JP2019529359A - ベータ−アミノ−イソキノリニルアミド化合物 - Google Patents

ベータ−アミノ−イソキノリニルアミド化合物 Download PDF

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Publication number
JP2019529359A
JP2019529359A JP2019509467A JP2019509467A JP2019529359A JP 2019529359 A JP2019529359 A JP 2019529359A JP 2019509467 A JP2019509467 A JP 2019509467A JP 2019509467 A JP2019509467 A JP 2019509467A JP 2019529359 A JP2019529359 A JP 2019529359A
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Japan
Prior art keywords
compounds
disease
compound
component
acid
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JP2019509467A
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English (en)
Japanese (ja)
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JP2019529359A5 (enExample
Inventor
エム スターディバント、ジル
エム スターディバント、ジル
エイ デロング、ミッチェル
エイ デロング、ミッチェル
エム ロイヤルティー、スーザン
エム ロイヤルティー、スーザン
Original Assignee
アエリエ ファーマシューティカルズ インコーポレイテッド
アエリエ ファーマシューティカルズ インコーポレイテッド
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Publication of JP2019529359A publication Critical patent/JP2019529359A/ja
Publication of JP2019529359A5 publication Critical patent/JP2019529359A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP2019509467A 2016-08-19 2017-03-31 ベータ−アミノ−イソキノリニルアミド化合物 Pending JP2019529359A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662377219P 2016-08-19 2016-08-19
US62/377,219 2016-08-19
PCT/US2017/025609 WO2018034702A1 (en) 2016-08-19 2017-03-31 Beta-amino-isoquinolinyl amide compounds

Publications (2)

Publication Number Publication Date
JP2019529359A true JP2019529359A (ja) 2019-10-17
JP2019529359A5 JP2019529359A5 (enExample) 2020-06-25

Family

ID=61191217

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019509467A Pending JP2019529359A (ja) 2016-08-19 2017-03-31 ベータ−アミノ−イソキノリニルアミド化合物

Country Status (10)

Country Link
US (1) US9963432B2 (enExample)
EP (1) EP3500251A4 (enExample)
JP (1) JP2019529359A (enExample)
KR (1) KR20190039587A (enExample)
CN (1) CN109640971A (enExample)
AU (1) AU2017312712B2 (enExample)
BR (1) BR112019003232A2 (enExample)
CA (1) CA3033184C (enExample)
MX (1) MX2019002019A (enExample)
WO (1) WO2018034702A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021113185A (ja) * 2019-12-31 2021-08-05 財團法人工業技術研究院Industrial Technology Research Institute βアミノ酸誘導体、これを含むキナーゼ阻害剤および医薬組成物ならびにその使用

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
WO2010126626A2 (en) 2009-05-01 2010-11-04 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
ES2776199T3 (es) 2013-03-15 2020-07-29 Aerie Pharmaceuticals Inc Conjugados de compuestos de isoquinolina y prostaglandinas
WO2018045091A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
CA3057872A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CA3095730A1 (en) * 2018-03-30 2019-10-03 Aerie Pharmaceuticals, Inc. Mono-(acid) salts of 6-aminoisoquinolines and uses thereof
WO2020047496A1 (en) * 2018-08-31 2020-03-05 Aerie Pharmaceuticals, Inc. Isoquinoline-steroid conjugates and uses thereof
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2021001713A1 (en) * 2019-06-29 2021-01-07 Micro Labs Limited Process for the preparation of (s)-netarsudil, its salts & polymorphs
AU2022264917A1 (en) * 2021-04-29 2023-11-02 Alcon Inc. Stable isoquinoline-corticosteroid conjugates and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515739A (ja) * 2007-01-10 2010-05-13 アエリエ・ファーマシューティカルズ・インコーポレーテッド ６−アミノイソキノリン化合物
JP2011529074A (ja) * 2008-07-25 2011-12-01 アエリエ・ファーマシューティカルズ・インコーポレーテッド ベータおよびガンマ−アミノ−イソキノリンアミド化合物および置換ベンズアミド化合物
JP2012525442A (ja) * 2009-05-01 2012-10-22 アエリエ・ファーマシューティカルズ・インコーポレーテッド 二重作用阻害剤およびその使用方法
JP2016515520A (ja) * 2013-03-15 2016-05-30 アエリエ・ファーマシューティカルズ・インコーポレーテッド 併用療法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017086941A1 (en) * 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US9643927B1 (en) * 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515739A (ja) * 2007-01-10 2010-05-13 アエリエ・ファーマシューティカルズ・インコーポレーテッド ６−アミノイソキノリン化合物
JP2011529074A (ja) * 2008-07-25 2011-12-01 アエリエ・ファーマシューティカルズ・インコーポレーテッド ベータおよびガンマ−アミノ−イソキノリンアミド化合物および置換ベンズアミド化合物
JP2012525442A (ja) * 2009-05-01 2012-10-22 アエリエ・ファーマシューティカルズ・インコーポレーテッド 二重作用阻害剤およびその使用方法
JP2012525386A (ja) * 2009-05-01 2012-10-22 アエリエ・ファーマシューティカルズ・インコーポレーテッド 疾患の治療のための二重機構阻害剤
JP2016053060A (ja) * 2009-05-01 2016-04-14 アエリエ・ファーマシューティカルズ・インコーポレーテッド 疾患の治療のための二重機構阻害剤
JP2016515520A (ja) * 2013-03-15 2016-05-30 アエリエ・ファーマシューティカルズ・インコーポレーテッド 併用療法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021113185A (ja) * 2019-12-31 2021-08-05 財團法人工業技術研究院Industrial Technology Research Institute βアミノ酸誘導体、これを含むキナーゼ阻害剤および医薬組成物ならびにその使用
JP7531379B2 (ja) 2019-12-31 2024-08-09 財團法人工業技術研究院 βアミノ酸誘導体、これを含むキナーゼ阻害剤および医薬組成物ならびにその使用

Also Published As

Publication number Publication date
US20180050990A1 (en) 2018-02-22
CA3033184A1 (en) 2018-02-22
CA3033184C (en) 2024-06-04
CN109640971A (zh) 2019-04-16
AU2017312712B2 (en) 2019-12-12
BR112019003232A2 (pt) 2019-06-18
AU2017312712A1 (en) 2019-02-21
EP3500251A4 (en) 2020-04-08
US9963432B2 (en) 2018-05-08
EP3500251A1 (en) 2019-06-26
WO2018034702A1 (en) 2018-02-22
KR20190039587A (ko) 2019-04-12
MX2019002019A (es) 2019-07-04

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