KR20190039587A - 베타-아미노-이소퀴놀리닐 아미드 화합물 - Google Patents
베타-아미노-이소퀴놀리닐 아미드 화합물 Download PDFInfo
- Publication number
- KR20190039587A KR20190039587A KR1020197007986A KR20197007986A KR20190039587A KR 20190039587 A KR20190039587 A KR 20190039587A KR 1020197007986 A KR1020197007986 A KR 1020197007986A KR 20197007986 A KR20197007986 A KR 20197007986A KR 20190039587 A KR20190039587 A KR 20190039587A
- Authority
- KR
- South Korea
- Prior art keywords
- disease
- compound
- compounds
- component
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662377219P | 2016-08-19 | 2016-08-19 | |
| US62/377,219 | 2016-08-19 | ||
| PCT/US2017/025609 WO2018034702A1 (en) | 2016-08-19 | 2017-03-31 | Beta-amino-isoquinolinyl amide compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190039587A true KR20190039587A (ko) | 2019-04-12 |
Family
ID=61191217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197007986A Ceased KR20190039587A (ko) | 2016-08-19 | 2017-03-31 | 베타-아미노-이소퀴놀리닐 아미드 화합물 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9963432B2 (enExample) |
| EP (1) | EP3500251A4 (enExample) |
| JP (1) | JP2019529359A (enExample) |
| KR (1) | KR20190039587A (enExample) |
| CN (1) | CN109640971A (enExample) |
| AU (1) | AU2017312712B2 (enExample) |
| BR (1) | BR112019003232A2 (enExample) |
| CA (1) | CA3033184C (enExample) |
| MX (1) | MX2019002019A (enExample) |
| WO (1) | WO2018034702A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010126626A2 (en) | 2009-05-01 | 2010-11-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| ES2776199T3 (es) | 2013-03-15 | 2020-07-29 | Aerie Pharmaceuticals Inc | Conjugados de compuestos de isoquinolina y prostaglandinas |
| WO2018045091A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| CA3057872A1 (en) | 2017-03-31 | 2018-10-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CA3095730A1 (en) * | 2018-03-30 | 2019-10-03 | Aerie Pharmaceuticals, Inc. | Mono-(acid) salts of 6-aminoisoquinolines and uses thereof |
| WO2020047496A1 (en) * | 2018-08-31 | 2020-03-05 | Aerie Pharmaceuticals, Inc. | Isoquinoline-steroid conjugates and uses thereof |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| WO2021001713A1 (en) * | 2019-06-29 | 2021-01-07 | Micro Labs Limited | Process for the preparation of (s)-netarsudil, its salts & polymorphs |
| CN113121443B (zh) * | 2019-12-31 | 2024-07-09 | 财团法人工业技术研究院 | β-氨基酸衍生物、含其之激酶抑制剂与医药组合物以及其用途 |
| AU2022264917A1 (en) * | 2021-04-29 | 2023-11-02 | Alcon Inc. | Stable isoquinoline-corticosteroid conjugates and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) * | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010126626A2 (en) * | 2009-05-01 | 2010-11-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| ES2776199T3 (es) * | 2013-03-15 | 2020-07-29 | Aerie Pharmaceuticals Inc | Conjugados de compuestos de isoquinolina y prostaglandinas |
| WO2017086941A1 (en) * | 2015-11-17 | 2017-05-26 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US9643927B1 (en) * | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
-
2017
- 2017-03-31 JP JP2019509467A patent/JP2019529359A/ja active Pending
- 2017-03-31 KR KR1020197007986A patent/KR20190039587A/ko not_active Ceased
- 2017-03-31 BR BR112019003232A patent/BR112019003232A2/pt not_active Application Discontinuation
- 2017-03-31 EP EP17841778.8A patent/EP3500251A4/en not_active Withdrawn
- 2017-03-31 CA CA3033184A patent/CA3033184C/en active Active
- 2017-03-31 WO PCT/US2017/025609 patent/WO2018034702A1/en not_active Ceased
- 2017-03-31 US US15/476,850 patent/US9963432B2/en active Active
- 2017-03-31 AU AU2017312712A patent/AU2017312712B2/en not_active Ceased
- 2017-03-31 MX MX2019002019A patent/MX2019002019A/es unknown
- 2017-03-31 CN CN201780050718.3A patent/CN109640971A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20180050990A1 (en) | 2018-02-22 |
| CA3033184A1 (en) | 2018-02-22 |
| CA3033184C (en) | 2024-06-04 |
| CN109640971A (zh) | 2019-04-16 |
| AU2017312712B2 (en) | 2019-12-12 |
| BR112019003232A2 (pt) | 2019-06-18 |
| JP2019529359A (ja) | 2019-10-17 |
| AU2017312712A1 (en) | 2019-02-21 |
| EP3500251A4 (en) | 2020-04-08 |
| US9963432B2 (en) | 2018-05-08 |
| EP3500251A1 (en) | 2019-06-26 |
| WO2018034702A1 (en) | 2018-02-22 |
| MX2019002019A (es) | 2019-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2017312712B2 (en) | Beta-amino-isoquinolinyl amide compounds | |
| US10899714B2 (en) | 6-aminoisoquinoline compounds | |
| AU2009206075B2 (en) | 6-and 7-amino isoquinoline compounds and methods for making and using the same | |
| US8034943B2 (en) | 6-aminoisoquinoline compounds | |
| AU2009273932C1 (en) | Beta-and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds | |
| KR20190135027A (ko) | 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물 | |
| KR20240031347A (ko) | 아제티디닐 피리미딘 및 그의 용도 | |
| JP2020530451A (ja) | ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト | |
| KR20170133493A (ko) | A2b 길항제로서 크산틴-치환된 알키닐 카르바메이트/리버스 카르바메이트 | |
| WO2021050994A1 (en) | Heterobicyclic carboxamides and uses thereof | |
| HK40007624A (en) | Beta-amino-isoquinolinyl amide compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20190319 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20200327 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20211030 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20220518 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20211030 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |