CN109876113A - A kind of Chinese medicine composition and its preparation method and application for treating carotid plaques - Google Patents

Abstract

The invention discloses a kind of for treating the Chinese medicine composition of carotid plaques, and the Chinese medicine composition includes: Cortex Magnoliae Officinalis, fructus amomi, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, caulis perllae, leaves of pulse plants stalk, Herba Lycopi.The invention also discloses the preparation method of the Chinese medicine composition for treating carotid plaques and purposes.The present invention is used to treat the Chinese medicine compositions of carotid plaques, and each Chinese medicine cooperates according to the compatibility relationship of " monarch, minister, help, make ", collective effect, to act on lesion, and then plays the curative effect for the treatment of carotid plaques.Clinical trial shows that the Chinese medicine composition in, severe carotid plaques, there is preferable therapeutic effect, and the total effective rate to carotid plaques is 86.6%, and controls difficulty in relapse after healing, has no toxic side effect, is with a wide range of applications.

Description

A kind of Chinese medicine composition and its preparation method and application for treating carotid plaques

Technical field

The invention belongs to the field of Chinese medicines, and in particular to a kind of for treating the Chinese medicine composition and its system of carotid plaques Preparation Method and application.

Background technique

Carotid plaques mostly occur in arteria carotis communis wooden fork (64.9%), are secondly internal carotid entrance and section start (19.9%), the carotid artery atherosclerosis plaques being present in mostly at carotid bifuracation are likely to result in local arteria carotis hair Raw obstruction, unstable patch easily fall off under blood flow impetus as embolus, with blood flow reach cerebrovascular system or The vitals such as person's heart, so that it is cardiovascular and cerebrovascular diseases associated to induce myocardial infarction, cerebral apoplexy etc..It is some to cause blood vessel athero- The risk factor of hardening can lead to Cervical Vessels patch and be formed, including the age, gender, smoking, high blood pressure, hyperlipidemia, Diabetes etc. can lead to the generation and further development of carotid artery atherosclerosis plaques.The damage smoked to arteria carotis is very Greatly, the harmful substances such as nicotine therein can destroy the system of defense of blood vessel, including carotid artery intima layer, will lead to theca interna Breakage, inflammatory reaction occurs for intima media, cause in blood flow some bad electrodeposition substances in carotid artery intima middle layer, This is also one of the cause of disease that carotid artery atherosclerosis plaques are formed.Have that researches show that age, male, total cholesterols (TC), glycerol Three esters (TG) and low-density lipoprotein etc. are the independent hazard factors that carotid plaques are formed.Simultaneously also it has been reported that inflammation, The danger that hyperhomocysteinemiainjury, low density lipoprotein cholesterol increase, long-term heavy drinking is carotid plaques formation Factor, Ying Jinhang active intervention.Zoopery also turns out that low-density lipoprotein (LDL) can directly activate endothelial cell, increases Add the expression of adhesion molecule；On the contrary, the effect of high-density lipoprotein (HDL) is to can protect endothelial cell, prevent endothelium thin Cellular damage.LDL cholesterol is that artery sclerosis is caused to act on a maximum factor, because its particle is small, pole in various lipoprotein The oxide layer being easily accessible under endarterium, LDL, which is oxidized, to be led to foam cells and monocyte is promoted to release inflammation Jie Matter, this is also the one of the major reasons for leading to atherosclerosis.

Currently, the treatment of carotid plaques, what is more approved is to combine aspirin using lipid-lowering statins to control It treats, has been reported that this treatment gram makes patch stabilization, becomes smaller and can effectively adjust blood lipid.If patch causes Serious Stenosis, Removal surgery, stent procedure, bypass surgery will be stripped off with the method for operation, such as patch, artery plaque can be quickly removed, dredged The problems such as leading to blood vessel, solving narrow pipe, blood supply insufficiency.But operation not can solve the regeneration Problems Concerning Their Recurrence of carotid plaques.

Therefore, the drug for studying the treatment carotid plaques that novel therapeutic effect is good, toxic side effect is small has important meaning Justice.

Summary of the invention

In order to solve problems in the prior art, the embodiment of the invention provides a kind of for treating in carotid plaques Drug composition and its preparation method and application.The technical solution is as follows:

On the one hand, a kind of for treating the Chinese medicine composition of carotid plaques, the Chinese medicine composition includes: Cortex Magnoliae Officinalis, sand Benevolence, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, caulis perllae, leaves of pulse plants stalk, Herba Lycopi.

Further, the Chinese medicine composition includes: Cortex Magnoliae Officinalis 5-25 parts by weight, fructus amomi 5-25 parts by weight, fried atractylodes 10- 30 parts by weight, Radix Curcumae 10-30 parts by weight, lotus leaf 5-25 parts by weight, Poria cocos 10-40 parts by weight, Rhizoma Chuanxiong 5-25 parts by weight, five pawls Imperial 10-40 parts by weight, Chinese peashrub root 10-30 parts by weight, caulis perllae 5-25 parts by weight, the leaves of pulse plants obstruct 5-25 parts by weight, Herba Lycopi 10-30 weight Part.

Further, the Chinese medicine composition includes: Cortex Magnoliae Officinalis 10-20 parts by weight, fructus amomi 10-20 parts by weight, fried atractylodes 15-25 parts by weight, Radix Curcumae 15-25 parts by weight, lotus leaf 10-20 parts by weight, Poria cocos 20-30 parts by weight, Rhizoma Chuanxiong 10-20 parts by weight, Cairo morningglory root or leaf 20-30 parts by weight, Chinese peashrub root 10-20 parts by weight, caulis perllae 10-20 parts by weight, the leaves of pulse plants obstruct 10-20 parts by weight, Herba Lycopi 15- 25 parts by weight.

Further, the Chinese medicine composition specifically includes: 10 parts by weight of Cortex Magnoliae Officinalis, 10 parts by weight of fructus amomi, 15 weight of fried atractylodes Measure part, 15 parts by weight of Radix Curcumae, 10 parts by weight of lotus leaf, 20 parts by weight of Poria cocos, 10 parts by weight of Rhizoma Chuanxiong, 20 parts by weight of cairo morningglory root or leaf, goldspink 10 parts by weight of root, 10 parts by weight of caulis perllae, the leaves of pulse plants obstruct 10 parts by weight, 15 parts by weight of Herba Lycopi；15 parts by weight of Cortex Magnoliae Officinalis, 15 parts by weight of fructus amomi, 20 parts by weight of fried atractylodes, 20 parts by weight of Radix Curcumae, 15 parts by weight of lotus leaf, 30 parts by weight of Poria cocos, 15 parts by weight of Rhizoma Chuanxiong, cairo morningglory root or leaf 30 Parts by weight, 15 parts by weight of Chinese peashrub root, 15 parts by weight of caulis perllae, the leaves of pulse plants obstruct 15 parts by weight, 20 parts by weight of Herba Lycopi；20 parts by weight of Cortex Magnoliae Officinalis, 20 parts by weight of fructus amomi, 30 parts by weight of fried atractylodes, 30 parts by weight of Radix Curcumae, 20 parts by weight of lotus leaf, 40 parts by weight of Poria cocos, 20 weight of Rhizoma Chuanxiong Measure part, 40 parts by weight of cairo morningglory root or leaf, 20 parts by weight of Chinese peashrub root, 20 parts by weight of caulis perllae, the leaves of pulse plants stalk 20 parts by weight, 30 parts by weight of Herba Lycopi.

It is on the other hand, a kind of for treating the preparation method of the Chinese medicine composition of carotid plaques, which comprises Cortex Magnoliae Officinalis, fructus amomi, the fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, caulis perllae, the leaves of pulse plants of selected parts by weight are taken respectively Stalk, Herba Lycopi add the water of water 550-650 parts by volume, decoct 20-40min, filter out medical fluid；Add water 350-450 again into the dregs of a decoction The water of parts by volume decocts 10-30min, filters out medical fluid；Will twice medical fluid merge after to obtain the final product.

Further, in the method, the dosage of each drug are as follows: 10 parts by weight of Cortex Magnoliae Officinalis, 10 parts by weight of fructus amomi, fried atractylodes 15 parts by weight, 15 parts by weight of Radix Curcumae, 10 parts by weight of lotus leaf, 20 parts by weight of Poria cocos, 10 parts by weight of Rhizoma Chuanxiong, 20 parts by weight of cairo morningglory root or leaf, 10 parts by weight of Chinese peashrub root, 10 parts by weight of caulis perllae, the leaves of pulse plants obstruct 10 parts by weight, 15 parts by weight of Herba Lycopi；15 parts by weight of Cortex Magnoliae Officinalis, 15 weight of fructus amomi Measure part, 20 parts by weight of fried atractylodes, 20 parts by weight of Radix Curcumae, 15 parts by weight of lotus leaf, 30 parts by weight of Poria cocos, 15 parts by weight of Rhizoma Chuanxiong, five pawls Imperial 30 parts by weight, 15 parts by weight of Chinese peashrub root, 15 parts by weight of caulis perllae, the leaves of pulse plants obstruct 15 parts by weight, 20 parts by weight of Herba Lycopi；20 weight of Cortex Magnoliae Officinalis Part, 20 parts by weight of fructus amomi, 30 parts by weight of fried atractylodes, 30 parts by weight of Radix Curcumae, 20 parts by weight of lotus leaf, 40 parts by weight of Poria cocos, Rhizoma Chuanxiong 20 Parts by weight, 40 parts by weight of cairo morningglory root or leaf, 20 parts by weight of Chinese peashrub root, 20 parts by weight of caulis perllae, the leaves of pulse plants obstruct 20 parts by weight, 30 parts by weight of Herba Lycopi.

In another aspect, application of the above-mentioned Chinese medicine composition in the drug of preparation treatment carotid plaques.

