CN109641938A - 衍生自精氨酸富集结构域的经修饰抗菌肽 - Google Patents

衍生自精氨酸富集结构域的经修饰抗菌肽 Download PDF

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Publication number
CN109641938A
CN109641938A CN201780032261.3A CN201780032261A CN109641938A CN 109641938 A CN109641938 A CN 109641938A CN 201780032261 A CN201780032261 A CN 201780032261A CN 109641938 A CN109641938 A CN 109641938A
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China
Prior art keywords
peptide
antibacterial peptide
hbcard
sequence
antibacterial
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Pending
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CN201780032261.3A
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English (en)
Chinese (zh)
Inventor
施嘉和
陈恒立
苏倍仪
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Academia Sinica
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Academia Sinica
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/40—Viruses, e.g. bacteriophages
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10031—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201780032261.3A 2016-05-27 2017-05-25 衍生自精氨酸富集结构域的经修饰抗菌肽 Pending CN109641938A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662342415P 2016-05-27 2016-05-27
US62/342,415 2016-05-27
PCT/US2017/034489 WO2017205631A1 (en) 2016-05-27 2017-05-25 Modified antimicrobial peptide derived from an arginine-rich domain

Publications (1)

Publication Number Publication Date
CN109641938A true CN109641938A (zh) 2019-04-16

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Family Applications (1)

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CN201780032261.3A Pending CN109641938A (zh) 2016-05-27 2017-05-25 衍生自精氨酸富集结构域的经修饰抗菌肽

Country Status (14)

Country Link
US (2) US20190144510A1 (enExample)
EP (1) EP3464329A4 (enExample)
JP (1) JP7161263B6 (enExample)
KR (1) KR102530478B1 (enExample)
CN (1) CN109641938A (enExample)
AU (1) AU2017270201A1 (enExample)
BR (1) BR112018074478A2 (enExample)
CA (1) CA3024873A1 (enExample)
IL (1) IL263086A (enExample)
MX (1) MX2018014490A (enExample)
SG (1) SG11201809928VA (enExample)
TW (1) TWI635095B (enExample)
WO (1) WO2017205631A1 (enExample)
ZA (1) ZA201807763B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202317598A (zh) * 2021-09-01 2023-05-01 美商艾姆麥克斯治療股份有限公司 具有抗微生物活性的胜肽
KR102544102B1 (ko) * 2021-11-05 2023-06-19 주식회사 레메디 상처 치료 및 항염증 활성을 가지는 펩타이드 및 이의 용도
US11713341B1 (en) 2022-06-17 2023-08-01 Vestaron Corporation Antimicrobial NCR13 variant peptides
CN116947974B (zh) * 2023-07-25 2025-03-11 武汉大学人民医院（湖北省人民医院） 一种来源于中药美洲大蠊的多聚精氨酸修饰肽及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1362969A (zh) * 1999-02-05 2002-08-07 埃吉尼克斯股份有限公司 抗微生物/中和内毒素的多肽
CN105101796A (zh) * 2013-02-06 2015-11-25 中央研究院 衍生自b型肝炎病毒核蛋白精氨酸密集区的抗菌胜肽

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001500012A (ja) * 1996-09-03 2001-01-09 ザ ジェネラル ホスピタル コーポレーション ウイルス複製の阻害
PL201419B1 (pl) 2002-12-04 2009-04-30 Inst Biotechnologii I Antybiot Białko chimeryczne, sekwencja, konstrukt, komórka roślinna, sposób otrzymywania białka chimerycznego, transgenicznej rośliny, transgeniczna roślina

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1362969A (zh) * 1999-02-05 2002-08-07 埃吉尼克斯股份有限公司 抗微生物/中和内毒素的多肽
CN105101796A (zh) * 2013-02-06 2015-11-25 中央研究院 衍生自b型肝炎病毒核蛋白精氨酸密集区的抗菌胜肽

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAMAMOTO K.等: "Antimicrobial activity and stability to proteolysis of small linear cationic peptides with D-amino acid substitutions", 《MICROBIOL. IMMUNOL.》 *
MITCHELL D.J.等: "Polyarginine enters cells more efficiently than other polycationic homopolymers", 《JOURNAL OF PEPTIDE RESEARCH》 *

Also Published As

Publication number Publication date
ZA201807763B (en) 2020-10-28
TWI635095B (zh) 2018-09-11
TW201808985A (zh) 2018-03-16
CA3024873A1 (en) 2017-11-30
US20210101939A1 (en) 2021-04-08
JP7161263B2 (ja) 2022-10-26
KR20190001954A (ko) 2019-01-07
SG11201809928VA (en) 2018-12-28
JP7161263B6 (ja) 2023-03-20
EP3464329A4 (en) 2020-08-26
JP2019523220A (ja) 2019-08-22
US12084479B2 (en) 2024-09-10
KR102530478B1 (ko) 2023-05-10
AU2017270201A1 (en) 2018-11-29
IL263086A (en) 2018-12-31
EP3464329A1 (en) 2019-04-10
WO2017205631A1 (en) 2017-11-30
US20190144510A1 (en) 2019-05-16
MX2018014490A (es) 2019-06-24
BR112018074478A2 (pt) 2019-03-19

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