过加入异丙基-β-D-硫代半乳糖苷(IPTG)至终浓度 0.3mM来诱导转氨酶的表达，继续发酵约16小时后放罐。使用Thermo MultifugeX3R离心机在4℃以8000rpm离心10min来收集湿菌体。收集的湿菌体直接用于以下下游回收工艺，或可在-20℃冷冻储存直到使用。
在4℃下将6g湿菌体用30mL含250uM吡哆醛5’-磷酸(PLP)的100mM磷酸钾盐缓冲液、 pH7.5中重悬浮。利用均质机800bar均质破碎2次，将转氨酶从胞内释放。使用ThermoMultifuge X3R离心机在4℃以8000rpm离心10min来澄清所得的破碎液。澄清上清液分配到浅容器中，在-20℃冷冻并使用冻干机冻干成酶粉。转氨酶酶粉在-20℃冻存。
实施例7工程化转氨酶多肽催化生成R-苯乙胺的反应工艺
以下为一个具代表性的50mL体积的反应流程。异丙胺混合溶液预配：量取8mL三乙醇胺缓冲液(0.1M，pH9)，加入6.9mL异丙胺，然后加盐酸调pH至9,再加三乙醇胺缓冲液至总体积为20mL。在容积为250mL的反应瓶里，加入0.25g酶粉(SEQ ID No：390)、17.07mL三乙醇胺缓冲液(pH为9)、20mL上述异丙胺混合液、500uL 10mM磷酸吡哆醛溶液、10mL甲醇，搅拌均匀后加入2.43mL苯乙酮。反应用水浴控温30℃，搅拌速度200rpm，对反应瓶施加负压以移除产生的丙酮。反应24小时后的转化率≥80％，产物R-苯乙胺的ee值≥99％。
实施例8工程化转氨酶多肽催化生成(R)-(+)-α-(1-萘基)乙胺的反应工艺
异丙胺混合溶液预配：量取8mL三乙醇胺缓冲液(0.1M，pH8)，加入6.9mL的异丙胺，然后加盐酸调pH至8,再加三乙醇胺缓冲液至总体积为20mL。在容积为250mL的反应瓶里，加入150mg酶粉(SEQ ID No：352)、38mL三乙醇胺缓冲液(pH为8)、6.5mL上述异丙胺混合液、500uL 10mM的磷酸吡哆醛溶液，搅拌均匀后加入α-萘乙酮的DMSO溶液(终浓度至10％DMSO，20g/L底物α-萘乙酮)。反应用水浴控温30℃，搅拌速度400rpm，对反应瓶施加负压以移除产生的丙酮。反应24小时后转化率为≥70％，产物(R)-(+)-α-(1-萘基)乙胺的ee值≥99.5％。
实施例9工程化转氨酶多肽催化生成(R)-3-氨基-4-(2，4，5-三氟苯基)丁酸甲酯的反应工艺
异丙胺混合溶液预配：量取8mL三乙醇胺缓冲液(0.1M，pH9.5)，加入6.9mL的异丙胺，然后加盐酸调pH至9.5,再加三乙醇胺缓冲液至总体积为20mL。在容积为250mL的反应瓶里，加入250mg酶粉(SEQ ID No：80)、38mL三乙醇胺缓冲液(pH为9.5)、6.5mL上述异丙胺混合液、500uL 10mM的磷酸吡哆醛溶液，搅拌均匀后加入DMSO和3-氧代-4-(2，4，5-三氟苯基)丁酸甲酯(终浓度至10％DMSO，2g/L底物3-氧代-4-(2，4，5-三氟苯基)丁酸甲酯)。反应用水浴控温30℃，搅拌速度400rpm。反应24小时后转化率为≥50％，产物(R)-3-氨基 -4-(2，4，5-三氟苯基)丁酸甲酯的ee值≥99％。
应理解，在阅读了本发明的上述内容之后，本领域技术人员可以对本发明作各种改动或修改，这些等价形式同样落于本申请所附权利要求书所限定的范围。
序列表
<110> 浙江医药股份有限公司新昌制药厂，宁波酶赛生物工程有限公司
<120> 工程化转氨酶多肽及其应用
<150> 2016111918834
<151> 2016-12-21
<160> 309
<170> SIPOSequenceListing 1.0
<210> 1
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 1
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt 180
atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg ggttatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaac aaagggactt tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat ctggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 2
<211> 323
<212> PRT
<213> 烟曲酶(Aspergillus fumigatus)
<400> 2
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Val Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Thr Lys Gly Leu Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 3
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 3
atggcttcga tggacaaagt cttctcaggt tactacgccc gtcaaaaact gctggaacgc 60
tcagataatc cgttctcaaa aggtattgcc tatgtcgaag gtaaactggt gctgccgagt 120
gatgcgcgca ttccgctgct ggacgaaggc tttatgcata gtgatctgac ctacgacgtt 180
atctccgtct gggacggccg tttctttcgc ctggatgacc acctgcagcg cattctggaa 240
tcatgcgata aaatgcgtct gaaatttccg ctggcactga gctctgtcaa aaatatcctg 300
gcagaaatgg tggctaaaag cggcattcgt gacgctttcg tcgaagtgat cgttacccgc 360
ggcctgacgg gtgttcgtgg ctctaaaccg gaagatctgt ataacaataa catttacctg 420
ctggtgctgc cgtatatctg gctgatggca ccggaaaatc agctgcatgg cggtgaagct 480
attatcaccc gtacggtgcg tcgcaccccg ccgggtgcct ttgatccgac gatcaaaaac 540
ctgcaatggg gtgacctgat taaaggcatg tttgaagcga tggatcgtgg tgccacctat 600
ccgttcctga cggatggcga caccaatctg acggaaggct gcggtttcaa tattgtcctg 660
gtgaaaaacg gtattatcta caccccggat cgtggtgttc tgcgcggcat tacgcgtaaa 720
tcagtgatcg atgttgcgcg cgccaactcg attgacatcc gtctggaagt ggttccggtg 780
gaacaagcgt accactccga tgaaattttc atgtgtacca cggccggcgg tattatgccg 840
atcaccctgc tggatggtca gccggttaac gacggtcaag tcggcccgat taccaagaaa 900
atttgggatg gctattggga aatgcactac aacccggctt attcgtttcc ggtggattat 960
ggcagcggt 969
<210> 4
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 4
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 5
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 5
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacgcgac ctatgatgtt 180
atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 6
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 6
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 7
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 7
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt 180
atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggac ctggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 8
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 8
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 9
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 9
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt 180
atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggaa gtggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 10
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 10
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 11
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 11
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt 180
atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tggaggggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 12
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 12
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 13
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 13
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt 180
atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgctcga ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 14
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 14
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 15
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 15
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctggcggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 16
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 16
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 17
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 17
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgacca gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 18
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 18
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 19
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 19
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgacca gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgttt ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggtccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 20
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 20
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Phe Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 21
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 21
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcacca ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 22
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 22
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 23
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 23
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgccta gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttgggcgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 24
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 24
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Pro Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Gly Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 25
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 25
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 26
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 26
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 27
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 27
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 28
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 28
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 29
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 29
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgttt ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 30
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 30
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Phe Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 31
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 31
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgacca gtgacctaac ctatgatacc 180
atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcagca ctggcggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 32
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 32
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 33
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 33
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg 60
agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt 120
gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt 180
atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa 240
agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg 300
gctgagatgg tcgccaagag tggtatccgg gatgcgtggg tggaagttat tgtgacacgt 360
ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg 420
cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct 480
atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat 540
ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac 600
ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg 660
gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa 720
agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg 780
gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct 840
ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag 900
atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat 960
ggcagtggc 969
<210> 34
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 34
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Trp Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 35
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 35
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatggcca gcgacctgac ctacgacacg 180
atccgcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 36
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 36
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Ala Ser Asp Leu Thr Tyr Asp Thr Ile Arg Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 37
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 37
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 38
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 38
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 39
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 39
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgcgca gcgacctgac ctacgacacg 180
atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 40
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 40
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Arg Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 41
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 41
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgggca gcgacctgac ctacgacacg 180
ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 42
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 42
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Gly Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 43
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 43
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgaaca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 44
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 44
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Asn Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 45
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 45
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
ttccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 46
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 46
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 47
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 47
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 48
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 48
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 49
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 49
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgcgca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgaggtcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 50
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 50
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Arg Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 51
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 51
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgagatcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 52
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 52
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 53
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 53
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
ttcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 54
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 54
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe Asn Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 55
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 55
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgggca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 56
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 56
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Gly Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 57
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 57
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgagca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg gcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 58
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 58
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Ser Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Gly Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 59
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 59
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 60
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 60
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 61
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 61
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgggca gcgacctgac ctacgacacg 180
atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 62
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 62
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Gly Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 63
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 63
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatggcca gcgacctgac ctacgacacg 180
atccacgttt gggacggtcg ctttttccgt ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg gcaagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 64
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 64
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Ala Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Gly Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 65
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 65
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg 180
ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 66
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 66
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 67
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 67
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 68
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 68
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 69
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 69
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatggcca gcgacctgac ctacgacacg 180
atcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 70
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 70
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Ala Ser Asp Leu Thr Tyr Asp Thr Ile Asn Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 71
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 71
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgaaca gcgacctgac ctacgacacg 180
atcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgacag gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 72
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 72
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Asn Ser Asp Leu Thr Tyr Asp Thr Ile Asn Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 73
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 73
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 74
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 74
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 75
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 75
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 76
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 76
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 77
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 77
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgagca gcgacctgac ctacgacacg 180
ttccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 78
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 78
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Ser Ser Asp Leu Thr Tyr Asp Thr Phe His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 79
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 79
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgaaca gcgacctgac ctacgacacg 180
atcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 80
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 80
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Asn Ser Asp Leu Thr Tyr Asp Thr Ile Asn Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 81
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 81
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg 180
atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgaggtcat tgttacccgc 360
ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 82
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 82
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 83
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 83
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac 120
gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg 180
atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc 360
ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg 840
atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat 960
ggtagcgat 969
<210> 84
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 84
Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 85
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 85
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttaatgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 86
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 86
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Asn Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 87
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 87
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttgatgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 88
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 88
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Asp Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 89
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 89
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcaa gagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 90
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 90
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Lys Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 91
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 91
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgctc tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 92
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 92
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Ser Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 93
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 93
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgccc gagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 94
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 94
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Pro Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 95
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 95
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
caggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 96
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 96
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Gln Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 97
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 97
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
acggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 98
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 98
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Thr Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 99
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 99
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggtttcgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 100
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 100
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Ser Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 101
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 101
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttcggc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 102
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 102
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Arg Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 103
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 103
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggcag gtttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 104
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 104
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 105
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 105
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttgt tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 106
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 106
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Val Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 107
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 107
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tttatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 108
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 108
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Tyr Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 109
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 109
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgttta gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 110
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 110
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Phe Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 111
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 111
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgttga gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 112
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 112
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met Leu Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 113
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 113
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacagtacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 114
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 114
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Ser Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 115
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 115
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 116
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 116
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 117
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 117
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 118
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 118
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 119
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 119
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 120
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 120
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ala Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 121
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 121
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tccatgttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 122
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 122
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val His Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 123
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 123
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tctatgttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca cctgaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 124
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 124
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Tyr Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 125
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 125
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tctttgttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 126
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 126
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Phe Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 127
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 127
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtgat 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 128
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 128
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Asp
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 129
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 129
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgtgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtagt 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 130
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 130
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Cys Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Ser
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 131
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 131
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtcag 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 132
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 132
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Gln
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 133
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 133
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ctgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 134
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 134
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Ser Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 135
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 135
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgag gaaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 136
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 136
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Arg Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 137
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 137
