CA3033184C - Beta-amino-isoquinolinyl amide compounds - Google Patents
Beta-amino-isoquinolinyl amide compounds Download PDFInfo
- Publication number
- CA3033184C CA3033184C CA3033184A CA3033184A CA3033184C CA 3033184 C CA3033184 C CA 3033184C CA 3033184 A CA3033184 A CA 3033184A CA 3033184 A CA3033184 A CA 3033184A CA 3033184 C CA3033184 C CA 3033184C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- enantiomer
- diastereomer
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662377219P | 2016-08-19 | 2016-08-19 | |
| US62/377,219 | 2016-08-19 | ||
| PCT/US2017/025609 WO2018034702A1 (en) | 2016-08-19 | 2017-03-31 | Beta-amino-isoquinolinyl amide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3033184A1 CA3033184A1 (en) | 2018-02-22 |
| CA3033184C true CA3033184C (en) | 2024-06-04 |
Family
ID=61191217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3033184A Active CA3033184C (en) | 2016-08-19 | 2017-03-31 | Beta-amino-isoquinolinyl amide compounds |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9963432B2 (enExample) |
| EP (1) | EP3500251A4 (enExample) |
| JP (1) | JP2019529359A (enExample) |
| KR (1) | KR20190039587A (enExample) |
| CN (1) | CN109640971A (enExample) |
| AU (1) | AU2017312712B2 (enExample) |
| BR (1) | BR112019003232A2 (enExample) |
| CA (1) | CA3033184C (enExample) |
| MX (1) | MX2019002019A (enExample) |
| WO (1) | WO2018034702A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010126626A2 (en) | 2009-05-01 | 2010-11-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| ES2776199T3 (es) | 2013-03-15 | 2020-07-29 | Aerie Pharmaceuticals Inc | Conjugados de compuestos de isoquinolina y prostaglandinas |
| WO2018045091A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| CA3057872A1 (en) | 2017-03-31 | 2018-10-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CA3095730A1 (en) * | 2018-03-30 | 2019-10-03 | Aerie Pharmaceuticals, Inc. | Mono-(acid) salts of 6-aminoisoquinolines and uses thereof |
| WO2020047496A1 (en) * | 2018-08-31 | 2020-03-05 | Aerie Pharmaceuticals, Inc. | Isoquinoline-steroid conjugates and uses thereof |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| WO2021001713A1 (en) * | 2019-06-29 | 2021-01-07 | Micro Labs Limited | Process for the preparation of (s)-netarsudil, its salts & polymorphs |
| CN113121443B (zh) * | 2019-12-31 | 2024-07-09 | 财团法人工业技术研究院 | β-氨基酸衍生物、含其之激酶抑制剂与医药组合物以及其用途 |
| AU2022264917A1 (en) * | 2021-04-29 | 2023-11-02 | Alcon Inc. | Stable isoquinoline-corticosteroid conjugates and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) * | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010126626A2 (en) * | 2009-05-01 | 2010-11-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| ES2776199T3 (es) * | 2013-03-15 | 2020-07-29 | Aerie Pharmaceuticals Inc | Conjugados de compuestos de isoquinolina y prostaglandinas |
| WO2017086941A1 (en) * | 2015-11-17 | 2017-05-26 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US9643927B1 (en) * | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
-
2017
- 2017-03-31 JP JP2019509467A patent/JP2019529359A/ja active Pending
- 2017-03-31 KR KR1020197007986A patent/KR20190039587A/ko not_active Ceased
- 2017-03-31 BR BR112019003232A patent/BR112019003232A2/pt not_active Application Discontinuation
- 2017-03-31 EP EP17841778.8A patent/EP3500251A4/en not_active Withdrawn
- 2017-03-31 CA CA3033184A patent/CA3033184C/en active Active
- 2017-03-31 WO PCT/US2017/025609 patent/WO2018034702A1/en not_active Ceased
- 2017-03-31 US US15/476,850 patent/US9963432B2/en active Active
- 2017-03-31 AU AU2017312712A patent/AU2017312712B2/en not_active Ceased
- 2017-03-31 MX MX2019002019A patent/MX2019002019A/es unknown
- 2017-03-31 CN CN201780050718.3A patent/CN109640971A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20180050990A1 (en) | 2018-02-22 |
| CA3033184A1 (en) | 2018-02-22 |
| CN109640971A (zh) | 2019-04-16 |
| AU2017312712B2 (en) | 2019-12-12 |
| BR112019003232A2 (pt) | 2019-06-18 |
| JP2019529359A (ja) | 2019-10-17 |
| AU2017312712A1 (en) | 2019-02-21 |
| EP3500251A4 (en) | 2020-04-08 |
| US9963432B2 (en) | 2018-05-08 |
| EP3500251A1 (en) | 2019-06-26 |
| WO2018034702A1 (en) | 2018-02-22 |
| KR20190039587A (ko) | 2019-04-12 |
| MX2019002019A (es) | 2019-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2017312712B2 (en) | Beta-amino-isoquinolinyl amide compounds | |
| US11021456B2 (en) | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds | |
| US10899714B2 (en) | 6-aminoisoquinoline compounds | |
| CA2712443C (en) | 6- and 7-amino isoquinoline compounds and methods for making and using the same | |
| US7671205B2 (en) | 6-aminoisoquinoline compounds | |
| EP3609871A1 (en) | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | |
| WO2021050994A1 (en) | Heterobicyclic carboxamides and uses thereof | |
| WO2020176579A1 (en) | Thienyl cyclopropyl-amino-isoquinolinyl amide compounds | |
| HK40007624A (en) | Beta-amino-isoquinolinyl amide compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220331 |
|
| R11 | Change to the name of applicant or owner or transfer of ownership requested |
Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R11-R127 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER RECORDAL REQUEST OR RESPONSE Effective date: 20240827 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 8TH ANNIV.) - STANDARD Year of fee payment: 8 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241224 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241224 Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20241224 |
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| W00 | Other event occurred |
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|
| R14 | Transfer of ownership recorded |
Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R14-R129 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER REQUIREMENTS DETERMINED COMPLIANT Effective date: 20250315 |
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| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260512 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260728 |