CN108403803B

CN108403803B - Chinese medicinal compound preparation for preventing and treating cardiovascular complications of diabetes

Info

Publication number: CN108403803B
Application number: CN201810246687.5A
Authority: CN
Inventors: 张芯; 毛竹君; 胡霖霖; 管家齐
Original assignee: Zhejiang Chinese Medicine University ZCMU
Current assignee: Zhejiang Chinese Medicine University ZCMU
Priority date: 2018-03-23
Filing date: 2018-03-23
Publication date: 2021-07-20
Anticipated expiration: 2038-03-23
Also published as: CN108403803A

Abstract

A Chinese medicine compound preparation for preventing and treating diabetes cardiovascular complications belongs to the technical field of Chinese medicines. The traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight: 20-40 parts of raw bighead atractylodes rhizome, 10-30 parts of raw hawthorn, 5-25 parts of salvia miltiorrhiza, 5-25 parts of trichosanthes root, 20-40 parts of kudzu root, 20-40 parts of raw oyster, 5-25 parts of lucid ganoderma, 5-25 parts of snakegourd fruit, 5-25 parts of ground beetle, 10-30 parts of fried cowherb seed and 5-25 parts of oriental blueberry fruit. The traditional Chinese medicine compound preparation for preventing and treating the cardiovascular complications of the diabetes is reasonable in compatibility, has the effects of activating spleen to dissipate turbidity, promoting blood circulation to remove stasis, is safe without toxic and side effects, and has a good effect on preventing and treating the cardiovascular complications of the diabetes.

Description

Chinese medicinal compound preparation for preventing and treating cardiovascular complications of diabetes

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes.

Background

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic elevated blood glucose levels, caused by defects in insulin secretion and/or action. Long-term disturbances of carbohydrate and fat and protein metabolism can cause multiple system damage, wherein diabetic cardiovascular diseases are common complications of diabetes and also main causes of death of diabetic patients. Studies have shown that diabetic patients are at comparable risk of developing myocardial infarction as non-diabetic patients who have a prior history of myocardial infarction. The existence of risk factors such as hyperglycemia, insulin resistance and the like can reduce the activity of nitric oxide, influence the vasodilatation function of blood vessels, stimulate the blood vessels to generate a large amount of cytokines, promote inflammatory reaction and oxidative stress, improve the permeability of the blood vessels, destroy the integrity of the blood vessels endothelium and cause the formation of dysfunction of the blood vessels endothelium. In the early stage of Atherosclerosis (AS), vascular endothelial dysfunction still has reversibility, and early reversal of vascular endothelial dysfunction has important clinical significance for inhibiting the progression of AS, thereby preventing occurrence and development of myocardial ischemic diseases. The cardiovascular complication of diabetes is a complex disease, which relates to pathological changes of multiple tissues and organs, and the single control of blood sugar and platelet aggregation and the like can not effectively prevent the occurrence and development of insulin resistance related vascular endothelial dysfunction. The traditional Chinese medicine classifies the disease into the categories of diabetes, chest stuffiness, palpitation and the like, has multi-angle and multi-level intervention effect on the occurrence and development of cardiovascular complications of diabetes, and has unique advantages in the aspect of treating complex diseases such as diabetic cardiovascular diseases.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to design and provide a technical scheme of a traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes.

The traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes is characterized by comprising the following traditional Chinese medicines in parts by weight: 20-40 parts of raw bighead atractylodes rhizome, 10-30 parts of raw hawthorn, 5-25 parts of salvia miltiorrhiza, 5-25 parts of trichosanthes root, 20-40 parts of kudzu root, 20-40 parts of raw oyster, 5-25 parts of lucid ganoderma, 5-25 parts of snakegourd fruit, 5-25 parts of ground beetle, 10-30 parts of fried cowherb seed and 5-25 parts of oriental blueberry fruit.

The traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes is characterized by comprising the following traditional Chinese medicines in parts by weight: 25-35 parts of raw bighead atractylodes rhizome, 15-25 parts of raw hawthorn, 10-20 parts of salvia miltiorrhiza, 10-20 parts of trichosanthes root, 25-35 parts of kudzu root, 25-35 parts of raw oyster, 10-20 parts of lucid ganoderma, 10-20 parts of snakegourd fruit, 10-20 parts of ground beetle, 15-25 parts of fried cowherb seed and 10-20 parts of oriental blueberry fruit.

The traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes is characterized by comprising the following traditional Chinese medicines in parts by weight: 30 parts of raw bighead atractylodes rhizome, 20 parts of raw hawthorn, 15 parts of salvia miltiorrhiza, 15 parts of trichosanthes root, 30 parts of kudzuvine root, 30 parts of raw oyster, 15 parts of lucid ganoderma, 15 parts of snakegourd fruit, 15 parts of ground beetle, 20 parts of fried cowherb seed and 15 parts of vaccinium bracteatum.

Raw Bai Zhu, sweet, bitter and warm. It enters spleen and stomach meridians. Has effects of invigorating spleen, activating spleen, and promoting spleen qi to disperse essence to irrigate with pouring, so that the turbid and clear fluid can be scored, and the damp turbidity can not be generated. Modern pharmacological studies show that the decoction of raw white atractylodes rhizome has the functions of regulating gastrointestinal tract and reducing blood sugar.

Raw Haw, sour and sweet, slightly warm. It enters spleen, stomach and liver meridians. The warm nature can enter blood system, promote blood circulation, remove blood stasis, resolve turbidity and reduce blood fat. Modern pharmacological research shows that lipolytic enzyme in hawthorn promotes lipolysis, and the extract can dilate coronary artery, increase coronary blood flow, reduce blood fat and resist atherosclerosis.

Dan Shen is bitter and slightly cold. It enters heart and liver meridians. It has the actions of activating blood and resolving stasis, and removing stasis and promoting tissue regeneration, is the essential herb for treating unsmooth blood circulation and blood stasis obstruction, and is called as Xiao Si Zi which can promote blood circulation and tonify. Modern pharmacological research shows that the salvia miltiorrhiza has the effects of expanding coronary artery, increasing coronary blood flow, regulating blood fat, reducing blood viscosity, resisting atherosclerosis, resisting inflammation and easing pain.

Trichosanthis radix is sweet, slightly bitter and slightly cold. It enters lung and stomach meridians. Not only can clear away the lung-heat and stomach excess heat, but also can promote the production of body fluid to quench thirst, has the characteristics of clearing heat without damaging vital qi, nourishing yin without obstructing spleen, and is an essential medicine for treating diabetes. Modern pharmacological research shows that the crude trichosanthin lectin has the function of reducing blood sugar.

Kudzu root, sweet, pungent and cool. It enters spleen, stomach and lung meridians. It can promote the ascending of qi of spleen and stomach to clear yang, and has the actions of promoting the production of body fluid to quench thirst, and its pungent taste can move, and has the action of clearing and activating the channels and collaterals. Modern pharmacological research shows that the pueraria flavonid can expand coronary artery and cerebral blood vessel, and different components contained in the pueraria flavonid also have the functions of reducing blood sugar, reducing blood fat, resisting oxidation and the like.

Raw mu Li is salty and slightly cold. It enters liver, gallbladder and kidney meridians. Has effects in suppressing yang hyperactivity, nourishing yin, invigorating qi, softening hard mass, and eliminating stagnation. Modern pharmacological research shows that the oyster active peptide has the functions of promoting islet tissue repair and recovering the secretion of the islet tissue, and the oyster extract has the function of reducing blood sugar.

Ganoderma lucidum is sweet and neutral. It enters heart, lung, liver and kidney meridians. Has effects in invigorating heart blood, invigorating heart-qi, tranquilizing mind, and tonifying qi and blood. Modern pharmacological research shows that ganoderma can reduce blood viscosity, increase myocardial contraction force and increase coronary blood flow, and ganoderma polysaccharide can regulate glycolipid metabolism.

Gua Lou is sweet and slightly cold. It enters lung, stomach and large intestine meridians. Has effects in clearing away heat, eliminating phlegm, relieving chest stuffiness, resolving hard mass, and activating qi-flowing. Modern pharmacological research shows that the snakegourd fruit has various activities of expanding coronary artery, increasing coronary blood flow, resisting blood coagulation, reducing serum cholesterol and the like, and the water extract of the snakegourd fruit can obviously increase the blood sugar level of hungry rabbits.

Eupolyphaga Seu Steleophaga, salty in flavor and cold in nature. It enters liver meridian. It is good in moving and fleeing, and has the functions of promoting blood circulation, dredging channels and resolving hard mass. Modern pharmacological research shows that the ground beetle water extract has the functions of regulating lipid metabolism, resisting oxidation free radicals and protecting vascular endothelial cells.

Royal jelly, semen Vaccariae, bitter and neutral. It enters liver and stomach meridians. It is good at promoting blood circulation, activating blood, dredging meridians and dissipating nodulation. Modern pharmacological research shows that the cowherb seed can resist angiogenesis, the n-butanol extract of the cowherb seed can inhibit the proliferation, migration and adhesion of endothelial cells and has good protection effect on the endothelial cells, and the cowherb seed and the salvia miltiorrhiza can prolong the blood coagulation time and reduce the viscosity of whole blood after being compatible.

Vaccinium bracteatum, sour, sweet and flat. It enters liver and kidney meridians. Has effects in nourishing liver and kidney, strengthening muscle and bone, and consolidating vital essence. The traditional Chinese medicine considers that the kidney is affected by long-term disease, so that the kidney essence is protected and qi is benefited.

The preparation method comprises the following steps:

a Chinese medicinal compound preparation for preventing and treating cardiovascular complications of diabetes is a preparation form of one of the following: firstly, decoction; ② granules; ③ pills; fourthly, capsules are prepared. The preparation consists of water extract of compound traditional Chinese medicine for preventing and treating diabetes cardiovascular complications and pharmaceutically acceptable excipients.

The preparation is decoction for preventing and treating the cardiovascular complications of diabetes, and the decoction for preventing and treating the cardiovascular complications of diabetes is prepared by the following method: weighing accurately, putting into Concha Ostreae, decocting for 30min, adding Atractylodis rhizoma, fructus crataegi, Saviae Miltiorrhizae radix, Trichosanthis radix, radix Puerariae, Ganoderma, fructus Trichosanthis, Eupolyphaga Seu Steleophaga, parched semen Vaccariae, and fructus Vaccariae, boiling with strong fire, maintaining with slow fire for about 20min, and pouring out the decoction. Adding clear water, boiling all the medicines with strong fire, maintaining with slow fire, pouring out the decoction, and mixing the two decoctions to obtain the Chinese medicinal decoction for preventing and treating diabetic cardiovascular complications.

The preparation is granules for preventing and treating the cardiovascular complications of diabetes, and the granules for preventing and treating the cardiovascular complications of diabetes are prepared by the following method: accurately weighing raw bighead atractylodes rhizome, raw hawthorn, salvia miltiorrhiza, radix trichosanthis, raw oyster, kudzu vine root, lucid ganoderma, snakegourd fruit, ground beeltle, fried cowherb seed and oriental blueberry fruit, appropriately cutting or crushing, putting the materials into an appropriate decocting container, adding appropriate amount of water to immerse the medicinal materials, heating and boiling the materials after soaking the materials for appropriate time, separating decoction after certain time, repeatedly decocting dregs for 2-3 times, collecting each decocted liquid, centrifugally separating or settling and filtering the decoction, concentrating the decoction at low temperature to a specified concentration, kneading the concentrated extract with a certain specific gravity and auxiliary materials, adding an appropriate amount of wetting agent if necessary, finishing the granules and drying to obtain the traditional Chinese medicine granules for preventing and treating the cardiovascular and cerebrovascular complications of diabetes.

