CN102961688B - Traditional Chinese medicine decoction capable of reducing alpha fetoprotein and preventing and treating liver cancer - Google Patents

Abstract

The invention discloses traditional Chinese medicine decoction capable of reducing alpha fetoprotein and preventing and treating liver cancer. The traditional Chinese medicine decoction is prepared from the following raw traditional Chinese medicines in parts by weight: 30 parts of oldenlandia diffusa, 10 parts of rhizoma sparganii, 20 parts of rhizoma atractylodis macrocephalae, 10 parts of curcuma zedoary, 10 parts of gardenia jasminoides ellis, 10 parts of fructus forsythiae, 15 parts of oriental wormwood, 10 parts of dandelion, 10 parts of carthamus tinctorius, 10 parts of peach kernel, 10 parts of prunella vulgaris, 10 parts of sculellaria barbata, 10 parts of radix bupleuri, 10 parts of astragalus mongholicus, 5 parts of ginseng, and 5 parts of liquorice. According to the traditional Chinese medicine decoction, the oldenlandia diffusa, the rhizoma sparganii and the rhizoma atractylodis macrocephalae are main medicines and have the effects of clearing heat, removing toxicity, expelling damp, dispelling melancholy, dispersing blood stasis, dredging collaterals, tonifying Qi and strengthening healthy energy; the curcuma zedoary, peach kernel, gardenia jasminoides ellis, fructus forsythiae and sculellaria barbata are assistant medicines and are used for providing assistance to the main medicines to realize the effects of promoting blood circulation, removing dampness, resolving toxin and dissipating binds; the carthamus tinctorius, dandelion, prunella vulgaris, radix bupleuri, astragalus mongholicus and ginseng have the effects of benefiting Qi, clearing heat, removing dampness and dispelling melancholy; and the liquorice is used for blending the other medicines. All the traditional Chinese medicines are combined to realize the effects of clearing heat, removing dampness, removing toxicity, promoting blood circulation, softening hard mass, removing stasis, tonifying Qi, and strengthening healthy energy.

Description

A kind ofly reduce the Chinese medicine decoction that alpha-fetoprotein is prevented and treated hepatocarcinoma

Technical field

The present invention relates to a kind of Chinese medicine decoction that alpha-fetoprotein is prevented and treated hepatocarcinoma that reduces.

Background technology

Primary hepatocarcinoma (abbreviation hepatocarcinoma) is one of modal malignant tumor in the world, annual approximately 1,000,000 examples of world's morbidity.China is one of district occurred frequently, and the world increases every year patient's 40%～50% newly and occurs in China.According to the statistics nineties in 20th century, mortality of liver cancer is in mortality of malignant tumors cis-position, and city and country is all the 2nd, and annual approximately 110,000 people of China die from hepatocarcinoma, account for 45% of world's PLC mortality number.

The protein that alpha-fetoprotein (AFP) is that hepatocarcinoma occurs, express in evolution, is considered to significant albumen and for the early diagnosis of hepatocarcinoma.Alpha-fetoprotein (AFP) is as one of bolting index system of hepatocarcinoma, has early diagnosis and evaluates therapeutic effect, estimates many-sided value such as postoperative recurrence and prognosis.The standard of the AFP diagnosing liver cancer that whole nation hepatocarcinoma research control cooperation meeting is definite is: counterelectrophoresis or radioimmunology >=400ng/L, continue more than 4 weeks, and get rid of activeness hepatopathy, gestation, gonad embryo source property tumor.Can carry out diagnosing primary hepatocarcinoma by detecting the content of Serum AFP clinically, positive rate can reach 90% left and right, and its accuracy is only second to liver biopsy, and can find asymptomatic case.Research recently finds that AFP has extremely complicated biological function, and the expressed AFP of hepatoma carcinoma cell has and can Immunosuppression system can promote the dual function of growth of cancer cells again.Its possible mechanism of action is: 1. induction of lymphocyte apoptosis Immunosuppression function: this is the effect that has t lymphocyte subset groups' such as changing CD4+ and CD8+ ratio and cause lymphocyte death due to AFP.2. promote liver cancer cell growth: AFP to follow all the time the growth of fetus, this process is the most vigorous period of cell division; AFP is synthesized by embryo liver, and when human development is ripe, AFP gene stops expressing substantially; When there is hepatocarcinoma or liver damage Regeneration and Repair, hepatocellular AFP gene is opened with regard to being again activated, and expresses a large amount of AFP.Observation in vitro discovery, low dose of AFP has obvious facilitation to human hepatoma HepG2 cell's growth.AFP can be receptor-mediated by the AFP on cell membrane, affects tumor necrosis factor (TNF) family of lymphocyte or hepatoma carcinoma cell and the expression of receptor thereof, causes hepatoma carcinoma cell to escape immunity of organism and monitor; Can promote oncogene expression again, cause liver cancer cell growth simultaneously.

Chronic hepatitis B accompanies the sickness rate of high AFP mass formed by blood stasis patient hepatocarcinoma apparently higher than other crowd, is considered to liver precancerous condition.The low-level rising of AFP or Flare-up (<200ng/ml) are often the indexs of liver cell regeneration after hepatic injury in chronic hepatitis B patient; And AFP continues high level rising (>400ng/ml), often indicating cAMP content or early hepatocarcinoma forms, especially serum alanine aminotransferase (ALT) declines and patient that AFP does not synchronously decline, the danger that hepatocarcinoma occurs is higher, this class crowd is implemented to effective intervention treatment and be expected to reduce hepatocarcinoma incidence rate.Hepatocarcinoma is the malignant tumor of a kind of multifactor, multistage, pathogenesis complexity, once occur, treatment is got up very difficult, and relapse rate is high, and prognosis is poor.Therefore a kind of find effective reduction AFP method occurs significant for prevention, blocking-up hepatocarcinoma.

Summary of the invention

Based on above-mentioned technical problem, the invention provides a kind of Chinese medicine decoction that alpha-fetoprotein is prevented and treated hepatocarcinoma that reduces.

Its technical solution is:

Reduce alpha-fetoprotein and prevent and treat a Chinese medicine decoction for hepatocarcinoma, it is that raw material of Chinese medicine by following weight portion proportioning is made: 25～35 parts of Herba Hedyotidis Diffusaes, 8～12 parts of Rhizoma Sparganii, 18～25 parts of the Rhizoma Atractylodis Macrocephalaes, 8～12 parts of Rhizoma Curcumae, 8～12 parts of Fructus Gardeniaes, 8～12 parts of Fructus Forsythiaes, 12～16 parts of Herba Artemisiae Scopariaes, 8～12 parts of Herba Taraxacis, 8～12 parts, Flos Carthami, 8～12 parts, Semen Persicae, 8～12 parts of Spica Prunellaes, 8～12 parts of Herba Scutellariae Barbataes, 8～12 parts of Radix Bupleuri, 8～12 parts of the Radixs Astragali, 4～6 parts of Radix Ginsengs, 4～6 parts, Radix Glycyrrhizae.

Preferably, the weight portion proportioning of each raw material of Chinese medicine is: 30 parts of Herba Hedyotidis Diffusaes, 10 parts of Rhizoma Sparganii, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Curcumae, 10 parts of Fructus Gardeniaes, 10 parts of Fructus Forsythiaes, 15 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Taraxacis, 10 parts, Flos Carthami, 10 parts, Semen Persicae, 10 parts of Spica Prunellaes, 10 parts of Herba Scutellariae Barbataes, 10 parts of Radix Bupleuri, 10 parts of the Radixs Astragali, 5 parts of Radix Ginsengs, 5 parts, Radix Glycyrrhizae.

Pharmacology of the present invention and beneficial effect are as follows:

Applicant by clinical observation in conjunction with the pathogenic cause of disease of chronic viral hepatitis B epidemic disease caused by damp-heat pathogen poison, think that the pathogenesis of precancerous lesion of hepatocellular carcinoma is mainly in noxious dampness and accumulate and stagnation in liver meridian, have healthy energy virtual loss concurrently simultaneously, damp-stagnancy, blood stasis, poison accumulate, weakened body resistance four interact, reciprocal causation, causes QI and blood being ill simultaneously, simulataneous insufficiency and excessive eventually, touching difficulty more, with the passing of time forms canceration gradually.In method for the treatment of, in conjunction with < < Plain Questions the most pure virginity, to discuss greatly > > " hard masses should be resolved gradually; disease caused by accumulations of pathogen should be treated with therapy of dispersion; disease with retention of pathogen in the body should be treated by elimination therapy " theory, drafted and take clearing away heat-damp and promoting diuresis removing toxic substances, Huoxue Jieyu eliminating stagnation as main, taken into account the Chinese medicine decoction that QI invigorating righting is the principles of formulating prescriptions.The both clearing away heat-damp and promoting diuresis removing toxic substances of this Chinese medicine decoction, again can Huoxue Jieyu eliminating stagnation, takes into account QI invigorating righting treatment, can effectively reduce AFP, blocks to a certain extent the incidence rate of hepatocarcinoma.

In side, Herba Hedyotidis Diffusae, Rhizoma Sparganii, the Rhizoma Atractylodis Macrocephalae are that monarch drug is with clearing away heat-damp and promoting diuresis removing toxic substances, Huoxue Jieyu eliminating stagnation, QI invigorating righting altogether.

Herba Hedyotidis Diffusae bitter in the mouth, sweet, cold in nature, GUIXIN, liver, spleen, large intestine channel.Function heat-clearing and toxic substances removing, dampness removing.< < Quanzhou book on Chinese herbal medicine > >: " heat clearing away dissipating blood stasis, eliminating carbuncle removing toxic substances.Control ulcer sores, scrofula.Again can lung heat clearing fire, eliminating the pathogens from the lung heat.Control lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest ".< < Guangxi Chinese herbal medicine > > records: " heat-clearing and toxic substances removing, diuresis of blood circulation promoting ".

Rhizoma Sparganii acrid in the mouth, hardship, property is flat, returns liver, spleen channel.The circulation of qi promoting of effect removing blood stasis, removing food stagnancy pain relieving.< < Japan hanako materia medica > >: " control married woman's blood vessels uncomfortable, cardiac and abdominal pain, the waist that the falls stagnant blood that disappears; mend labor, logical menstruation, controls flatulence; disappear and flutter damage blood stasis, puerperal abdonimal pain blood fortune, and stagnated blood not under ".< < Decoction and Material Medica > > cloud: " control flatulence, blood vessels are uncomfortable, mend five kinds of over strain, logical menstruation, repercussive blood.Color is white, the gas in removing blood stasis ".< < Jing Yue's complete work > the >: " gas in energy promoting the circulation of blood.Kind removing mass gas, removing blood stasis blood, the diet distension that disappears, abdominal pain due to stagnation of QI, except Xuan addiction mass in the abdomen, gathers caking, Tong Yueshui, also induced abortion and puerperal stagnant blood, flutter damage blood stasis, and it is swollen hard to control skin ulcer ".The < < book on Chinese herbal medicine > > that looks for the truth: " Rhizoma Sparganii specially enters liver.Bitter in the mouth gas is flat, and the black meat of skin is white, the gas of broken greatly Liver Channel blood system.Therefore all blood stasis are depressed, the hard food of skin ulcer stops, and old piece is hard long-pending, wastes not bitter in the mouth by this, enters with blood system, goes its stagnation of QI, in order to do blood from gas and under.If but this is with the same throwing of blood medicine, can lead in blood; With gas medicine, with entering, in gas, can control ".

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.Effect invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.< < Japan hanako materia medica > >: " control a wind cutting disease, five kinds of strain and seven kinds of impairment, cold air abdominal distention, mends waist knee joint ".< < medicine class on the analogy of natural things > >: " except warm beneficial dry, and middle QI invigorating, blood between sharp waist umbilicus, except pathogenic heat in the stomach.Go all warps wet, reason stomach ".< < Records of Tradition Chinese and Western Medicine in Combination > >: " warm in nature and dry, gas perfume (or spice) is not altered, and bitter but slightly sweet taste is micro-pungent.Kind strengthening the spleen and stomach, expectorant water, stopping leak rushes down.Control and insufficiency of the spleenly do swollenly, spleen is wet to be done yearningly, and the weak quadruped locomotion of spleen is unable, even do to ache.With the same use of cool demulcen, be apt to again tonifying the lung; With the loose same use of medicine of liter, be apt to again adjust liver; With the same use of Zhenan County's medicine, be apt to again nourish heart; With the same use of drugs for nourishing yin, kind the kidney invigorating, is the key medicine of rear natural gift life again.Therefore can be in lung, liver, kidney, the heart four is dirty all can be also of some help ".

In side, Rhizoma Curcumae, Semen Persicae, Fructus Gardeniae, Fructus Forsythiae, Herba Scutellariae Barbatae are that ministerial drug is with principal drug assistance activating blood and eliminatng dampness, detoxicating and resolving stagnation of pathogens altogether.

Rhizoma Curcumae acrid in the mouth, hardship, warm in nature, enter liver, spleen channel.Effect circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.< < Japan hanako materia medica > >: " control all gas.Appetizing, helps digestion, logical menstruation, and repercussive blood, only flutters and damages pain hematochezia, and interior damage stagnant blood etc. ".< < herbal classic is met former > >: " Rhizoma Curcumae enters liver removing blood stasis, controls married woman's vim and vigour knots long-pending, accumulation of phlegm in the hypochondrium cold air; fall to flutter and damage pain, hematochezia, and interior damage stagnant blood; the poly-blood of logical Liver Channel, covers blood in the special dispelling the stagnated QI of this medicine also ".The newly organized > > of < < book on Chinese herbal medicine: " blood system Chinese medicine also.Blood in special dispelling the stagnated QI, mass beside the umbilicus can go, only distressed, logical menstruation, repercussive blood, controls cholera, rushes down and gathers, gas in reason.Specially enter edema caused by disorder of QI with removing blood stasis, though removing blood stasis is not so felt frustrated yet ".

Semen Persicae bitter in the mouth, sweet, property are flat, enter the heart, liver, large intestine channel.Effect blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.< < Sheng Nong's herbal classic > >: " cure mainly blood stasis, blood closes abdominal mass pathogen ... ".< < Mingyi Bielu > >: " hardness in the epigastrium that disappears, except soldier hits blood cruelly, broken abdominal mass disease, Tong Yueshui, pain relieving ".< < Bencao Jingshu > >: " Semen Persicae is reported the gas on ground two, and the gas in the sky five that gets both is with life.Start with, meridian of Foot-JUE YIN.Husband's blood person, also, tangible person also for the moon.Circumfluence the whole body person also.One has sluggishly, and Ze is mass in the abdomen, and blood stasis blood closes, or married woman's moon water is obstructed, or hits and flutter trauma hematocele, and the hard pain of stagnated blood under the heart, all from the foot the moon of fainting, is subject to disease, take its as the viscus of storing blood also.Hardship can be let out stagnant, pungent energy eliminating stagnation, the current and slow liver of sweet temperature ... ".

Fructus Gardeniae bitter in the mouth, cold in nature, GUIXIN, liver, lung, stomach, tri-jiao channel.Effect pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.< < Amplification on Materia Medica addendum > >: " the descending pathogenic fire reducing of flexing, can control the fire in piece again ".< < Bencao Beiyao > >: " fire of removing pathogen in the heart lung three warmers ".< < book on Chinese herbal medicine lease making > >: " pathogenic heat of removing pathogen in the heart lung, make it descending, are gone out by urine.Separate three warmers stagnated fire, the blood of clearing stomach gastral cavity ".

Fructus Forsythiae bitter in the mouth, cold nature, returns lung, the heart, small intestine meridian.Effect heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.< < Sheng Nong's herbal classic > >: " curing mainly cold and heat, scrofula scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites ".< < Yaoxing Fu > >: " rushing down the exopathogenic heat of all warps, loose all swollen skin infection ".< < Bencao Beiyao > >: " gently declaring eliminating stagnation pathogenic fire purging ".< < herbal classic is met former > >: " Fructus Forsythiae gently floats clearly, few cloudy, the cloudy edema caused by disorder of QI medicine of fainting of this hands, and removing pathogen in the heart is through exopathogenic heat, and removing blood stasis is tied, the gas that falls apart gathers, detumescence poison, diuresis ".< < Records of Tradition Chinese and Western Medicine in Combination > >: " the loose power of floating a surname of tool liter, circulation QI and blood, controls 12 and gather through blood clotting gas ".

