CN109715630B - β-内酰胺酶抑制剂化合物 - Google Patents

β-内酰胺酶抑制剂化合物 Download PDF

Info

Publication number
CN109715630B
CN109715630B CN201780057302.4A CN201780057302A CN109715630B CN 109715630 B CN109715630 B CN 109715630B CN 201780057302 A CN201780057302 A CN 201780057302A CN 109715630 B CN109715630 B CN 109715630B
Authority
CN
China
Prior art keywords
mmol
methyl
oxo
tert
diazabicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780057302.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN109715630A (zh
Inventor
贾内尔·科米塔-普莱瓦尔
托马斯·佛朗索瓦·杜兰德-雷维尔
利兹·高蒂尔
约翰·奥唐奈
扬·罗梅罗
鲁本·托马斯
杰伦·库涅拉·维尔海连
吴新和
吴晓云
张靖
格雷戈里·S·巴萨拉布
比尔·莫斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Priority to CN202210161577.5A priority Critical patent/CN114591223B/zh
Publication of CN109715630A publication Critical patent/CN109715630A/zh
Application granted granted Critical
Publication of CN109715630B publication Critical patent/CN109715630B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0892—Compounds with a Si-O-N linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201780057302.4A 2016-09-16 2017-09-15 β-内酰胺酶抑制剂化合物 Active CN109715630B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210161577.5A CN114591223B (zh) 2016-09-16 2017-09-15 β-内酰胺酶抑制剂化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662395464P 2016-09-16 2016-09-16
US62/395,464 2016-09-16
US201762456423P 2017-02-08 2017-02-08
US62/456,423 2017-02-08
PCT/US2017/051692 WO2018053215A1 (en) 2016-09-16 2017-09-15 Beta-lactamase inhibitor compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210161577.5A Division CN114591223B (zh) 2016-09-16 2017-09-15 β-内酰胺酶抑制剂化合物

Publications (2)

Publication Number Publication Date
CN109715630A CN109715630A (zh) 2019-05-03
CN109715630B true CN109715630B (zh) 2022-02-22

Family

ID=60083416

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780057302.4A Active CN109715630B (zh) 2016-09-16 2017-09-15 β-内酰胺酶抑制剂化合物
CN202210161577.5A Active CN114591223B (zh) 2016-09-16 2017-09-15 β-内酰胺酶抑制剂化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202210161577.5A Active CN114591223B (zh) 2016-09-16 2017-09-15 β-内酰胺酶抑制剂化合物

Country Status (24)

Country Link
US (1) US10800778B2 (https=)
EP (1) EP3512851B1 (https=)
JP (2) JP6997178B2 (https=)
KR (2) KR102537340B1 (https=)
CN (2) CN109715630B (https=)
AU (1) AU2017325863B2 (https=)
CA (1) CA3036557A1 (https=)
CY (1) CY1125826T1 (https=)
DK (1) DK3512851T3 (https=)
ES (1) ES2927986T3 (https=)
HR (1) HRP20221217T1 (https=)
HU (1) HUE060282T2 (https=)
IL (2) IL289686B2 (https=)
LT (1) LT3512851T (https=)
MA (1) MA46242A (https=)
MX (2) MX392515B (https=)
PH (1) PH12019500558B1 (https=)
PL (1) PL3512851T3 (https=)
PT (1) PT3512851T (https=)
SG (1) SG11201901658PA (https=)
SI (1) SI3512851T1 (https=)
SM (1) SMT202200397T1 (https=)
TW (1) TWI773687B (https=)
WO (1) WO2018053215A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114591223B (zh) * 2016-09-16 2025-01-24 恩塔西斯治疗有限公司 β-内酰胺酶抑制剂化合物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX389349B (es) 2016-06-30 2025-03-20 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos.
WO2018208769A1 (en) 2017-05-08 2018-11-15 Entasis Therapeutics, Inc. Compounds and methods for treating bacterial infections
EP3781576B1 (en) 2018-04-20 2024-06-12 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3833665B1 (en) 2018-08-09 2023-07-19 Antabio SAS Diazabicyclooctanones as inhibitors of serine beta-lactamases
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN112209928B (zh) * 2019-07-10 2023-02-17 华东理工大学 共价键标记丝氨酸类beta-内酰胺酶的试剂及制备和应用
CN110898999A (zh) * 2019-11-26 2020-03-24 中国矿业大学 一种煤焦油基煤泥浮选药剂及其制备方法
AU2021266715A1 (en) 2020-05-05 2022-11-17 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
CN111790439B (zh) * 2020-07-29 2022-12-27 成都能特科技发展有限公司 一种手性二级胺二苯基膦芳甲酰胺双功能催化剂及其制备方法与应用
CN115151544B (zh) 2020-09-01 2024-08-16 宁夏农林科学院 β-内酰胺酶抑制剂及其制备
JP2024512793A (ja) * 2021-04-05 2024-03-19 キューペックス バイオファーマ， インコーポレイテッド セフチブテン投与レジメン
CN115605480B (zh) 2021-05-07 2024-04-05 宁夏农林科学院 磺酰脒取代的化合物及其作为β-内酰胺酶抑制剂的用途
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation
WO2023206580A1 (en) 2022-04-29 2023-11-02 Entasis Therapeutics Limited Durlobactam crystalline forms
US20230398101A1 (en) * 2022-06-09 2023-12-14 Fleurir Abx Llc Co-agents as Therapy Against Anaerobic Pathogens
CN118271319B (zh) * 2022-12-30 2025-02-28 成都四面体药物研究有限公司 一种β-内酰胺酶抑制剂含脲双环化合物、其制备方法及其用途
CN118772145B (zh) * 2023-04-04 2025-10-10 上海医药工业研究院有限公司 一种二氮杂双环辛烯化合物的制备方法
CN116693531A (zh) * 2023-06-09 2023-09-05 河南师范大学 一种桥联多环内酰胺类化合物的合成方法
WO2025106662A1 (en) * 2023-11-15 2025-05-22 Entasis Therapeutics, Inc. Preparation of boronic acid intermediates useful for the preparation of compounds for treating bacterial infections

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101918407A (zh) * 2008-01-18 2010-12-15 默沙东公司 β-内酰胺酶抑制剂
WO2013030733A1 (en) * 2011-08-27 2013-03-07 Wockhardt Limited 1,6- diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
CN104364254A (zh) * 2012-04-02 2015-02-18 阿斯利康(瑞典)有限公司 作为β-内酰胺酶抑制剂的杂二环化合物
WO2016081452A1 (en) * 2014-11-17 2016-05-26 Entasis Therapeutics Limited Combination therapy for treatment of resistant bacterial infections

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607041A (en) * 1983-04-27 1986-08-19 Fisons Plc Antihypertensive 2-phenyl Hantzsch dihydropyridines
CZ282567B6 (cs) 1993-12-29 1997-08-13 Pfizer Inc. Diazabicyklické sloučeniny a farmaceutické prostředky na jejich bázi
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2848210B1 (fr) 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2914923B1 (fr) 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
FR2930553B1 (fr) 2008-04-29 2010-05-21 Novexel Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases
EP2921559A1 (en) 2008-06-19 2015-09-23 Astra Zeneca Holding France Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1]octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (fr) 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2951171A1 (fr) 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
CA2796750C (en) * 2010-04-20 2017-09-19 Taisho Pharmaceutical Co., Ltd. Novel hydroxamic acid derivative
WO2013014497A1 (en) 2011-07-26 2013-01-31 Wockhardt Limited Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor
NZ616806A (en) 2011-07-26 2015-03-27 Wockhardt Ltd Pharmaceutical compositions comprising sulbactam and beta-lactamase inhibitor
CA2845108C (en) 2011-08-30 2015-06-16 Wockhardt Limited 1,6-diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of bacterial infections
CA2846107C (en) 2011-09-13 2016-06-21 Wockhardt Limited Nitrogen containing compounds and their use
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
EP2814483A2 (en) 2012-02-15 2014-12-24 Rempex Pharmaceuticals, Inc. Methods of treating bacterial infections
WO2013149136A1 (en) 2012-03-30 2013-10-03 Cubist Pharmaceuticals, Inc. ISOXAZOLE β-LACTAMASE INHIBITORS
US8940897B2 (en) 2012-03-30 2015-01-27 Cubist Pharmaceuticals, Inc. 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors
US8969570B2 (en) 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
HUE046893T2 (hu) 2012-05-30 2020-04-28 Meiji Seika Pharma Co Ltd Új ß-laktamáz inhibitor és eljárás elõállítására
RU2614418C2 (ru) 2012-08-25 2017-03-28 Вокхардт Лимитед Производные 1,6-диазабицикло[3.2.1]октан-7-она и их применение для лечения бактериальных инфекций
US20150258072A1 (en) 2012-09-03 2015-09-17 Wockhardt Limited Antibacterial compositions
EP2953626A1 (en) 2013-02-06 2015-12-16 Astrazeneca AB Combination therapy for the treatment of nosocomial pneumonia
WO2014141132A1 (en) 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS
US10072006B2 (en) * 2015-03-31 2018-09-11 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
DK3512851T3 (en) * 2016-09-16 2022-10-17 Entasis Therapeutics Ltd Beta-lactamase inhibitor compounds
KR20230007830A (ko) * 2021-07-06 2023-01-13 현대자동차주식회사 고강성 저선팽창 열가소성 수지 조성물 및 이를 포함하는 성형체

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101918407A (zh) * 2008-01-18 2010-12-15 默沙东公司 β-内酰胺酶抑制剂
WO2013030733A1 (en) * 2011-08-27 2013-03-07 Wockhardt Limited 1,6- diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
CN104364254A (zh) * 2012-04-02 2015-02-18 阿斯利康(瑞典)有限公司 作为β-内酰胺酶抑制剂的杂二环化合物
WO2016081452A1 (en) * 2014-11-17 2016-05-26 Entasis Therapeutics Limited Combination therapy for treatment of resistant bacterial infections

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114591223B (zh) * 2016-09-16 2025-01-24 恩塔西斯治疗有限公司 β-内酰胺酶抑制剂化合物

Also Published As

Publication number Publication date
CY1125826T1 (el) 2026-02-25
IL289686A (en) 2022-03-01
US20190202832A1 (en) 2019-07-04
TWI773687B (zh) 2022-08-11
ES2927986T3 (es) 2022-11-14
SMT202200397T1 (it) 2022-11-18
BR112019005053A2 (pt) 2019-06-18
KR20230078830A (ko) 2023-06-02
JP2019532928A (ja) 2019-11-14
IL265276A (en) 2019-05-30
KR20190043630A (ko) 2019-04-26
CA3036557A1 (en) 2018-03-22
IL265276B (en) 2022-02-01
DK3512851T3 (en) 2022-10-17
MX2021010077A (es) 2022-05-23
LT3512851T (lt) 2022-10-25
MX385507B (es) 2025-03-18
AU2017325863A1 (en) 2019-03-14
SI3512851T1 (sl) 2022-11-30
TW201823207A (zh) 2018-07-01
AU2017325863B2 (en) 2021-08-19
WO2018053215A1 (en) 2018-03-22
JP7281527B2 (ja) 2023-05-25
SG11201901658PA (en) 2019-04-29
PL3512851T3 (pl) 2022-11-14
PT3512851T (pt) 2022-10-11
EP3512851A1 (en) 2019-07-24
IL289686B (en) 2022-11-01
PH12019500558B1 (en) 2023-09-08
HRP20221217T1 (hr) 2022-12-23
HUE060282T2 (hu) 2023-02-28
CN114591223B (zh) 2025-01-24
MX2019003060A (es) 2019-07-08
KR102537340B1 (ko) 2023-05-26
NZ751016A (en) 2025-02-28
IL289686B2 (en) 2023-03-01
MX392515B (es) 2025-03-24
CN114591223A (zh) 2022-06-07
JP2022046563A (ja) 2022-03-23
MA46242A (fr) 2019-07-24
CN109715630A (zh) 2019-05-03
KR102667828B1 (ko) 2024-05-20
JP6997178B2 (ja) 2022-02-03
US10800778B2 (en) 2020-10-13
PH12019500558A1 (en) 2019-07-29
EP3512851B1 (en) 2022-07-06

Similar Documents

Publication Publication Date Title
CN109715630B (zh) β-内酰胺酶抑制剂化合物
CN107438614B (zh) 杂环化合物及它们在预防或治疗细菌感染中的应用
CN102666507A (zh) 噁嗪衍生物及其在治疗神经病症中的用途
TWI754613B (zh) 雜環化合物及其用於預防或治療細菌感染之用途
CN110520413B (zh) 大环广谱抗生素
CN107531708A (zh) 新型杂环化合物及它们在预防或治疗细菌感染中的应用
CN109906226A (zh) 杂环化合物及它们在预防或治疗细菌感染中的应用
IE921170A1 (en) Beta-Lactames
CN107438610A (zh) 杂环化合物及它们在预防或治疗细菌感染中的应用
CN112513049A (zh) 杂环化合物及它们在预防或治疗细菌感染中的用途
EA044428B1 (ru) Соединения-ингибиторы бета-лактамаз
HK40011101A (en) Beta-lactamase inhibitor compounds
HK40011101B (en) Beta-lactamase inhibitor compounds
EA037916B1 (ru) Соединения-ингибиторы бета-лактамаз
BR112019005053B1 (pt) Compostos inibidores de beta-lactamase, usos dos mesmos, composição farmacêutica, e processo para formação de um composto
HK40099768A (zh) Lactivicin化合物及其制备和作为抗菌剂的用途
HK1241877A1 (en) Heterocyclic compounds and their use in preventing or treating bacterial infections

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant