CN109777791B - 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用 - Google Patents

抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用 Download PDF

Info

Publication number
CN109777791B
CN109777791B CN201910110866.0A CN201910110866A CN109777791B CN 109777791 B CN109777791 B CN 109777791B CN 201910110866 A CN201910110866 A CN 201910110866A CN 109777791 B CN109777791 B CN 109777791B
Authority
CN
China
Prior art keywords
leu
seq
arg
ala
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201910110866.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN109777791A (zh
Inventor
金商在
金京姫
李圭庸
高成昊
金范埈
朴贤喜
许成珍
李宇珍
张华仁
河正顺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GemVax and Kael Co Ltd
Original Assignee
GemVax and Kael Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020120079096A external-priority patent/KR20140012385A/ko
Priority claimed from KR1020120089167A external-priority patent/KR20140022699A/ko
Priority claimed from KR1020120089162A external-priority patent/KR20140022698A/ko
Application filed by GemVax and Kael Co Ltd filed Critical GemVax and Kael Co Ltd
Priority to CN201910110866.0A priority Critical patent/CN109777791B/zh
Publication of CN109777791A publication Critical patent/CN109777791A/zh
Application granted granted Critical
Publication of CN109777791B publication Critical patent/CN109777791B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
CN201910110866.0A 2012-07-20 2013-03-15 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用 Active CN109777791B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910110866.0A CN109777791B (zh) 2012-07-20 2013-03-15 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
KR1020120079096A KR20140012385A (ko) 2012-07-20 2012-07-20 항염증 활성을 갖는 펩티드 및 이를 포함하는 염증질환 치료용 조성물
KR10-2012-0079096 2012-07-20
KR20120089161 2012-08-14
KR10-2012-0089162 2012-08-14
KR10-2012-0089167 2012-08-14
KR1020120089167A KR20140022699A (ko) 2012-08-14 2012-08-14 텔로머라제 펩티드를 포함하는 염증 예방 또는 억제용 조성물
KR1020120089162A KR20140022698A (ko) 2012-08-14 2012-08-14 텔로머라제 펩티드를 포함하는 염증 예방 또는 억제용 조성물
KR10-2012-0089161 2012-08-14
KR20120104144 2012-09-19
KR10-2012-0104207 2012-09-19
KR10-2012-0104144 2012-09-19
KR20120104207 2012-09-19
PCT/EP2013/055326 WO2014012683A1 (en) 2012-07-20 2013-03-15 Anti-inflammatory peptides and composition comprising the same
CN201380038045.1A CN104470947B (zh) 2012-07-20 2013-03-15 抗炎性肽及包含其的组合物
CN201910110866.0A CN109777791B (zh) 2012-07-20 2013-03-15 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380038045.1A Division CN104470947B (zh) 2012-07-20 2013-03-15 抗炎性肽及包含其的组合物

Publications (2)

Publication Number Publication Date
CN109777791A CN109777791A (zh) 2019-05-21
CN109777791B true CN109777791B (zh) 2023-12-01

Family

ID=47882177

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201380038045.1A Active CN104470947B (zh) 2012-07-20 2013-03-15 抗炎性肽及包含其的组合物
CN201910110866.0A Active CN109777791B (zh) 2012-07-20 2013-03-15 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用
CN202311502816.XA Pending CN117551631A (zh) 2012-07-20 2013-03-15 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201380038045.1A Active CN104470947B (zh) 2012-07-20 2013-03-15 抗炎性肽及包含其的组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202311502816.XA Pending CN117551631A (zh) 2012-07-20 2013-03-15 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用

Country Status (8)