It further, further include pharmaceutically acceptable auxiliary material in the drug.

Further, the drug includes decoction, liquid medicine, tablet, capsule, powder, mixture, pill, granule, sugar Starch agent, emplastrum, suppository, aerosol, ointment or injection.

Technical solution provided in an embodiment of the present invention has the benefit that the present invention for treating carotid plaques Chinese medicine composition, each Chinese medicine cooperates according to the compatibility relationship of " monarch, minister, help, make ", collective effect, to act on disease Stove, and then play the curative effect for the treatment of carotid plaques.Clinical trial shows the Chinese medicine composition in, severe arteria carotis spot Block has preferable therapeutic effect, and the total effective rate to carotid plaques is 86.6%, and controls difficulty in relapse after healing, nontoxic pair Effect, is with a wide range of applications.

Specific embodiment

To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention is made below further Ground detailed description.

Embodiment 1

Cortex Magnoliae Officinalis 10g, fructus amomi 10g, fried atractylodes 15g, Radix Curcumae 15g, lotus leaf 12g, Poria cocos 20g, Rhizoma Chuanxiong 12g, five pawls are taken respectively Imperial 20g, Chinese peashrub root 15g, caulis perllae 12g, the leaves of pulse plants obstruct 12g, Herba Lycopi 15g, add water 600mL, then decoct 30min, decoct to medical fluid residue 200mL or so filters out medical fluid；It is added 400mL water again into the dregs of a decoction, decocts 20min, decoct to medical fluid residue 200mL or so, Filter out medical fluid；Will twice medical fluid merge after to obtain the final product.Suitable pharmaceutic adjuvant is added into obtained medical fluid, according to common process, Decoction is made.

Embodiment 2

Cortex Magnoliae Officinalis 15, fructus amomi 15, fried atractylodes 20, Radix Curcumae 20, lotus leaf 15, Poria cocos 30, Rhizoma Chuanxiong 15, cairo morningglory root or leaf 30, gold are taken respectively Sparrow root 15, caulis perllae 15, the leaves of pulse plants obstruct 15, Herba Lycopi 20, add water 550mL, then decoct 40min, decoct to medical fluid residue 150mL or so, filter Medical fluid out；It is added 350mL water again into the dregs of a decoction, decocts 30min, decoct to medical fluid residue 150mL or so, filter out medical fluid；By two After secondary medical fluid merging to obtain the final product.Suitable pharmaceutic adjuvant is added into obtained medical fluid, according to common process, syrup is made.

Embodiment 3

Take respectively the Cortex Magnoliae Officinalis of selected weight, fructus amomi, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, Caulis perllae, leaves of pulse plants stalk, Herba Lycopi, add water 650mL, then decoct 20min, decoct to medical fluid residue 250mL or so, filter out medical fluid；To the dregs of a decoction In be added 450mL water again, decoct 10min, decoct to medical fluid residue 250mL or so, filter out medical fluid；After inciting somebody to action medical fluid merging twice To obtain the final product.Suitable pharmaceutic adjuvant is added into obtained medical fluid, according to common process, powder is made.

Embodiment 4

Take respectively the Cortex Magnoliae Officinalis of selected weight, fructus amomi, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, Caulis perllae, leaves of pulse plants stalk, Herba Lycopi, add water 580mL, then decoct 25min, decoct to medical fluid residue 180mL or so, filter out medical fluid；To the dregs of a decoction In be added 360mL water again, decoct 15min, decoct to medical fluid residue 170mL or so, filter out medical fluid；After inciting somebody to action medical fluid merging twice To obtain the final product.Suitable pharmaceutic adjuvant is added into obtained medical fluid, according to common process, pill is made.

Embodiment 5

Take respectively the Cortex Magnoliae Officinalis of selected weight, fructus amomi, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, Caulis perllae, leaves of pulse plants stalk, Herba Lycopi, add water 610mL, then decoct 28min, decoct to medical fluid residue 220mL or so, filter out medical fluid；To the dregs of a decoction In be added 370mL water again, decoct 23min, decoct to medical fluid residue 190mL or so, filter out medical fluid；After inciting somebody to action medical fluid merging twice To obtain the final product.Suitable pharmaceutic adjuvant is added into obtained medical fluid, according to common process, tablet is made.

Embodiment 6

Take respectively the Cortex Magnoliae Officinalis of selected weight, fructus amomi, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, Caulis perllae, leaves of pulse plants stalk, Herba Lycopi, add water 620mL, then decoct 35min, decoct to medical fluid residue 230mL or so, filter out medical fluid；To the dregs of a decoction In be added 390mL water again, decoct 28min, decoct to medical fluid residue 210mL or so, filter out medical fluid；After inciting somebody to action medical fluid merging twice To obtain the final product.Suitable pharmaceutic adjuvant is added into obtained medical fluid, according to common process, capsule is made.

After obtaining medical fluid also suitable pharmaceutic adjuvant can be added into obtained medical fluid, press according to different preparation needs It is a variety of that liquid medicine, mixture, granule, emplastrum, suppository, aerosol, ointment or injection etc. is made in more solito preparation process Dosage form.

There is no this name of disease of carotid plaques in Chinese medicine ancient literature, the " dizzy of Chinese medicine is attributed to according to its syndrome It is dizzy ", " amnesia ", the scopes such as " card of fainting ".In conjunction with its site of pathological change and symptom category " vessle-Bi symptom-complex " scope.It, can since its generation is in neck To be referred to as " neck vessle-Bi symptom-complex ".Neck vessle-Bi symptom-complex belongs to the card of asthenia in origin and asthenia in superficiality, and specifically have following argument: (1) this void is attributed to liver and spleen Kidney, wherein spleen deficiency is important factor；(2) actually wet turbid, phlegm, hemostasis are marked；(3) patient's condition develops, early stage spleen deficiency, endogenous damp formation, Influence the catharsis of liver, the gasification of kidney, long phlegm and blood stasis, sering obstruction, formation neck vessle-Bi symptom-complex.

It is presently believed that this void of carotid plaques essentially consists in spleen, mark is that wet turbid, phlegm-blood stasis is hindered in neck channels actually, It effects a permanent cure in treatment and answers tonifying spleen, temporary solution then answers clearing damp turbid promoting blood circulation and removing obstruction in channels, it can the turbid Huoxue Therapeutic Method arteria carotis spot of tonifying spleen clearing damp Block.

Cortex Magnoliae Officinalis: bitter in taste, pungent, warm, returns spleen stomach, large intestine channel, gas consumption product, eliminating dampness except full, relieving asthma.For dyspepsia The stagnation of the circulation of vital energy, abdominal distention constipation, damp retention in middle-jiao, abdominal swelling and diarrhea, phlegm stops up the circulation of vital energy in the wrong direction, chest full of cough.

Fructus amomi: pungent-warm, returns spleen stomach, kidney channel, dampness elimination appetizing is warming spleen and stopping diarrha, regulating the flow of vital energy and preventing miscarriage.For abdominal distension, indigestion, Feeling of oppression and fullness in the chest and epigastrium, hiccup are vomited and diarrhoea, and abdomen secret anguish, four limbs are not warm, hyperemesis gravidarum, threatened abortion.

Fried atractylodes: acrid, bitter, warm, drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight are warded off dirty.

Radix Curcumae: it is pungent, bitter, cold, return liver, the heart, lung, promoting blood circulation and stopping pain, promote breath and open depression, clear away heart-fire cool blood, normalizing gallbladder to cure jaundice.For chest Side of body shouting pain, chest impediment and cardialgia, amenorrhea and algomenorrhea, swollen breasts, epilepsy are gone mad, blood-head tells nosebleed, jaundice and reddish urine.

Lotus leaf: toil micro-puckery, cool in nature, return heart, liver, the spleen channel, summer heat relieving and dampness eliminating, invigorating the spleen rising Yang, dissipating stasis and stanching bleeding.For hot summer weather Polydipsia, headache and dizziness, oedema, deficiency of food abdominal distension, dysentery, leukorrhea, rectal prolapse are spitted blood, hematochezia, post partum longtime lochia.

Poria cocos: sweet in flavor, light, mild-natured, return heart, lung, spleen, kidney channel, clearing damp and promoting diuresis, invigorating the spleen calming heart.For edema and little urine, phlegm Dizziness palpitaition, spleen eating less are drunk, loose stool diarrhea is had no peace of mind, insomnia of palpitating with fear.

Rhizoma Chuanxiong: pungent-warm returns liver and gallbladder to pass through.Promote breath and open depression dispels pathogenic wind and remove dampness, promoting blood circulation and stopping pain.For headache and dizziness, hypochondriac pain abdominal pain, Arthritis muscle contraction, amenorrhea and algomenorrhea, rheumatic arthralgia.

Cairo morningglory root or leaf: sweet in flavor, slight bitter, mild-natured, dispelling wind and eliminating dampness, eliminating stasis to resolve swelling.For rheumatism flaccidity syndrome and arthralgia syndrome, pain in waist and lower extremities, oedema, band Under, dysentery, traumatic injury.

Chinese peashrub root: pungent, bitter, flat, return lung, the spleen channel, clearing lung-heat benefit spleen, blood circulation and channel invigorating reduce blood pressure.It for dizziness, coughs, roars Asthma, damp and hot itch, traumatic injury, joint pain.

Caulis perllae: pungent-warm, return lung, the spleen channel, promoting the circulation of qi is in, regulating the flow of vital energy and preventing miscarriage.Bored for chest diaphragm ruffian, gastral cavity pain, belch is vomitted It spits, threatened abortion.

Leaves of pulse plants stalk: acrid flavour, tepor, returns spleen, stomach, lung channel.Clearing damp inducing diaphoresis, removing dampness to restore normal functioning of the stomach.It catches a cold for the summertime, the vomiting of gastral cavity ruffian, It generates heat uncomfortable in chest, abdominal pain vomiting and diarrhea.

Herba Lycopi: acrid flavour, tepor return liver and spleen to pass through, row water of invigorating blood circulation.Yong Yu Disorder lump in the abdomen, postpartum stasis abdominal pain, body and face edema fall and flutter Damage, carbuncle swells.

The present invention fully considers the channel tropism and nature and flavor of each Chinese medicine on the basis of Chinese medicine clearing dampization is turbid, selects cairo morningglory root or leaf dissolving stasis Detumescence, Herba Lycopi activating blood and promoting diuresis, Rhizoma Chuanxiong wind-damp dispelling blood-activating and qi-promoting open strongly fragrant, the Radix Curcumae promoting flow of qi and blood circulation, comprehensive dampness elimination dispel it is wet turbid, it is dry Wet Li Shui, sending down abnormally ascending remove abdominal distension, promoting blood circulation detumescence block.And the proportion for selecting each Chinese medicine mutual, form treatment arteria carotis spot The Chinese medicine composition of block.

Embodiment 7

Patient Zhang, male, 60 years old, Beijing people from Tongzhou, main suit was interrupted 1 year dizzy, exacerbation one week, in November, 2017 It is hospitalized for treatment within 1st.

Present illness history: patient is dizzy without the appearance of obvious inducement the year before, heavy with giddy, heaviness of the head as if it were tightly bandaged, and dizziness in nearly one week adds Weight, in the attached Lu He hospital row neck ultrasound prompt of the Capital University of Medical Sciences: carotid plaques form (0.4cm × 0.5cm), neck Arteriarctia Shuai≤60, blood biochemical prompt: cholesterol 7.62mmol/L, triglycerides 2.63mmmol/L.It is dynamic to be diagnosed as neck Arteries and veins patch is formed, angiopathic vertigo, dizzy still not alleviated through western medicine, and is hospitalized for treatment.

I.e. toward history: suffering from hyperlipidemia 3 years, once take simvastatin, the medicines such as enteric coated aspirin.Deny cerebral infarction, coronary disease Disease and allergies, deny familial heredity medication history.

Human health screening: T:36.1 DEG C, P:80 beats/min, R:24 beats/min, BP:135/80mmHg, patient is conscious, essence Refreshing normal, development is normal, and physical examination whole skin mucous membrane does not touch enlargement, head without xanthochromia and blutpunkte, whole body superficial lymph knot Face are without deformity, and Dual-eyelid is without oedema, and sclera is without xanthochromia, and conjunctiva is without hyperemia, the positive great circle of dicoria, to light reflection sensitive, auricle Without deformity, the unobstructed secretion without exception of external auditory canal, for mastoid process without tenderness, external nose is normal, and ventilation is smooth, and without tenderness, lip is purple for each nose room Dark purple, Shen tongue center, the soft passivity of neck, tracheae is placed in the middle, and for thyroid gland without enlargement, thorax is in bucket chest, and percussion hyperresonant note auscultates double lungs Breathing is not heard and dry moist rale, and pareordia is without protuberance, and 80 beats/min of heart rate, Lv Qiwu noise, the flat no tenderness of abdomen, liver and spleen rib Under do not touch, gurgling sound normal presence, abdomen depth tenderness, backbone four limbs are without deformity, and without redness, four limbs muscular strength is normal in each joint, Double lower limb is without edema.

Head CT is checked after being admitted to hospital；Seen in the no abnormality seen of head.Blood routine: WBC8.9 × 109/L, S85%, L15%； Electrocardiogram: substantially normal；Routine urinalysis: no abnormality seen；Blood lipid chemical examination: TC7.62, TG2.63, fasting blood-glucose 6.5mmol/L.

Admission diagnosis: carotid plaques are formed, angiopathic vertigo.

After being admitted to hospital patient symptoms include: dizzy, giddy is such as wrapped up in, usually cold, abdominal distension, dare not feed cool food, then diarrhea after food, Dry sleeps and easily wakes up, difficult after waking up to fall asleep, viscous not well, the red white and greasy fur of tongue of defecating, wiry and rolling pulse.It is diagnosed as spleen deficiency weight in wet base, Clean air does not rise, failure in sending down turbid yin and dizziness.The decoction for giving the Chinese medicine composition of the preparation of embodiment 1 is treated, and oral medication 10 days, 12 days in hospital.Patient's dizziness is substantially reduced when discharge, and giddy is heavy also improvement, and viscous wait of abdominal distension stool is taken a favorable turn.After discharge Adhere to taking the decoction treatment of the Chinese medicine composition of the preparation of embodiment 1, later institute's check in three months, carotid ultrasound inspection always It looks into, carotid plaques are 0.2cm × 0.3cm, and dizziness is not occurring, and appetite improves, and the diseases such as abdominal distension also improve, and stool switchs to just Often.

Embodiment 8

Patient Mr. Wang, women, 58 years old, the area Tong Zhou, the city Bei Jing people from the county and town Kuo, main cause was dizzy, and giddy is covered unclear one week, in It is hospitalized for treatment on August 12nd, 2016.

: there is dizzy, unclear, uncomfortable in chest with shortness of breath, the cold symptom of giddy illiteracy without obvious inducement in present illness history before Yu Yizhou, In local Health Center with dizziness, the treatment such as diphenidol is given, has no and is relieved, while with shortness of breath, it is uncomfortable in chest to wait not It can alleviate and carry out hospitalization；Be admitted to hospital and give brain CT and show: brain has no infarction lesion, electrocardiogram: sinus rate, ST section It is abnormal, take in hospitalization.

Past medical history: blood pressure slightly increases, and does not take depressor persistently.Deny trauma history and diabetic history, denies hypertension Medical history, one Nian Yu of coronary insufficiency deny food and drug allergy history, and no habits of smoking and alcohol drinking give birth to 2 sons, deny family Genetic history.

Human health screening: 36.7 DEG C of body temperature, 78 beats/min of heart rate, 24 beats/min, BP142/90mmHg are breathed, development is normal, battalion It supports medium.Expression understands, helps into ward, horizontal position, physical examination cooperation.Whole skin and mucous membrane are without xanthochromia, no blutpunkte.Pi Wen Normally, elasticity attenuation, whole body superficial lymph knot do not touch enlargement, and neck activity is normal, and lip cyanosis, the placed in the middle, pharynx that lolls are omited Red, bilateral amygdala is without enlargement.Jugular vein is without full.Chest is without deformity, and bilateral respiratory movement degree is consistent, and intercostal space is without broadening And narrow, percussion voiceless sound, double lungs are heard and bubble and explosion sound.It does not hear and pleural friction sound.Pareordia is without protuberance, and heart circle is not Greatly, heart sound is pure, and just, slightly fastly, 78 beats/min of heart rate, abdomen is soft, and no tenderness, liver and spleen are not and backbone four limbs are without deformity for rule.Double lower limb Without edema, physiological reaction exists, and pathologic reflex is not drawn.

Check after being admitted to hospital: brain CT no abnormality seen, the prompt of neck ultrasound: carotid plaques are formed, about 3.2cm × 2.1cm, Blood biochemistry, TC6.21mmol/L, TG2.3mmol/L.Electrocardiogram prompt: coronary insufficiency, ST-T change.Fasting blood Sugared 5.4mmol/L；Routine urinalysis: no abnormality seen.

Admission diagnosis: carotid plaques, coronary insufficiency, hyperlipidemia.

It is dizzy according to patient after being admitted to hospital, unclear, uncomfortable in chest, the shortness of breath of giddy illiteracy, cold, loose watery stool, loss of appetite, the soreness of waist, White and greasy fur, the symptoms such as small and wiry pulse, dialectical is the insufficiency of the spleen with overabundance of dampness, heart kidney deficiency.Give Betahistine symptomatic treatment, chinkuei shin chewan pills, Danshen Root dropping ball is oral, while giving the decoction treatment of the Chinese medicine composition of the preparation of embodiment 1, and one week in hospital, the conscious head of patient Dizzy, giddy illiteracy is unclear, and shortness of breath uncomfortable in chest has been clearly better, and leaves hospital on August 19th, 2016, continues to give the system of embodiment 1 after discharge The decoction of standby Chinese medicine composition is treated 3 months, and institute's check is carried out, and carotid plaques are 1.2cm × 0.9cm, and the items such as blood lipid refer to Mark has improvement, continues medication medicine-feeding, regular follow-up check.

Embodiment 9

In order to show the traditional chinese medicine composition of the invention to the therapeutic effect of carotid plaques, to Tongzhou District, Beijing City traditional Chinese and western medicine System clinical observation is carried out in conjunction with the typical case of hospital and 60 carotid plaques of Baoding city first hospital of traditional Chinese medicine, is controlled Treatment group and control group each 30, and record its medical history, the state of an illness, age and former treatment method and compare experiment.It is examined through clinic Disconnected, 30 cases for the treatment of group and 30 of control group all suffer from carotid plaques, and difference is locating occurrent time not Together.

Treatment group: the decoction of Chinese medicine composition prepared by embodiment 1 takes orally, 2 times a day, 200 milliliters every time, is used in conjunction 12 Week is as a treatment course.

Control group: his pungent weary fourth of Western medicine is oral, and surrounding is used in conjunction one time a day in dosage 10mg；Dosage is changed to after four weeks 5mg is used in conjunction 8 weeks, 12 weeks as a treatment course one time a day.

Judgement of the traditional chinese medicine composition of the invention to the therapeutic effect of carotid plaques, referring to carotid plaques diagnostic criteria (being deeply conscious of chief editor's version in 2011 referring to " vascular surgery " king that People's Health Publisher publishes).Clinically, coloured silk can be passed through Color Doppler ultrasonic diagnosis apparatus checks whether carotid artery vascular intima-media thickness (IMT) has carotid plaques to diagnose Formation.Under normal circumstances, IMT value should be less than 1.0 millimeters, if IMT value is in 1.0 to 1.2 millimeters of referred to as blood Pipe intimal thickening, IMT value is between 1.2 millimeters to 1.4 millimeters of the formation that can be defined as patch, when IMT value is greater than 1.4 millis It is that Cervical Vessels are narrow in the case where rice.

Tcm diagnosis standard: it is taught according to " Chinese Internal Medicine " and " new Chinese medicine guideline of clinical investigations " (tentative) etc. Material formulates the diagnosis of this time research.

Primary symptom: dizzy, headache, nausea and vomiting.

Minor symptom: epigastric abdominal fullness, deficiency of food is indigestion and loss of appetite, fatigue and weakness, extremity numbness, heaviness of the head as if it were tightly bandaged.

Tongue vein: white and greasy fur, wiry and rolling pulse.Dialectical requirement: have main symptom 1, secondary card 2 or more person, tongue vein and accord with substantially It closes, i.e., it is diagnosable.

Efficacy assessment standard sorting looks into two aspects of efficacy evaluation and tcm syndrome efficacy evaluation:

1, laboratory checks efficacy assessment standard: Carotid ultrasonography curative effect determinate standard [63] (is published referring to people's health Society publishes " color doppler in diagnosing ").

It is effective: >=20% is reduced before IMT value is relatively treated after treatment.

It is effective: to reduce by 20% > IMT >=10% before IMT value is relatively treated after treatment.

Invalid: the above standard person is not achieved in IMT value after treatment.

2, the efficacy assessment standard of tcm syndrome: " the new Chinese medicine clinic issued referring to Ministry of Health of the People's Republic of China Study guideline " use Nimodipine method, therapeutic index (n)=[(pre-treatment score-post treatment integral) ÷ treatment foreset Point] × 100%.

Clinical recovery: tcm clinical practice symptom disappear or mostly disappear, syndrome integral reduce >=95%.

Effective: tcm clinical practice symptom improves, and syndrome integral reduces > 70%~95%.

Effective: tcm clinical practice symptom improves, and syndrome integral reduces 30%~70%.

Invalid: tcm clinical practice symptom is not improved, even aggravating, syndrome integral reduces < 30%.

It specifically can refer to 1 disease of table to score.

The clinical disease table of integrals of table 1

It based on the above evaluation criterion, is handled using 13.0 medical statistics of SPSS, measurement data Normal Distribution is adopted It is examined with the t of Group Design data, taking P < 0.05 is that difference is statistically significant, and specific clinical trial results are as shown in table 2. It is statistically analyzed and shows that treatment group compares that there were significant differences with control group, P < 0.05, treatment group is significant in efficacy to be higher than control Group.

2 clinical trial results of table

As shown in Table 2, the traditional chinese medicine composition of the invention is 86.6% to the total effective rate that carotid plaques are treated.

In addition, we are to blood urine routine, hepatic and renal function, the electrocardiogram etc. before and after patient medication in above-mentioned clinical trial It has done and has checked and record, compared no abnormal, it is seen that the traditional chinese medicine composition of the invention has no toxic side effect.

In conclusion the traditional chinese medicine composition of the invention, which forms carotid plaques, has preferable therapeutic effect, it is total effective Rate reaches 86.6%, and controls difficulty in relapse after healing, has no toxic side effect, and is with a wide range of applications.

Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments. For those of ordinary skill in the art, other various forms of changes can also be made on the basis of the above description Change or changes.There is no necessity and possibility to exhaust all the enbodiments.And obvious change extended from this Change or changes still within the protection scope of the invention.

The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (9)

1. a kind of for treating the Chinese medicine composition of carotid plaques, which is characterized in that the Chinese medicine composition include: Cortex Magnoliae Officinalis, Fructus amomi, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, caulis perllae, leaves of pulse plants stalk, Herba Lycopi.

2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition includes: Cortex Magnoliae Officinalis 5-25 weight Measure part, fructus amomi 5-25 parts by weight, fried atractylodes 10-30 parts by weight, Radix Curcumae 10-30 parts by weight, lotus leaf 5-25 parts by weight, Poria cocos 10- 40 parts by weight, Rhizoma Chuanxiong 5-25 parts by weight, cairo morningglory root or leaf 10-40 parts by weight, Chinese peashrub root 10-30 parts by weight, caulis perllae 5-25 parts by weight, the leaves of pulse plants Obstruct 5-25 parts by weight, Herba Lycopi 10-30 parts by weight.

3. Chinese medicine composition according to claim 2, which is characterized in that the Chinese medicine composition includes: Cortex Magnoliae Officinalis 10-20 weight Measure part, fructus amomi 10-20 parts by weight, fried atractylodes 15-25 parts by weight, Radix Curcumae 15-25 parts by weight, lotus leaf 10-20 parts by weight, Poria cocos 20-30 parts by weight, Rhizoma Chuanxiong 10-20 parts by weight, cairo morningglory root or leaf 20-30 parts by weight, Chinese peashrub root 10-20 parts by weight, caulis perllae 10-20 weight Part, the leaves of pulse plants obstruct 10-20 parts by weight, Herba Lycopi 15-25 parts by weight.

4. Chinese medicine composition according to claim 3, which is characterized in that the Chinese medicine composition specifically includes: Cortex Magnoliae Officinalis 10 Parts by weight, 10 parts by weight of fructus amomi, 15 parts by weight of fried atractylodes, 15 parts by weight of Radix Curcumae, 10 parts by weight of lotus leaf, 20 parts by weight of Poria cocos, river 10 parts by weight of rhizome of chuanxiong, 20 parts by weight of cairo morningglory root or leaf, 10 parts by weight of Chinese peashrub root, 10 parts by weight of caulis perllae, the leaves of pulse plants obstruct 10 parts by weight, 15 weight of Herba Lycopi Part；15 parts by weight of Cortex Magnoliae Officinalis, 15 parts by weight of fructus amomi, 20 parts by weight of fried atractylodes, 20 parts by weight of Radix Curcumae, 15 parts by weight of lotus leaf, Poria cocos 30 Parts by weight, 15 parts by weight of Rhizoma Chuanxiong, 30 parts by weight of cairo morningglory root or leaf, 15 parts by weight of Chinese peashrub root, 15 parts by weight of caulis perllae, the leaves of pulse plants obstruct 15 parts by weight, 20 parts by weight of Herba Lycopi；20 parts by weight of Cortex Magnoliae Officinalis, 20 parts by weight of fructus amomi, 30 parts by weight of fried atractylodes, 30 parts by weight of Radix Curcumae, 20 weight of lotus leaf Part, 40 parts by weight of Poria cocos, 20 parts by weight of Rhizoma Chuanxiong, 40 parts by weight of cairo morningglory root or leaf, 20 parts by weight of Chinese peashrub root, 20 parts by weight of caulis perllae, the leaves of pulse plants stalk 20 parts by weight, 30 parts by weight of Herba Lycopi.

5. a kind of for treating the preparation method of the Chinese medicine composition of carotid plaques, which is characterized in that the described method includes: point Do not take the Cortex Magnoliae Officinalis of selected parts by weight, fructus amomi, fried atractylodes, Radix Curcumae, lotus leaf, Poria cocos, Rhizoma Chuanxiong, cairo morningglory root or leaf, Chinese peashrub root, caulis perllae, leaves of pulse plants stalk, Herba Lycopi adds the water of water 550-650 parts by volume, decocts 20-40min, filters out medical fluid；Add water 350-450 volume again into the dregs of a decoction The water of part decocts 10-30min, filters out medical fluid；Will twice medical fluid merge after to obtain the final product.

6. preparation method according to claim 5, which is characterized in that in the method, the dosage of each drug are as follows: Cortex Magnoliae Officinalis 10 Parts by weight, 10 parts by weight of fructus amomi, 15 parts by weight of fried atractylodes, 15 parts by weight of Radix Curcumae, 10 parts by weight of lotus leaf, 20 parts by weight of Poria cocos, river 10 parts by weight of rhizome of chuanxiong, 20 parts by weight of cairo morningglory root or leaf, 10 parts by weight of Chinese peashrub root, 10 parts by weight of caulis perllae, the leaves of pulse plants obstruct 10 parts by weight, 15 weight of Herba Lycopi Part；15 parts by weight of Cortex Magnoliae Officinalis, 15 parts by weight of fructus amomi, 20 parts by weight of fried atractylodes, 20 parts by weight of Radix Curcumae, 15 parts by weight of lotus leaf, Poria cocos 30 Parts by weight, 15 parts by weight of Rhizoma Chuanxiong, 30 parts by weight of cairo morningglory root or leaf, 15 parts by weight of Chinese peashrub root, 15 parts by weight of caulis perllae, the leaves of pulse plants obstruct 15 parts by weight, 20 parts by weight of Herba Lycopi；20 parts by weight of Cortex Magnoliae Officinalis, 20 parts by weight of fructus amomi, 30 parts by weight of fried atractylodes, 30 parts by weight of Radix Curcumae, 20 weight of lotus leaf Part, 40 parts by weight of Poria cocos, 20 parts by weight of Rhizoma Chuanxiong, 40 parts by weight of cairo morningglory root or leaf, 20 parts by weight of Chinese peashrub root, 20 parts by weight of caulis perllae, the leaves of pulse plants stalk 20 parts by weight, 30 parts by weight of Herba Lycopi.

7. application of the Chinese medicine composition according to claim 1 in the drug of preparation treatment carotid plaques.

8. application according to claim 7, which is characterized in that further include pharmaceutically acceptable auxiliary material in the drug.

9. application according to claim 7, which is characterized in that the drug includes decoction, liquid medicine, tablet, capsule, dissipates Agent, mixture, pill, granule, syrup, emplastrum, suppository, aerosol, ointment or injection.