CN109608454A - 一种合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物的新方法 - Google Patents
一种合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物的新方法 Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 22
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title claims abstract description 21
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims abstract description 21
- -1 benzamide compound Chemical class 0.000 claims abstract description 15
- PCRAJOWHMTYSKR-UHFFFAOYSA-N iodobenzene;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.IC1=CC=CC=C1 PCRAJOWHMTYSKR-UHFFFAOYSA-N 0.000 claims abstract description 9
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims abstract description 5
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 3
- 239000007800 oxidant agent Substances 0.000 claims abstract description 3
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 239000000376 reactant Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 238000005580 one pot reaction Methods 0.000 claims 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract description 6
- 125000000524 functional group Chemical group 0.000 abstract description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 21
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 5
- 238000005160 1H NMR spectroscopy Methods 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- HROIRNYLDHJBJN-UHFFFAOYSA-N N1(CN=CC2=CC=CC=C12)C#N Chemical compound N1(CN=CC2=CC=CC=C12)C#N HROIRNYLDHJBJN-UHFFFAOYSA-N 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 125000003367 polycyclic group Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- LHRUDEBUIUHOFL-UHFFFAOYSA-N 5-tert-butyl-1h-pyridin-2-one Chemical compound CC(C)(C)C=1C=CC(=O)NC=1 LHRUDEBUIUHOFL-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000007098 aminolysis reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000005935 nucleophilic addition reaction Methods 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
一种合成6氢‑吡啶[1,2‑c]喹唑啉‑6‑酮类化合物的新方法。本发明涉及一种合成6氢‑吡啶[1,2‑c]喹唑啉‑6‑酮类化合物的新方法,具体的说是使用二(三氟乙酸)碘苯氧化剂,在室温的条件下,在乙腈溶剂中,2‑(2‑吡啶基)苯甲酰胺类化合物经过一步反应得6氢‑吡啶[1,2‑c]喹唑啉‑6‑酮类化合物的方法。该方法具有操作简单、反应条件温和、官能团兼容性好、区域选择性好和产品产率高等优点。
Description
技术领域
本发明涉及一种合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物的新方法,具体的说是使用二 (三氟乙酸)碘苯乙腈,室温氧化剂,在室温的条件下,在乙腈溶剂中,2-(2-吡啶基)苯甲酰胺类化合物经过一步反应得6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物的方法。该方法具有操作简单、反应条件温和、官能团兼容性好、区域选择性好和产品产率高等优点。
背景技术