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcat tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 138
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 138
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Leu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 139
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 139
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 140
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 140
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 141
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 141
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcaa ttgatccgac gattaaaaac 540
taccaatggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 142
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 142
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Ile Asp Pro
165 170 175
Thr Ile Lys Asn Tyr Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 143
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 143
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 144
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 144
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 145
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 145
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcac gtgatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 146
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 146
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Arg Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 147
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 147
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 148
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 148
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 149
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 149
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attccgattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 150
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 150
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Pro Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 151
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 151
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 152
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 152
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 153
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 153
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggaa tatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 154
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 154
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 155
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 155
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 156
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 156
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 157
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 157
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
catgaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 158
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 158
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu His Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 159
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 159
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgtctg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 160
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 160
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 161
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 161
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg taataaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 162
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 162
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 163
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 163
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgttggg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 164
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 164
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu Leu Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 165
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 165
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgattgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 166
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 166
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu Ile Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 167
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 167
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 168
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 168
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 169
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 169
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagctgcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 170
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 170
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 171
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 171
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaatttgcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 172
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 172
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Phe Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 173
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 173
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacgctga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 174
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 174
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 175
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 175
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 176
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 176
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 177
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 177
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgcaaccag gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatcccgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 178
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 178
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Asn Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 179
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 179
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgccaagag gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 180
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 180
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Gln Glu Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 181
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 181
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgccaacag gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 182
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 182
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Gln Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 183
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 183
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaacag gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 184
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 184
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 185
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 185
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgcaaccag gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatgccgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 186
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 186
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Asn Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 187
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 187
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgccaagag gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 188
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 188
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Gln Glu Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 189
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 189
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagccaagcg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 190
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 190
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Gln Ala Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 191
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 191
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 192
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 192
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 193
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 193
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 194
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 194
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 195
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 195