Country Link
US (6) US20150125438A1 (OSRAM)
EP (3) EP2875042B1 (OSRAM)
JP (6) JP6352911B2 (OSRAM)
KR (2) KR102302392B1 (OSRAM)
CN (3) CN104470947B (OSRAM)
ES (2) ES2871899T3 (OSRAM)
TW (6) TWI836435B (OSRAM)
WO (1) WO2014012683A1 (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320058D0 (en) 1993-09-29 1993-11-17 Gillette Co Savety razors
CN115927242A (zh) 2012-05-11 2023-04-07 珍白斯凯尔有限公司 具有抗炎活性的肽及其在制备抗炎组合物中的应用
ES2981865T3 (es) 2012-07-11 2024-10-10 Gemvax & Kael Co Ltd Conjugado que comprende un péptido de penetración celular y composiciones que comprenden el mismo
US20150125438A1 (en) 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
CN107312759B (zh) 2012-09-19 2025-10-28 珍白斯凯尔有限公司 细胞穿透肽、包含该肽的缀合物、及包含该缀合物的组合物
TWI655204B (zh) 2012-09-19 2019-04-01 韓商傑姆維克斯＆凱爾有限公司 穿膜胜肽以及包含該胜肽之共軛物及組成物(三)
DK3783011T5 (da) 2013-03-15 2024-08-19 Promega Corp Aktivering af bioluminescens via strukturel komplementering
CN105535931A (zh) 2013-06-07 2016-05-04 凯尔杰姆维克斯有限公司 在癌症免疫疗法中有用的生物标记
EP3011967B1 (en) 2013-06-21 2020-06-17 Gemvax & Kael Co., Ltd. Hormone secretion regulator, composition containing same, and method for controlling hormone secretion using same
WO2015005723A1 (ko) * 2013-07-12 2015-01-15 주식회사 카엘젬백스 세포 투과성 펩티드 및 이를 포함하는 컨쥬게이트
JP6553605B2 (ja) 2013-11-22 2019-07-31 ジェムバックス アンド カエル カンパニー，リミティド 血管新生抑制活性を有するペプチド、及びそれを含む組成物
JP6367950B2 (ja) 2013-12-17 2018-08-01 ジェムバックス アンド カエル カンパニー，リミティド 前立腺癌治療用組成物
CN106456697B (zh) * 2014-04-11 2019-12-17 珍白斯凯尔有限公司 具有纤维化抑制活性的肽和含有其的组合物
KR102232320B1 (ko) 2014-04-30 2021-03-26 주식회사 젬백스앤카엘 장기, 조직 또는 세포 이식용 조성물, 키트 및 이식 방법
EP3193906B1 (en) * 2014-09-18 2020-11-11 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth near Dublin Use of peptide inhibitors of il-36 proteolytic processing for the treatment and/or reduction of inflammation
KR102413243B1 (ko) 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물
CN107405380B (zh) 2015-02-27 2021-04-20 珍白斯凯尔有限公司 用于预防听觉损伤的肽及其包含该肽的组合物
KR101662438B1 (ko) * 2015-04-07 2016-10-04 가톨릭대학교 산학협력단 X형 구조의 dna를 유효성분으로 포함하는 아토피 피부염 예방 또는 치료용 조성물
KR101734529B1 (ko) 2015-05-08 2017-05-11 건국대학교 산학협력단 패혈증 치료제의 스크리닝 방법 및 패혈증 치료용 약학 조성물
WO2016190660A1 (ko) 2015-05-26 2016-12-01 주식회사 젬백스앤카엘 신규 펩티드 및 이를 포함한 조성물
EP3318265B1 (en) 2015-07-02 2021-08-18 Gemvax & Kael Co., Ltd. Peptide having anti-viral effect and composition containing same
CA2996951C (en) * 2015-08-28 2024-05-07 The Medical College Of Wisconsin, Inc. Peptide inhibitors of telomerase translocation and therapeutic uses thereof
CA3006044A1 (en) * 2015-09-09 2017-03-16 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with cerebro-craniofacial health
ES2949697T3 (es) * 2016-04-07 2023-10-02 Gemvax & Kael Co Ltd Péptido que tiene efectos de aumento de la actividad telomerasa y de extensión de los telómeros, y composición que contienen el mismo
KR101831888B1 (ko) * 2016-04-15 2018-04-16 (주)케어젠 항염증 활성을 갖는 펩타이드 및 이의 용도
KR101887577B1 (ko) * 2016-10-19 2018-09-10 (주)케어젠 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도
US11339191B2 (en) * 2016-12-22 2022-05-24 Universite De Montpellier Stapled peptides and uses thereof
JP6601848B2 (ja) * 2017-08-21 2019-11-06 株式会社大一商会 遊技機
JP6601849B2 (ja) * 2017-08-21 2019-11-06 株式会社大一商会 遊技機
KR102092843B1 (ko) * 2018-08-30 2020-03-24 충남대학교 산학협력단 암 예방 또는 치료용 펩타이드 및 이의 용도
KR102274658B1 (ko) * 2018-11-16 2021-07-09 주식회사 카인사이언스 염증성 피부질환 치료용 펩타이드 및 이의 용도
KR102032945B1 (ko) * 2018-12-03 2019-10-16 순천대학교 산학협력단 항염증 활성을 나타내는 펩타이드 및 이를 유효성분으로 포함하는 항염증용 조성물
KR102146937B1 (ko) * 2018-12-11 2020-08-21 대한민국 왕사마귀로부터 유래된 테노데라신-1 펩타이드, 이를 유효성분으로 포함하는 항균, 항진균 또는 항염증용 조성물
KR102266613B1 (ko) * 2020-09-21 2021-06-18 자안바이오 주식회사 항염증 활성을 갖는 신규한 펩티드 및 이의 용도
US20240174714A1 (en) * 2021-02-08 2024-05-30 Bacoba Ag Treatment of skin disorders
KR20230156265A (ko) * 2022-05-03 2023-11-14 한국생명공학연구원 신규 펩타이드 및 이의 항염 및 재생 용도
KR102827929B1 (ko) * 2023-01-26 2025-07-09 ㈜에빅스젠 신규한 뇌 질환 치료제 및 이의 용도

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
CN1223651A (zh) * 1996-06-25 1999-07-21 美国辉瑞有限公司 取代的吲哚衍生物以及它们作为iv型磷酸二酯酶(pde)和肿瘤坏死因子(tnf)抑制剂的用途
CN1555272A (zh) * 2001-07-31 2004-12-15 �ո��� 调节免疫应答的组合物和方法
CN101011571A (zh) * 2006-03-13 2007-08-08 上海交通大学医学院 GADD45 β 蛋白及其抑制剂在类风湿关节炎中的应用
CN102021153A (zh) * 1996-10-01 2011-04-20 杰龙公司 人类的端粒酶催化亚单位
WO2011101173A1 (en) * 2010-02-16 2011-08-25 Oslo University Hospital Hf Polypeptides

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
DE4330664A1 (de) * 1993-09-10 1995-03-16 Beiersdorf Ag Verwendungen von Pflanzenölen
US6610839B1 (en) * 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
JP2002514928A (ja) * 1997-07-01 2002-05-21 キャンビア バイオシステムス リミティド ライアビリティー カンパニー 脊椎動物テロメラーゼ遺伝子およびタンパク質ならびにその使用
US7030211B1 (en) * 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
JP2005502335A (ja) * 2001-08-08 2005-01-27 インサイト・ゲノミックス・インコーポレイテッド 細胞成長、分化および細胞死関連タンパク質
US8492438B2 (en) * 2002-04-26 2013-07-23 Asan Laboratories Company (Cayman), Limited Treatment skin disorders
AU2004236708A1 (en) * 2003-05-01 2004-11-18 Musc Foundation For Research Development An autologous upregulation mechanism allowing optimized cell type-specific and regulated gene expression cells
CA2665816C (en) * 2006-09-21 2016-07-12 Vaxil Biotherapeutics Ltd. Antigen specific multi epitope vaccines
AU2007306368B2 (en) * 2006-10-12 2012-05-03 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof
AU2008252628A1 (en) 2007-05-18 2008-11-27 Inhibox Ltd. Bicyclosulfonyl acid (BCSA) compounds and their use as therapeutic agents
WO2009025871A1 (en) 2007-08-23 2009-02-26 University Of Medicine And Dentistry Of Nj Telomerase reverse transcriptase variant
GB2455539B (en) 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
ES2602453T3 (es) * 2008-06-16 2017-02-21 Mediolanum Farmaceutici S.P.A. Inmunoterapia antitumoral
US8252282B2 (en) * 2008-06-19 2012-08-28 University Of Medicine & Dentistry Of New Jersey Nuclear telomerase reverse transcriptase variant
WO2010032322A1 (ja) 2008-09-22 2010-03-25 日清ファルマ株式会社 抗炎症性ペプチド
EP2337795A2 (en) * 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
KR101284772B1 (ko) 2011-05-24 2013-07-17 정종문 항염증, 진통효과를 가지는 기능성 식품 조성물
KR20120133661A (ko) 2011-05-31 2012-12-11 주식회사 바이오포트코리아 아스타잔틴을 포함하는 항염증제
CN115927242A (zh) 2012-05-11 2023-04-07 珍白斯凯尔有限公司 具有抗炎活性的肽及其在制备抗炎组合物中的应用
US20150125438A1 (en) 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
CN107312759B (zh) 2012-09-19 2025-10-28 珍白斯凯尔有限公司 细胞穿透肽、包含该肽的缀合物、及包含该缀合物的组合物
TWI655204B (zh) 2012-09-19 2019-04-01 韓商傑姆維克斯＆凱爾有限公司 穿膜胜肽以及包含該胜肽之共軛物及組成物(三)
CN110064056B (zh) 2012-09-19 2022-10-28 珍白斯凯尔有限公司 细胞穿透性肽、包含该肽的缀合物、及包含该缀合物的组合物
CN105535931A (zh) * 2013-06-07 2016-05-04 凯尔杰姆维克斯有限公司 在癌症免疫疗法中有用的生物标记
WO2015005723A1 (ko) 2013-07-12 2015-01-15 주식회사 카엘젬백스 세포 투과성 펩티드 및 이를 포함하는 컨쥬게이트
WO2016190660A1 (ko) 2015-05-26 2016-12-01 주식회사 젬백스앤카엘 신규 펩티드 및 이를 포함한 조성물
US20170112941A1 (en) 2015-10-13 2017-04-27 Symic Ip, Llc Ve-cadherin binding bioconjugate

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
CN1223651A (zh) * 1996-06-25 1999-07-21 美国辉瑞有限公司 取代的吲哚衍生物以及它们作为iv型磷酸二酯酶(pde)和肿瘤坏死因子(tnf)抑制剂的用途
CN102021153A (zh) * 1996-10-01 2011-04-20 杰龙公司 人类的端粒酶催化亚单位
CN1555272A (zh) * 2001-07-31 2004-12-15 �ո��� 调节免疫应答的组合物和方法
CN101011571A (zh) * 2006-03-13 2007-08-08 上海交通大学医学院 GADD45 β 蛋白及其抑制剂在类风湿关节炎中的应用
WO2011101173A1 (en) * 2010-02-16 2011-08-25 Oslo University Hospital Hf Polypeptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
端粒、端粒酶与再生;童庭辉;《中国烧伤创疡杂志》;20040222(第01期);全文 *
端粒酶与头颈部肿瘤;冯旭等;《中国医学文摘(耳鼻咽喉科学)》;20060127(第01期);全文 *
端粒酶在皮肤科领域的研究进展;李慧忠;《中国麻风皮肤病杂志》;20030630(第03期);全文 *

Also Published As

Publication number Publication date
EP3428182A3 (en) 2019-02-27
ES2693321T3 (es) 2018-12-11
JP2024056904A (ja) 2024-04-23
CN104470947B (zh) 2019-03-08
US20200208127A1 (en) 2020-07-02
US11905536B2 (en) 2024-02-20
EP2875042A1 (en) 2015-05-27
CN104470947A (zh) 2015-03-25
JP7741218B2 (ja) 2025-09-17
TW202417473A (zh) 2024-05-01
US20200140832A1 (en) 2020-05-07
TWI836435B (zh) 2024-03-21
WO2014012683A1 (en) 2014-01-23
EP3896078A1 (en) 2021-10-20
TW202033540A (zh) 2020-09-16
US20170275603A1 (en) 2017-09-28
US20150125438A1 (en) 2015-05-07
JP2017158561A (ja) 2017-09-14
TW201742921A (zh) 2017-12-16
TW202237629A (zh) 2022-10-01
EP2875042B1 (en) 2018-08-08
JP7440581B2 (ja) 2024-02-28
TWI658141B (zh) 2019-05-01
JP6514259B2 (ja) 2019-05-15
TW201938579A (zh) 2019-10-01
ES2871899T3 (es) 2021-11-02
TWI779287B (zh) 2022-10-01
KR20200085927A (ko) 2020-07-15
EP3896078B1 (en) 2025-11-19
EP3428182A2 (en) 2019-01-16
JP6788062B2 (ja) 2020-11-18
JP7128246B2 (ja) 2022-08-30
EP3428182B1 (en) 2021-04-21
JP2022166225A (ja) 2022-11-01
US20210388328A1 (en) 2021-12-16
TW201406957A (zh) 2014-02-16
CN117551631A (zh) 2024-02-13
KR102302392B1 (ko) 2021-09-16
KR20150031413A (ko) 2015-03-24
JP2015525768A (ja) 2015-09-07
JP2021011502A (ja) 2021-02-04
CN109777791A (zh) 2019-05-21
JP2019151638A (ja) 2019-09-12
TWI647311B (zh) 2019-01-11
TWI700290B (zh) 2020-08-01
US11098294B2 (en) 2021-08-24
US20240158768A1 (en) 2024-05-16
JP6352911B2 (ja) 2018-07-04

Similar Documents

Publication Publication Date Title
CN109777791B (zh) 抗炎性肽、其编码多核苷酸及其在制备抗炎组合物和试剂盒中的应用
CN104507961B (zh) 抗炎性肽及包含其的组合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant