CN109715660A - 一种能够特异性地结合il-17a的抗体及其功能片段 - Google Patents

一种能够特异性地结合il-17a的抗体及其功能片段 Download PDF

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CN109715660A
CN109715660A CN201780056725.4A CN201780056725A CN109715660A CN 109715660 A CN109715660 A CN 109715660A CN 201780056725 A CN201780056725 A CN 201780056725A CN 109715660 A CN109715660 A CN 109715660A
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seq
antibody
sequence
function fragment
disease
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宋楠萌
刘家望
杨亚平
杨阳
杨东歌
张红娟
金孟燮
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Beijing Hanmi Pharmaceutical Co Ltd
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Beijing Hanmi Pharmaceutical Co Ltd
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Abstract

一种能够特异性地结合IL‑17A的抗体及其功能片段，所述抗体或其功能片段包括IL‑17A嵌合抗体及其功能片段及IL‑17A人源化抗体及其功能片段。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201780056725.4A 2016-09-14 2017-09-08 一种能够特异性地结合il-17a的抗体及其功能片段 Withdrawn CN109715660A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016108270972 2016-09-14
CN201610827097 2016-09-14
PCT/CN2017/101083 WO2018050028A1 (zh) 2016-09-14 2017-09-08 一种能够特异性地结合il-17a的抗体及其功能片段

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CN109715660A true CN109715660A (zh) 2019-05-03

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AU (1) AU2017328310B2 (zh)
BR (1) BR112019004990A2 (zh)
CA (1) CA3036913C (zh)
CL (1) CL2019000659A1 (zh)
CO (1) CO2019002370A2 (zh)
DO (1) DOP2019000062A (zh)
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EA201990673A1 (ru) * 2016-09-14 2019-08-30 Бэйцзин Ханми Фарм. Ко., Лтд. Антитела, специфически связывающиеся с il-17a, и их функциональные фрагменты
GB201719447D0 (en) 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
CN110551215A (zh) * 2018-05-30 2019-12-10 中山康方生物医药有限公司 抗白细胞介素-17a抗体、其药物组合物及其用途
EP3878870A4 (en) * 2018-11-05 2022-08-03 Beijing Hanmi Pharmaceutical Co., Ltd. ANTI-TNFA/ANTI-IL-17A NATURAL ANTIBODY STRUCTURE-LIKE HETERODIMER FORM OF A BISPECIFIC ANTIBODY AND METHODS FOR ITS PRODUCTION
CN109402178B (zh) * 2018-11-16 2021-08-03 佛山科学技术学院 一种小鼠精原干细胞高效重编程的方法及应用
CN111303283A (zh) * 2018-12-12 2020-06-19 上海君实生物医药科技股份有限公司 抗il-17a抗体及其应用
TW202043268A (zh) * 2018-12-18 2020-12-01 美商健生生物科技公司 產生異二聚體抗體之方法
CN110124030A (zh) * 2019-06-10 2019-08-16 通化东宝生物科技有限公司 一种苏金单抗注射液及其制备方法
CN114127108A (zh) * 2019-07-30 2022-03-01 江苏恒瑞医药股份有限公司 Il-17拮抗剂治疗自身免疫疾病的方法
CN116024212A (zh) * 2022-07-29 2023-04-28 硅羿科技（上海）有限公司 抑制IL-25基因表达的siRNA及其应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101589061A (zh) * 2006-10-18 2009-11-25 Ucb医药有限公司 结合il-17a和il-17f的抗体分子
CN101646690A (zh) * 2006-08-11 2010-02-10 先灵公司 抗il-17a抗体
WO2011053763A2 (en) * 2009-10-30 2011-05-05 Centocor Ortho Biotech Inc. Il-17a antagonists
CN102164959A (zh) * 2008-09-29 2011-08-24 罗氏格黎卡特股份公司 针对人il17的抗体及其应用
WO2015070697A1 (zh) * 2013-11-18 2015-05-21 上海恒瑞医药有限公司 Il-17a结合物及其用途
CN105315371A (zh) * 2015-03-05 2016-02-10 北京百特美博生物科技有限公司 抗人il-17单克隆抗体
CN107556382B (zh) * 2016-09-14 2021-04-20 北京韩美药品有限公司 一种能够特异性地结合il-17a的抗体及其功能片段

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10140492A1 (de) 2001-08-17 2003-08-14 Gruenenthal Gmbh Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
PT1963368E (pt) 2005-12-13 2012-09-14 Lilly Co Eli Anticorpos anti-il-17
US20070218065A1 (en) 2006-03-10 2007-09-20 Jaspers Stephen R Antibodies that bind both il-17a and il-17f and methods of using the same
TW200815469A (en) 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
KR101508086B1 (ko) 2008-05-05 2015-04-07 노비뮨 에스 에이 항-ｉｌ-１７ａ／ｉｌ-１７ｆ 교차-반응성 항체 및 그의 사용 방법
EP2810652A3 (en) 2009-03-05 2015-03-11 AbbVie Inc. IL-17 binding proteins
ES2632583T3 (es) 2011-01-14 2017-09-14 Ucb Biopharma Sprl Anticuerpo que se une a IL-17A e IL-17F
JP6362587B2 (ja) 2012-05-22 2018-07-25 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｉｌ−１７ａ／ｆｉｌ−２３二重特異性抗体およびその使用
EP2711016A1 (en) 2012-09-21 2014-03-26 Covagen AG Novel IL-17A binding molecules and medical uses thereof
CU24300B1 (es) 2013-02-08 2017-12-08 Novartis Ag Anticuerpos anti-il-17a útiles en el tratamiento de trastornos autoinmunes e inflamatorios
CN104231080B (zh) 2013-03-15 2019-07-02 中国医学科学院药物研究所 全人源抗人白介素17a单链抗体
CN104250302B (zh) 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 抗pd‑1抗体及其应用
RU2577228C2 (ru) 2014-03-14 2016-03-10 Закрытое Акционерное Общество "Биокад" Анти-il-17-антитела, способ их получения и способ применения
GB201500463D0 (en) * 2015-01-12 2015-02-25 Cresendo Biolog Ltd Therapeutic molecules

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101646690A (zh) * 2006-08-11 2010-02-10 先灵公司 抗il-17a抗体
CN101589061A (zh) * 2006-10-18 2009-11-25 Ucb医药有限公司 结合il-17a和il-17f的抗体分子
CN102164959A (zh) * 2008-09-29 2011-08-24 罗氏格黎卡特股份公司 针对人il17的抗体及其应用
WO2011053763A2 (en) * 2009-10-30 2011-05-05 Centocor Ortho Biotech Inc. Il-17a antagonists
WO2015070697A1 (zh) * 2013-11-18 2015-05-21 上海恒瑞医药有限公司 Il-17a结合物及其用途
CN105315371A (zh) * 2015-03-05 2016-02-10 北京百特美博生物科技有限公司 抗人il-17单克隆抗体
CN107556382B (zh) * 2016-09-14 2021-04-20 北京韩美药品有限公司 一种能够特异性地结合il-17a的抗体及其功能片段

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAVRDOVÁ 等: "Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study", 《JOURNAL OF NEUROLOGY》 *
赵永刚: "人IL-17基因克隆、表达及其单克隆抗体的制备", 《中国优秀博硕士学位论文全文数据库(硕士)医药卫生科技辑》 *

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