CN109608442A - 一种嘧啶衍生物和制备方法及其应用 - Google Patents
一种嘧啶衍生物和制备方法及其应用 Download PDFInfo
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- CN109608442A CN109608442A CN201811623543.3A CN201811623543A CN109608442A CN 109608442 A CN109608442 A CN 109608442A CN 201811623543 A CN201811623543 A CN 201811623543A CN 109608442 A CN109608442 A CN 109608442A
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- pyrimidine derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010673510.0A CN111747930A (zh) | 2018-09-12 | 2018-12-28 | 一种含有一个氘原子的嘧啶衍生物及其制备方法和应用 |
US17/255,719 US20210269424A1 (en) | 2018-09-12 | 2019-09-10 | Pyrimidine derivative and preparation process and use thereof |
PCT/CN2019/105043 WO2020052539A1 (zh) | 2018-09-12 | 2019-09-10 | 一种嘧啶衍生物和制备方法及其应用 |
US17/156,794 US20210139464A1 (en) | 2018-09-12 | 2021-01-25 | Pyrimidine derivative containing one deuterium atom and preparation process and use thereof |
US18/223,652 US20230365532A1 (en) | 2018-09-12 | 2023-07-19 | Pyrimidine derivative and preparation process and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811059596.7A CN108752322A (zh) | 2018-09-12 | 2018-09-12 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
CN2018110595967 | 2018-09-12 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010673510.0A Division CN111747930A (zh) | 2018-09-12 | 2018-12-28 | 一种含有一个氘原子的嘧啶衍生物及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109608442A true CN109608442A (zh) | 2019-04-12 |
CN109608442B CN109608442B (zh) | 2020-08-21 |
Family
ID=63968089
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811059596.7A Pending CN108752322A (zh) | 2018-09-12 | 2018-09-12 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
CN201811623543.3A Active CN109608442B (zh) | 2018-09-12 | 2018-12-28 | 一种嘧啶衍生物和制备方法及其应用 |
CN202010673510.0A Pending CN111747930A (zh) | 2018-09-12 | 2018-12-28 | 一种含有一个氘原子的嘧啶衍生物及其制备方法和应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811059596.7A Pending CN108752322A (zh) | 2018-09-12 | 2018-09-12 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010673510.0A Pending CN111747930A (zh) | 2018-09-12 | 2018-12-28 | 一种含有一个氘原子的嘧啶衍生物及其制备方法和应用 |
Country Status (3)
Country | Link |
---|---|
US (3) | US20210269424A1 (zh) |
CN (3) | CN108752322A (zh) |
WO (1) | WO2020052539A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020052539A1 (zh) * | 2018-09-12 | 2020-03-19 | 广州新民培林医药科技有限公司 | 一种嘧啶衍生物和制备方法及其应用 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4089095A4 (en) | 2020-01-07 | 2024-03-27 | Medshine Discovery Inc | DEUTERATED THIENOPYRIDINE COMPOUND |
CN112137979B (zh) * | 2020-10-29 | 2023-08-25 | 瑞阳制药股份有限公司 | 特泊替尼片剂及其制备方法 |
CN114957132A (zh) * | 2021-02-20 | 2022-08-30 | 中国科学院上海药物研究所 | 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用 |
CN116082309B (zh) * | 2023-01-04 | 2023-10-24 | 广东莱恩医药研究院有限公司 | 嘧啶衍生物1d228盐酸盐晶型及其制备方法和应用 |
CN116332911B (zh) * | 2023-05-19 | 2023-10-13 | 广东莱恩医药研究院有限公司 | 嘧啶衍生物1d228的游离碱或盐酸盐与分散剂的共无定型物及其制备方法和应用 |
CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101687857A (zh) * | 2007-07-12 | 2010-03-31 | 默克专利有限公司 | 嘧啶基哒嗪酮衍生物 |
CN102015694A (zh) * | 2008-04-21 | 2011-04-13 | 默克专利有限公司 | 哒嗪酮衍生物 |
CN102264727A (zh) * | 2008-12-23 | 2011-11-30 | 默克专利有限公司 | 哒嗪酮衍生物 |