Herba Scutellariae Barbatae acrid in the mouth, hardship, cold in nature, return lung, liver, kidney channel.Function heat-clearing and toxic substances removing, dissipating blood stasis analgesic therapy.< < Quanzhou book on Chinese herbal medicine > >: " heat clearing away, removing toxic substances, dispels the wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis, pain relieving ".< < Nanjing medicinal herbs > among the people > calls it: " removing blood stasis stimulates the menstrual flow ".

In side, Flos Carthami, Herba Taraxaci, Spica Prunellae, Radix Bupleuri, the Radix Astragali, Radix Ginseng are that adjuvant drug is with the merit of gain gas, clearing away heat-damp and promoting diuresis resolving depression.

Flos Carthami acrid in the mouth, warm in nature, enter the heart, Liver Channel.Effect promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.< < Jing Yue's complete work > >: " few by the tying-in of can invigorating blood circulation, the logical stasis of blood of multiplex energy removing blood stasis.Moisturize and invigorate blood circulation, pain relieving is stimulated the menstrual flow, also detumescence poison ".The < < book on Chinese herbal medicine > > that looks for the truth: " Flos Carthami specially enters pericardium, liver.For the logical stasis of blood, invigorate blood circulation and want agent ".< < must join herbal > >: " few the moon of starting with, meridian of Foot-JUE YIN blood system.Removing blood stasis with potent drugs blood, row fresh blood, loose swollen pain relieving.Blood pain is from stopping ".

Herba Taraxaci bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.Effect heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis for treating stranguria syndrome.< < Bencao Jingshu > >: " Herba Taraxaci obtains the qi of chong channel ascending adversely of water, therefore its sweet in the mouth is flat, its property is nontoxic, when being into liver, entering stomach, the key medicine of antipyretic removing heat from blood ".The < < book on Chinese herbal medicine > > that looks for the truth: " clearing away stomach-heat, cool liver blood ".< < book on Chinese herbal medicine lease making > >: " removing toxic substances that purges heat, specially controls acute mastitis furunculosis, is also treating stranguria quality goods ".

Spica Prunellae bitter in the mouth, pungent, cold in nature, return liver, gallbladder meridian.Effect purging liver-fire, eliminating stagnation blood stasis dispelling.Bencao Jingshu > >: " Spica Prunellae obtains the gas in Jinsui River, therefore its bitter in the mouth is pungent, and cold in nature nontoxic.For controlling the key medicine of scrofula, scrofula.Enter sufficient faint the moon, shaoyang channel.Dan Xi calls the faint blood of cloudy liver man of its benefit, pungent again can eliminating stagnation, bitter cold can descend drop-down heat, therefore control all cold and heat, and the scrofula scrofula that disappears, breaks the Disorder wart stagnation of QI that falls apart ".< < Jing Yue's complete work > >: " the kind irritability of separating, nourishing the liver blood, therefore energy eliminating stagnation dissipating depression of QI ".< < book on Chinese herbal medicine lease making > >: " stagnated fire of loose Liver Channel is separated interior-heat, eliminating stagnation gas ".

Radix Bupleuri bitter in the mouth, pungent, cold nature.Return liver, gallbladder meridian.Effect induce sweat bring down a fever, preventing the attack (or recurrence) of malaria, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.< < Sheng Nong's herbal classic > >: " bitter in the mouth, flat.Cure mainly trusted subordinate, remove stagnation of QI in the intestines and stomach, diet gathers, and cold and heat pathogen, pushes away Chen Zhixin ".< < Records of Tradition Chinese and Western Medicine in Combination > >: " mildly bitter flavor, property is flat.Reporting the gas of few positive hair growth promoting, is the few positive principal agent of foot, and the double foot the moon of fainting of controlling.The smooth person of depression of liver-QI, this can relax it; The very flourishing person of gallbladder fire, this can fall apart it; To diseases caused by exogenous pathogenic factor, few positive person, can help again its pivotable to rise from it with saturating diaphragm, therefore < < Sheng Nong's herbal classic > > calls its main cold and heat, the heresy of the few positive diseases caused by exogenous pathogenic factor of cold and heat person also.Call again stagnation of QI in its main trusted subordinate's the intestines and stomach, diet gathers, and really, with the five elements' reason, wood can be dredged soil, is the wood gas of the few sun of Radix Bupleuri Starch 1500, and the gas self energy of few sun dredging stomach soil is strongly fragrant, and its stagnation of QI diet gathers self-digestion also ".

Radix Astragali sweet in the mouth, warm in nature, return lung, spleen channel, the righting of function QI invigorating.< < Yaoxing Fu > > calls its " beneficial vigour and mend three warmers ".< < cures mainly secret formula > > cloud: " mending all empty deficiencies, beneficial vigour ... strong taste ".In < < Japan hanako materia medica > >, record " help gas, strengthening bone and muscle, put on flesh, enrich blood ".< < does not record > > and says " determining lung qi, settling five organs ".The just > > of < < book on Chinese herbal medicine calls its " power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, gas in strong fortune ".

Radix Ginseng sweet in the mouth, micro-hardship, property is flat, returns spleen, lung, heart channel.Effect strongly invigorating primordial QI, multiple arteries and veins are admittedly de-, invigorating the spleen to benefit the lung, the Fructus Alpiniae Oxyphyllae of promoting the production of body fluid, calm the nerves.< < Sheng Nong's herbal classic > >: " main tonifying five ZANG-organs, peace spirit, determines soul, and spasmolytic is throbbed with fear, except pathogen, improving eyesight, happy Fructus Alpiniae Oxyphyllae ".< < property of medicine opinion > > calls its " main five hide QI-insufficiency, and five kinds of strain and seven kinds of impairment is deficient, thin and weakly tell contraryly, and lower food, the cholera unhappiness sound of vomiting of vomitting only, tonifying five ZANG-organs six internal organs, keep god in guarantor ".

Radix Glycyrrhizae is for making medicine with coordinating the actions of various ingredients in a prescription.

Radix Glycyrrhizae is sweet, flat, GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.< < Amplification on Materia Medica addendum > >: " Radix Glycyrrhizae sweet in the mouth, slow greatly all fire.Part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels medicine is use less, probably large slow can not going directly ".< < explaining abstruseness of the canon of materia medica > >: " Radix Glycyrrhizae, sweet flat product, solely enter taste, and Li Shizhen (1518-1593 A.D.) is said and can be passed into 12 through person, also non-.Sowing and reaping is done sweet, and the positive taste of soil, therefore Radix Glycyrrhizae is Middle Palace tonic ".The positive > > of < < book on Chinese herbal medicine: " Radix Glycyrrhizae, taste, to sweet, obtains the property of neutralization; have the merit of adjusting benefits, therefore its poison of the solution that poison obtains, just medicine obtains its property of sum; what medicine administered to bring out the cold obtained helps outside it, put in poison delay its speed.Eliminating evil heat, hard muscles and bones, strengthening the spleen and stomach, longue meat.With gas medicine, enter gas, with blood medicine, enter blood, without toward can not, Gu Cheng state is old ".< < medicineization justice > >: " Radix Glycyrrhizae, raw with cool and pathogenic fire purging, main loose pathogenic factor in the exterior; subduing inflammation, sore-throat relieving pain, separates hundred poison of drug; except stomach accumulated heat, goes urinary catheter bitterly, and the power of this sweet cool heat extraction is also.Process with temperature and invigorating middle warmer, main insufficiency of the spleen cunning is rushed down, and insufficiency of stomach is thirsty, and cold and heat cough, breathes hard sleepy, and forced labour is deficient, and the merit that this sweet temperature helps spleen also.”

In sum, in Chinese medicine decoction of the present invention, Herba Hedyotidis Diffusae, Rhizoma Sparganii, the Rhizoma Atractylodis Macrocephalae dry with heat-clearing and toxic substances removing for monarch drug altogether, resolving depression disperse blood stasis and dredge collateral, QI invigorating righting; Rhizoma Curcumae, Semen Persicae, Fructus Gardeniae, Fructus Forsythiae, Herba Scutellariae Barbatae are that ministerial drug is with principal drug assistance activating blood and eliminatng dampness, detoxicating and resolving stagnation of pathogens altogether; Assistant is the merit with gain gas, clearing away heat-damp and promoting diuresis resolving depression with Flos Carthami, Herba Taraxaci, Spica Prunellae, Radix Bupleuri, the Radix Astragali, Radix Ginseng; Radix Glycyrrhizae is for making medicine with coordinating the actions of various ingredients in a prescription.All medicine compatibilities, play the effect of clearing away heat-damp and promoting diuresis removing toxic substances, movable blood soft hard eliminating stagnation, QI invigorating righting altogether.

Side's medicine modern pharmacological research is as follows:

The selected medicine of we mostly has good adjusting body immunity, antitumor, antiinflammatory, the effect many-sided, too many levels such as protects the liver through modern pharmacological research proof.

In Herba Hedyotidis Diffusae, sterols, flavonoid, terpenoid and polysaccharide pharmacologically active are obvious, and Multiple components all has antitumor, strengthens phagocytosis.

Rhizoma Sparganii decoct not only has anti-thrombosis function, also has thrombolytic effect.Rhizoma Sparganii decoct can distend the blood vessels, blood flow rate is accelerated, and reaches good antiinflammatory action.

The Rhizoma Atractylodis Macrocephalae can strengthen the phagocytic function of reticuloendothelial system, promotes cellular immune function, strengthens the content of IgG in serum; Rhizoma Atractylodis Macrocephalae volatile oil has obvious antitumor action, can strengthen the antigenicity of cancerous cell and the specificity active immunity of antibody.

Rhizoma Curcumae has certain anti-thrombosis function.Rhizoma Curcumae volatile oil has the effect of killing cancerous cell; Curcumenol has tumor-inhibiting action; Oleum Curcumae can make host specificity immunostimulant obtain obvious immunoprotective effec by immune system; Also has Radiosensitizing tumor-inhibiting action simultaneously.

Semen Persicae has blood vessel dilating, increases the effect of Tissue Blood flow; The content of cAMP in platelet be can improve, thrombosis and blood coagulation suppressed; Also has certain haemolysis simultaneously.The contained amygdalin of Semen Persicae can make to be generated hydrocyanic acid and benzaldehyde by the enzyme hydrolysis of β-glycoside in vivo, and cancerous cell is to concertedness lethal effect.

Fructus Gardeniae has hepatoprotective effect.Gardenoside can make the rat blood serum bilirubin, glutamate pyruvate transaminase and the content of alkaline phosphatase that because isothiocyanic acid α-naphthylacetate is poisoning, cause decline.Fructus Gardeniae can alleviate CCl ₄due to hepatic injury, alleviate hepatocellular degeneration and necrosis, the glycogen storing in hepatocyte and rna content also recover to some extent.Glutamate pyruvate transaminase and bilirubin diphosphonic acid urea glycosides-glucal acyltransferase vigor decline or multiple normal that Fructus Gardeniae gavage can make ligation ductus choledochus animal raise, rise the liver diphosphonic acid urea glycosides-glucose dehydrogenase vigor reducing.