The preparation is a pill for preventing and treating the cardiovascular complications of diabetes, and the pill for preventing and treating the cardiovascular complications of diabetes is prepared by the following method: accurately weighing raw rhizoma Atractylodis Macrocephalae, raw fructus crataegi, radix Salviae Miltiorrhizae, radix Trichosanthis, raw Concha Ostreae, radix Puerariae, Ganoderma, fructus Trichosanthis, Eupolyphaga Seu Steleophaga, parched semen Vaccariae, and fructus Vaccariae, pulverizing into fine powder, sieving, mixing, refining with Mel, mixing, making into pill, and drying to obtain the Chinese medicinal pill for preventing and treating diabetes and cardiovascular complications.

The preparation is a capsule for preventing and treating the cardiovascular complications of diabetes, and the capsule for preventing and treating the cardiovascular complications of diabetes is prepared by the following method: accurately weighing raw bighead atractylodes rhizome, raw hawthorn, salvia miltiorrhiza, radix trichosanthis, raw oyster, kudzu vine root, lucid ganoderma, snakegourd fruit, ground beeltle, fried cowherb seed and oriental blueberry fruit, appropriately cutting or crushing, putting the crushed raw materials into an appropriate decocting container, adding appropriate amount of water to immerse the medicinal materials, heating and boiling the medicinal materials after soaking the medicinal materials for appropriate time, separating decoction after certain time, repeatedly decocting medicinal residues for 2-3 times, collecting each decoction, centrifugally separating or settling and filtering the decoction, concentrating the decoction at low temperature to a specified concentration, and adding or not adding pharmaceutically acceptable excipients to prepare the content of the capsule for preventing and treating the cardiovascular complications of diabetes.

The traditional Chinese medicine compound preparation for preventing and treating the cardiovascular complications of the diabetes is reasonable in compatibility, has the effects of activating spleen to dissipate turbidity, promoting blood circulation to remove stasis, is safe without toxic and side effects, and has a good effect on preventing and treating the cardiovascular complications of the diabetes.

Detailed Description

The present invention is further illustrated by the following examples.

Example 1

A traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes mellitus is composed of the following traditional Chinese medicines by weight: 30g of raw bighead atractylodes rhizome, 20g of raw hawthorn, 15g of salvia miltiorrhiza, 15g of trichosanthes root, 30g of kudzuvine root, 30g of raw oyster, 15g of lucid ganoderma, 15g of snakegourd fruit, 15g of ground beetle, 20g of fried cowherb seed and 15g of vaccinium bracteatum.

Example 2

A traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes mellitus is composed of the following traditional Chinese medicines by weight: 25g of raw bighead atractylodes rhizome, 15g of raw hawthorn, 10g of salvia miltiorrhiza, 10g of trichosanthes root, 25g of kudzuvine root, 25g of raw oyster, 10g of lucid ganoderma, 10g of snakegourd fruit, 10g of ground beetle, 15g of fried cowherb seed and 10g of vaccinium bracteatum.

Example 3

A traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes mellitus is composed of the following traditional Chinese medicines by weight: 35 g of raw bighead atractylodes rhizome, 25g of raw hawthorn, 20g of salvia miltiorrhiza, 15g of trichosanthes root, 35 g of kudzuvine root, 35 g of raw oyster, 20g of lucid ganoderma, 15g of snakegourd fruit, 15g of ground beetle, 15g of fried cowherb seed and 5g of vaccinium bracteatum.

