CN109640971A - β-氨基异喹啉基酰胺化合物 - Google Patents

β-氨基异喹啉基酰胺化合物 Download PDF

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Publication number
CN109640971A
CN109640971A CN201780050718.3A CN201780050718A CN109640971A CN 109640971 A CN109640971 A CN 109640971A CN 201780050718 A CN201780050718 A CN 201780050718A CN 109640971 A CN109640971 A CN 109640971A
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CN
China
Prior art keywords
disease
compound
group
acid
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780050718.3A
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English (en)
Chinese (zh)
Inventor
吉尔·M·斯特迪文特
米切尔·A·德朗
苏珊·M·尤伊尔缇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aerie Pharmaceuticals Inc
Original Assignee
Aerie Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerie Pharmaceuticals Inc filed Critical Aerie Pharmaceuticals Inc
Publication of CN109640971A publication Critical patent/CN109640971A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201780050718.3A 2016-08-19 2017-03-31 β-氨基异喹啉基酰胺化合物 Pending CN109640971A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662377219P 2016-08-19 2016-08-19
US62/377,219 2016-08-19
PCT/US2017/025609 WO2018034702A1 (en) 2016-08-19 2017-03-31 Beta-amino-isoquinolinyl amide compounds

Publications (1)

Publication Number Publication Date
CN109640971A true CN109640971A (zh) 2019-04-16

Family

ID=61191217

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780050718.3A Pending CN109640971A (zh) 2016-08-19 2017-03-31 β-氨基异喹啉基酰胺化合物

Country Status (10)

Country Link
US (1) US9963432B2 (enExample)
EP (1) EP3500251A4 (enExample)
JP (1) JP2019529359A (enExample)
KR (1) KR20190039587A (enExample)
CN (1) CN109640971A (enExample)
AU (1) AU2017312712B2 (enExample)
BR (1) BR112019003232A2 (enExample)
CA (1) CA3033184C (enExample)
MX (1) MX2019002019A (enExample)
WO (1) WO2018034702A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2553827T3 (es) 2009-05-01 2015-12-14 Aerie Pharmaceuticals, Inc. Inhibidores de mecanismo doble para el tratamiento de enfermedad
HUE061618T2 (hu) 2013-03-15 2023-07-28 Aerie Pharmaceuticals Inc Vegyület szemrendellenességek kezelésére
WO2018045091A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
JP2020515583A (ja) 2017-03-31 2020-05-28 アエリエ ファーマシューティカルズ インコーポレイテッド アリールシクロプロピル−アミノ−イソキノリニルアミド化合物
BR112020020008A2 (pt) * 2018-03-30 2021-01-05 Aerie Pharmaceuticals, Inc. Sais mono ácido de 6-aminoisoquinolinas e seus usos
KR20210053301A (ko) * 2018-08-31 2021-05-11 에어리 파마슈티컬즈, 인코포레이티드 이소퀴놀린-스테로이드 컨쥬게이트 및 이의 용도
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2021001713A1 (en) * 2019-06-29 2021-01-07 Micro Labs Limited Process for the preparation of (s)-netarsudil, its salts & polymorphs
TWI777325B (zh) * 2019-12-31 2022-09-11 財團法人工業技術研究院 β-胺基酸衍生物、含其之激酶抑制劑與醫藥組成物以及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100280011A1 (en) * 2009-05-01 2010-11-04 Delong Mitchell A Dual mechanism inhibitors for the treatment of disease
CN105263494A (zh) * 2013-03-15 2016-01-20 爱瑞制药公司 联合治疗

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) * 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
KR102579582B1 (ko) * 2015-11-17 2023-09-15 에어리 파마슈티컬즈, 인코포레이티드 키나아제 억제제 및 이의 중간체의 제조 방법
US9643927B1 (en) * 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100280011A1 (en) * 2009-05-01 2010-11-04 Delong Mitchell A Dual mechanism inhibitors for the treatment of disease
CN105263494A (zh) * 2013-03-15 2016-01-20 爱瑞制药公司 联合治疗

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JILL M. STURDIVANT ET AL: "Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Also Published As

Publication number Publication date
JP2019529359A (ja) 2019-10-17
AU2017312712B2 (en) 2019-12-12
BR112019003232A2 (pt) 2019-06-18
AU2017312712A1 (en) 2019-02-21
EP3500251A1 (en) 2019-06-26
EP3500251A4 (en) 2020-04-08
WO2018034702A1 (en) 2018-02-22
US9963432B2 (en) 2018-05-08
CA3033184C (en) 2024-06-04
MX2019002019A (es) 2019-07-04
CA3033184A1 (en) 2018-02-22
US20180050990A1 (en) 2018-02-22
KR20190039587A (ko) 2019-04-12

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