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggagcgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgactgggg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aaatccacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc tgttgtagca ccgctggcgg tattatgccg 840
atcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
attatggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 196
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 196
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Asp Trp Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ile His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Cys Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 197
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 197
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctgacgcgc 60
tctgataacc cttttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgacca gcaacagggg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgccacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc tgttgtagca ccgctggcgg tattatgccg 840
gtcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
attatggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 198
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 198
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Thr Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Asn Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Cys Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Val Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 199
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 199
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggagcgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgtctgggg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgccacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
atcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 200
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 200
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Trp Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 201
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 201
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggcgcgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgacca gcgtctgggg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactccacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
atcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
attatggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 202
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 202
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Ala Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Trp Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 203
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 203
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg gtggaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 204
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 204
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Val Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 205
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 205
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgatgtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 206
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 206
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Met Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 207
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 207
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gcatgaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 208
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 208
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu His Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 209
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 209
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gattgaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 210
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 210
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Ile Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 211
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 211
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tgggttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 212
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 212
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Trp Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 213
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 213
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtacgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 214
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 214
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Thr Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 215
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 215
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 216
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 216
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 217
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 217
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 218
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 218
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 219
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 219
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 220
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 220
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 221
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 221
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 222
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 222
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 223
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 223
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 224
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 224
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 225
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 225
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 226
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 226
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 227
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 227
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 228
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 228
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 229
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 229
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 230
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 230
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 231
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 231
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 232
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 232
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 233
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 233
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 234
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 234
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 235
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 235
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 236
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 236
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 237
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 237
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 238
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 238
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 239
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 239
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 240
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 240
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 241
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 241
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 242
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 242
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 243
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 243
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 244
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 244
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 245
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 245
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 246
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 246
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 247
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 247
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 248
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 248
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 249
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 249
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 250
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 250
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 251
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 251
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 252
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 252
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 253
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 253
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc 360
ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 254
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 254
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 255
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 255
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacgcgga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 256
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 256
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 257
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 257
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
catgaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tccatgttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacgcgga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 258
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 258
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ala Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu His Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val His Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 259
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 259
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
catgaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 260
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 260
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ala Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu His Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 261
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 261
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacgcgga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 262
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 262
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ala Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 263
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 263
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgtcgg gcgttggcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 264
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 264
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Gly Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 265
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 265
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgtcgg gcgttggcaa gagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 266
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 266
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Gly Lys Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 267
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 267
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgacgg gcgttgacaa gagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 268
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 268
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Asp Lys Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 269
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 269
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgtcgg gcgttggcaa gaacaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 270
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 270
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Gly Lys Asn
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 271
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 271
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgtcgg gcgttcacgg tagcaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 272
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 272
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val His Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 273
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 273
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaagaac 540
ttcatgtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 274
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 274
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Met Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 275
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 275
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gcttatggca ccggaaaagc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 276
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 276
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Lys Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 277
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 277
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcatactg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat cactcgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 278
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 278
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Ile Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 279
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 279
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcttactg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat cactcgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 280
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 280
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Leu Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 281
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 281
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgagggg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 282
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 282
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu Arg Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 283
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 283
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgacg 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 284
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 284
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Thr Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 285
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 285
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgtttttg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 286
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 286
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Phe Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 287
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 287
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tgtgatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 288
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 288
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Val Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 289
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 289
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attgtgaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 290
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 290
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Val Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 291
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 291
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcctgta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 292
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 292
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser
115 120 125
Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 293
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 293
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgacca gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg 660
gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa 720
agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt 780
gaaaccgcat accacgcgga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
gtgaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 294
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 294
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Asn Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu
245 250 255
Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Val Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 295
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 295
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 296
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 296
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 297
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 297
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 298
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 298
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 299
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 299
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgatca gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 300
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 300
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Ile Ser Asn Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 301
