CN109641901B - 阿维巴坦游离酸 - Google Patents

阿维巴坦游离酸 Download PDF

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Publication number
CN109641901B
CN109641901B CN201780052135.4A CN201780052135A CN109641901B CN 109641901 B CN109641901 B CN 109641901B CN 201780052135 A CN201780052135 A CN 201780052135A CN 109641901 B CN109641901 B CN 109641901B
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CN
China
Prior art keywords
avibactam
diazabicyclo
carbamoyl
oxo
acid
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CN201780052135.4A
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English (en)
Chinese (zh)
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CN109641901A (zh
Inventor
M·菲舍尔
A·莱希纳
B·斯塔格尔
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Sandoz AG
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Sandoz AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780052135.4A 2016-08-26 2017-08-25 阿维巴坦游离酸 Active CN109641901B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16185913.7 2016-08-26
EP16185913 2016-08-26
PCT/EP2017/071471 WO2018037124A1 (en) 2016-08-26 2017-08-25 Avibactam free acid

Publications (2)

Publication Number Publication Date
CN109641901A CN109641901A (zh) 2019-04-16
CN109641901B true CN109641901B (zh) 2022-12-09

Family

ID=56802364

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780052135.4A Active CN109641901B (zh) 2016-08-26 2017-08-25 阿维巴坦游离酸

Country Status (8)

Country Link
US (1) US11124513B2 (OSRAM)
EP (1) EP3504207B1 (OSRAM)
JP (1) JP7183147B2 (OSRAM)
KR (1) KR102482826B1 (OSRAM)
CN (1) CN109641901B (OSRAM)
AU (1) AU2017315164B2 (OSRAM)
CA (1) CA3034470A1 (OSRAM)
WO (1) WO2018037124A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110267956B (zh) 2017-02-08 2022-07-15 桑多斯股份公司 用于制备阿维巴坦钠结晶形式c的方法
CN113105455B (zh) * 2020-01-10 2024-05-17 四川科伦药物研究院有限公司 晶型b阿维巴坦钠的制备方法
CN115677697B (zh) * 2022-09-19 2024-08-06 瑞阳制药股份有限公司 粒度可调控且流动性好的b晶型阿维巴坦钠析晶方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112592B2 (en) * 2000-08-01 2006-09-26 Aventis Pharma S.A. Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
CN102834395A (zh) * 2009-10-09 2012-12-19 诺维塞尔公司 药物化合物的多晶型形式和假多晶型形式
WO2012172368A1 (en) * 2011-06-17 2012-12-20 Astrazeneca Ab Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
WO2016046845A1 (en) * 2014-09-25 2016-03-31 Manu Chaudhary Stealth, targeted nanoparticles (stn) for oral drug delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105143226A (zh) 2013-03-08 2015-12-09 沃克哈特有限公司 制备(2s,5r)-2-甲酰胺基-7-氧代-6-磺酰氧基-1,6-二氮杂-双环[3.2.1]辛烷的钠盐的方法
US10265326B2 (en) 2015-08-10 2019-04-23 Sandoz Ag Form C of avibactam sodium
CN106699756B (zh) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112592B2 (en) * 2000-08-01 2006-09-26 Aventis Pharma S.A. Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
CN102834395A (zh) * 2009-10-09 2012-12-19 诺维塞尔公司 药物化合物的多晶型形式和假多晶型形式
WO2012172368A1 (en) * 2011-06-17 2012-12-20 Astrazeneca Ab Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
WO2016046845A1 (en) * 2014-09-25 2016-03-31 Manu Chaudhary Stealth, targeted nanoparticles (stn) for oral drug delivery

Also Published As

Publication number Publication date
AU2017315164A1 (en) 2019-02-28
US20190185473A1 (en) 2019-06-20
KR102482826B1 (ko) 2022-12-28
EP3504207B1 (en) 2022-06-01
KR20190040988A (ko) 2019-04-19
EP3504207A1 (en) 2019-07-03
JP2019524829A (ja) 2019-09-05
CN109641901A (zh) 2019-04-16
US11124513B2 (en) 2021-09-21
CA3034470A1 (en) 2018-03-01
JP7183147B2 (ja) 2022-12-05
AU2017315164B2 (en) 2021-12-09
WO2018037124A1 (en) 2018-03-01

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