CO2019002370A2 - Anticuerpo que se une específicamente a il-17a y fragmento funcional del mismo - Google Patents
Anticuerpo que se une específicamente a il-17a y fragmento funcional del mismoInfo
- Publication number
- CO2019002370A2 CO2019002370A2 CONC2019/0002370A CO2019002370A CO2019002370A2 CO 2019002370 A2 CO2019002370 A2 CO 2019002370A2 CO 2019002370 A CO2019002370 A CO 2019002370A CO 2019002370 A2 CO2019002370 A2 CO 2019002370A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibody
- functional fragment
- specifically binds
- fragment
- functional
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 5
- 102000013691 Interleukin-17 Human genes 0.000 title abstract 2
- 108050003558 Interleukin-17 Proteins 0.000 title abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/567—Framework region [FR]
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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- Neurology (AREA)
- Urology & Nephrology (AREA)
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- Diabetes (AREA)
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- Pain & Pain Management (AREA)
Abstract
Un anticuerpo que se une específicamente a IL-17A o un fragmento funcional del mismo. El anticuerpo o el fragmento funcional del mismo incluye un anticuerpo quimérico anti-IL-17A y un fragmento funcional del mismo y un anticuerpo humanizado anti-IL-17A y un fragmento funcional del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610827097 | 2016-09-14 | ||
PCT/CN2017/101083 WO2018050028A1 (zh) | 2016-09-14 | 2017-09-08 | 一种能够特异性地结合il-17a的抗体及其功能片段 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019002370A2 true CO2019002370A2 (es) | 2019-05-10 |
Family
ID=60980760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0002370A CO2019002370A2 (es) | 2016-09-14 | 2019-03-14 | Anticuerpo que se une específicamente a il-17a y fragmento funcional del mismo |
Country Status (21)
Country | Link |
---|---|
US (1) | US11072651B2 (es) |
EP (1) | EP3514176B1 (es) |
JP (1) | JP6802381B2 (es) |
KR (1) | KR102329490B1 (es) |
CN (2) | CN109715660A (es) |
AU (1) | AU2017328310B2 (es) |
BR (1) | BR112019004990A2 (es) |
CA (1) | CA3036913C (es) |
CL (1) | CL2019000659A1 (es) |
CO (1) | CO2019002370A2 (es) |
DO (1) | DOP2019000062A (es) |
EA (1) | EA201990673A1 (es) |
EC (1) | ECSP19018356A (es) |
ES (1) | ES2905917T3 (es) |
IL (1) | IL265350A (es) |
MX (1) | MX2019002970A (es) |
MY (1) | MY185578A (es) |
PE (1) | PE20191075A1 (es) |
PH (1) | PH12019500551A1 (es) |
TN (1) | TN2019000082A1 (es) |
WO (1) | WO2018050028A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109715660A (zh) * | 2016-09-14 | 2019-05-03 | 北京韩美药品有限公司 | 一种能够特异性地结合il-17a的抗体及其功能片段 |
GB201719447D0 (en) | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
CN110551215A (zh) * | 2018-05-30 | 2019-12-10 | 中山康方生物医药有限公司 | 抗白细胞介素-17a抗体、其药物组合物及其用途 |
JP2022506411A (ja) * | 2018-11-05 | 2022-01-17 | 北京韓美薬品有限公司 | 抗TNFα/抗IL-17A天然抗体構造様ヘテロダイマー二重特異性抗体及びその製造方法 |
CN109402178B (zh) * | 2018-11-16 | 2021-08-03 | 佛山科学技术学院 | 一种小鼠精原干细胞高效重编程的方法及应用 |
CN111303283A (zh) * | 2018-12-12 | 2020-06-19 | 上海君实生物医药科技股份有限公司 | 抗il-17a抗体及其应用 |
TW202043268A (zh) * | 2018-12-18 | 2020-12-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
CN110124030A (zh) * | 2019-06-10 | 2019-08-16 | 通化东宝生物科技有限公司 | 一种苏金单抗注射液及其制备方法 |
WO2021018191A1 (zh) * | 2019-07-30 | 2021-02-04 | 江苏恒瑞医药股份有限公司 | Il-17拮抗剂治疗自身免疫疾病的方法 |
CN116024212A (zh) * | 2022-07-29 | 2023-04-28 | 硅羿科技(上海)有限公司 | 抑制IL-25基因表达的siRNA及其应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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DE10140492A1 (de) | 2001-08-17 | 2003-08-14 | Gruenenthal Gmbh | Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung |
GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
SI2481753T1 (en) | 2005-12-13 | 2018-06-29 | Eli Lilly And Company | Anti-IL-17 antibodies |
JP2009534297A (ja) | 2006-03-10 | 2009-09-24 | ザイモジェネティクス, インコーポレイテッド | Il−17aおよびil−17fの両方に結合する抗体ならびにその使用方法 |
TW200815469A (en) | 2006-06-23 | 2008-04-01 | Astrazeneca Ab | Compounds |
GB0612928D0 (en) | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
PE20080739A1 (es) * | 2006-08-11 | 2008-06-14 | Schering Corp | Anticuerpos para il-17a |
GB0620729D0 (en) * | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
KR20110025649A (ko) | 2008-05-05 | 2011-03-10 | 노비뮨 에스 에이 | 항-il-17a/il-17f 교차-반응성 항체 및 그의 사용 방법 |
MX2011003184A (es) * | 2008-09-29 | 2011-04-21 | Roche Glycart Ag | Anticuerpos contra il17 humana y usos de los mismos. |
EP2810652A3 (en) | 2009-03-05 | 2015-03-11 | AbbVie Inc. | IL-17 binding proteins |
BR112012010280B1 (pt) * | 2009-10-30 | 2020-09-24 | Janssen Biotech, Inc. | Anticorpo isolado ou fragmento do mesmo que se liga especificamente a il-17a humana, seu uso, e composição farmacêutica |
MA34907B1 (fr) | 2011-01-14 | 2014-02-01 | Ucb Pharma Sa | Molécules d'anticorps se liant à il-17a et il-17f |
EP2852615B1 (en) * | 2012-05-22 | 2018-12-05 | Bristol-Myers Squibb Company | Il-17a/f il-23 bispecific antibodies and their uses |
EP2711016A1 (en) | 2012-09-21 | 2014-03-26 | Covagen AG | Novel IL-17A binding molecules and medical uses thereof |
EA031537B1 (ru) * | 2013-02-08 | 2019-01-31 | Новартис Аг | Антитела против il-17a и их применение для лечения аутоиммунных и воспалительных нарушений |
CN104231080B (zh) | 2013-03-15 | 2019-07-02 | 中国医学科学院药物研究所 | 全人源抗人白介素17a单链抗体 |
CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
HUE052184T2 (hu) | 2013-11-18 | 2021-12-28 | Shanghai hengrui pharmaceutical co ltd | IL-17A kötõanyag és felhasználásai |
RU2577228C2 (ru) | 2014-03-14 | 2016-03-10 | Закрытое Акционерное Общество "Биокад" | Анти-il-17-антитела, способ их получения и способ применения |
GB201500463D0 (en) * | 2015-01-12 | 2015-02-25 | Cresendo Biolog Ltd | Therapeutic molecules |
CN105315371B (zh) * | 2015-03-05 | 2018-05-29 | 北京百特美博生物科技有限公司 | 抗人il-17单克隆抗体 |
CN109715660A (zh) * | 2016-09-14 | 2019-05-03 | 北京韩美药品有限公司 | 一种能够特异性地结合il-17a的抗体及其功能片段 |
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- 2017-09-08 EA EA201990673A patent/EA201990673A1/ru unknown
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- 2017-09-08 WO PCT/CN2017/101083 patent/WO2018050028A1/zh unknown
- 2017-09-08 MY MYPI2019001350A patent/MY185578A/en unknown
- 2017-09-08 TN TNP/2019/000082A patent/TN2019000082A1/en unknown
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- 2017-09-08 BR BR112019004990A patent/BR112019004990A2/pt not_active Application Discontinuation
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- 2019-03-14 EC ECSENADI201918356A patent/ECSP19018356A/es unknown
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KR102329490B1 (ko) | 2021-11-23 |
KR20190045348A (ko) | 2019-05-02 |
EA201990673A1 (ru) | 2019-08-30 |
CA3036913C (en) | 2023-05-16 |
EP3514176A4 (en) | 2020-04-29 |
WO2018050028A1 (zh) | 2018-03-22 |
CN109715660A (zh) | 2019-05-03 |
JP6802381B2 (ja) | 2020-12-16 |
EP3514176A1 (en) | 2019-07-24 |
US11072651B2 (en) | 2021-07-27 |
AU2017328310A1 (en) | 2019-04-18 |
IL265350A (en) | 2019-05-30 |
AU2017328310A9 (en) | 2019-05-30 |
TN2019000082A1 (en) | 2020-07-15 |
NZ752189A (en) | 2021-10-29 |
MY185578A (en) | 2021-05-22 |
ECSP19018356A (es) | 2019-05-31 |
PH12019500551A1 (en) | 2019-11-04 |
ES2905917T3 (es) | 2022-04-12 |
PE20191075A1 (es) | 2019-08-20 |
MX2019002970A (es) | 2019-09-18 |
DOP2019000062A (es) | 2019-05-31 |
CL2019000659A1 (es) | 2019-07-19 |
AU2017328310B2 (en) | 2020-10-15 |
JP2020500206A (ja) | 2020-01-09 |
CA3036913A1 (en) | 2018-03-22 |
CN107556382A (zh) | 2018-01-09 |
BR112019004990A2 (pt) | 2019-06-04 |
US20190256588A1 (en) | 2019-08-22 |
CN107556382B (zh) | 2021-04-20 |
EP3514176B1 (en) | 2021-12-15 |
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