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 301
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
gtgaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag 900
attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 302
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 302
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Val Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 303
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 303
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 304
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 304
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 305
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 305
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat tacaaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtagattat 960
ggtagcgat 969
<210> 306
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 306
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Asp
<210> 307
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 307
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg 840
attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag 900
atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac 960
ggtagcggt 969
<210> 308
<211> 323
<212> PRT
<213> 人工序列(artificial sequence)
<400> 308
Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys
1 5 10 15
Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val
20 25 30
Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp
35 40 45
Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp
50 55 60
Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu
65 70 75 80
Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val
85 90 95
Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala
100 105 110
Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg
115 120 125
Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro
130 135 140
Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala
145 150 155 160
Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro
165 170 175
Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu
180 185 190
Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr
195 200 205
His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly
210 215 220
Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys
225 230 235 240
Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu
245 250 255
Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr
260 265 270
Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro
275 280 285
Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly
290 295 300
Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr
305 310 315 320
Gly Ser Gly
<210> 309
<211> 969
<212> DNA
<213> 人工序列(artificial sequence)
<400> 309
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc 60
tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc 120
gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc 180
attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa 240
tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg 300
gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc 360
ggtctgaccg gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg 420
ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca 480
attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac 540
tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat 600
ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg 660
gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa 720
agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt 780
gaacaggc 788

Claims (24)

1.一种工程化转氨酶多肽，所述转氨酶多肽包括与SEQ ID NO：2至少80％相同的氨基酸序列，且在合适的反应条件下，能够以比SEQ ID NO：2更好的催化活性和/或稳定性将苯乙酮转化为R-(+)-α-苯乙胺。
2.如权利要求1所述的转氨酶多肽，其中所述合适的反应条件包括约1g/L-200g/L苯乙酮的载量，约0.5M-2.0M异丙胺，约50μM-5mM PLP，约pH7.0-11.0，约10-60℃。
3.如权利要求1或2任一项所述的转氨酶多肽，其中所述氨基酸序列包括在SEQ ID NO：2所示序列的第3、4、9、18、19、31、36、40、41、47、50、53、54、56、59、60、61、62、72、78、86、98、101、113、114、115、116、122、123、124、125、126、127、128、129、130、141、143、148、153、155、156、159、162、167、173、174、175、181、182、186、187、188、190、191、194、199、209、214、219、226、235、240、243、244、252、253、262、266、271、272、273、275、278、281、287、291、302、307、312、323位氨基酸残基中的一个或多个位点经过取代且具有转氨酶活性的多肽。
4.如权利要求3所述的转氨酶多肽，其中所述氨基酸序列另外包含选自下列的一个或多个残基位置处的氨基酸残基差异：
X3是T；
X4是I；
X9是A；
X18是H或I；
X19是T或A；
X31是W；
X36是F；
X40是Y或T；
X41是E；
X47是P；
X50是A；
X53是T、P、A、R、G、N、S、F或L；
X54是A；
X56是A、V或S；
X59是S或T；
X60是T；
X61是F；
X62是R、H、N或A；
X72是G；
X78是L；
X86是C；
X98是K；
X101是V或H；
X113是M或W；
X114是G；
X115是K、H、Y或F；
X116是I；
X122是T；
X123是S或I；
X124是S；
X125是D或N；
X126是Q、N、D、W、G或H；
X127是F、K、S或P；
X128是R或N；
X129是N或Q；
X130是Q、E或A；
X141是Q或T；
X143是S或R；
X148是L；
X153是D或K；
X155是S、I或R；
X156是L、I或R；
X159是S；
X162是V；
X167是V；
X173是D；
X174是S或I；
X175是Y或G；
X181是Y或F；
X182是M；
X186是F；
X187是I、N或R；
X188是R；
X190是M；
X191是V；
X194是K、L、R、E、N、V、D、I或G；
X199是K、Q或E；
X209是H；
X214是C或P；
X219是I或L；
X226是L；
X235是E；
X240是D、S或Q；
X243是F；
X244是E；
X252是P；
X253是V；
X262是T、A或F；
X266是A；
X271是C；
X272是T；
X273是S；
X275是G；
X278是V；
X281是V；
X287是K；
X291是G；
X302是M；
X307是N；
X312是A或N；或
X323是D。
5.一种工程化多肽，所述的工程化多肽是如下(a)或(b)的多肽：
(a)SEQ ID No 4、6、8、10、12、14、16、18、20、22、24、26、28、30、32、34、36、38、40、42、44、46、48、50、52、54、56、58、60、62、64、66、68、70、72、74、76、78、80、82、84、86、88、90、92、94、96、98、100、102、104、106、108、110、112、114、116、118、120、122、124、126、128、130、132、134、136、138、140、142、144、146、148、150、152、154、156、158、160、162、164、166、168、170、172、174、176、178、180、182、184、186、188、190、192、194、196、198、200、202、204、206、208、210、212、214、216、218、220、222、224、226、228、230、232、234、236、238、240、242、244、246、248、250、252、254、256、258、260、262、264、266、268、270、272、274、276、278、280、282、284、286、288、290、292、294、296、298、300、302、304、306、308、310、312、314、316、318、320、322、324、326、328、330、332、334、336、338、340、342、344、346、348、350、352、354、356、358、360、362、364、366、368、370、372、374、376、378、380、382、384、386、388、390、392、394、396、398、400所示的氨基酸序列；
(b)由(a)的氨基酸序列中经过取代、缺失或添加一个或多个氨基酸残基且具有转氨酶活性的由(a)衍生的并和(a)的氨基酸序列具有至少80％同一性的多肽。
6.一种工程化转氨酶多肽，所述转氨酶多肽在合适的反应条件下，能够以大于SEQ IDNO：2多肽的催化活性和/或稳定性将苯乙酮转化为R-(+)-α-苯乙胺。
7.一种通过化学键或物理吸附的方法被固定在固体材质上的多肽，所述多肽选自权利要求1-6任一项所述的转氨酶多肽。
8.一种多核苷酸，所述多核苷酸编码权利要求1-6任一项的多肽。
9.如权利要求8所述的多核苷酸，其中所述多核苷酸序列为对应SEQ ID No：3、5、7、9、11、13、15、17、19、21、23、25、27、29、31、33、35、37、39、41、43、45、47、49、51、53、55、57、59、61、63、65、67、69、71、73、75、77、79、81、83、85、87、89、91、93、95、97、99、101、103、105、107、109、111、113、115、117、119、121、123、125、127、129、131、133、135、137、139、141、143、145、147、149、151、153、155、157、159、161、163、165、167、169、171、173、175、177、179、181、183、185、187、189、191、193、195、197、199、201、203、205、207、209、211、213、215、217、219、221、223、225、227、229、231、233、235、237、239、241、243、245、247、249、251、253、255、257、259、261、263、265、267、269、271、273、275、277、279、281、283、285、287、289、291、293、295、297、299、301、303、305、307、309、311、313、315、317、319、321、323、325、327、329、331、333、335、337、339、341、343、345、347、349、351、353、355、357、359、361、363、365、367、369、371、373、375、377、379、381、383、385、387、389、391、393、395、397、399的序列。
10.一种表达载体，所述表达载体包含权利要求8-9所述的多核苷酸。
11.如权利要求10所述的表达载体，所述表达载体包括质粒、粘粒、噬菌体或病毒载体。
12.一种宿主细胞，所述宿主细胞包括权利要求10-11任一项的表达载体，所述宿主细胞优选大肠杆菌(E.coli)。
13.一种转氨酶多肽的制备方法，其包括如下步骤：培养权利要求12所述的宿主细胞，以及从培养物中获得转氨酶多肽。
14.一种转氨酶催化剂，其选自权利要求10-13任一项的培养物，通过从培养物中获得的含转氨酶多肽的宿主细胞或培养液，或者用其加工的制品；其中，所述制品是指由转化体细胞得到的提取物，通过对提取物中的转氨酶进行分离或纯化得到的分离产品，或通过固定化转化体细胞及其提取物或提取物的分离产品而得到的固定化制品。
15.一种制备结构式(I)化合物的方法：
所述结构式(I)的胺产物在标为*的手性中心具有所示的立体化学构型；所示结构式(I)的胺产物与相应的对映异构体相比过量，其中
R1是任选地取代的芳基或杂芳基，或是任选地取代的C1-C8烃基；
R2是任选地取代的C1-C6烃基、卤素(如-F、-Cl、-Br和-I)、-NO2、-NO、-SO2R’或-SOR’、-SR’、-N R’R’、-O R’、-CO2R’或-COR’、-C(O)NR’、-SO2NH2或-SO NH2、-CN、CF3；
其中每个R’独立地选自-H或(C1-C4)烃基，所述方法包括在适于转化酮底物为胺产物的反应条件下，将氨基供体和结构式(II)的酮底物：
与权利要求1-7任一项的工程化多肽接触的步骤。
16.如权利要求15所述的方法，其中结构式(I)的β-羟基-α-氨基酸产物是：
其中R2是任选地取代的C1-C6烃基、卤素(如-F、-Cl、-Br和-I)、-NO2、-NO、-SO2R’或-SOR’、-S R’、-N R’R’、-O R’、-CO2R’或-COR’、-C(O)NR’、-SO2NH2或-SO NH2、-CN、CF3，其中每个R’独立地选自-H或(C1-C4)烃基；R3或R4是C1-C4烃基、-H、卤素(如-F、-Cl、-Br和-I)、-NO2、-NO、-SO2R’或-SOR’、-S R’、-NR’R’、-O R’、-CO2R’或-COR’、-C(O)NR’、-SO2NH2或-SONH2、-CN、CF3，其中每个R’独立地选自-H或(C1-C4)烃基；
R3或R4是也可以是
且结构式(II)的醛底物是：
17.如权利要求15或16所述的方法，其中结构式(I)的手性胺产物是：
其中R2和R3如权利要求16所定义。
18.如权利要求15或16所述的方法，其中结构式(I)的手性胺产物是：
19.一种制备结构式A2化合物R-(+)-α-苯乙胺的方法：
所述方法包括在适于转化式A1化合物为式A2化合物的反应条件下，在适当的有机溶剂中，在氨基供体存在下，将结构式A1化合物苯乙酮
与权利要求1-7任一项的工程化转氨酶多肽接触的步骤。
20.如权利要求15-19任一项所述的方法，其中所述手性胺产物以至少70％、80％、85％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更大的对映体过量产生。
21.如权利要求15-19任一项所述的方法，其中所述反应溶剂包括水，甲醇，乙醇，丙醇，异丙醇，乙酸异丙酯，二甲基亚砜(DMSO)或二甲基甲酰胺(DMF)。
22.如权利要求15-19任一项所述的方法，其中所述反应条件包括10℃至60℃的温度。
23.如权利要求15-19任一项所述的方法，其中所述反应条件包括pH7.0至pH11.0。
24.如权利要求15-19任一项所述的方法，其中所述酮底物以1g/L至200g/L的载量存在。
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CN112048485B (zh) * 2019-06-07 2022-09-27 宁波酶赛生物工程有限公司 一种制备西他列汀的工程化转氨酶多肽
CN110749692A (zh) * 2019-10-15 2020-02-04 扬子江药业集团有限公司 L-谷氨酸二乙酯盐酸盐及其光学异构体的分离检测方法
CN110724675A (zh) * 2019-10-31 2020-01-24 宁波酶赛生物工程有限公司 转氨酶催化剂和酶法合成(r)-1-叔丁氧羰基-3-氨基哌啶的方法
CN110982801A (zh) * 2019-12-27 2020-04-10 中国科学院苏州生物医学工程技术研究所 转氨酶突变体及其构建方法和应用
CN111349666A (zh) * 2020-04-10 2020-06-30 宁波酶赛生物工程有限公司 一种苯乙胺的生产方法及其设备
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WO2023061237A1 (zh) * 2021-10-14 2023-04-20 弈柯莱生物科技(上海)股份有限公司 转氨酶及其用于制备西他列汀或其中间体的用途

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