CN101766755A - Traditional Chinese pill for reducing blood glucose and preparation method thereof - Google Patents
Traditional Chinese pill for reducing blood glucose and preparation method thereof Download PDFInfo
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- CN101766755A CN101766755A CN200810240620A CN200810240620A CN101766755A CN 101766755 A CN101766755 A CN 101766755A CN 200810240620 A CN200810240620 A CN 200810240620A CN 200810240620 A CN200810240620 A CN 200810240620A CN 101766755 A CN101766755 A CN 101766755A
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Abstract
The invention discloses a traditional Chinese pill for reducing blood glucose and a preparation method thereof, belonging to the field of traditional Chinese medicine and aiming at providing a new medicine section for vast patients and being convenient for treating the patients. The pill is prepared by the following 10 traditional Chinese herbs that are adopted as raw materials: salvia miltiorrhiza bge, bighead atractylodes rhizome, angelica sinensis, radix paeoniae rubra, radix achyranthis bidentatae, campanumaea pilosula, astragalus mongholicus, rhizoma polygonati, white hyacinth bean and bighead atractylodes rhizome. Research results of a medicinal effect test show that the traditional Chinese pill has the functions and effects of promoting blood circulation, removing blood stasis, assisting in building up healthful vital energy, enhancing the circulation of qi and blood, obviously reducing the blood glucose, enhancing the immunity, and preventing as well as treating cardiovascular and cerebrovascular complications caused by diabetes.
Description
Technical field
The invention belongs to tcm field, a kind of hypoglycemic Chinese medicine dripping pills and preparation method thereof that is used for.
Background technology
In the human cause of death, diabetes occupy the 5th, and heart disease, cerebrovascular and renal failure are the main fatal complication of diabetes.Insulin be applied to clinical before, ketoacidosis is the diabetics major causes of death, insulin be applied to clinical after, because of ketoacidosis death person seldom, cardiovascular and cerebrovascular disease is the type ii diabetes major causes of death at present, and renal failure is the type i diabetes major causes of death.
Diabetes merge heart disease sickness rate height, clinical symptoms is light, but the state of an illness is heavy, the mortality rate height, even sudden death appears.Main cause is that the diabetes patient lacks necessary cardiac work up, and chemical Antidiabetic Drug is kept on a diet, used in strictness in addition, makes heart be in the malnutrition state for a long time, causes deficiency myocardial blood supply, and coronary heart disease takes place.Because diabetes can not get effective treatment, heart disease can continue outbreak again, and the state of an illness is on the rise, threat to life.
Cerebrovascular (as cerebral thrombosis, cerebral infarction) is the main fatal complication of diabetes.Pilosity is born in the type ii diabetes of the morbidity of growing up, and based in, Microinfarct and multiple lacuna infraction.And easily take place repeatedly, its mortality rate and disability rate obviously increase.Therefore diabetics should be gone necessary cerebral tissue and tip circular test, early finds, early treatment, and treatment must aim at the pathogenesis of disease recovers islet function with Chinese medicine, reaches the diabetes clinical cure, removes that cerebrovascular takes place and the risk factor of development.
The hypoglycemic Chinese medicine dripping pills of the present invention preparation has good effect, taking convenience, and blood sugar decreasing effect is remarkable, and can effectively prevent and treat the effect of the cardiovascular and cerebrovascular vessel complications that diabetes cause.
Summary of the invention
The invention provides a kind of hypoglycemic Chinese medicine dripping pills and preparation method thereof that is used for, purpose is to select for extensive patients provides new medication, makes things convenient for patient treatment.
The present invention is achieved by the following technical solutions:
A kind ofly be used for hypoglycemic Chinese medicine dripping pills, it is that raw material is made by following parts by weight of Chinese traditional medicine material:
10～50 parts of 5～45 parts of Radix Angelicae Sinensis of 5～30 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
10～30 parts of 10～20 parts of Radixs Astragali of 10～40 parts of Radix Codonopsis of Radix Achyranthis Bidentatae
10～25 parts of 10～30 parts of Rhizoma Atractylodis Macrocephalaes of 15～30 portions of Semen Lablab Albums of Rhizoma Polygonati
And the weight portion proportioning of described each Chinese crude drug raw material is:
30 parts of 30 parts of Radix Angelicae Sinensis of 20 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
20 parts of 15 parts of Radixs Astragali of 20 parts of Radix Codonopsis of Radix Achyranthis Bidentatae
9 parts of 22 parts of Rhizoma Atractylodis Macrocephalaes of 24 portions of Semen Lablab Albums of Rhizoma Polygonati
Described preparation is a drop pill.
Described adjuvant includes but not limited to one or more in Macrogol 4000, polyethylene glycol 6000, tween 80, ethanol, sodium stearate, glycerin gelatine, stearic acid, glyceryl monostearate, Cera Flava, insect wax, hydrogenated oil and fat, the vegetable oil.
The preparation method of this drop pill is:
(1) gets Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and be ground into coarse powder, with 20～90% ethanol extractions 2～5 times, each 6～15 times of amounts 2～5 hours filter, and medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into relative density 1.05～1.10 (30～90 ℃), stand at low temperature 12～48 hours, filter, supernatant concentration is to the thick paste of relative density 1.10～1.30 (30～90 ℃);
(2) get that Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae are ground into coarse powder and above-mentioned medicinal residues merge, decoct with water 2～5 times, each 6～15 times of amounts 1～3 hour filter, collecting decoction, be concentrated into the thick paste of relative density 1.05～1.30 (30～80 ℃), add ethanol and make and contain the alcohol amount and be about 30～80%, stir evenly, left standstill 12～48 hours, filter, filtrate recycling ethanol, and be concentrated into the thick paste of relative density 1.05～1.20 (40～85 ℃);
(3) taking polyethylene glycol is an amount of, and heating makes fusion, adds above-mentioned steps (1) (2) gained thick paste, and mixing splashes in the refrigerative silicone oil, makes drop pill, promptly.
For beneficial effect of the present invention better is described, we have carried out following experimental study:
Adopt following principal agent for square substantially:
Radix Salviae Miltiorrhizae 20g Radix Paeoniae Rubra 30g Radix Angelicae Sinensis 30g
Radix Achyranthis Bidentatae 20g Radix Codonopsis 15g Radix Astragali 20g
Rhizoma Polygonati 24g Semen Lablab Album 22g Rhizoma Atractylodis Macrocephalae 9g
One, pharmacodynamic experiment
1. material and instrument
1.1 be subjected to the reagent thing
The drop pill of the present invention's preparation
1.2 control drug
Blood sugar lowering first sheet: Pharmaceutical Factory of Beijing University of Chinese Medicine, authentication code: the accurate word Z11020266 of traditional Chinese medicines, product batch number: 070105.Glibenclamide sheet: Yangzhou stars pharmaceutcal corporation, Ltd, authentication code: the accurate word H32021039 of traditional Chinese medicines, product batch number: 070101.
1.3 the KY2000clinical Spectrophotometer of instrument Hitachi semi-automatic biochemical analyzer, model: 16F-0010, lot number: NO.1603-010; TDZ 5.40 multitube frame autobalance centrifuges, the DT-2000 electronic balance,
1.4 260 of animal Kunming mouses, the scale of construction are 19g ± 3, are bought the certification of fitness number by the Beijing University of Chinese Medicine Experimental Animal Center: the moving word of doctor 07-014 number
1.5 every group of 6～8 sub-cage rearings of feeding environment in the IVC system, room temperature (24 ± 2) ℃, relative humidity 40%～60%, Artificial Control is each 12h round the clock, is provided with standard Mus feedstuff, freely drinks water, and changes 1 time/d of bedding and padding
2 methods
2.1 260 of Kunming mouses are got in modelling, male and female half and half adapt to 48h at laboratory.After water 4h is can't help in fasting, claim the body constitution amount to mark.Therefrom leave and take 40 at random as the normal control group, male and female half and half.Remain after normal Kunming mouse fasting can't help water 12h, tail vein injection 0.6%Alloxan 60mg/kg (facing) with preceding normal saline preparation, water 4h is can't help in fasting behind the 72h, randomly draws each 12 of modeling and normal mouses and surveys blood glucose values, observes the modeling situation.
2.2 the preparation of medicine preparation the present invention preparation is configured to 6.0%, 3.0%, the confession reagent liquid of 1.0% large, medium and small 3 dosage.Blood sugar lowering first sheet is made into 20.0% for reagent liquid.The glibenclamide sheet is made into 0.06% for reagent liquid.
2.3 detecting, grouping, administration and index will observe remaining 210 Alloxan diabetic mices after the modeling, be divided into 6 groups at random, every group 35, be respectively: the large, medium and small dosage group (1.8 of preparation of model group, blood sugar lowering first sheet group (4.0g/kg), glibenclamide sheet group, the present invention's preparation, 0.9,0.3g/kg).Every group 35, got 17 on the tenth day in every group, got 18 in 20 days, male and female half and half, put to death eye socket venous plexus blood sampling back, and blood plasma is preserved the 2h coagulant at 4 ℃ of refrigerators, and separation of serum-20 is ℃ frozen.With determination of glucose oxidase blood glucose.All put to death until administration posterior orbit venous plexus blood sampling in the 20th day back.Measure each time point blood glucose (GLU) with semi-automatic biochemical analyzer.
2.4 statistical procedures result represents with x meansigma methods ± s, organizes a t check, adopts SPSS10.0.Statistics software carries out statistical analysis.
3 results
3.1 observe the result of modeling: experimental result shows, compares with the normal group mice, and model group mouse blood sugar value obviously raises (P＜0.001), illustrates that model prepares successfully.The results are shown in Table 1.
Table 1 alloxan is induced the diabetic mice model result (mmolL of x ± s)
-1
3.2 the influence to blood glucose: each model group and normal group mice relatively blood glucose value all significantly raise (P＜0.001), illustrate that model stability is reliable.The large, medium and small dosage group of the present invention in the 10th day preparation and blood sugar lowering first sheet group and glibenclamide group blood glucose value all reduce, compare with model group, have obvious statistical significance (P＜0.05), wherein big or middle dosage group and glibenclamide group have significant hypoglycemic activity (P＜0.001).The large, medium and small dosage group and the glibenclamide group blood glucose value of the present invention in the 20th day preparation all reduce after the administration, relatively have significant statistical significance (P＜0.001) with model group.The results are shown in Table 2
Table 2 preparation of the present invention is to the influence of blood glucose in diabetic mice (x ± s)
4, conclusion: preparation of the present invention has, blood circulation promoting and blood stasis dispelling, and auxiliary healthy energy, the effect of enhancing QI-blood circulation has remarkable blood sugar lowering, the effect of enhancing immunity, and effect all is better than matched group.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment 1: the present invention is used for hypoglycemic Traditional Chinese Medicine Dropping Pill
Radix Salviae Miltiorrhizae 20g Radix Paeoniae Rubra 30g Radix Angelicae Sinensis 30g
Radix Achyranthis Bidentatae 20g Radix Codonopsis 15g Radix Astragali 20g
Rhizoma Polygonati 24g Semen Lablab Album 22g Rhizoma Atractylodis Macrocephalae 9g
(1) get Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and be ground into coarse powder, with 75% ethanol extraction 2 times, 6 times of amounts are 2 hours for the first time; Measured 1 hour for 5 times for the second time, filter, medicinal residues are standby, and merging filtrate reclaims ethanol, is concentrated into relative density 1.10 (30 ℃), and stand at low temperature 36 hours filters, and supernatant concentration is to the thick paste of relative density 1.25 (40 ℃);
(2) get that Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae are ground into coarse powder and above-mentioned medicinal residues merge, decoct with water 3 times, 8 times of amounts are 2 hours for the first time; For the second time 10 times of amounts are 1 hour, filter, and collecting decoction is concentrated into the thick paste of relative density 1.25 (50 ℃), add ethanol and make and contain the alcohol amount and be about 60%, stir evenly, and leave standstill 48 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste of relative density 1.20 (50 ℃);
(3) taking polyethylene glycol 6000,76g, and heating makes fusion, adds above-mentioned steps (1) (2) gained thick paste 190g altogether, and mixing splashes in the refrigerative silicone oil, makes 2370 of drop pill, promptly.
Embodiment 2: the present invention is used for hypoglycemic Traditional Chinese Medicine Dropping Pill
Radix Salviae Miltiorrhizae 30g Radix Paeoniae Rubra 40g Radix Angelicae Sinensis 20g
Radix Achyranthis Bidentatae 30g Radix Codonopsis 15g Radix Astragali 30g
Rhizoma Polygonati 25g Semen Lablab Album 24g Rhizoma Atractylodis Macrocephalae 22g
(1) gets Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and be ground into coarse powder, with 65% ethanol extraction 3 times, each 5 times of amounts 1.5 hours filter, and medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into relative density 1.10 (50 ℃), stand at low temperature 24 hours, filter, supernatant concentration is to the thick paste of relative density 1.20 (50 ℃);
(2) get that Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae are ground into coarse powder and above-mentioned medicinal residues merge, decoct with water 2 times, each 10 times of amounts 2 hours filter, collecting decoction, be concentrated into the thick paste of relative density 1.25 (50 ℃), add ethanol and make and contain the alcohol amount and be about 65%, stir evenly, left standstill 36 hours, filter, filtrate recycling ethanol, and be concentrated into the thick paste of relative density 1.18 (50 ℃);
(3) get the 96g polyethylene glycol 6000, heating makes fusion, adds above-mentioned steps (1) (2) gained thick paste, and mixing splashes in the refrigerative silicone oil, makes 2400 of drop pill, promptly.
