CN109803654A - 一种多奈哌齐半帕莫酸盐的粉针剂、包含其的组合物及它们的制备方法 - Google Patents
一种多奈哌齐半帕莫酸盐的粉针剂、包含其的组合物及它们的制备方法 Download PDFInfo
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- CN109803654A CN109803654A CN201880003588.2A CN201880003588A CN109803654A CN 109803654 A CN109803654 A CN 109803654A CN 201880003588 A CN201880003588 A CN 201880003588A CN 109803654 A CN109803654 A CN 109803654A
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- donepezil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
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- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种多奈哌齐半帕莫酸盐的粉针剂及其制备方法,以及含有该粉针剂的组合物及其制备方法。所述粉针剂包含多奈哌齐半帕莫酸盐晶体,晶体的平均粒径为0.5‑100μm。
Description
PCT国内申请,说明书已公开。
Claims (13)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2017100991845 | 2017-02-23 | ||
CN201710099184 | 2017-02-23 | ||
PCT/CN2018/076599 WO2018153315A1 (zh) | 2017-02-23 | 2018-02-13 | 一种多奈哌齐半帕莫酸盐的粉针剂、包含其的组合物及它们的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN109803654A true CN109803654A (zh) | 2019-05-24 |
CN109803654B CN109803654B (zh) | 2022-06-28 |
Family
ID=63253116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201880003588.2A Active CN109803654B (zh) | 2017-02-23 | 2018-02-13 | 一种多奈哌齐半帕莫酸盐的粉针剂、包含其的组合物及它们的制备方法 |
Country Status (3)
Country | Link |
---|---|
US (2) | US11197850B2 (zh) |
CN (1) | CN109803654B (zh) |
WO (1) | WO2018153315A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109803654B (zh) * | 2017-02-23 | 2022-06-28 | 上海华汇拓医药科技有限公司 | 一种多奈哌齐半帕莫酸盐的粉针剂、包含其的组合物及它们的制备方法 |
CN108976163B (zh) * | 2017-06-05 | 2023-08-11 | 上海奥博生物医药股份有限公司 | 一种多奈哌齐双羟萘酸盐新的制备方法 |
KR102227100B1 (ko) * | 2020-08-14 | 2021-03-12 | 주식회사 종근당 | 도네페질 에테르 팔미테이트 또는 이의 약제학적으로 허용가능한 염 |
CN117597111A (zh) * | 2021-08-05 | 2024-02-23 | 浙江华海药业股份有限公司 | 一种沃替西汀帕莫酸盐冻干粉针剂及其制备方法 |
WO2023249461A1 (ko) * | 2022-06-23 | 2023-12-28 | 주식회사 지투지바이오 | 도네페질과 파모산을 함유하는 서방성 미립구 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101039910A (zh) * | 2004-09-15 | 2007-09-19 | 埃吉斯药物工厂 | 适合制备药物组合物的多奈哌齐盐 |
US20140243278A1 (en) * | 2011-07-05 | 2014-08-28 | Sunil Sadanand Nadkarni | Acid Addition Salt of Donepezil and Pharmaceutical Composition Thereof |
CN104039765A (zh) * | 2011-11-29 | 2014-09-10 | 顾自强 | 多奈哌齐双羟萘酸盐、制备方法及其应用 |
CN105338966A (zh) * | 2013-04-03 | 2016-02-17 | 东国制药株式会社 | 包含多奈哌齐的非口服用药物组合物 |
US20160310411A1 (en) * | 2011-11-29 | 2016-10-27 | Zi-Qiang Gu | Rivastigmine pamoate, memantine pamoate, methods of preparation and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61275320A (ja) * | 1985-05-29 | 1986-12-05 | Mitsubishi Gas Chem Co Inc | オキシメチレン共重合体の製造方法 |
EP1562546A1 (en) * | 2002-10-25 | 2005-08-17 | Pfizer Products Inc. | Depot formulations of arylheterocyclic active agents in the form of a suspension |
EP3102186B1 (en) * | 2014-02-04 | 2021-01-27 | Forest Laboratories Holdings Limited | Donepezil compositions and method of treating alzheimer's disease |
CN109803654B (zh) * | 2017-02-23 | 2022-06-28 | 上海华汇拓医药科技有限公司 | 一种多奈哌齐半帕莫酸盐的粉针剂、包含其的组合物及它们的制备方法 |
-
2018
- 2018-02-13 CN CN201880003588.2A patent/CN109803654B/zh active Active
- 2018-02-13 US US16/465,116 patent/US11197850B2/en active Active
- 2018-02-13 WO PCT/CN2018/076599 patent/WO2018153315A1/zh active Application Filing
-
2021
- 2021-11-10 US US17/523,229 patent/US11801239B2/en active Active
Patent Citations (5)
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CN101039910A (zh) * | 2004-09-15 | 2007-09-19 | 埃吉斯药物工厂 | 适合制备药物组合物的多奈哌齐盐 |
US20140243278A1 (en) * | 2011-07-05 | 2014-08-28 | Sunil Sadanand Nadkarni | Acid Addition Salt of Donepezil and Pharmaceutical Composition Thereof |
CN104039765A (zh) * | 2011-11-29 | 2014-09-10 | 顾自强 | 多奈哌齐双羟萘酸盐、制备方法及其应用 |
US20160310411A1 (en) * | 2011-11-29 | 2016-10-27 | Zi-Qiang Gu | Rivastigmine pamoate, memantine pamoate, methods of preparation and uses thereof |
CN105338966A (zh) * | 2013-04-03 | 2016-02-17 | 东国制药株式会社 | 包含多奈哌齐的非口服用药物组合物 |
Non-Patent Citations (1)
Title |
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WENJIA GUO等: "Sustained release donepezil loaded PLGA microspheres for injection: Preparation, in vitro and in vivo study", 《ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
Also Published As
Publication number | Publication date |
---|---|
CN109803654B (zh) | 2022-06-28 |
US11197850B2 (en) | 2021-12-14 |
US20200108055A1 (en) | 2020-04-09 |
US20220062249A1 (en) | 2022-03-03 |
WO2018153315A1 (zh) | 2018-08-30 |
US11801239B2 (en) | 2023-10-31 |
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