CN105106884B - Qi and activate blood circulation lets out turbid side - Google Patents

Abstract

The invention discloses a kind of qi and activate blood circulations to let out turbid side.This is let out turbid side and decoction is made as component and is used using Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, rhizoma zingiberis, leech, lycopodium calvatum.Qi and activate blood circulation of the present invention lets out turbid side and treats that middle and advanced stage efficacy on diabetic nephropathy is significant, and clinical effectiveness is satisfied, and safely and effectively without side-effects, can prolonged application.

Description

Qi and activate blood circulation lets out turbid side

Technical field

The invention belongs to medical sci-tech fields, specifically, the present invention relates to a kind of qi and activate blood circulations to let out turbid side.

Background technique

Diabetes (DM) are one of popular most wide, maximum diseases of harm in worldwide.It counts, ends according to WHO The number of the infected of the whole world of in September, 2006 diabetes is up to 1.8 hundred million, it is contemplated that will be up to 3.7 hundred million people to the year two thousand thirty.Diabetic nephropathy (DN) is DM common microvascular complication, disease incidence account for about the 35-40% of diabetes patient, because diabetes lead to uremia Died Patients The 27-31% [1] of diabetes patient is accounted for, diabetic nephropathy is the principal element for leading to DM death, and diabetic nephropathy has become The main reason of American-European countries's end-stage renal disease, about 45%.U.S.'s end-stage renal disease associated treatment in 2002 is taken according to statistics With up to 17,000,000,000 U.S. dollars, the 6.7% of total medical expense is accounted for.China's diabetic nephropathy has become the second morbidity of end-stage renal disease Reason, the annual new patient numbers into hemodialysis are up to 5000 or so, and only year new dialysis expense is as high as hundred million yuan of people of 4-5 Coin.Since DN leads to uremia, huge pain can be not only brought to patient, many families drive into poverty by medical crises, back into poverty by medical crises, simultaneously Also heavy financial burden is brought to society.Therefore, how to prevent the generation of diabetes and delay the development of diabetic nephropathy It is medical field problem in the urgent need to address, there is important social value and economic value.

The basic pathology variation of diabetic nephropathy be the capillary ball of glomerulus is loose, basilar memebrane thickens in various degree, Mesangial cell increases, extracellular matrix increases, renal tubule atrophy and kidney region fibrosis and glomerulosclerosis, falls into disuse.And it is exact Pathogenesis not yet illustrates completely so far, and concluding its pathogenesis, there are many theories, mainly different with inherent cause, haemodynamics Often, vaso-active substance and cell factor metabolic disorder, oxidative stress etc. caused by Dyslipidemia, hypertension, inflammation etc. It is related, renal fibrosis is eventually led to, is developed as end-stage renal disease.

The drug for the treatment of diabetes and its complication relies primarily on chemistry and biochemistry class drug at present, is mainly used for controlling Protopathy is treated, short-term blood sugar reducing function is obvious, but treatment method is single, toxic side effect is big, is easy to cause hypoglycemia, and price is high Expensive, long for the course of disease and serious patient's curative effect is not significant.Chinese medicine is cheap, action temperature and persistently, can diagnosis and treatment based on an overall analysis of the illness and the patient's condition, plus-minus Flexibly, toxic side effect is small, and the complex treatment effect with polytropism, stage construction, multiple target point, can play of diagnosis and treatment The treatment of body superior combination, effectively delays the occurrence and development of complication.

Therefore this field needs a kind of drug of suitable treatment middle and advanced stage diabetic nephropathy.

Summary of the invention

The object of the present invention is to provide a kind of centering Late-stage diabetic nephrosis active treatment effect, and safe and effective, nothing Side effect, can the qi and activate blood circulation of prolonged application let out turbid side.

The first aspect of the present invention provides a kind of qi and activate blood circulation and lets out turbid side, and the qi and activate blood circulation lets out turbid side and contains bulk pharmaceutical chemicals The extract of material or the raw medicinal material, wherein the raw medicinal material includes: Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, does Ginger, leech, lycopodium calvatum,

Also, the parts by weight of the raw medicinal material are as follows:

Radix Astragali 25-35

Radix Angelicae Sinensis 25-35

Ganoderma lucidum 25-35

Root of Chinese clematis 25-35

Safflower 10-20

Rhizoma zingiberis 10-20

Leech 5-15

Lycopodium calvatum 10-20.

