AU2017315164B2 - Avibactam free acid - Google Patents

Avibactam free acid Download PDF

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Publication number
AU2017315164B2
AU2017315164B2 AU2017315164A AU2017315164A AU2017315164B2 AU 2017315164 B2 AU2017315164 B2 AU 2017315164B2 AU 2017315164 A AU2017315164 A AU 2017315164A AU 2017315164 A AU2017315164 A AU 2017315164A AU 2017315164 B2 AU2017315164 B2 AU 2017315164B2
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AU
Australia
Prior art keywords
crystalline form
formula
diazabicylco
octan
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017315164A
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English (en)
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AU2017315164A1 (en
Inventor
Michael Fischer
Andreas Lechner
Brigitte STAGGL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU2017315164A1 publication Critical patent/AU2017315164A1/en
Application granted granted Critical
Publication of AU2017315164B2 publication Critical patent/AU2017315164B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2017315164A 2016-08-26 2017-08-25 Avibactam free acid Active AU2017315164B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16185913.7 2016-08-26
EP16185913 2016-08-26
PCT/EP2017/071471 WO2018037124A1 (en) 2016-08-26 2017-08-25 Avibactam free acid

Publications (2)

Publication Number Publication Date
AU2017315164A1 AU2017315164A1 (en) 2019-02-28
AU2017315164B2 true AU2017315164B2 (en) 2021-12-09

Family

ID=56802364

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017315164A Active AU2017315164B2 (en) 2016-08-26 2017-08-25 Avibactam free acid

Country Status (8)

Country Link
US (1) US11124513B2 (OSRAM)
EP (1) EP3504207B1 (OSRAM)
JP (1) JP7183147B2 (OSRAM)
KR (1) KR102482826B1 (OSRAM)
CN (1) CN109641901B (OSRAM)
AU (1) AU2017315164B2 (OSRAM)
CA (1) CA3034470A1 (OSRAM)
WO (1) WO2018037124A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7072002B2 (ja) 2017-02-08 2022-05-19 サンド・アクチエンゲゼルシヤフト アビバクタムナトリウムの結晶形ｃの製造方法
CN113105455B (zh) * 2020-01-10 2024-05-17 四川科伦药物研究院有限公司 晶型b阿维巴坦钠的制备方法
CN115677697B (zh) * 2022-09-19 2024-08-06 瑞阳制药股份有限公司 粒度可调控且流动性好的b晶型阿维巴坦钠析晶方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112592B2 (en) * 2000-08-01 2006-09-26 Aventis Pharma S.A. Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
WO2011042560A1 (en) * 2009-10-09 2011-04-14 Novexel Sa Polymorphic and pseudopolymorphic forms of a pharmaceutical compound
WO2012172368A1 (en) * 2011-06-17 2012-12-20 Astrazeneca Ab Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013380573B2 (en) 2013-03-08 2016-07-07 Wockhardt Limited A process for sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
US11471422B2 (en) * 2014-09-25 2022-10-18 Manu Chaudhary Stealth, targeted nanoparticles (STN) for oral drug delivery
JP7075884B2 (ja) 2015-08-10 2022-05-26 サンド・アクチエンゲゼルシヤフト アビバクタムナトリウムのｃ形
CN106699756B (zh) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112592B2 (en) * 2000-08-01 2006-09-26 Aventis Pharma S.A. Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
WO2011042560A1 (en) * 2009-10-09 2011-04-14 Novexel Sa Polymorphic and pseudopolymorphic forms of a pharmaceutical compound
WO2012172368A1 (en) * 2011-06-17 2012-12-20 Astrazeneca Ab Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"New Drug Application (NDA) 206494", published 2 September 2015, retrieved from Internet on 29 September 2017, <URL: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206494s001lbl.pdf> *
ChemCats Database Accession No. 1760583761 & CAS Registry File RN 1192500-31-4, 23 February 2015 *

Also Published As

Publication number Publication date
EP3504207B1 (en) 2022-06-01
AU2017315164A1 (en) 2019-02-28
CA3034470A1 (en) 2018-03-01
US20190185473A1 (en) 2019-06-20
WO2018037124A1 (en) 2018-03-01
CN109641901A (zh) 2019-04-16
US11124513B2 (en) 2021-09-21
KR102482826B1 (ko) 2022-12-28
KR20190040988A (ko) 2019-04-19
JP2019524829A (ja) 2019-09-05
JP7183147B2 (ja) 2022-12-05
CN109641901B (zh) 2022-12-09
EP3504207A1 (en) 2019-07-03

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