Fructus Forsythiae water extract and dissolve with ethanol position have the effect of stronger inhibition S180 tumor cell proliferation, in addition, still have antiinflammatory, hepatoprotective effect.

Scutellaria Barbata D. Don Polysaccharides SPS4 can promote mouse boosting cell, the lymphocyte transformation of concanavalin A induction, promotes the delayed allergy of D N CB induction, has the effect that promotes cellular immunization.Herba Scutellariae Barbatae ethanol extract has significant inhibitory action to transplantation tumor (sarcoma S180 and hepatocarcinoma H22), and the propagation of mouse boosting cell is had to facilitation, and has good dose-dependence, may realize antitumaous effect by enhancing human body immunity power.

In Flos Carthami, Carthamus yellow II, III and quinone glycoside mother solution have anticoagulant, antithrombotic effect; Carthamus yellow can obviously improve microcirculation disturbance.Flos Carthami polysaccharide has the dual regulation effect that not only suppresses but also promote to immunologic function.

Herba Taraxaci protects the liver, choleretic effect; Herba Taraxaci has antiendotoxin, antitumor action; Herba Taraxaci has the effect of excitating organism immunologic function.In vitro tests discovery, Herba Taraxaci decoct can significantly improve the conversion ratio of peripheral blood lymphocyte.

Spica Prunellae has anticoagulation, can obviously extend thrombinogen and the plasma globulin level dissolution time of stasis syndrome rat model; Spica Prunellae can pass through to promote the immunoregulation effects such as lymphocyte proliferation and inducement interferon, thereby reach antifungal and antiviral effect.It also has the biological activitys such as immunosuppressive activity, antioxidation, removing free radical and antitumor.Its antineoplastic approach is: 1, antiproliferative effect.2, act on cell cycle, affect the division of tumor cell.3, promote apoptosis of tumor cells.4, antioxidation anti-radical action, and can direct killing tumor cell.Spica Prunellae contains numerous anti-tumor active ingredients, and kinds of tumors is had to good inhibition.

The contained flavones ingredient of Radix Bupleuri has hepatoprotective choleretic effect.Radix Bupleuri has the effect that strengthens immunologic function.Radix Bupleuri has antitumor action.Radix Bupleuri has lipoid peroxidization resistant.

The Radix Astragali can resist the effect of immunosuppressant, humoral immunization, cellular immunization, reticuloendothelial system, outer system are all had to the effect that strengthens its function, some immune cell factor is induced to effect, and have inducement interferon, strengthen the effect of natural killer cell, to panimmunity because have good regulating action; The Radix Astragali still has antitumor action.

Radix Ginseng can promote the synthetic of protein, hepatocyte lipid, and the metabolism of energy adjusting energy; Radix Ginseng can improve organism adaptation, has resisting fatigue, anti-stress effect; Radix Ginseng can promote body's immunity; Radix Ginseng has antitumor action; Radix Ginseng energy anticoagulant, has potentiation to the main viscera tissue serum of intact animal; And can effectively suppress serotonin, and the Tissue Blood flow that endotoxin causes reduces, and Radix Ginseng has anti-hemolysis, anti thrombotic action, can make erythrocyte, leukocyte and hemoglobin increase, enhancing body hemopoietic function.

Radix Glycyrrhizae has obvious antiinflammatory action, and liver is had to significant protective effect, also has lipotropism matter Oxidation; Glycyrrhizin has activation to reticuloendothelial system, and the Radix Glycyrrhizae ammonium of variable concentrations all has significant enhancing to mice natural killer cell activity; Radix Glycyrrhizae also can strengthen specific immune function; Radix Glycyrrhizae has antitumor action; Radix Glycyrrhizae all has dual regulation in square medicine combination, formula, immunity.

1. clinical data

According to < < new Chinese medicine guideline of clinical investigations > >, adopt random, the experimental technique of contrast, choose 2010.01-2011.07 at the chronic hepatitis B patient that meets inclusive criteria of Qingdao Shi Huangdao Qu Zhong Yi Yuan's hospitalization, adopt the method for table of random number, by study subject, divide two groups, test group 30 examples, male's 17 examples wherein, women's 13 examples, light according to state of an illness calibration, moderate person is respectively 19, 11 examples, 49.7 ± 9.8 years old mean age, average course of disease 16.2 ± 6.3 years, matched group 32 examples, male's 21 examples wherein, women's 11 examples,, moderate person light according to state of an illness calibration is respectively 17,15 examples, 49.3 ± 8.6 years old mean age, average course of disease 15.6 ± 6.1 years.Two groups of patients are Epidemiological Analysis there was no significant difference (P>0.05) by statistics at aspects such as sex, age, the course of disease, the pathological changes order of severity, liver function, virus load, AFP content, and data has comparability.

2. Therapeutic Method

The oral Chinese medicine decoction of the present invention of test group, is decocted in water for oral dose, and day potion takes 6 weeks courses for the treatment of at twice.Matched group oral administered compound wood chicken granule (Dandong Pharmaceuticals Co., Ltd) 10g, every day 3 times, 6 weeks courses for the treatment of.

3. observation index

3.1 safety indexes are observed

1. general physical examination: detect body temperature, respiratory frequency, pulse, blood pressure;

2. blood, urine, stool routine examination inspection, electrocardiogram, kidney function test, check once before test and after off-test.