In another preferred example, the raw medicinal material by Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, rhizoma zingiberis, leech, stretch Muscle grass is constituted.

In another preferred example, the drug is for treating middle and advanced stage diabetic nephropathy.

In another preferred example, the extract includes: water extract or aqueous extract.

In another preferred example, the aqueous extract refers to the extract with aqueous solvent extraction.

In another preferred example, the aqueous solvent refers to by water and solvent compatible with water (such as alcohol, including ethyl alcohol) institute The mixed solvent of composition, wherein water content is 10-99.5wt%, preferably 50-90wt%.

In another preferred example, the raw medicinal material includes:

30 grams of Radix Astragali

30 grams of Radix Angelicae Sinensis

30 grams of ganoderma lucidum

30 grams of the root of Chinese clematis

15 grams of safflower

15 grams of rhizoma zingiberis

10 grams of leech

15 grams of lycopodium calvatum.

In another preferred example, the drug also contains pharmaceutically acceptable carrier.

In another preferred example, the content of the pharmaceutically acceptable carrier is 5-99wt%, preferably 10- 90wt%, by the total weight of the drug.

In another preferred example, the pharmaceutically acceptable carrier include: water, filler, corrigent, glycerol, other Suitable additive, or combinations thereof.

In another preferred example, the dosage form of the drug includes decoction.

In another preferred example, the drug is decoction, and more preferably, specification is 100 or 150g/ parts.

In another preferred example, the raw medicinal material is powdered.

In another preferred example, the partial size of the raw medicinal material is 1-10mm.

The second aspect of the present invention provides a kind of combination of raw medicinal material, and the combination includes following raw medicinal material: Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, rhizoma zingiberis, leech, lycopodium calvatum,

Also, the parts by weight of the raw medicinal material are as follows:

Radix Astragali 25-35

Radix Angelicae Sinensis 25-35

Ganoderma lucidum 25-35

Root of Chinese clematis 25-35

Safflower 10-20

Rhizoma zingiberis 10-20

Leech 5-15

Lycopodium calvatum 10-20.

In another preferred example, the raw medicinal material by Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, rhizoma zingiberis, leech, stretch Muscle grass composition.

The third aspect of present aspect provides raw medicinal material as described in the first aspect of the invention or as described in second aspect Raw medicinal material combined purposes, be used to prepare treatment middle and advanced stage diabetic nephropathy drug.

In another preferred example, the amount of application of the drug is 1-3 agent for each person every day, and daily administration dosage is equivalent to 30-300 grams is done total medicinal material, is preferably equivalent to 50-200 grams and is done total medicinal material.

Fourth aspect present invention provides a kind of method for preparing qi and activate blood circulation and letting out turbid side, the method includes the steps:

(a) raw medicinal material is provided, the raw medicinal material includes: Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, rhizoma zingiberis, water Leech, lycopodium calvatum,

Also, the parts by weight of the raw medicinal material are as follows:

Radix Astragali 25-35

Radix Angelicae Sinensis 25-35

Ganoderma lucidum 25-35

Root of Chinese clematis 25-35

Safflower 10-20

Rhizoma zingiberis 10-20

Leech 5-15

Lycopodium calvatum 10-20；

(b) raw medicinal material is extracted, to obtain the extract of the medicinal material；With

(c) optionally, by the powdered mixture or the extract and pharmaceutically acceptable carrier of the medicinal material It is mixed, so that the qi and activate blood circulation, which is made, lets out turbid side.

In another preferred example, the dosage form of the drug includes decoction.

It should be understood that above-mentioned each technical characteristic of the invention and having in below (eg embodiment) within the scope of the present invention It can be combined with each other between each technical characteristic of body description, to form a new or preferred technical solution.As space is limited, exist This no longer tires out one by one states.

Specific embodiment

The present inventor has found a kind of benefit by largely screening and testing by long-term extensive and in-depth research for the first time Turbid side is let out in gas promoting blood circulation, which lets out turbid side with Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, rhizoma zingiberis, leech, lycopodium calvatum and be Ingredient reaches effective therapeutic effect by scientific matching.Clinical tests prove that it is safe and effective and without side-effects, it can answer for a long time With.The present invention is completed on this basis.

