CN100479843C - Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes - Google Patents
Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes Download PDFInfo
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Abstract
The capsule is prepared with astragalus root )2-6 weight portions, ophiopogon root 1-5 weight portions, red sage 1-5 weight portions and selenium-rich bean powder 0.5-2.5 weight portions. It is used in treating type II diabetes with hyperlipemia, high blood viscosity disease, cardiac and cerebral vascular diseases, etc. through natural balance therapy to repair islet cells, restore islet function, raise insulin activity and acceptor sensitivity, lower blood viscosity, lower blood fat, invigorate pulse and active collaterals.
Description
Technical field: the present invention relates to a kind of treatment diabetes (II type) and merge hyperlipemia, blood high viscosity syndrome and lack the medicine-Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes of the multiple disease that selenium causes.Be the medicine that preparation of raw material is formed specifically with Chinese medicine extract and biological soybean flour rich in selenoaminoacid.
Background technology: diabetes are commonly encountered diseases, frequently-occurring diseases of serious harm human health, and its prevalence is obvious ascendant trend, the rejuvenation day by day of the age of onset of non-insulin-dependent diabetes mellitus.Whole world diabetics has exceeded 1.48 hundred million, and wherein about is diabetes (II types) more than 90%.The how generation of effectively preventing diabetes, develop and make thoroughly rehabilitation of diabetics? this is the problem of the diligent exploration of whole world medical profession personage always.
Diabetes are a kind of chronic expendable whole body endocrine metabolism diseases.Diabetes (II type) are mainly due to long-term trace element deficiency in the body, cause the body yin and yang imbalance, it is unusual that the body yin and yang imbalance causes metabolism of trace elements again, and cause beta Cell of islet point-like and ring-type necrosis, glucose tolerance factor to reduce, thereby make the link generation obstacles such as synthetic, split, drainage, transhipment and receptors bind of insulin, cause sugar, protein, fat, water and metabolic disturbance of electrolyte in the body.From the tcm syndrome differentiation and typing theory, diabetes (II type) patient's deficiency of both QI and YIN, the double stasis of blood of holding under the arm are turbid for its main disease type, and double blood stasis or the turbid damp held under the arm is the basis that its many complication takes place, and wherein hyperlipemia, blood high viscosity syndrome are again most common complication.Along with the very easily concurrent whole body blood capillary of the prolongation of the course of disease, macroangiopathy, and the chronic pathological changes of histoorgans such as the initiation heart, brain, kidney, nerve and eye, human beings'health and life security in serious threat.
The medicine that is used for the treatment of at present diabetes both at home and abroad is a lot, most of diabetics need be by various mechanism blood sugar lowering, but since curative effect single, can't effect a radical cure, can not effectively control, cure diabetes and complication, need take medicine throughout one's life, the result causes medicine that organs such as patient's stomach, intestinal, liver, kidney, the heart are caused injury in various degree.Therefore invent a kind of safety, specially good effect, diabetes and complication are had Comprehensive Treatment, rehabilitation synchronously, finally break away from drug dependence, the medicine particular importance that diabetes (II type) patient is thoroughly cured.
Summary of the invention: the objective of the invention is at above-mentioned the deficiencies in the prior art, and provide a kind of without any side effects, evident in efficacy, a medicine multiple-effect, treating both the principal and secondary aspects of a disease, complication such as diabetes (II type) and hyperlipemia, blood high viscosity syndrome, cardiovascular and cerebrovascular disease can be treated simultaneously, and decrement is taken the medicine that also can prevent above disease to take place.
For achieving the above object, the present invention adopts following technical proposals: Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes, mainly by following raw material and weight share preparation: the Radix Astragali (life) 2-6; Radix Ophiopogonis 1-5; Radix Salviae Miltiorrhizae 1-5 and biological soybean flour rich in selenoaminoacid 0.5-2.5, above-mentioned prescription is called A.Described biological soybean flour rich in selenoaminoacid contains sugar, lipid metabolism in selenium (Se) adjustable body, improves immunologic function, control cardiovascular and cerebrovascular disease, has the effect similar to insulin.Cause that free radical scavenging is obstructed owing to lack selenium in the body, activities of antioxidant enzymes reduces, atrophy of pancreas, and the β cell function generation obstacle of pancreas, insulin secretion reduces, and causes impaired glucose tolerance.Therefore selenium supplement is extremely important to the symptom of improving diabetes.Biologic state selenium (Se) physiologically active height is easy to absorb in human body, and the influence of other factors in the unable to take food thing when absorbing, and body burden also is easy to when superfluous drain, and can not produce savings and poison.
Its method for preparing A is undertaken by following processing step:
1, the Radix Astragali (life), Radix Ophiopogonis and Radix Salviae Miltiorrhizae are decocted with water secondary, each 2 hours, collecting decoction filtered, and filtrate is concentrated into the clear paste that relative density is 1.03-1.05 (45 ℃);
2, add ethanol, make to contain the alcohol amount and reach 65%, left standstill 18 hours, filter, reclaim ethanol, filtrate is concentrated into the thick paste that relative density is 1.29-1.30 (50 ℃), and vacuum drying is ground into fine powder 80-120 order, other adds biological soybean flour rich in selenoaminoacid, makes granule, incapsulates promptly.
The Radix Astragali (processing) 2-6 that in above-mentioned raw materials, also can add the weight share preparation; Radix Codonopsis 5-9; Radix Scrophulariae 1-5; Fructus Corni 1-5; Semen Coicis 3-7; Rhizoma Chuanxiong 1-5; Radix Trichosanthis 3-7; Fructus Mume 1-5; Radix Glycyrrhizae 0.5-2.5, above-mentioned prescription is called B.
Its method for preparing B is undertaken by following processing step:
1, take by weighing each raw material by above-mentioned weight, it is stand-by that Rhizoma Chuanxiong power is broken into fine powder;
2, the Radix Astragali (life), the Radix Astragali (processing), Radix Codonopsis, Radix Ophiopogonis, Radix Scrophulariae, Fructus Corni, Semen Coicis, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Fructus Mume and Radix Glycyrrhizae are decocted with water secondary, each 2 hours, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.03-1.05 (45 ℃);
3, add ethanol, make to contain alcohol amount and reach 65%, left standstill 18 hours, filter, reclaim ethanol, filtrate is concentrated into the thick paste that relative density is 1.29-1.30 (50 ℃), with above-mentioned Rhizoma Chuanxiong fine powder mixing, vacuum drying, be ground into fine powder 80-120 order, other adds biological soybean flour rich in selenoaminoacid, makes granule, incapsulates promptly.
The present invention uses the theory of Chinese medical science elite and combines with modern molecular biology, at diabetes (II type) disease type, pathology is used for reference domestic and international pharmacological research achievement, by drafting benefiting qi and nourishing yin after the clinical practice, blood circulation promoting and blood stasis dispelling is with additional, the balance of nature therapy that trace element combines in the balanced body, adopt the Radix Astragali of QI invigorating tonify deficiency, the Radix Ophiopogonis of Yin-nourishing and body fluid promoting, the Radix Salviae Miltiorrhizae of blood circulation promoting and blood stasis dispelling and biological soybean flour rich in selenoaminoacid are the medicine that preparation of raw material is formed, do not contain any chemistry and western medicine composition, have no side effect, many target spots, multipath, dialectical executing controlled, nourish comprehensively, repair impaired unbalance islets of langerhans α, β, gamma cells, make its autonomous normal secretion, recover islet function, improve insulin active and receptor sensitivity, cleaning blood and reducing fat, it is active to promote blood circulation, fundamentally correct, adjust body because the not normal yin and yang imbalance that causes of metabolism of trace elements, thereby reach " treatment of deficiency-syndrome by reinforcement ", " internal organs balance ", treating both the principal and secondary aspects of a disease, recover organism metabolism and blood glucose autoregulation function comprehensively, finally make diabetes (II type) and hyperlipemia, blood high viscosity syndrome, complication such as cardiovascular and cerebrovascular disease are thoroughly cured, and keeping the blood glucose long-term stability, decrement is taken the generation that also can prevent above disease.
The specific embodiment:
Embodiment one
Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes is mainly by following preparation of raw material: the Radix Astragali (life) 200g; Radix Ophiopogonis 100g; Radix Salviae Miltiorrhizae 100g and biological soybean flour rich in selenoaminoacid 50g.