6氢-吡啶[1,2-c]喹唑啉-6-酮类骨架结构是非常重要的多并杂环类化合物,一些具有活性的分子常常含有这一结构单元。文献调研显示,目前合成这类化合物的方法主要是通过构建 -RNC(O)NR-桥从而构建6氢-吡啶[1,2-c]喹唑啉-6-酮类骨架结构,而已报道的构建 -RNC(O)NR-桥的方法主要有三种:1)通过胺解氨基甲酸酯类化合物形成脲基团桥,构建这类多环化合物,Sawant,R.T.;Stevens,M.Y.;C.;Odell,L.R.,OrganicLetters 2016,18, 5392-5395。2)通过含氮化合物的N原子和N原子之间的插羰反应构建这类多环化合物,Sasada, T.;Moriuchi,M.;Sakai,N.;Konakahara,T.,European Journalof Organic Chemistry 2009,2009, 5738-5743;Markey,M.D.;Kelly,T.R.,Tetrahedron2008,64,8381-8388;Molina,P.;Aller,E.; Lorenzo,P.;Rioja,I.;Ubeda,A.;Terencio,M.C.;Alcaraz,M.J.,Journal of Medicinal Chemistry 2001,44,1011-1014;Molina,P.;Lorenzo,A.;Aller,E.,Tetrahedron 1992,48,4601-4616。3)通过异氰酸酯和胺类化合物亲核加成反应得到这类多环化合物,Vovk,M.V.; Lebed,P.S.;Pirozhenko,V.V.;Tsymbal,I.F.,Russian Journal of Organic Chemistry 2004,40,1669-1678。
虽然上述三种方法都可以构建-RNC(O)NR-桥,从而得到6氢-吡啶[1,2-c]喹唑啉-6-酮类骨架结构,但是,为了适应这类具有生物活性的分子的活性筛选需要,发展更加多样和普适的构建6氢-吡啶[1,2-c]喹唑啉-6-酮类骨架的新的合成策略,仍然是有机合成化学方法学研究急需解决并迫切需要的研究方向。目前在该领域主要有两个亟待解决的问题:1)高产率的生成-RNC(O)NR-桥,从而高产率的构建6氢-吡啶[1,2-c]喹唑啉-6-酮类骨架结构;2)反应条件温和,以利于工业化生产。
发明内容
本发明以2-(2-吡啶基)苯甲酰胺类化合物为原料,二(三氟乙酸)碘苯为氧化剂,在乙腈溶剂中,在室温的条件下,经过一步反应合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物。本发明的目的在于建立一种简单、有效的合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物的新方法。为实现上述目的,本发明提供的方法是在室温下进行,通过一步反应即可将2-(2-吡啶基)苯甲酰胺类化合物高产率的转化为6氢-吡[1,2-c]喹唑啉-6-酮类化合物,该方法具有操作简单、反应条件温和、反应条件温和、官能团兼容性好、区域选择性好和产品产率高等优点。
本发明采用的技术方案如下:
其中:
反应物为邻位带有甲酰胺基和吡啶基的芳基化合物或者杂环类化合物;
取代基R1选自氢,苯基,二苯氨基,叔丁基,腈基;
取代基R2选自氢,甲基;
反应的促进剂为二(三氟乙酸)碘苯;
反应在乙腈中进行;
反应在室温下进行。
综上所述,本发明的方法中,反应步骤仅需一步。反应所使用的二(三氟乙酸)碘苯是易得的化学化工产品;在使用1.2倍量的二(三氟乙酸)碘苯时,反应能达到很好的效果,反应过程简单。在乙腈溶剂中,原料2-(2-吡啶基)苯甲酰胺类化合物通过分子内重排、偶联反应得到 6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物。总之,本发明方法条件温和,技术难度低,化学选择性高,易于操作。本发明方法反应结束以后只需要将反应混合进行萃取,柱层析后即可得到 6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物。这些优点有利于该发明方法应用于大规模工业化生产。
具体实施方式
下面通过实例详述本发明。当然,本发明不限于下述的实例。
实例1
向圆底烧瓶(25毫升)中加入1a(39.6毫克,0.2毫摩尔),二(三氟乙酸)碘苯(94.6毫克,0.22毫摩尔),在2毫升乙腈中,使反应混合物在室温下充分反应(通过TLC监测整个反应过程)。反应完成后,将反应用饱和碳酸氢钠溶液淬灭(10毫升),将混合物用二氯甲烷(3×5毫升)萃取,合并有机相,然后将有机溶剂真空浓缩。乙醚重结晶得到黄色固体2a (35.6毫克,91%)。
6氢-吡啶[1,2-c]喹唑啉-6-酮(2a)
黄色固体。熔点:214-216℃;产率:91%,1H NMR(400MHz,DMSO)δ9.70(d,J=6.8Hz,1H), 9.20(d,J=8.4Hz,1H),8.85(t,J=8.0Hz,1H),8.70(d,J=8.0Hz,1H),8.20(t,J=7.0Hz,1H),7.91(t,J=7.8Hz 1H),7.56(t,J=7.6Hz,2H).13C NMR(100MHz,DMSO)δ148.00,147.34, 143.79,137.38,136.00,135.95,125.90,124.76,124.70,122.59,117.20,112.45.
11-甲基-6氢-吡啶[1,2-c]喹唑啉-6-酮(2b)
黄色固体。熔点:>300℃;产率:93%,1H NMR(600MHz,CDCl3)δ9.91(d,J=6.0Hz,1H), 8.28(d,J=8.4Hz,1H),8.13(d,J=7.2Hz,1H),7.66-7.58(m,3H),7.19-7.17(m,1H),3.08(s, 3H).13C NMR(150MHz,CDCl3)δ150.80,147.95,146.88,144.26,134.40,133.71,133.66, 127.09,126.68,121.07,120.52,113.53,25.73.