Diabetic nephropathy

The basic pathology variation of diabetic nephropathy (DKD) is that the capillary ball of glomerulus is loose, basilar memebrane is different degrees of It thickens, mesangial cell increases, extracellular matrix increases, renal tubule atrophy and kidney region fibrosis and glomerulosclerosis, falls into disuse.And it is true The pathogenesis cut not yet illustrates completely so far, concludes its pathogenesis there are many theory, mainly with inherent cause, hemodynamic It learns vaso-active substance caused by exception, Dyslipidemia, hypertension, inflammation etc. and cell factor metabolic disorder, oxidation is answered It is sharp etc. related, renal fibrosis is eventually led to, is developed as end-stage renal disease.

And famous Chinese medicine scholar professor Ye Jinghua thinks, the immanent cause of diabetic nephropathy morbidity and its pathology machine turn is spleen Deficiency of the kidney is empty, simultaneously as the disease course of disease is long and delay is refractory, necessarily leads to stagnation of blood stasis.Diabetic nephropathy is derived from diabetes, therefore The cause of disease traces back to the source of the generation of diabetes, i.e. spleen deficiency qi exhaustion, yin jin flows down, and the spleen being the foundation of acquired constitution is source of generating QI and blood, people Relying and survive, modern temper virtual loss, elevator dereliction of duty, yin jin is dirty.On not give conscience then scorching, under the not nourishing liver kidney then deficiency of Yin, yin Empty scorching, multiple and undermine spleen yin therefore be unable to metaplasia body fluid, occurring as soon as thirsty drink in early days does not extricate oneself, hungry and insatiable hunger.Be hard and dry equal spies Point.The main principle that the clinical application experience that professor Ye summarizes formulates diabetic nephropathy treatment is: 1. flat mend are better than high benefit, laxative It is rushed down better than high；2. activating microcirculation and removing stasis medicinal runs through treatment always；3. reusing promoting blood circulation does not forget invigorating the spleen；4. the differentiation of disease is mutually tied with differentiation of symptoms and signs for classification of syndrome by stages It closes.

Drug component

1. Radix Astragali

Radix Astragali pharmacological property temperature, sweet in flavor, return lung, the spleen channel.Effect: invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema.With In treatment deficiency of vital energy and acking in strength, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, the deficiency of blood withers Huang, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..Shennong's Herbal: " main ulcer loses sore, Apocenosis pain relieving long.Qi-restoratives, children All kinds of diseases and ailments." " Japan hanako materia medica ": it " helps gas to strengthen the bone, puts on flesh and enrich blood.

2. Radix Angelicae Sinensis

Radix Angelicae Sinensis flavour of a drug are sweet；It is pungent；It is bitter；It is warm-natured, enter the heart, liver, the spleen channel.It enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturizing dryness and lubricating intestine.The main deficiency of blood All cards；Irregular menstruation；Menostasis；Dysmenorrhea；Abdominal mass knot is poly-；Metrorrhagia and metrostaxis；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness；Intestines are dry and shit is difficult；After dysentery with bloody stool Weight；Ulcer sores；Injury from falling down.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, intestinal dryness is just It is secret, rheumatic arthralgia, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia, injury from falling down. " detailed outline ": headache, all pains of trusted subordinate, ease constipation stomach muscles and bones skin are controlled.Ulcer is controlled, Apocenosis pain relieving and blood are enriched blood." book on Chinese herbal medicine is new again ": it controls Swelling from head to foot, blood vessels discord, yin point deficiency, peaceful tire, stillborn foetus of falling." Japan hanako materia medica ": controlling a wind cutting, all blood mend all Labor breaks extravesated blood, supports new blood and primary symptom addiction.

3. ganoderma lucidum

Ganoderma lucidum is warm-natured, lightly seasoned, return heart, lung, liver and kidney channel.Replenishing qi and blood；Tranquilizing mind；Strengthening the spleen and stomach.Main consumptive disease；Palpitaition；Insomnia； It is dizzy；Spiritlessness and weakness；Chronic cough asthma；Coronary heart disease；Silicosis；Tumour.For dizziness egersis, shortness of breath and palpitation, consumptive disease cough and asthma.

4. the root of Chinese clematis

Root of Chinese clematis pharmacological property: pungent, salty, temperature.Return bladder meridian effect: wind-damp dispelling is removed obstruction in channels to relieve pain, " Bencao Jingshu ": " root of Chinese clematis, Main all wind, and be that preferably leading for expelling wind drug is apt to the person of walking.It is cold stagnant in abdomen, mostly due to cold-dampness, heart diaphragm phlegm water, be drink be stopped at, in two cokes , wind can clear damp.Diseases caused by dampness happiness is dry, therefore main.Bladder place purulence water unfit to drink wastes not by wet institute at the cold pain of waist and knee, also edge is wet flows down portion It invades muscle and causes it, dispelling wind and eliminating dampness, disease is with going.It says Jiu Ji Disorder lump in the abdomen, Xuan addiction, air parcel and injured.Then sick, gas divide person more in blood system person It is few, and may not be all due to wet, that applies fears to take to save and here may be used also without working as."

5. safflower

Safflower nature and flavor are warm-natured, acrid flavour.The channel tropism heart, Liver Channel " drugization justice ": safflower is apt to tonneau passages through which vital energy circulates, is gas medicine in blood, It can rush down and can mend, respectively there is wonderful justice.

6. rhizoma zingiberis

Rhizoma zingiberis, acrid flavour, property heat.Returns spleen, stomach, the heart, lung channel.Effect warming spleen and stomach for dispelling cold, recover Yang and smooth venation." haigoushen ": " waist kidney is controlled Wind is removed in cold, the cold air of middle pain, blood-breaking, leads to extremities joint, opens the vital organs of the human body, go the cold numbness of wind toxin, more urinating at night.It controls and coughs, main middle benefit gas, Cholera is more than, abdominal pain, and cold dysentery is expired in dissipate-swelling, controls blood and closes.Patient is empty and cold, preferably plus uses it."

7. leech

Leech, nature and flavor are salty, bitter, put down；It is slightly poisonous.Return liver, bladder meridian." detailed outline ": " Liver Channel blood system." " key medicine divides agent ": " enters Liver, bladder two pass through."

8. lycopodium calvatum

Lycopodium calvatum, expelling wind and clearing away cold, dehumidification swelling, relaxing tendons and activating collaterals.Control wind-cold-dampness arthralgia, joint pain, numbness of skin, four limbs are soft It is weak, oedema, traumatic injury.Supplement to the Herbal: " main to suffer from wandering arthritis long, foot knee aches cold, munbness, and strength is weak.

Application method

Daily 1 dose, 500ml/ times, early, evening each immersion once, merges the decoction after decocting and takes.

Main advantages of the present invention include:

Drug of the invention can significant qi and activate blood circulation let out it is turbid, in terms for the treatment of diabetic nephropathy middle and advanced stage renal insufficiency compared with Simple Western medicine has apparent clinical and experimental effect, can delay renal failure and have spy safely and effectively without side-effects Point, can prolonged application.

Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention Rather than it limits the scope of the invention.In the following examples, the experimental methods for specific conditions are not specified, usually according to conventional strip Part, or according to the normal condition proposed by manufacturer.Unless otherwise stated, otherwise percentage and number are weight percent and weight Number.

Preparation example 1

Water decocting method

It is formulated as follows:

30 grams of Radix Astragali

30 grams of Radix Angelicae Sinensis

30 grams of ganoderma lucidum

30 grams of the root of Chinese clematis

15 grams of safflower

15 grams of rhizoma zingiberis

10 grams of leech

15 grams of lycopodium calvatum.

Daily 1 dose, 500ml/ times, early, evening each immersion is once.

Embodiment 1

Clinical research

Research method: research object is III-IV phase patient of diabetic nephropathy of 108 stable diseases, is randomly divided into Control group (conventional therapy), Chinese medicine group (conventional therapy+qi and activate blood circulation lets out turbid side), Shenshuaining group (conventional therapy+Shenshuaining Grain), every group 36,2 months are as a treatment course, totally 3 courses for the treatment of, each course for the treatment of looks into an associated treatment, after follow-up observation 2 months Look into an index.Three groups of general information comparing differences are not statistically significant (P > 0.05), are comparable.

As a result: after the treatment of Chinese medicine group, tcm syndrome curative effect and integral are significantly increased, for 24 hours quantity of proteinuria, urine Microalbunin White (UAER), urea nitrogen (BUN), serum creatinine (Sc), fasting blood-glucose (FPG), 2h-plasma glucose (2hPG), glycosylated hemoglobin water Flat (HbA1c), systolic pressure (SBP), diastolic pressure (DBP), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDLC), transforminggrowthfactor-β1 (TGF-β 1), Urine MCP-1 (MCP-1), tumor necrosis factor (TNF- α), glomerular filtration rate (GFR), renal plasma flow (RPF) significantly reduce, and high-density lipoprotein (HDLC) significantly increases, Chinese medicine Compared with other 2 groups, the above indicator difference all has statistical significance (P < 0.05) group, alanine aminotransferase (ALT), Aspartate aminotransferase (AST), there was no significant difference for alkaline phosphatase (ALP).

Conclusion: qi and activate blood circulation is carried out for spleen kidney qi deficiency, wet turbid blood stasis blocking type clinic period diabetic nephropathy patient and lets out turbid Fang Zhi It treats, there is specific aim.It not only reduces Diabetic Nephropathy patients Proteinuria level, hypoglycemic, blood pressure lowering, reduce inflammatory cytokine Expression improves blood lipid metabolism, protection renal function, and will not influence liver function, illustrates that qi and activate blood circulation lets out turbid side in middle evening Period diabetic nephropathy renal insufficiency (spleen kidney qi deficiency, wet turbid blood stasis blocking type) treatment aspect has a better effect, and has originality.And Have the characteristics that safely and effectively it is without side-effects, can prolonged application.

Embodiment 2

Typical case 1

Name: golden * * gender: male age: 65 years old

Head examines the date: 2014-05-17

Main suit: the soreness of waist, out of strength, more than ten years of edema of pair of lower extremities repeatedly.

Present illness history: having nephrophthisis to cut off history for patient 61 years, and specifically unknown, diabetic history for many years, renal function occurred before 10 years Incomplete, the soreness of waist, out of strength, edema of pair of lower extremities, do not give attention repeatedly, and to control based on glycemic therapeutic, the present is further treats kidney function It can not go to a doctor entirely.At present patient receive can, defecate 3-4 times/day, urine amount is few, slightly dry, and night sleeps can.

Past medical history: hypertension history several years the past, oral blood pressure lowering drug, blood pressure do not give periodic monitoring.

Tongue fur pulse condition: red tongue body, yellow and greasy fur, veins string are slow.

Physical examination: cardiopulmonary are without exception, blood pressure: 170/90mmhg, abdomen put down it is soft, under liver and spleen rib not and, double lower limb is slightly recessed Property edema.

Laboratory checks: renal function: urea nitrogen: 15mmol/l creatinine: 243umol/l uric acid: 580umol/l, interior myogenic Acid anhydride clearance rate: 24.6ml/ minutes, twenty-four-hour urine protein quantification 1.89g/24 hours.Red blood cell count(RBC): 3.44*10¹²The blood red egg of/l It is white: 119g/l.

Dialectical analysis: damp and hot to accumulate the lower coke of resistance.

Principle of reatment: clearing away heat and eliminating dampeness, softening hard masses are rushed down turbid.

Diagnosis: tcm diagnosis: pain in the loins -- damp and hot kidney deficiency；

Doctor trained in Western medicine diagnosis: chronic renal insufficiency azotemia phase；Diabetes B, diabetic nephropathy；

2 grades of hypertension high-risk.

Prescription: qi and activate blood circulation lets out turbid side, and daily 1 dose, 500ml/ times, early, evening each immersion is once.Its medicine group becomes: yellow Stilbene 30, Radix Angelicae Sinensis 30, ganoderma lucidum 30, the root of Chinese clematis 30, safflower 15, rhizoma zingiberis 15, leech 10, lycopodium calvatum 15.

Renal failure cream navel is treated * 10 times, opens same piece 1, three times per day.

Patient's disease feelings are steady after medication, and for self-induction without substantially changeing, Prolonged ambulatory turns side, suitably add and subtract, and when blood pressure has Fluctuation gives voluntarily plus uses antihypertensive drugs.