Example 4

A traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes mellitus is composed of the following traditional Chinese medicines by weight: 20g of raw bighead atractylodes rhizome, 10g of raw hawthorn, 5g of salvia miltiorrhiza, 5g of trichosanthes root, 20g of kudzuvine root, 20g of raw oyster, 5g of lucid ganoderma, 5g of snakegourd fruit, 5g of ground beetle, 10g of fried cowherb seed and 10g of vaccinium bracteatum.

Example 5

A traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes mellitus is composed of the following traditional Chinese medicines by weight: 40 g of raw bighead atractylodes rhizome, 30g of raw hawthorn, 25g of salvia miltiorrhiza, 15g of trichosanthes root, 40 g of kudzuvine root, 40 g of raw oyster, 25g of lucid ganoderma, 15g of snakegourd fruit, 15g of ground beetle, 25g of fried cowherb seed and 15g of vaccinium bracteatum.

Test example 1

1 clinical data

1.1 general data

240 patients are treated at the department of outpatient service of Zhejiang university of traditional Chinese medicine from 2016 (1 month) to 2017 (12 months), and the patients are divided into a control group and a treatment group by randomly drawing numbers according to a computer, wherein each group comprises 120 patients. Comparison of baseline data for gender, age and duration of disease in two groups of patients, with no statistical significance of the differences (P> 0.05) are comparable. See table 1 for details.

TABLE 1 comparison of baseline data for two groups of patients

1.2 diagnostic criteria

Patients with type 2 diabetes meet the diagnostic criteria of the guidelines for prevention and treatment of type 2 diabetes in china (2010 version).

1.3 inclusion criteria

Meeting the diagnosis standard; ② 35-70 years old; ③ the course of disease is more than 1 year; and fourthly, the users voluntarily participate in and sign the informed consent.

1.4 exclusion criteria

Patients who do not meet the diagnosis standard and inclusion standard; ② ketoacidosis, diabetic foot and other serious diabetic complications; ③ patients with serious system diseases such as cardiovascular, nervous, respiratory, digestive and urinary diseases and mental diseases; type I diabetes and other secondary diabetes; fifth, pregnant and lactating women.

2 method of treatment

The control group is treated by conventional sugar-reducing treatment of western medicine, and the treatment group is treated by a spleen activating and turbid resolving method and a blood activating and stasis resolving method on the basis of the treatment of the control group, and is prepared by a self-planned spleen activating and blood activating and stasis resolving formula: 30g of raw bighead atractylodes rhizome, 20g of raw hawthorn, 15g of salvia miltiorrhiza, 15g of trichosanthes root, 30g of kudzuvine root, 30g of raw oyster, 15g of lucid ganoderma, 15g of snakegourd fruit, 15g of ground beetle, 20g of cowherb seed and 15g of vaccinium bracteatum. 1 dose of the medicine is decocted in water for 400mL each day, and the medicine is taken warmly in the morning and at night. The treatment course is 4 weeks, and the treatment effect is evaluated after 4 weeks. Both groups of patients underwent diabetes knowledge education and diabetes dietary guidance during the test period.

3 evaluation of therapeutic Effect

3.1 Observation items

Insulin resistance related indexes including Fasting Blood Glucose (FBG), Fasting Insulin (FINS) and insulin resistance index (HOMA-IR); ② the vascular inflammatory index interleukin-6 (interleukin-6, IL-6), adopting ELISA kit (GeneTech) to detect.

3.2 statistical tools and data processing

By usingSPSS16.0 statistical software, counting dataχ ²Inspection and measurement data adoptiontAnd (4) checking, wherein the grade data adopts rank sum check.

4 therapeutic results

4.1 comparison of insulin resistance-related indices before and after treatment in two groups of patients

As can be seen from Table 2, the differences between the relevant pre-treatment insulin resistance indicators of the two diabetic patients are not statistically significant: (P> 0.05) are comparable. The improvement of FBG, FINS and HOMA-IR after the treatment of the treatment group is better than that of the control group, and the difference has statistical significance (P<0.05) indicating that the improvement of the related index of insulin resistance after the treatment of the treatment group is obviously better than that of the control group.