Its preparation method is undertaken by following processing step:
1, takes by weighing each raw material for standby by above-mentioned weight;
2, the Radix Astragali (life), Radix Ophiopogonis, Radix Salviae Miltiorrhizae are decocted with water secondary, each 2 hours, collecting decoction filtered, and filtrate is concentrated into the clear paste that relative density is 1.03-1.05 (45 ℃);
3, add ethanol, make to contain the alcohol amount and reach 65%, left standstill 18 hours, filter, reclaim ethanol, filtrate is concentrated into the thick paste that relative density is 1.29-1.30 (50 ℃), and vacuum drying is ground into fine powder 80-120 order, other adds biological soybean flour rich in selenoaminoacid, makes granule, incapsulates promptly.
Embodiment two
Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes is mainly by following preparation of raw material: the Radix Astragali (life) 389g; Radix Ophiopogonis 278g; Radix Salviae Miltiorrhizae 278g and biological soybean flour rich in selenoaminoacid 140g.
Its preparation method is identical with embodiment one.
Embodiment three
Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes is mainly by following preparation of raw material: the Radix Astragali (life) 600g; Radix Ophiopogonis 500g; Radix Salviae Miltiorrhizae 500g and biological soybean flour rich in selenoaminoacid 250g.
Its preparation method is identical with embodiment one.
Embodiment four
Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes is by following preparation of raw material: the Radix Astragali (life) 200g; The Radix Astragali (processing) 200g; Radix Ophiopogonis 100g; Radix Salviae Miltiorrhizae 100g; Radix Codonopsis 500g; Radix Scrophulariae 100g; Fructus Corni 100g; Semen Coicis 300g; Rhizoma Chuanxiong 100g; Radix Trichosanthis 300g; Fructus Mume 100g; Radix Glycyrrhizae 50g and biological soybean flour rich in selenoaminoacid 50g;
Its preparation method is undertaken by following processing step:
1, take by weighing each raw material by above-mentioned weight, it is stand-by that Rhizoma Chuanxiong power is broken into fine powder;
2, the Radix Astragali (life), the Radix Astragali (processing), Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Radix Scrophulariae, Fructus Corni, Semen Coicis, Radix Trichosanthis, Fructus Mume and Radix Glycyrrhizae are decocted with water secondary, each 2 hours, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.03-1.05 (45 ℃);
3, add ethanol, make to contain alcohol amount and reach 65%, left standstill 18 hours, filter, reclaim ethanol, filtrate is concentrated into the thick paste that relative density is 1.29-1.30 (50 ℃), with above-mentioned Rhizoma Chuanxiong fine powder mixing, vacuum drying, be ground into fine powder 80-120 order, other adds biological soybean flour rich in selenoaminoacid, makes granule, incapsulates promptly.
Embodiment five
Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes is by following preparation of raw material: the Radix Astragali (life) 389g; The Radix Astragali (processing) 389g; Radix Ophiopogonis 278g; Radix Salviae Miltiorrhizae 278g; Radix Codonopsis 722g; Radix Scrophulariae 278g; Fructus Corni 278g; Semen Coicis 556g; Rhizoma Chuanxiong 222g; Radix Trichosanthis 556g; Fructus Mume 222g; Radix Glycyrrhizae 111g and biological soybean flour rich in selenoaminoacid 140g.
Its preparation method is identical with embodiment four.
Embodiment six
Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes is by following preparation of raw material: the Radix Astragali (life) 600g; The Radix Astragali (processing) 600g; Radix Ophiopogonis 500g; Radix Salviae Miltiorrhizae 500g; Radix Codonopsis 900g; Radix Scrophulariae 500g; Fructus Corni 500g; Semen Coicis 700g; Rhizoma Chuanxiong 500g; Radix Trichosanthis 700g; Fructus Mume 500g; Radix Glycyrrhizae 250g and biological soybean flour rich in selenoaminoacid 250g.
Its preparation method is identical with embodiment four.
The present invention can be made into pill, tablet, electuary and capsule.
The Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes pharmacodynamic experiment:
The present invention presses the basic demand of new Chinese medicine pharmacodynamic study, with the animal model of standard observe that positive control drug " diabetes pill " and " Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes " (A) is organized, " Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes " (B) pharmacodynamics between organizing concern, between organizing on the same model platform, relatively select for use targetedly index to observe.Animal experimental model sees Table one, zoopery the results are shown in Table two, table three, table four.
Animal experiment method: select totally 160 of female, male two kinds of rats half and half for use, body weight 170 ± 8g normally fed 7 days, got 30 at random as normal control, normal diet, normal drinking-water.Raise simultaneously with high lipid food with the model induced by alloxan hyperglycemia model for 130 and form the diabetes and hyperlipidemia complications animal model, totally 120 of conformance with standard, be divided into 4 groups at random, every group 30, begin the administration of dividing into groups, respectively at irritating stomach the morning, experimental drug agent amount is all selected middle dosage group for use, quite 20 times of the clinical application amount.Diabetes pill: 0.08g/100g; , Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes (A) group: 7.9g/100g; , Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes (B) group: 7.9g/100g; Irritate stomach after 4 weeks, weekly all every measure body weight, the index of carrying out blood glucose, blood fat, hemorheology in abdominal aortic blood detected to pentobarbital sodium anesthesia in the 40th day after the experiment beginning.
Table one animal experimental model blood glucose and Blood Lipid (X ± SD)
The influence (mmol/L) of table two pair hyperglycemia hyperlipemia rat blood glucose
The influence (mmol/L) of table three pair hyperglycemia hyperlipemia rat blood fat
The influence of table four pair hyperglycemia hyperlipemia rat hemorheology index
Above zoopery result shows, aspect blood sugar lowering (GLU): Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes (A) group, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes (B) group all have obvious blood sugar lowering (GLU) effect, and is identical with the effect of contrast medicine diabetes pill group.At triglyceride reducing (TG), serum total cholesterol (CHO) content, improve and all be better than contrasting medicine diabetes pill group aspect the high density lipoprotein (HDL-C), Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes (A) group, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes (B) group are in that to improve aspect hyperlipemia and the blood high viscosity syndrome effect remarkable.
The experiment of Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes animal toxicity:
Laboratory mice is selected for use female, male two kind half and half, totally 30, body weight 19 ± 2g, after mouse stomach gives the Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes extractum 63.2g crude drug/kg of maximal dose, do not see that animal has the undue toxicity to react, also do not have dead the appearance, so its LD50 is greater than 63.2g crude drug/kg.
The clinical experiment of Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes treatment diabetes (II type):
At diabetes (II type) disease type, pathology, use the theory of Chinese medical science elite and combine with modern molecular biology, use for reference domestic and international pharmacological research achievement and by clinical practice, draft Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes, surplus clinical and experimentation obtained satisfied effect through 3 years, and experimental result is as follows:
1, clinical data
Selected case, according to pharmaceutical control and administration department of Ministry of Health of the People's Republic of China new drug (Chinese medicine) treatment diabetes (diabetes) clinical technology guideline, be defined as diabetes (II type), totally 56 examples, man's 25 examples, woman's 31 examples, age 32-67 year, average 45.1 ± 5.7 years old, the course of disease is at 1-8, average 3 years, all there are not complication such as the serious heart, brain, kidney, all there is not islets of langerhans extract for treating history.Grouping: be divided into treatment at random and organize 30 examples, matched group 26 examples, two groups of physical data are similar.
2, Therapeutic Method
Two groups of cases are all in treating preceding 1 week, inactive in principle any hypoglycemic medicine, detect every lab index after, the treatment group is thrown: Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes on its basis of keeping on a diet requiring; It is main that matched group is then thrown supplementing QI and nourishing YIN: YUQUAN WAN, by its separately prescription make decoction, all take with decoction, each 150ml, day clothes 2 times, 2 months is a course of treatment.
3, therapeutic outcome
Clinical efficacy is judged by the mentioned above principle standard, treatment group obvious effective rate 63.3%, improvement rate 23.7%, inefficiency 13.3%, total effective rate 86.6%.Matched group obvious effective rate 26.9%, improvement rate 42.3%, inefficiency 30%, total effective rate 69.2%.Clinical effectiveness shows that treatment back patient's clinical symptoms disappears substantially, blood pressure and blood lipoid descends, and is very obvious with deficiency of both vital energy and Yin doing well,improvings such as weak, xerostomias especially, even experimental index changes its symptom of unconspicuous patient and also obviously alleviates, as seen the present invention's pathogenesis that hits is effective.Two groups of therapeutic outcomes see Table one, table two, table three.
Fasting glucose and cholesterol change before and after the treatment of table one or two group
| Group | N | FBG(mmol/L) | TG(mmol/L) |
| Matched group | Treat back 2 months before the treatment and treat back 3 months | 10.98±2.07 9.61±0.77? 8.58±1.88? | 6.34±0.42 5.67±0.41 |
| The treatment group | Treat back 2 months before the treatment and treat back 3 months | 11.16±2.52 8.61±1.08? 6.89±0.78? | 6.98±1.1? 5.30±0.43 |
The variation relation (X+SD) of HbAlc and HDL before and after the table two liang group treatment
| Group | t ? | HbAlc(％) | HDL(mg/L) |
| Matched group | Treat back 2 months before the treatment and treat back 3 months | 10.45+2.02 8.26+1.72? 7.83+1.15? | 43.43+4.79 45.51+4.72 |
| The treatment group | Treat back 2 months before the treatment and treat back 3 months | 10.82+1.85 6.43+1.46? 5.52+0.87? | 42.39+5.09 50.32+4.18 |
The comparison of table three insulin release test (X+SD)
Experiment conclusion: glycolated hemoglobin (HbAlc) concentration is directly proportional with blood sugar level and hyperglycemia persistent period, owing to 2-3 before its reaction assay month average blood sugar level rather than be subjected to interference factor to cause variation in a short time, for the Blood glucose control situation great reference value is arranged, analyzing its synthesis rate from this result of study increases extremely obvious in the deficiency of both QI and YIN stage, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes can be controlled glycolated hemoglobin (HbAlc) concentration preferably, the steady blood sugar lowering concentration of the present invention's energy long time is described, and prevents proteic glycosylation degeneration in other histiocyte.In diabetes (II type) patient's blood, basal insulin content is not low, mainly be that glucoreceptor on the β cell membrane is unusual, not normal to the blunt insulin secretion function that causes of the irritant reaction of high concentration blood glucose, therefore detecting the test of islets of langerhans release function is to understand one of main method of its function, after Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes group patient takes medicine, each time limit insulin secretion level is significantly improved, be better than matched group, show that Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes can improve the sensitivity of saccharide acceptor on the β cell membrane, thereby strengthened the ability of beta Cell of islet quick excreting insulin under hyperglycemia state, hyperlipidemia is that diabetes (II type) form the cardiovascular and cerebrovascular complication main cause, and high density lipoprotein (HDL) level to lipidemia obviously lowly also is a major reason in the type of deficiency of both QI and YIN patient blood, from this experimental result, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes high density lipoprotein (HDL) value after treatment obviously raises, with the matched group significant difference, show that Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes passes through to improve the content of patient's blood plasma middle-high density lipoprotein (HDL) with the usefulness of its cooling blood and removing stasis, promote the ability of its combined cholesterol, reach the generation of the cardiovascular and cerebrovascular complication that prevents or delay that diabetes cause, development.
Claims (10)
1, a kind of Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes is characterized in that it is mainly by following raw material and weight share preparation: Radix Astragali 2-6; Radix Ophiopogonis 1-5; Radix Salviae Miltiorrhizae 1-5 and biological attitude trace element Selenium rich Semen Glycines powder 0.5-2.5.
2, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes as claimed in claim 1 is characterized in that: the Radix Astragali Preparata 2-6 that also can add the weight share preparation; Radix Codonopsis 5-9; Radix Scrophulariae 1-5; Fructus Corni 1-5; Semen Coicis 3-7; Rhizoma Chuanxiong 1-5; Radix Trichosanthis 3-7; Fructus Mume 1-5; Radix Glycyrrhizae 0.5-2.5.
3, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes as claimed in claim 1 is characterized in that the concrete consumption of each raw material: Radix Astragali 200g; Radix Ophiopogonis 100g; Radix Salviae Miltiorrhizae 100g and biological soybean flour rich in selenoaminoacid 50g.
4, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes as claimed in claim 1 is characterized in that the concrete consumption of each raw material: Radix Astragali 389g; Radix Ophiopogonis 278g; Radix Salviae Miltiorrhizae 278g and biological soybean flour rich in selenoaminoacid 140g.
5, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes as claimed in claim 1 is characterized in that the concrete consumption of each raw material: Radix Astragali 600g; Radix Ophiopogonis 500g; Radix Salviae Miltiorrhizae 500g and biological soybean flour rich in selenoaminoacid 250g.
6, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes as claimed in claim 1 or 2 is characterized in that the concrete consumption of each raw material: Radix Astragali 200g; Radix Astragali Preparata 200g; Radix Ophiopogonis 100g; Radix Salviae Miltiorrhizae 100g; Radix Codonopsis 500g; Radix Scrophulariae 100g; Fructus Corni 100g; Semen Coicis 300g; Rhizoma Chuanxiong 100g; Radix Trichosanthis 300g; Fructus Mume 100g; Radix Glycyrrhizae 50g and biological soybean flour rich in selenoaminoacid 50g.
7, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes as claimed in claim 1 or 2 is characterized in that the concrete consumption of each raw material: Radix Astragali 389g; Radix Astragali Preparata 389g; Radix Ophiopogonis 278g; Radix Salviae Miltiorrhizae 278g; Radix Codonopsis 722g; Radix Scrophulariae 278g; Fructus Corni 278g; Semen Coicis 556g; Rhizoma Chuanxiong 222g; Radix Trichosanthis 556g; Fructus Mume 222g; Radix Glycyrrhizae 111g and biological soybean flour rich in selenoaminoacid 140g.
8, Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes as claimed in claim 1 or 2 is characterized in that the concrete consumption of each raw material: Radix Astragali 600g; Radix Astragali Preparata 600g; Radix Ophiopogonis 500g; Radix Salviae Miltiorrhizae 500g; Radix Codonopsis 900g; Radix Scrophulariae 500g; Fructus Corni 500g; Semen Coicis 700g; Rhizoma Chuanxiong 500g; Radix Trichosanthis 700g; Fructus Mume 500g; Radix Glycyrrhizae 250g and biological soybean flour rich in selenoaminoacid 250g.
9, preparation is characterized in that as the method for claim 1 or 3 or 4 or 5 described Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes:
(a) with Radix Astragali, Radix Ophiopogonis and Radix Salviae Miltiorrhizae, decoct with water secondary, each 2 hours, collecting decoction filtered, and it is 1.03-1.05 that filtrate is concentrated into relative density, and temperature is 45 ℃ a clear paste;
(b) add ethanol, make to contain the alcohol amount and reach 65%, left standstill 18 hours, filter, reclaim ethanol, it is 1.29-1.30 that filtrate is concentrated into relative density, and temperature is 50 ℃ a thick paste, vacuum drying, be ground into fine powder 80-120 order, other adds biological soybean flour rich in selenoaminoacid, makes granule, incapsulates promptly.
10, preparation is characterized in that as the method for claim 2 or 6 or 7 or 8 described Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes:
(a) take by weighing each raw material by above-mentioned weight, it is stand-by that Rhizoma Chuanxiong power is broken into fine powder;
(b) Radix Astragali, Radix Astragali Preparata, Radix Codonopsis, Radix Ophiopogonis, Radix Scrophulariae, Fructus Corni, Semen Coicis, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Fructus Mume and Radix Glycyrrhizae are decocted with water secondary, each 2 hours, collecting decoction filtered, it is 1.03-1.05 that filtrate is concentrated into relative density, and temperature is 45 ℃ a clear paste;
(c) add ethanol, make to contain the alcohol amount and reach 65%, left standstill 18 hours, filter, reclaim ethanol, it is 1.29-1.30 that filtrate is concentrated into relative density, and temperature is 50 ℃ a thick paste, with above-mentioned Rhizoma Chuanxiong fine powder mixing, vacuum drying is ground into fine powder 80-120 order, and other adds biological soybean flour rich in selenoaminoacid, make granule, incapsulate promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610047750XA CN100479843C (en) | 2006-09-15 | 2006-09-15 | Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610047750XA CN100479843C (en) | 2006-09-15 | 2006-09-15 | Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes |
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| Publication Number | Publication Date |
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| CN1931316A CN1931316A (en) | 2007-03-21 |
| CN100479843C true CN100479843C (en) | 2009-04-22 |
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| CNB200610047750XA Expired - Fee Related CN100479843C (en) | 2006-09-15 | 2006-09-15 | Xiaokezhinian capsule for treating diabetet, hyperlipemia and likes |
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| CN (1) | CN100479843C (en) |
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2006
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