The further consultation date: 2014-06-27

Patient's disease feelings are steady, and no significant discomfort, self-induction spirit improves earlier above, receive can, big loose stool, 5-6 times/day, the soreness of waist compared with Preceding slightly heavy, edema of pair of lower extremities is substantially reduced, and urine volume 2000ml/24 hours, tongue nature was light red, thin greasy in tongue fur, the thin string of arteries and veins, blood pressure 120/80mmhg。

Laboratory checks: renal function: urea nitrogen: 12.2mmol/l creatinine: 194umol/l uric acid: 576umol/l.24 is small When quantity of proteinuria 1.49g/24 hours.

Prescription: qi and activate blood circulation lets out turbid side, and daily 1 dose, 500ml/ times, once, medicine group becomes: yellow for early, evening each immersion Stilbene 30, Radix Angelicae Sinensis 30, ganoderma lucidum 30, the root of Chinese clematis 30, safflower 15, rhizoma zingiberis 15, leech 10, lycopodium calvatum 15.

The further consultation date: 2014-10-31

Patient's disease feelings are steady, and no significant discomfort, self-induction spirit improves earlier above, receive can, defecate 2 times/day, edema of lower extremity is unknown It is aobvious, Urine proteins+, tongue nature is light, the thin string of the thin arteries and veins of tongue fur, blood pressure 120/80mmhg.

Laboratory checks: renal function: urea nitrogen: 10.7mmol/l creatinine: 153umol/l uric acid: 457umol/l urinates egg White (+).

Former Regimen Chemotherapy is still given, follow-up advises its wind sheltering cold, careful diet, periodic review.

Conditions of patients is more stable, and double lower limb has no that edema, soreness of waist disease feelings mitigate earlier above, receive can, defecate 2 times/day, urine volume base Originally it can maintain 1500-2000ml/24 hours, regular follow-up.

Note:

The disease arises from concurrent renal insufficiency caused by diabetes, and disease arises from blood glucose and causes vascular sclerosis for a long time, delays And hide, the gasification function of disease and systemic vasculature and kidney then kidney is impaired, and waist is the internal organs of kidney, the exhausted then chronic problem of kidney, or acid Or pain, the disturbance in qi transformation of kidney, aqueous is poly- and is swollen.

Diabetes are searched to the bottom, and be Spleen-Qi Deficiency are this, and gas inability of food and drink to be digested and transported is precise and tiny, it is poly- and be it is turbid, it is wet turbid with the passing of time to change Heat, the wet turbid stasis of blood are then micro- accumulation state in channels and collaterals, and sugar is sticky, and it is just being wet turbid for being.It is wet turbid evil for yin, negative position is easily attacked, kidney is water Burnt under dirty residence, most vulnerable to heresy, the first syntrophism day after tomorrow of condition spleen kidney, the present is same empty and the body that arrives more loses, and disease long will be at consumptive disease.

Embodiment 2

Patient Cai * *, women, 77 years old, admission number: 113377

Head examines the date: 2014-3-12

Main suit: " edema of pair of lower extremities April, discovery renal insufficiency one week "

Medical history: patient has diabetes and hypertension history more than 11 years, only keeps on a diet and takes orally usually and drops piece and nitre benzene again Horizon Treatment of Hypertension, blood glucose controlling of blood pressure are unknown.At the beginning of one month this year, patient repeated coughing is with shortness of breath, Leukocyte Counts liter Height repeatedly sees a doctor and gives antibiotic vein treatment, and oral mycin allergy once occurs, hereafter occurs biped back edema repeatedly, And delay to knee joint, foam increases in urine, 14/03/05 discovery renal dysfunction, and the day before yesterday comes our hospital and has urine examined routine: Urine proteins+ +, renal function: urea nitrogen: 23.40mmol/l creatinine: 482.4umol/l, hemoglobin 102g/l, for the quasi- " sugar of further treatment Urinate sick nephrosis " it hospitalizes and is admitted to hospital.Inscribe: patient mental is soft, and stomach receives difference, slightly coughs, edema of pair of lower extremities is obvious, with a large amount of foams Urine.Physical examination: 37.2 DEG C of body temperature, 80 beats/min of pulse, 20 beats/min are breathed, blood pressure 160/96mmHg.Mind is clear, and spirit is slightly soft, Renal failure anaemia looks, tongue nature is light dim, moss thin yellow, thready and hesitant pulse, and lip is swallowed without redness, both tonsils are without enlargement, two pulmonary respiration without cyanosis Sound is clear, and not and dry and wet rale, heart circle 89 beats/min of heart rate, are restrained together, each valve area is not heard and obvious noise without expansion.Abdomen put down it is soft, Without tenderness and rebound tenderness, under liver and spleen rib not and, double lower limb impression (+).

Chinese medical discrimination: patient's spiritlessness and weakness receives the poor soreness of waist, is not intended to feed, and the middle part of gastric cavity uncomfortable in chest is uncomfortable, dimly red tongue, greasy and thin fur, Thready rapid pulse.The differentiation of disease is consumptive disease, and card belongs to deficiency of spleen and stomach, the turbid poison retardance of the stasis of blood.

Tcm diagnosis: consumptive disease-deficiency of spleen and stomach, the turbid malicious internal resistance of the stasis of blood；

Doctor trained in Western medicine diagnosis: diabetic nephropathy

Treatment: promoting blood circulation and removing obstruction in channels: Radix Salviae Miltiorrhizae Injection intravenous infusion.Control infection: amoxyxillin intravenous infusion.

Chinese medicine is clearing heat and detoxicating, promoting blood circulation let out it is turbid treated for method, intend side it is as follows:

Qi and activate blood circulation lets out turbid side, and daily 1 dose, 500ml/ times, once, medicine group becomes for early, evening each immersion: Radix Astragali 30, Radix Angelicae Sinensis 30, ganoderma lucidum 30, the root of Chinese clematis 30, safflower 15, rhizoma zingiberis 15, leech 10, lycopodium calvatum 15.

After treating 2 weeks, complexion improves, and in high spirits, tongue nature is light red, and tongue fur is thin, receive can, night sleeps peace, and two just freely.Give out Out-patient Department Follow-up.

Chemical examination: routine urinalysis: Urine proteins+, renal function: urea nitrogen: 13.40mmol/l creatinine: 282.4umol/l, blood red egg White 108g/l.

The further consultation date: 2014-5-11

Patient's disease feelings are steady, no significant discomfort, receive can, defecate 1 times/day, edema of lower extremity is unobvious, Urine proteins+, tongue nature It is light, the thin string of the thin arteries and veins of tongue fur, blood pressure 130/80mmhg.

Laboratory checks: renal function: urea nitrogen: 10.7mmol/l creatinine: 173umol/l uric acid: 457umol/l urinates egg White (+).

Former Regimen Chemotherapy is still given, follow-up advises its wind sheltering cold, careful diet, periodic review.

Note:

Diabetes are to lead to one of the common disease factor of chronic glomerulus microangiopathies, the treatment that traditional Chinese and western medicine there is no at present Effect.Chinese medical discrimination belongs to yin deficiency affecting yang more, injures caused by kidney, and basic pathogenesis is mostly kidney deficiency in both YIN and YANG, and cause is spleen-lung Qi deficiency, and gas is not Take the photograph essence, congestion blood block is stopped in wet poison.Deficiency in both YIN and YANG is preferably followed in treatment, by it with the original of sweet medicine and treating YANG within YIN, treating YIN within YANG Then, it is equipped with and activates blood circulation and disperses blood clots, the method for promoting diuresis to remove toxic substance can prove effective.

Embodiment 3

Patient, Zou, women, 35 years old, first visit in July, 2014.

Patient has diabetic nephropathy medical history 10 years, and frequent a small amount of albuminuria, serum creatinine, determination of urea nitrogen slightly increase, For the renal function compensatory phase, but due to thinking little of disease, infrequently takes medicine, adhere to going to work.Recently, dizzy aggravation, nausea are uncomfortable in chest Do not relax, eye face is impractical, it is difficult to feed, when have vomiting it is to hospital.

Physical examination: blood pressure 150/80mmHg, complexion ash is stagnant, and spirit is withered soft, and edema is unobvious, and 102 beats/min of heart rate, rule is neat, can News and systolic murmur.

Chemical examination: blood routine: HB98g/L, red blood cell 3.3*10^12/L, leucocyte 5.4*10^9/L.Renal function: creatinine 320umol/L, urea nitrogen 17mol/L.Serum creatinine clearance rate 31%.

The author thinks that prolonged illness is void, and asthenia in origin and asthenia in superficiality, taste two lose, qi depression to blood stasis, wet essential resistance of turbid.

It gives qi and activate blood circulation and lets out turbid side, daily 1 dose, 500ml/ times, once, medicine group becomes: Radix Astragali for early, evening each immersion 30, Radix Angelicae Sinensis 30, ganoderma lucidum 30, the root of Chinese clematis 30, safflower 15, rhizoma zingiberis 15, leech 10, lycopodium calvatum 15.

It is aided with out with 4, three times a day, takes orally.Can be 2 first, twice a day, take orally.

After treatment 2 months, complexion is clearly better, and in high spirits, tongue nature is light red, and tongue fur is thin, and check blood index take a favorable turn.

Chemical examination: blood routine: HB101g/L, red blood cell 3.8*10^12/L, leucocyte 5.3*10^9/L.Renal function: creatinine 220umol/L, urea nitrogen 11mol/L.Serum creatinine clearance rate 41%.

Note:

Patient comes into the moderate azotemia phase, using complex treatments such as oral medicinal herb, bowel lavage, achieves more satisfied Curative effect, when the author treats, according to patient's different phase give it is dialectical treat, symptomatic treatment in acute condition, radical treatment in chronic case, giving consideration to both the incidental and fundamental helps Positive eliminating evil, therapy of combing traditional Chinese and Western medicine and produce effects favourable.

All references mentioned in the present invention is incorporated herein by reference, independent just as each document It is incorporated as with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can To make various changes or modifications to the present invention, such equivalent forms equally fall within model defined by the application the appended claims It encloses.

Claims (8)

1. a kind of qi and activate blood circulation lets out turbid Chinese medicine composition, which is characterized in that the Chinese medicine composition contain raw medicinal material or The extract of the raw medicinal material, wherein the raw medicinal material by Radix Astragali, Radix Angelicae Sinensis, ganoderma lucidum, the root of Chinese clematis, safflower, rhizoma zingiberis, leech and Lycopodium calvatum is constituted,

Also, the parts by weight of the raw medicinal material are as follows:

Radix Astragali 25-35

Radix Angelicae Sinensis 25-35

Ganoderma lucidum 25-35

Root of Chinese clematis 25-35

Safflower 10-20

Rhizoma zingiberis 10-20

Leech 5-15

Lycopodium calvatum 10-20.

2. Chinese medicine composition as described in claim 1, which is characterized in that the Chinese medicine composition is for treating middle and advanced stage sugar Urinate sick nephrosis.

3. Chinese medicine composition as described in claim 1, which is characterized in that the extract includes: water extract or aqueous Extract, wherein the aqueous extract refers to the extract with aqueous solvent extraction, and the aqueous solvent refers to by water The mixed solvent constituted with solvent compatible with water, wherein water content is 10-99.5wt%.

4. Chinese medicine composition as described in claim 1, which is characterized in that the weight of the raw medicinal material is as follows:

30 grams of Radix Astragali

30 grams of Radix Angelicae Sinensis

30 grams of ganoderma lucidum

30 grams of the root of Chinese clematis

15 grams of safflower

15 grams of rhizoma zingiberis

10 grams of leech

15 grams of lycopodium calvatum.

5. Chinese medicine composition as described in claim 1, which is characterized in that the raw medicinal material is powdered.

6. Chinese medicine composition as claimed in claim 5, which is characterized in that the partial size of the raw medicinal material is 1-10mm.

7. the purposes of Chinese medicine composition as described in claim 1, which is characterized in that be used to prepare treatment middle and advanced stage diabetogenous nephrosis The drug of disease.

8. a kind of preparation method of Chinese medicine composition described in claim 1, which is characterized in that comprising steps of

(a) raw medicinal material is extracted, to obtain the extract of medicinal material；With

(b) extract of the medicinal material is mixed with pharmaceutically acceptable carrier, to be made described in claim 1 Chinese medicine composition.