TABLE 2 comparison of insulin resistance-related indices before and after treatment in two groups of patients: (

±s）

Note: compared with the control group after the treatment,^* P＜0.05。

4.2 comparison of IL-6 levels before and after treatment in two groups of patients

As can be seen from Table 3Comparison of IL-6 levels before treatment in two groups of diabetic patients, the differences were not statistically significant (P> 0.05) are comparable. The IL-6 level after the treatment was lower than that of the control group, and the difference was statistically significant (PLess than 0.05), suggesting that the level of IL-6 after the treatment of the treatment group is improved obviously better than that of the control group.

TABLE 3 Change in IL-6 levels before and after treatment in two groups of patients: (

±s，ng/L）

Note: compared with the control group after the treatment,^* P＜0.05。

discussion of 5

The diabetic cardiovascular disease is a common complication of diabetes, the existence of factors such as hyperglycemia, insulin resistance and the like can damage the vasodilatation function of blood vessels, and the synthesis and secretion of endothelial-derived active substances are influenced along with the activation of endothelial cells, so that vasoconstrictor spasm, the sustained inflammatory reaction, the activation of blood platelets, the proliferation of smooth muscle cells and vascular remodeling can be caused, atherosclerosis is gradually aggravated, or unstable plaques are ruptured to cause myocardial infarction. The traditional Chinese medicine considers that the disease belongs to the categories of diabetes, thoracic obstruction, palpitation and the like, and under the physiological condition, blood sugar and blood fat are derived from food essence and are generated by spleen and stomach and are necessary nutrient substances for human bodies. However, when food is not drunk for a long time, food tends to feel thick like cream or cold drink, or hunger and fullness are not frequent, the spleen and stomach are injured for a long time, the spleen and stomach are disordered in transportation and transformation, food essence cannot generate qi and blood, and the clear and turbid can not be effective respectively, so that the dampness is accumulated into phlegm, the turbid qi flows out of the vessels, and at the moment, high-level sugar and fat in the blood become the genus of phlegm-dampness and turbid qi. For example, phlegm turbidity obstructs the vessel channel, which affects the circulation of qi and blood and causes qi and blood stasis; the lingering phlegm-turbidity lingers for a long time, which can lead to the syndrome of intermingled phlegm and blood stasis. From the above analysis, it can be known that the cardiovascular disease of diabetes mainly involves two aspects, namely spleen dysfunction and transportation, and phlegm and blood stasis. Therefore, the treatment principles of activating the spleen to eliminate turbid pathogen, promoting blood circulation and dissipating stagnation should be used to achieve the purpose of treating both principal and secondary aspect of disease. According to the embodiment, the purposes of activating spleen and dissolving turbidity, promoting blood circulation and removing stasis are achieved by reasonably proportioning the raw bighead atractylodes rhizome, the raw hawthorn, the salvia miltiorrhiza, the trichosanthes root, the kudzuvine root, the raw oyster, the lucid ganoderma, the snakegourd fruit, the ground beeltle, the cowherb seed and the Chinese candlelia fruit and mutually supplementing each other among the components, and the cardiovascular complications of the diabetes can be effectively prevented and treated.

The following are typical cases of the present invention:

case 1:

lie, woman, 57 years old. The patient with diabetes has a history of 3 years, and the metformin hydrochloride tablet is taken 0.5g (2 tablets) once and is taken 3 times a day. Patients feel palpitation in the near days, fasting blood glucose is 10.8mmol/L, the mouth is dry, the urine is excessive, the stomach is thin and sticky, the stool is sticky, one line is in 1-2 days, the tongue is red, the tongue coating is thin and white, and the pulse is intermittent. Ventricular premature beat frequently occurs through electrocardiogram. And (3) diagnosis: and (3) Western diagnosis: traditional Chinese medicine diagnosis of type 2 diabetes frequent ventricular premature beat: diabetes and palpitation. After the traditional Chinese medicine decoction is used for treatment, the symptoms such as palpitation, dry mouth, sticky stool and the like are obviously relieved after the double-diagnosis after 2 weeks, the fasting blood sugar is 7.5mmol/L, the metformin hydrochloride tablet is reduced to 2 tablets once, and the oral administration is carried out 2 times a day; after 4 weeks, the symptoms such as palpitation and dry mouth disappear, the stool and urine are normal, the fasting blood sugar is 7.1mmol/L, and the electrocardiogram shows that the sinus rhythm is approximately normal electrocardiogram.

Case 2:

neat, male, 49 years old. After the patient has the diabetes for more than 1 year, hypoglycemic drugs (metformin hydrochloride tablets, repaglinide tablets and the like) are taken, the effect is not obvious, the fasting blood sugar is 9.2mmol/L, and the blood pressure is 140-160/90-100 mmHg. Precordial pain, chest distress, thirst, difficulty in defecation, red tongue with purple spots, white coating and wiry pulse in 2-4 days. The electrocardiogram II, III, aVF and V2-4 ST segment are pressed down. And (3) diagnosis: and (3) Western diagnosis: traditional Chinese medicine diagnosis of type 2 diabetes coronary heart disease: diabetes with chest stuffiness and pain. After 2 weeks of treatment by the traditional Chinese medicine decoction, the symptoms of chest pain and chest distress of a patient are obviously relieved, 1 day of defecation occurs, the fasting blood sugar is 8.7mmol/L, and the blood pressure is 130-140/85-95 mmHg. After 4 weeks, the symptoms of chest distress and chest pain disappear after the re-diagnosis, the bowels are normal, the fasting blood sugar is 7.0mmol/L, the blood pressure is 130-140/80-90 mmHg, the electrocardiogram shows sinus rhythm, and the normal electrocardiogram shows. After the local formula is changed for a plurality of times, the blood sugar is controlled stably, and the symptoms of chest distress and chest pain are not generated.

Claims

1. A traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes is characterized by comprising the following traditional Chinese medicines in parts by weight: 20-40 parts of raw bighead atractylodes rhizome, 10-30 parts of raw hawthorn, 5-25 parts of salvia miltiorrhiza, 5-25 parts of trichosanthes root, 20-40 parts of kudzu root, 20-40 parts of raw oyster, 5-25 parts of lucid ganoderma, 5-25 parts of snakegourd fruit, 5-25 parts of ground beetle, 10-30 parts of fried cowherb seed and 5-25 parts of oriental blueberry fruit.

2. The compound traditional Chinese medicine preparation for preventing and treating cardiovascular complications of diabetes as claimed in claim 1, which is characterized by comprising the following traditional Chinese medicines in parts by weight: 25-35 parts of raw bighead atractylodes rhizome, 15-25 parts of raw hawthorn, 10-20 parts of salvia miltiorrhiza, 10-20 parts of trichosanthes root, 25-35 parts of kudzu root, 25-35 parts of raw oyster, 10-20 parts of lucid ganoderma, 10-20 parts of snakegourd fruit, 10-20 parts of ground beetle, 15-25 parts of fried cowherb seed and 10-20 parts of oriental blueberry fruit.

3. The compound traditional Chinese medicine preparation for preventing and treating cardiovascular complications of diabetes as claimed in claim 1, which is characterized by comprising the following traditional Chinese medicines in parts by weight: 30 parts of raw bighead atractylodes rhizome, 20 parts of raw hawthorn, 15 parts of salvia miltiorrhiza, 15 parts of trichosanthes root, 30 parts of kudzuvine root, 30 parts of raw oyster, 15 parts of lucid ganoderma, 15 parts of snakegourd fruit, 15 parts of ground beetle, 20 parts of fried cowherb seed and 15 parts of vaccinium bracteatum.