Embodiment 3: the present invention is used for hypoglycemic Traditional Chinese Medicine Dropping Pill
Radix Salviae Miltiorrhizae 15g Radix Paeoniae Rubra 7g Radix Angelicae Sinensis 15g
Radix Achyranthis Bidentatae 17g Radix Codonopsis 12g Radix Astragali 17g
Rhizoma Polygonati 19g Semen Lablab Album 14g Rhizoma Atractylodis Macrocephalae 17g
(1) gets Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and be ground into coarse powder, with 80% ethanol extraction 2 times, each 6 times of amounts 2 hours filter, and medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into relative density 1.09 (40 ℃), stand at low temperature 48 hours, filter, supernatant concentration is to the thick paste of relative density 1.22 (40 ℃);
(2) get that Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae are ground into coarse powder and above-mentioned medicinal residues merge, decoct with water 2 times, each 8 times of amounts 1.5 hours filter, collecting decoction, be concentrated into the thick paste of relative density 1.20 (60 ℃), add ethanol and make and contain the alcohol amount and be about 70%, stir evenly, left standstill 36 hours, filter, filtrate recycling ethanol, and be concentrated into the thick paste of relative density 1.20 (60 ℃);
(3) get the 50g polyethylene glycol 6000, heating makes fusion, adds above-mentioned steps (1) (2) gained thick paste, and mixing splashes in the refrigerative silicone oil, makes 1260 drop pill, promptly.
Claims (3)
1. prescription that is used for hypoglycemic Chinese medicine dripping pills is characterized in that it is made up of by the raw material of Chinese medicine of part following unit of weight:
10～50 parts of 5～45 parts of Radix Angelicae Sinensis of 5～30 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
10～30 parts of 10～20 parts of Radixs Astragali of 10～40 parts of Radix Codonopsis of Radix Achyranthis Bidentatae
10～25 parts of 10～30 parts of Rhizoma Atractylodis Macrocephalaes of 15～30 portions of Semen Lablab Albums of Rhizoma Polygonati.
2. a kind of prescription that is used for hypoglycemic Chinese medicine dripping pills according to claim 1, wherein the weight portion proportioning of each raw material of Chinese medicine is:
30 parts of 30 parts of Radix Angelicae Sinensis of 20 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
20 parts of 15 parts of Radixs Astragali of 20 parts of Radix Codonopsis of Radix Achyranthis Bidentatae
9 parts of 22 parts of Rhizoma Atractylodis Macrocephalaes of 24 portions of Semen Lablab Albums of Rhizoma Polygonati.
3. according to each described a kind of prescription that is used for hypoglycemic Chinese medicine dripping pills of claim 1-2, its preparation method is:
(1) gets Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and be ground into coarse powder, with 20～90% ethanol extractions 2～5 times, each 6～15 times of amounts 2～5 hours filter, and medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into relative density 1.05～1.10 (30～90 ℃), stand at low temperature 12～48 hours, filter, supernatant concentration is to the thick paste of relative density 1.10～1.30 (30～90 ℃);
(2) get that Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae are ground into coarse powder and above-mentioned medicinal residues merge, decoct with water 2～5 times, each 6～15 times of amounts 1～3 hour filter, collecting decoction, be concentrated into the thick paste of relative density 1.05～1.30 (30～80 ℃), add ethanol and make and contain the alcohol amount and be about 30～80%, stir evenly, left standstill 12～48 hours, filter, filtrate recycling ethanol, and be concentrated into the thick paste of relative density 1.05～1.20 (40～85 ℃);
(3) taking polyethylene glycol is an amount of, and heating makes fusion, adds above-mentioned steps (1) (2) gained thick paste, and mixing splashes in the refrigerative silicone oil, makes drop pill, promptly.
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| CN200810240620A CN101766755A (en) | 2008-12-26 | 2008-12-26 | Traditional Chinese pill for reducing blood glucose and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107126501A (en) * | 2017-04-12 | 2017-09-05 | 合肥海大生物医药科技有限公司 | It is a kind of to treat Chinese medicine composition of diabetes and preparation method thereof |
| CN108403803A (en) * | 2018-03-23 | 2018-08-17 | 浙江中医药大学 | A kind of compound Chinese medicinal preparation of prevention diabetic cardiovascular complications |
-
2008
- 2008-12-26 CN CN200810240620A patent/CN101766755A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107126501A (en) * | 2017-04-12 | 2017-09-05 | 合肥海大生物医药科技有限公司 | It is a kind of to treat Chinese medicine composition of diabetes and preparation method thereof |
| CN108403803A (en) * | 2018-03-23 | 2018-08-17 | 浙江中医药大学 | A kind of compound Chinese medicinal preparation of prevention diabetic cardiovascular complications |
| CN108403803B (en) * | 2018-03-23 | 2021-07-20 | 浙江中医药大学 | Chinese medicinal compound preparation for preventing and treating cardiovascular complications of diabetes |
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Open date: 20100707 |