3.2 health giving quality index observings

1. tcm symptom quantizes integration: according to the criterion of tcm symptom scalar quantization, before and after treatment, each record once;

2. each detects once before and after treatment for Serum AFP, courage type-B ultrasonic;

3. blood biochemistry index: alanine aminotransferase (ALT), aspartate amino transferase (AST), total bilirubin (TBil), albumin (Alb), each detects once before and after treatment.

4. curative effect determinate standard

< < new Chinese medicine guideline of clinical investigations (trying) > > formulation curative effect determinate standard with reference to version in 2002 is as follows:

4.1 comprehensive therapeutic effect criterion

Effective: after treatment finishes, transference cure or obviously alleviate (tcm syndrome therapeutic index >=70%), each biochemical abnormal index improves >=50%;

Effective: after treatment finishes, remission (tcm syndrome therapeutic index >=30%), each biochemical abnormal index improves >=20% but <50%;

Invalid: after treatment finishes, not reach above-mentioned standard person.

4.2 tcm syndrome curative effect determinate standards

Calculate as follows tcm syndrome therapeutic index

Integration * 100% before tcm syndrome therapeutic index (N)=(the rear integration of integration-treatment before treatment)/treatment;

Effective: tcm syndrome therapeutic index (N) >=70%;

Effective: tcm syndrome therapeutic index (N) >=30%;

Invalid: tcm syndrome therapeutic index (N) <30%.

The curative effect determinate standard of 4.3 cardinal symptoms

Clinic control: after treatment finishes, transference cure.

Effective: after treatment finishes, symptom integral reduces 4 minutes.

Effective: after treatment finishes, symptom integral reduces 2 minutes.

Invalid: not reach above-mentioned standard person.

4.4 reduce AFP curative effect determinate standard

Effective: AFP is lower than 20ng/ml, and B ultrasonic is not found reality occupy-place in liver;

Effective: AFP is lower than 200ng/ml but higher than 20ng/ml, and B ultrasonic is not found reality occupy-place in liver;

Invalid: AFP does not find reality occupy-place in liver without significant change and (or) B ultrasonic.

5. statistical method

Application SPSS13.0 version statistical software analyzes.Result is with mean ± standard deviation

represent.Measurement data is checked with t, rate relatively use χ ²check, ranked data adopt Ridit to analyze.

6. result

The Comprehensive Clinical curative effect comparison of 6.1 liang of groups

Table 1

Note: with matched group comparison, △, P<0.05.

Table 1 shows: effective 12 examples of test group, effective 13 examples, invalid 5 examples, total effective rate 83%; Effective 5 examples of matched group, effective 14 examples, invalid 13 examples, total effective rate 59%.The comparison of Comprehensive Clinical curative effect, test group is obviously better than matched group (P<0.05).

6.2 tcm syndrome curative effect comparisons

Table 2

Note: with matched group comparison, △ △, P<0.01.

Table 2 shows: effective 14 examples of test group, and effective 12 examples, total effective rate is 87%; Effective 4 examples of matched group, effective 14 examples, total effective rate is 56%.Aspect tcm syndrome curative effect, test group is obviously better than matched group (P<0.01), has significant differences.

6.3 tcm symptom sign curative effect comparisons

Table 3

Note: relatively front with treatment, * *, P<0.01; With matched group comparison, △ △, P<0.01.

Table 3 is tcm symptom somatic feature score comparison before and after two groups of treatments

as can be seen from Table 3, two groups of tcm symptom somatic feature scores all have reduction before treating more separately, difference tool statistical significance, and between group, relatively have significant differences (P<0.01).

6.4 improve the comparison of liver function curative effect

Table 4

Note: relatively front with treatment, * *, P<0.01; With matched group comparison, △, P<0.05.

Table 4 is the main liver function index comparisons of two groups of patient treatments after 6 weeks

table 4 shows: improving aspect liver function, two groups all have significant differences (P<0.01) with comparing before treatment.Test group is being better than matched group aspect reduction AST, and difference has significance (P<0.05); Aspect reduction ALT, Tbil, rising Alb, test group is also better than matched group, but difference not statistically significant (P>0.05).

Table 5

Note: relatively front with treatment: * *, P<0.01; With matched group comparison: △, P<0.05.

Table 5 is AFP comparison before and after two groups of treatments

table 5 shows: aspect reduction AFP, test group is obviously better than matched group, and difference has significance (P<0.05).

6.5 TCM Syndrome Type curative effect comparisons

Table 6

Note: with type of obstruction of the spleen by dampness comparison: *, P<0.05, * *, P<0.01.

Table 6 shows: aspect reduction AFP, test group is obvious to syndrome of dampness-heat of liver and gallbladder, syndrome of static blood blocking collaterals and syndrome of stagnation of liver qi and spleen deficiency curative effect, especially more remarkable with syndrome of dampness-heat of liver and gallbladder, syndrome of static blood blocking collaterals, compare with damp pathogen obstructing the spleen card, difference has statistical significance (P<0.05 or P<0.01); Each pattern of syndrome curative effect of matched group also has certain difference, but difference not statistically significant.

In sum, test group can effectively reduce AFP, improve clinical symptoms sign and liver function, wherein reducing AFP, AST, improve the aspects such as clinical symptoms and be better than matched group (P<0.05 or P<0.01).Test group total effective rate 83%, matched group 59%, test group curative effect is obviously better than matched group (P<0.05).