1-(吡啶-2-基)-2-萘甲酰胺(2c)
黄色固体。熔点:215-217℃;产率:98%,1H NMR(600MHz,DMSO)δ9.77(d,J=6.6Hz,1H),9.29(d,J=8.4Hz,1H),8.81(t,J=7.8Hz,1H),8.73(dd,J=8.4,3.3Hz,1H),8.44(d,J=9.0Hz, 1H),8.22-8.13(m,2H),7.88(t,J=7.8Hz,1H),7.74(t,J=7.5Hz,1H),7.62(t,J=8.7Hz,1H). 13C NMR(150MHz,DMSO)δ147.64,146.67,144.78,140.48,138.37,136.13,131.08,130.58, 130.51,128.43,127.05,126.68,124.99,124.03,117.40,107.22.
3-(二苯基氨基)-6氢-吡啶[1,2-c]喹唑啉-6-酮(2d)
黄色固体。熔点:>300℃;产率:95%,1H NMR(400MHz,CDCl3)δ9.63(d,J=6.8Hz,1H), 8.29(d,J=8.8Hz,1H),8.06(t,J=7.8Hz,1H),7.87(d,J=9.2Hz,1H),7.46(t,J=7.4Hz,1H), 7.35(t,J=5.2Hz,4H),7.27-7.16(m,6H),6.95(d,J=2.4Hz,1H),6.90(dd,J=9.2,2.4Hz,1H) 13C NMR(150MHz,DMSO)δ154.48,148.19,146.31,144.83,144.52,139.37,135.09,130.87, 128.10,127.68,127.37,122.50,121.92,115.50,104.99,101.42.
3-(叔丁基)-6-氧代-6氢-吡啶[1,2-c]喹唑啉-1-腈(2e)
黄色固体。熔点:208-210℃;产率:95%,1H NMR(600MHz,DMSO)δ9.89(d,J=6.6Hz,1H), 9.61(d,J=8.4Hz,1H),9.05(t,J=8.4Hz,1H),8.34(t,J=6.9Hz,1H),8.26(s,1H),7.81(d,J= 28.8Hz,1H),1.39(s,9H).13C NMR(150MHz,DMSO)δ158.86,148.40,145.70,144.21,137.66, 131.88,126.09,123.13,120.39,119.07,109.70,108.32,35.96,30.50。
Claims (1)
1.一种合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物的新方法,以2-(2-吡啶基)苯甲酰胺类化合物为原料,二(三氟乙酸)碘苯为氧化剂,在乙腈溶剂中,在室温的条件下,经过一步反应合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物。
其中:
反应物为邻位带有甲酰胺基和吡啶基的芳基化合物或者杂环类化合物;
取代基R1选自氢,苯基,二苯氨基,叔丁基,腈基;
取代基R2选自氢,甲基;
反应的促进剂为二(三氟乙酸)碘苯;
反应在乙腈中进行;
反应在室温下进行。
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CN103172636A (zh) * | 2013-03-13 | 2013-06-26 | 上海大学 | 吡啶并喹唑啉酮类化合物及其制备方法 |
CN107698586A (zh) * | 2017-09-19 | 2018-02-16 | 广州大学 | 一种由铜化合物催化制备吡啶并喹唑啉酮类化合物的方法 |
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CN103172636A (zh) * | 2013-03-13 | 2013-06-26 | 上海大学 | 吡啶并喹唑啉酮类化合物及其制备方法 |
CN107698586A (zh) * | 2017-09-19 | 2018-02-16 | 广州大学 | 一种由铜化合物催化制备吡啶并喹唑啉酮类化合物的方法 |
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Title |
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WENGJING GAO等: "The Hofmann reaction involving annulation of o-(pyridin-2-yl)aryl amides selectively and rapidly leads to potential photocatalytically active 6H-pyrido[1,2-c]quinazolin-6-one derivatives", 《GREEN CHEM.》 * |
YAMENG,WAN等: "De novo design and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions", 《CHEMICAL SCIENCE》 * |
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CN110105359A (zh) * | 2019-04-25 | 2019-08-09 | 河南师范大学 | 一种合成茚螺异吲哚[2,1-b]异喹啉三酮类化合物的方法 |
CN110105359B (zh) * | 2019-04-25 | 2021-08-03 | 河南师范大学 | 一种合成茚螺异吲哚[2,1-b]异喹啉三酮类化合物的方法 |
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