CN102264672A (zh) * | 2008-12-24 | 2011-11-30 | 诺瓦提斯公司 | 使用转移氢化制备旋光化合物的方法 |
CN102272125A (zh) * | 2009-01-07 | 2011-12-07 | 默克专利有限公司 | 哒嗪酮衍生物 |
CN102603734A (zh) * | 2012-01-19 | 2012-07-25 | 盛世泰科生物医药技术(苏州)有限公司 | 一种蛋白激酶抑制剂及其应用 |
CN108752322A (zh) * | 2018-09-12 | 2018-11-06 | 广州新民培林医药科技有限公司 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
-
2018
- 2018-09-12 CN CN201811059596.7A patent/CN108752322A/zh active Pending
- 2018-12-28 CN CN201811623543.3A patent/CN109608442B/zh active Active
- 2018-12-28 CN CN202010673510.0A patent/CN111747930A/zh active Pending
-
2019
- 2019-09-10 US US17/255,719 patent/US20210269424A1/en active Pending
- 2019-09-10 WO PCT/CN2019/105043 patent/WO2020052539A1/zh active Application Filing
-
2021
- 2021-01-25 US US17/156,794 patent/US20210139464A1/en active Pending
-
2023
- 2023-07-19 US US18/223,652 patent/US20230365532A1/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101687857A (zh) * | 2007-07-12 | 2010-03-31 | 默克专利有限公司 | 嘧啶基哒嗪酮衍生物 |
CN102015694A (zh) * | 2008-04-21 | 2011-04-13 | 默克专利有限公司 | 哒嗪酮衍生物 |
CN102264727A (zh) * | 2008-12-23 | 2011-11-30 | 默克专利有限公司 | 哒嗪酮衍生物 |
CN102264672A (zh) * | 2008-12-24 | 2011-11-30 | 诺瓦提斯公司 | 使用转移氢化制备旋光化合物的方法 |
CN102272125A (zh) * | 2009-01-07 | 2011-12-07 | 默克专利有限公司 | 哒嗪酮衍生物 |
CN102603734A (zh) * | 2012-01-19 | 2012-07-25 | 盛世泰科生物医药技术(苏州)有限公司 | 一种蛋白激酶抑制剂及其应用 |
CN108752322A (zh) * | 2018-09-12 | 2018-11-06 | 广州新民培林医药科技有限公司 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
Non-Patent Citations (1)
Title |
---|
DIETER DORSCH等: "Identification and optimization of pyridazinones as potent and", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020052539A1 (zh) * | 2018-09-12 | 2020-03-19 | 广州新民培林医药科技有限公司 | 一种嘧啶衍生物和制备方法及其应用 |
US20210269424A1 (en) * | 2018-09-12 | 2021-09-02 | Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd. | Pyrimidine derivative and preparation process and use thereof |
Also Published As
Publication number | Publication date |
---|---|
CN108752322A (zh) | 2018-11-06 |
CN111747930A (zh) | 2020-10-09 |
US20210139464A1 (en) | 2021-05-13 |
WO2020052539A1 (zh) | 2020-03-19 |
US20230365532A1 (en) | 2023-11-16 |
CN109608442B (zh) | 2020-08-21 |
US20210269424A1 (en) | 2021-09-02 |
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CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Xingshu Inventor after: Chen Xinzi Inventor after: Yang Wei Inventor after: Guo Jianmin Inventor after: Hu Jinhui Inventor after: An Baijiao Inventor after: Huang Ling Inventor before: Li Xingshu Inventor before: Hu Jinhui Inventor before: An Baijiao Inventor before: Chen Xinzi Inventor before: Huang Ling |
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Effective date of registration: 20191230 Address after: 510990 floor 2, 3, 4, 5, building a, No. 18, Gaohu Road, high tech Industrial Park, Conghua Economic Development Zone, Guangzhou City, Guangdong Province Applicant after: Guangdong Lane Pharmaceutical Research Institute Co Ltd Applicant after: Guangzhou zhongkelian Pharmaceutical Research Co., Ltd Address before: 510006 self compiled one production building 411, 8 Ring Road South, Nansha District, Guangzhou, Guangdong. Applicant before: Guangzhou Xinmin Medicine Technology Co., Ltd. |
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