7. untoward reaction

We all observe safety indexes such as the hemanalysis before and after study subject treatment, urinalysis, stool routine examination, liver, renal function, electrocardiogram, Abdominal B type ultrasonography, the all patients of result are good to this treatment toleration, during treatment, do not find obvious adverse reaction, medicine to each system all without recent toxicity damage.

8. follow up a case by regular visits to

The method of taking treatment limit, limit to follow up a case by regular visits to, two groups of patients after finishing 1 course for the treatment of are continued irregularly to follow up a case by regular visits to, follow up a case by regular visits to problem and complete and find that test group has 1 example that hepatocarcinoma occurs, matched group has 4 examples that hepatocarcinoma occurs, and difference has significance (P<0.05).

9. toxicologic study conclusion

Through entrusting the Ding Hua of medical college pharmaceutical research institute of Shandong University etc. to do maximum dosage-feeding experiment to decoction of the present invention, reach a conclusion: the maximum dosage-feeding of the oral decoction of the present invention of mice is 93g/kg, be equivalent to crude drug amount 1748.4g/kg, 429 times of behaviour quantity (4.07g/kg), the activity all the time of experimental session mice freely, the mental status and breathing, feed are all normal, no abnormal, and the mice that administration was randomly drawed after 8 days is dissected also no abnormal.Conclusion shows: Chinese medicine decoction of the present invention is safe.

The specific embodiment

Embodiment 1

By following proportioning, take raw material of Chinese medicine:

Herba Hedyotidis Diffusae 30g, Rhizoma Sparganii 10g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Curcumae 10g, Fructus Gardeniae 10g, Fructus Forsythiae 10g, Herba Artemisiae Scopariae 15g, Herba Taraxaci 10g, Flos Carthami 10g, Semen Persicae 10g, Spica Prunellae 10g, Herba Scutellariae Barbatae 10g, Radix Bupleuri 10g, Radix Astragali 10g, Radix Ginseng 5g, Radix Glycyrrhizae 5g.

Preparation method is as follows:

The raw material of Chinese medicine of load weighted above-mentioned weight portion is put into drug-decocting appliance, add clean water, amount of water is advisable to surpass liquid level 2～3cm; Enter to decoct and front above-mentioned raw material of Chinese medicine is soaked to half an hour, make it fully moistening, fully fried in order to medicine juice; Then (suddenly) fire of useing force boils, then uses literary composition (micro-) fire instead and decoct.When decocting about 15-30 minute, stop, removing medicinal residues, get decoction.

Embodiment 2

By following proportioning, take raw material of Chinese medicine:

Herba Hedyotidis Diffusae 25g, Rhizoma Sparganii 8g, Rhizoma Atractylodis Macrocephalae 25g, Rhizoma Curcumae 12g, Fructus Gardeniae 12g, Fructus Forsythiae 8g, Herba Artemisiae Scopariae 16g, Herba Taraxaci 8g, Flos Carthami 8g, Semen Persicae 12g, Spica Prunellae 8g, Herba Scutellariae Barbatae 12g, Radix Bupleuri 12g, Radix Astragali 12g, Radix Ginseng 4g, Radix Glycyrrhizae 6g.

Preparation method is with embodiment 1.

Embodiment 3

By following proportioning, take raw material of Chinese medicine:

Herba Hedyotidis Diffusae 35g, Rhizoma Sparganii 12g, Rhizoma Atractylodis Macrocephalae 18g, Rhizoma Curcumae 8g, Fructus Gardeniae 8g, Fructus Forsythiae 12g, Herba Artemisiae Scopariae 12g, Herba Taraxaci 12g, Flos Carthami 12g, Semen Persicae 8g, Spica Prunellae 12g, Herba Scutellariae Barbatae 8g, Radix Bupleuri 8g, Radix Astragali 8g, Radix Ginseng 6g, Radix Glycyrrhizae 4g.

Preparation method is with embodiment 1.

Claims (2)

1. reduce alpha-fetoprotein and prevent and treat a Chinese medicine decoction for hepatocarcinoma, it is characterized in that it is that raw material of Chinese medicine by following weight portion proportioning is made: 25～35 parts of Herba Hedyotidis Diffusaes, 8～12 parts of Rhizoma Sparganii, 18～25 parts of the Rhizoma Atractylodis Macrocephalaes, 8～12 parts of Rhizoma Curcumae, 8～12 parts of Fructus Gardeniaes, 8～12 parts of Fructus Forsythiaes, 12～16 parts of Herba Artemisiae Scopariaes, 8～12 parts of Herba Taraxacis, 8～12 parts, Flos Carthami, 8～12 parts, Semen Persicae, 8～12 parts of Spica Prunellaes, 8～12 parts of Herba Scutellariae Barbataes, 8～12 parts of Radix Bupleuri, 8～12 parts of the Radixs Astragali, 4～6 parts of Radix Ginsengs, 4～6 parts, Radix Glycyrrhizae.

2. a kind of Chinese medicine decoction that alpha-fetoprotein is prevented and treated hepatocarcinoma that reduces according to claim 1, is characterized in that the weight portion proportioning of each raw material of Chinese medicine is: 30 parts of Herba Hedyotidis Diffusaes, 10 parts of Rhizoma Sparganii, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Curcumae, 10 parts of Fructus Gardeniaes, 10 parts of Fructus Forsythiaes, 15 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Taraxacis, 10 parts, Flos Carthami, 10 parts, Semen Persicae, 10 parts of Spica Prunellaes, 10 parts of Herba Scutellariae Barbataes, 10 parts of Radix Bupleuri, 10 parts of the Radixs Astragali, 5 parts of Radix Ginsengs, 5 parts, Radix Glycyrrhizae.