MX2019002019A - Compuestos de beta-amino-isoquinolinil amida. - Google Patents

Compuestos de beta-amino-isoquinolinil amida.

Info

Publication number
MX2019002019A
MX2019002019A MX2019002019A MX2019002019A MX2019002019A MX 2019002019 A MX2019002019 A MX 2019002019A MX 2019002019 A MX2019002019 A MX 2019002019A MX 2019002019 A MX2019002019 A MX 2019002019A MX 2019002019 A MX2019002019 A MX 2019002019A
Authority
MX
Mexico
Prior art keywords
compounds
beta
amide compounds
diseases
amino
Prior art date
Application number
MX2019002019A
Other languages
English (en)
Inventor
A Delong Mitchell
M Sturdivant Jill
M Royalty Susan
Original Assignee
Aerie Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerie Pharmaceuticals Inc filed Critical Aerie Pharmaceuticals Inc
Publication of MX2019002019A publication Critical patent/MX2019002019A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen compuestos de beta-amino isoquinolin amida y compuestos de benzamida substituidos. En particular, la invención proporciona compuestos que afectan la función de quinasas en una célula y que son útiles como agentes terapéuticos o con agentes terapéuticos. Los compuestos de la invención son útiles en el tratamiento de una variedad de enfermedades y condiciones que incluyen enfermedades del ojo tales como glaucoma, enfermedades cardiovasculares y enfermedades caracterizadas por crecimiento anormal, tales como cánceres. La invención proporciona además composiciones que contienen compuestos de isoquinolin amida.
MX2019002019A 2016-08-19 2017-03-31 Compuestos de beta-amino-isoquinolinil amida. MX2019002019A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662377219P 2016-08-19 2016-08-19
PCT/US2017/025609 WO2018034702A1 (en) 2016-08-19 2017-03-31 Beta-amino-isoquinolinyl amide compounds

Publications (1)

Publication Number Publication Date
MX2019002019A true MX2019002019A (es) 2019-07-04

Family

ID=61191217

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019002019A MX2019002019A (es) 2016-08-19 2017-03-31 Compuestos de beta-amino-isoquinolinil amida.

Country Status (10)

Country Link
US (1) US9963432B2 (es)
EP (1) EP3500251A4 (es)
JP (1) JP2019529359A (es)
KR (1) KR20190039587A (es)
CN (1) CN109640971A (es)
AU (1) AU2017312712B2 (es)
BR (1) BR112019003232A2 (es)
CA (1) CA3033184A1 (es)
MX (1) MX2019002019A (es)
WO (1) WO2018034702A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
CN110396085A (zh) 2013-03-15 2019-11-01 爱瑞制药公司 联合治疗
MX2019002396A (es) 2016-08-31 2019-07-08 Aerie Pharmaceuticals Inc Composiciones oftalmicas.
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
MX2020010300A (es) * 2018-03-30 2020-10-20 Aerie Pharmaceuticals Inc Sales monoacidas de 6-aminoisoquinolinas y usos de las mismas.
SG11202101517PA (en) * 2018-08-31 2021-03-30 Aerie Pharmaceuticals Inc Isoquinoline-steroid conjugates and uses thereof
EP3849555A4 (en) 2018-09-14 2022-05-04 Aerie Pharmaceuticals, Inc. ARYL CYCLOPROPYL AMINO ISOCHINOLINYL AMIDE COMPOUNDS
WO2021001713A1 (en) * 2019-06-29 2021-01-07 Micro Labs Limited Process for the preparation of (s)-netarsudil, its salts & polymorphs
CN113121443A (zh) * 2019-12-31 2021-07-16 财团法人工业技术研究院 β-氨基酸衍生物、含其之激酶抑制剂与医药组合物以及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) * 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) * 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
CN110396085A (zh) * 2013-03-15 2019-11-01 爱瑞制药公司 联合治疗
AU2015414743B2 (en) * 2015-11-17 2019-07-18 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US9643927B1 (en) * 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof

Also Published As

Publication number Publication date
EP3500251A4 (en) 2020-04-08
JP2019529359A (ja) 2019-10-17
CA3033184A1 (en) 2018-02-22
WO2018034702A1 (en) 2018-02-22
AU2017312712B2 (en) 2019-12-12
AU2017312712A1 (en) 2019-02-21
EP3500251A1 (en) 2019-06-26
CN109640971A (zh) 2019-04-16
KR20190039587A (ko) 2019-04-12
US9963432B2 (en) 2018-05-08
BR112019003232A2 (pt) 2019-06-18
US20180050990A1 (en) 2018-02-22

Similar Documents

Publication Publication Date Title
MX2019002019A (es) Compuestos de beta-amino-isoquinolinil amida.
MX2019011784A (es) Compuestos de aril ciclopropil-amino-isoquinolinil amida.
MD4800C1 (ro) Compuşi de aminopirimidinil ca inhibitori de JAK
PH12018501151A1 (en) Tank-binding kinase inhibitor compounds
MX2017004234A (es) Inhibidor del egfr y preparacion y aplicacion del mismo.
EA033163B1 (ru) Ингибиторы глутаминазы
GEP20247593B (en) Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders
GEP20197046B (en) Substituted oxopyridine derivatives
WO2015073587A3 (en) Synthetic membrane-receiver complexes
MX2021002220A (es) Forma cristalina de base libre de lorlatinib.
JO3316B1 (ar) مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل
PH12018500047B1 (en) Notch pathway signaling inhibitor compounds
MX2022007436A (es) Inhibidores de la autotaxina y sus usos.
MX2021015102A (es) Inhibidores del receptor del factor estimulante de colonias 1 (csf-1r).
MY186271A (en) Ophthalmic compositions and methods of use therefor
PH12018500315A1 (en) Fumagillol heterocyclic compounds and methods of making and using same
MX2018006700A (es) Inhibidores aza-bencimidazol de peptidilarginina desiminasa (pad4).
MX2020006596A (es) Hidroxiisoxazolinas y derivados de estos.
PH12018501279A1 (en) Compositions comprising 15-hepe and methods of using the same
MX2020004666A (es) Compuestos de pilocarpina con ácido lipoico para el tratamiento de trastornos oculares.
MX2020000523A (es) Compuestos de isocromano y usos de los mismos.
MX2017014456A (es) Usos terapeuticos de l-4-cloroquinurenina.
PH12019500198A1 (en) Compounds and compositions and uses thereof
MX2019001634A (es) Compuestos amidas, composiciones farmacéuticas de estos y métodos para utilizarlos.
GEP201706795B (en) Hexahydrofuropyrroles as pde1 inhibitors