AU2017312712B2 - Beta-amino-isoquinolinyl amide compounds - Google Patents

Beta-amino-isoquinolinyl amide compounds Download PDF

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Publication number
AU2017312712B2
AU2017312712B2 AU2017312712A AU2017312712A AU2017312712B2 AU 2017312712 B2 AU2017312712 B2 AU 2017312712B2 AU 2017312712 A AU2017312712 A AU 2017312712A AU 2017312712 A AU2017312712 A AU 2017312712A AU 2017312712 B2 AU2017312712 B2 AU 2017312712B2
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AU
Australia
Prior art keywords
compounds
alkyl
group
compound
ingredient
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2017312712A
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English (en)
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AU2017312712A1 (en
Inventor
Mitchell A. Delong
Susan M. Royalty
Jill M. Sturdivant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AU2017312712A1 publication Critical patent/AU2017312712A1/en
Application granted granted Critical
Publication of AU2017312712B2 publication Critical patent/AU2017312712B2/en
Assigned to ALCON INC. reassignment ALCON INC. Request for Assignment Assignors: AERIE PHARMACEUTICALS, INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2017312712A 2016-08-19 2017-03-31 Beta-amino-isoquinolinyl amide compounds Ceased AU2017312712B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662377219P 2016-08-19 2016-08-19
US62/377,219 2016-08-19
PCT/US2017/025609 WO2018034702A1 (en) 2016-08-19 2017-03-31 Beta-amino-isoquinolinyl amide compounds

Publications (2)

Publication Number Publication Date
AU2017312712A1 AU2017312712A1 (en) 2019-02-21
AU2017312712B2 true AU2017312712B2 (en) 2019-12-12

Family

ID=61191217

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017312712A Ceased AU2017312712B2 (en) 2016-08-19 2017-03-31 Beta-amino-isoquinolinyl amide compounds

Country Status (10)

Country Link
US (1) US9963432B2 (enExample)
EP (1) EP3500251A4 (enExample)
JP (1) JP2019529359A (enExample)
KR (1) KR20190039587A (enExample)
CN (1) CN109640971A (enExample)
AU (1) AU2017312712B2 (enExample)
BR (1) BR112019003232A2 (enExample)
CA (1) CA3033184C (enExample)
MX (1) MX2019002019A (enExample)
WO (1) WO2018034702A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2672624T3 (es) 2009-05-01 2018-06-15 Aerie Pharmaceuticals, Inc. Inhibidores de mecanismo doble para el tratamiento de enfermedades
PT3811943T (pt) 2013-03-15 2023-03-15 Aerie Pharmaceuticals Inc Composto para uso no tratamento de distúrbios oculares
MX2019002396A (es) 2016-08-31 2019-07-08 Aerie Pharmaceuticals Inc Composiciones oftalmicas.
BR112019020078A2 (pt) 2017-03-31 2020-04-28 Aerie Pharmaceuticals Inc compostos e composições farmacêuticas à base de arilciclopropil-amino-isoquinolinil amida e métodos de uso dos mesmos
CN117050013A (zh) * 2018-03-30 2023-11-14 爱瑞制药公司 6-氨基异喹啉的单(酸)盐及其用途
EP3843736A4 (en) * 2018-08-31 2022-06-15 Aerie Pharmaceuticals, Inc. ISOQUINOLINE STEROID CONJUGATES AND USES THEREOF
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2021001713A1 (en) * 2019-06-29 2021-01-07 Micro Labs Limited Process for the preparation of (s)-netarsudil, its salts & polymorphs
TWI777325B (zh) * 2019-12-31 2022-09-11 財團法人工業技術研究院 β-胺基酸衍生物、含其之激酶抑制劑與醫藥組成物以及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8394826B2 (en) * 2009-05-01 2013-03-12 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
US8759388B2 (en) * 2008-07-25 2014-06-24 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US9415043B2 (en) * 2013-03-15 2016-08-16 Aerie Pharmaceuticals, Inc. Combination therapy
WO2017086941A1 (en) * 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US9643927B1 (en) * 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759388B2 (en) * 2008-07-25 2014-06-24 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US9096569B2 (en) * 2008-07-25 2015-08-04 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8394826B2 (en) * 2009-05-01 2013-03-12 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
US8716310B2 (en) * 2009-05-01 2014-05-06 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
US9415043B2 (en) * 2013-03-15 2016-08-16 Aerie Pharmaceuticals, Inc. Combination therapy
WO2017086941A1 (en) * 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAS RN 1254032-87-5 "Benzeneacetamide, N-6-isoquinolinyl-α-[[(1-methylethyl)amino]methyl]-", STN Entry Date 23 Nov 2010 *
CAS RN 1254032-96-6 "Acetic acid, 2-[4-[1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl]phenoxy]-", STN Entry Date 23 Nov 2010 *
Sturdivant, J. M. et al., "Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle Glaucoma", Bioorganic & Medicinal Chemistry Letters (01 April 2016), 26(10), 2475-2480 *

Also Published As

Publication number Publication date
CN109640971A (zh) 2019-04-16
BR112019003232A2 (pt) 2019-06-18
US20180050990A1 (en) 2018-02-22
JP2019529359A (ja) 2019-10-17
AU2017312712A1 (en) 2019-02-21
EP3500251A1 (en) 2019-06-26
CA3033184C (en) 2024-06-04
US9963432B2 (en) 2018-05-08
WO2018034702A1 (en) 2018-02-22
MX2019002019A (es) 2019-07-04
KR20190039587A (ko) 2019-04-12
EP3500251A4 (en) 2020-04-08
CA3033184A1 (en) 2018-02-22

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: ALCON INC.

Free format text: FORMER OWNER(S): AERIE PHARMACEUTICALS, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired