CN109601861A - 一种预防骨质疏松的全谷物营养粉及其制备方法 - Google Patents
一种预防骨质疏松的全谷物营养粉及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种预防骨质疏松的全谷物营养粉及其制备方法，按质量百分比计，包括如下组分：全谷物粉40‑60％、火麻脱脂粉10‑15％、葛根粉5‑8％、黑芝麻粉5‑10％、微量元素混合粉1‑2％、鱼骨胶原蛋白肽粉2‑3％、维生素混合粉1‑2％、益生菌微胶囊3‑5％、益生元3‑5％、木糖醇5‑8％、麦芽糊精3‑5％。本发明以全谷物基质，添加火麻脱脂粉、葛根、维生素及益生元、益生菌等营养元素，获得针对老年骨质疏松人群的全谷物食品，通过调节血脂、肠道菌群，增加钙离子吸收、转换，益于骨骼健康，有利于人体健康。
Description
技术领域
本发明属于功能性营养食品技术领域，具体涉及一种预防骨质疏松的全谷物营养粉及其制备方法。
背景技术
骨代谢则是一个平衡状态，由成骨细胞、破骨细胞的功能与数量来维持骨量的相对稳定。这个平衡状态一旦被打破，破骨大于成骨时，则表现出骨质疏松。骨质疏松主要表现为骨密度与骨量的下降，骨质疏松所致骨折可产生剧痛、残疾甚至会造成死亡，并且产生巨额的经济负担。骨质疏松影响着约40％的绝经期后女性，而且随着年龄的增长，此项数据还有上升的趋势。近年来，随着骨质疏松的发病率不断升高，它已经成为一个全球的健康问题，全世界每年有890万例骨质疏松继发骨折发生，由于其较高的发病率和流行趋势以及骨质疏松导致骨折的严重后果，世界卫生组织(WHO)将其列入主要公共健康问题。我国是世界上老年人口数量最多的国家之一，同时，我国也拥有世界上最多的骨质疏松患者。随着人口老龄化的加剧，老年性疾病特别是骨质疏松的发病率也逐年上升。根据WHO预测，至2050年，全球一半以上骨质疏松性髋部骨折病症将出现在亚洲，我国约有9000万骨质疏松患者，我国骨质疏松患者将增至2亿以上，我国也将骨质疏松作为国家重点攻关的三大老年疾病之一。近年来多项研究发现，骨质疏松的病因包括：(1)血脂异常如血浆总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)水平升高导致骨密度下降，细胞内胆固醇平衡失调影响成骨细胞和破骨细胞的分化，与骨质疏松的发病密切相关。高脂血症能影响成骨细胞、破骨细胞及骨母细胞生成及活性，加剧骨质疏松病程；(2)随着年龄的增长，人体内的胶原蛋白逐渐流失，三重螺旋分子结构遭到严重破坏，钙盐无法有效沉积在胶原蛋白基质上形成坚硬的骨骼，骨矿物质流失增多，致使骨代谢异常，骨胶原肽可降低减少骨量的丢失速度；(3)维生素K摄入不足及衰老造成的内源性K2转化偏低，将严重影响骨钙素的羧化及钙在骨骼的矿化活性，从而有损骨骼健康，诱发骨质疏松。
肠道菌群对骨代谢具有重要调控作用，其可以通过影响钙吸收、调节免疫系统而影响破骨细胞数量与功能，调节肠道激素分泌，影响骨代谢。益生菌能够通过多种途径抑制骨吸收，促进骨形成及矿化，益生元通过直接或间接作用促进骨形成，抑制骨吸收，增加骨密度，改善骨微结构，保护骨骼健康。
全谷物因为保留了其糠层而富含维生素、膳食纤维等营养成分和酚类等植物活性物质，全谷物富含膳食纤维和多种活性成分，这些物质不能被小肠消化吸收利用，能够在大肠处被肠道菌群利用使其增殖并产生代谢物，从而改善有益菌的生长环境，促进肠道内有益菌的增殖，改善肠道菌群结构，保护肠屏障功能，促进肠蠕动，减少肠道间有害物质的停留从而对慢性疾病的发生起到预防作用。适当增加主食中全谷物的摄入比例对预防慢性疾病具有重要作用。
目前针对骨质疏松人群的营养补充剂主要补充钙制剂、维生素和钙的复合制剂等，主要通过促进钙的吸收来治疗骨质疏松。而老年骨质疏松人群伴常有高脂血症及钙营养吸收不良等症状，目前尚缺乏针对骨质疏松的病因，结合老年骨质疏松人群体质特征的全谷物营养食品。
发明内容
为了解决上述技术问题，本发明提供一种预防骨质疏松的全谷物营养粉及其制备方法，旨在结合老年骨质疏松人群伴有高脂血症及钙吸收不良等症状，以全谷物为基质，添加火麻脱脂粉、葛根粉、矿物质、维生素及益生元、益生菌等营养元素，获得针对老年骨质疏松人群的全谷物食品，通过增加钙离子吸收、转换，调节血脂、肠道菌群，益于老年骨质疏松人群的健康。
本发明是这样实现的，一种预防骨质疏松的全谷物营养粉，按质量百分比计，包括如下组分：全谷物粉40-60％、火麻脱脂粉10-15％、葛根粉5-8％、黑芝麻粉5-10％、微量元素混合粉1-2％、鱼骨胶原蛋白肽粉2-3％、维生素混合粉1-2％、益生菌微胶囊3-5％、益生元3-5％、木糖醇5-8％、麦芽糊精3-5％。
进一步地，按重量份计，所述全谷物包括2份小麦和1份玉米、1份燕麦、1份荞麦、1份小米中的至少1种。
进一步地，所述微量元素混合粉按重量份数计，包括钙35-60份，钾21-40份，磷8-19份，镁2-9份；
所述维生素混合粉按重量份数计，包括维生素A 0.05-0.25份，维生素C 60-70份，维生素D3 15-20份，维生素E 5-15份、维生素Bl 0.1-0.6份，维生素B20.1-0.6份，维生素B60.2-1.2份，维生素B12 0.0005-0.004份，维生素K2粉0.5-2份、烟酸1-5份；
所述益生菌微胶囊内，按重量份数计，包括植物乳杆菌45-55份，长双歧杆菌35-45份，双歧杆菌25-35份，保加利亚乳杆菌15-20份；
所述益生元按重量份计，包括低聚果糖30-40份、菊粉5-10份、低聚半乳糖5-10份。
本发明还提供了上述预防骨质疏松的全谷物营养粉的制备方法，包括如下步骤：
1)选料：优选颗粒饱满、无病害虫及机械损伤、无腐烂的全谷物；
2)清洗：将全谷物于清水中清洗5-10min，去掉残杂，沥水后于65-75℃烘干；
3)粉碎：使用粉碎机将清洗后的全谷物粉碎成60-80目颗粒；
4)一次挤压膨化：将步骤3)得到的全谷物颗粒与葛根粉、火麻脱脂粉混合在一起得混合料，并使混合料含水分为20-30％，调整双螺旋杆挤压膨化机参数为螺杆转速200-300r/min，膨化温度130-150℃，对物料进行挤压膨化，然后在55℃的恒温箱中干燥3-4h，干燥粉碎；
5)二次挤压膨化：调质使一次挤压膨化后的物料水分含量为15-25％，进行二次挤压，工艺条件为：膨化温度130-150℃，螺杆转速200-300r/min，收集挤出物，55-60℃的恒温箱中干燥3-4h，粉碎后密封保存；
6)取黑芝麻粉、微量元素混合粉、鱼骨胶原蛋白肽粉、维生素混合粉、益生元加入到步骤5)制备的三种物质的混合粉中，再放入三维混合罐中进行混合；
7)向步骤6)得到的混合粉中加入麦芽糊精、木糖醇和益生菌微胶囊，混合均匀得成品。
进一步地，按重量份计，所述全谷物包括2份小麦和1份玉米、1份燕麦、1份荞麦、1份小米中的至少1种。
进一步地，所述微量元素混合粉按重量份数计，包括钙35-60份，钾21-40份，磷8-19份，镁2-9份；
所述维生素混合粉按重量份数计，包括维生素A 0.05-0.25份，维生素C 60-70份，维生素D3 15-20份，维生素E 5-15份、维生素Bl 0.1-0.6份，维生素B2 0.1-0.6份，维生素B60.2-1.2份，维生素B12 0.0005-0.004份，维生素K2粉0.5-2份、烟酸1-5份；
所述益生菌微胶囊内，按重量份数计，包括植物乳杆菌45-55份，长双歧杆菌35-45份，双歧杆菌25-35份，保加利亚乳杆菌15-20份；
所述益生元按重量份计，包括低聚果糖30-40份、菊粉5-10份、低聚半乳糖5-10份。
与现有技术相比，本发明的优点在于：
1、营养均衡、口感细腻、味道独特，且在加工过程中仅脱去种子外面的谷壳，最大限度保留了谷物的糊粉层、胚芽和胚根，减少加工过程中营养成份的流失，获得针对老年骨质疏松人群的全谷物食品，营养均衡及健康养生，同时容易携带，食用方便；
2、以全谷物营养粉为原料，同时添加火麻脱脂粉、胶原蛋白肽粉，使混合的食物使蛋白质、维生素等营养元素含量更加丰富，提高混合蛋白质的生物价，实现低脂、营养均衡的目的；
3、将全谷物、火麻脱脂粉与葛根粉混合，通过两次挤压膨化，改善全谷物和葛粉在食用过程中冲调性，提高感官品质，同时对膳食纤维改性，发挥其对益生菌的定植作用，促进肠道内有益菌的增殖，改善肠道菌群结构，增加钙离子吸收、转换，增强骨密度；
4、针对骨质疏松的病因，结合老年骨质疏松人群的体质特征，将全谷物与“药食同源之中药”的葛根有机结合起来，利用全谷物和葛根“酚类”活性物质的健康效应，调节机体功能；
5、调节肠道菌群，利用益生菌提高钙的利用率，促进维生素D3吸收，产生维生素K2及维生素B，减少胆固醇的吸收，适合老年骨质疏松人群食用。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，下面结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用于解释本发明，并不用于限定本发明。
本发明选用的主要成分具有如下的功能特点：
全谷物是由小麦、玉米、燕麦、荞麦、小米的种子混合，谷物籽粒完整，未经精细化加工，保留了完整谷粒所具备的胚乳、胚芽、麸皮组成及其天然营养成分的谷物，保留了其糠层而富含维生素、膳食纤维等营养成分和酚类等植物活性物质。中国居民膳食指南推荐了每天的全谷物摄入量，全谷物富含膳食纤维和多种活性成分，这些物质不能被小肠消化吸收利用，能够在大肠处被肠道菌群利用使其增殖并产生代谢物，适当增加主食中全谷物的摄入比例对预防慢性疾病具有重要作用。
火麻脱脂粉由火麻仁经低温压榨脱脂后，经挤压后产生小分子量短肽，这些蛋白短肽可促进矿物质被人体吸收利用。
葛根含有葛根素、葛根素木糖试、金雀异黄素等异黄酮类化合物是葛根的主要有效成份，具有降血脂、降血糖、抗衰老、抗疲劳、增强机体免疫力等多种生理功能；葛根素使血清中钙磷比适合的骨形成、骨钙含量和骨密度明显增加，并能促进成骨细胞增值分化的同时，也对破骨细胞产生抑制作用；葛根中的纤维素不被人和动物肠道吸收，可以促进双歧杆菌及其它肠道有益菌群的增殖。
胶原蛋白肽能促进成骨细胞增殖、分化和骨基质矿化，减少破骨细胞的骨吸收，增加骨密度、避免骨吸收，增加Ⅰ型胶原蛋白和粘多糖产生，从而预防和治疗骨质疏松症；而且其富含人体需要的甘氨酸、脯氨酸、羟脯氨酸等氨基酸，具有调节脂代谢紊乱、调节肠道微生态及与钙金属元素螯合以及免疫调节等多种活性。
益生菌能调节骨代谢通路增加骨密度，抑制炎症反应减少骨吸收、促进成骨细胞活性、抑制破骨细胞活性，帮助骨骼矿化，增加骨骼中钙含量，促进骨骼健康。
益生元是一类不能被人体消化的食物成分，可改善肠道菌群环境，更好的促进益生菌的增殖，改善肠道菌群环境，促进钙离子吸收、对骨转换具有一定影响、改善骨强度，还能增强其他益于骨骼健康制剂的作用。
维生素D3是维护骨骼健康重要的营养素，饮食中摄入充足维生素D3，是预防和治疗骨质疏松症的基础，其能通过骨骼、肠道、肾脏和甲状旁腺调节钙平衡和骨代谢，维持钙平衡及减少骨量丢失。
维生素K2能促进钙被人体有效的吸收，将“肠钙”转化为“血钙”，维生素K2摄入不足是导致中老年骨质疏松及骨折的独立风险因素。如果维生素K2摄入不足及衰老造成的内源性K2转化偏低，致使中老年人体组织中K2浓度显著下降，从而诱发钙紊乱疾病如骨质疏松等。
黑芝麻含有丰富的矿物质和微量元素，尤其是钙含量非常丰富(黑芝麻中含钙接近8g/kg)，膳食纤维的含量也相当丰富，而且黑芝麻香味浓郁在本发明中起到了增香的作用。
实施例1、
一种预防骨质疏松的全谷物营养粉，按质量百分比计，包括如下组分：全谷物粉(按重量份包括2份小麦和1份玉米)40％、火麻脱脂粉15％、葛根粉8％、黑芝麻粉7％、微量元素混合粉(按重量份包括钙35份，钾21份，磷19份，镁9份)2％、鱼骨胶原蛋白肽粉3％、维生素混合粉(按重量份包括维生素A 0.05份，维生素C 60份，维生素D3 15份，维生素E 15份、维生素Bl 0.6份，维生素B20.6份，维生素B6 1.2份，维生素B12 0.004份，维生素K2粉0.5份、烟酸5份)2％，益生菌微胶囊(植物乳杆菌45份，长双歧杆菌35份，双歧杆菌25份，保加利亚乳杆菌20份)5％、益生元为(低聚果糖30份、菊粉5份、低聚半乳糖10份)5％、木糖醇8％、麦芽糊精5％。
上述的预防骨质疏松的全谷物营养粉的制备方法，包括如下步骤：
1)选料：优选颗粒饱满、无病害虫及机械损伤、无腐烂的全谷物；
2)清洗：将全谷物于清水中清洗5-10min，去掉残杂，沥水后于65-75℃烘干；
3)粉碎：使用粉碎机将清洗后的全谷物粉碎成60-80目颗粒；
4)一次挤压膨化：将步骤3)得到的全谷物颗粒与葛根粉、火麻脱脂粉混合在一起得混合料，并使混合料含水分为20％，调整双螺旋杆挤压膨化机参数为螺杆转速200r/min，膨化温度130℃，对物料进行挤压膨化，然后在55℃的恒温箱中干燥3-4h，干燥粉碎；
5)二次挤压膨化：调质使一次挤压膨化后的物料水分含量为15％，进行二次挤压，工艺条件为：膨化温度130℃，螺杆转速200r/min，收集挤出物，55℃的恒温箱中干燥3-4h，粉碎后密封保存；
6)混合干粉：取黑芝麻粉、微量元素混合粉、鱼骨胶原蛋白肽粉、维生素混合粉、益生元加入到步骤5)制备的三种物质的混合粉中，再放入三维混合罐中进行混合；
7)向步骤6)得到的混合粉中加入麦芽糊精、木糖醇和益生菌微胶囊，混合均匀得成品。
实施例2、
一种预防骨质疏松的全谷物营养粉，按质量百分比计，包括如下组分：全谷物粉(全谷物包括2份小麦和1份玉米、1份燕麦、1份荞麦)50％、火麻脱脂粉11％、葛根粉8％、黑芝麻粉8％、微量元素混合粉(按重量份包括钙60份，钾40份，磷8份，镁2份)2％、鱼骨胶原蛋白肽粉3％、维生素混合粉(按重量份包括维生素A 0.25份，维生素C 70份，维生素D3 20份，维生素E15份、维生素Bl 0.6份，维生素B20.1份，维生素B6 0.2份，维生素B12 0.0005份，维生素K2粉1.2份、烟酸1份)2％，益生菌微胶囊(植物乳杆菌55份，长双歧杆菌45份，双歧杆菌25份，保加利亚乳杆菌15份)5％、益生元为(低聚果糖40份、菊粉10份、低聚半乳糖10份)3％、木糖醇5％、麦芽糊精3％。
上述的预防骨质疏松的全谷物营养粉的制备方法，包括如下步骤：
1)选料：优选颗粒饱满、无病害虫及机械损伤、无腐烂的全谷物；
2)清洗：将全谷物于清水中清洗5-10min，去掉残杂，沥水后于65-75℃烘干；
3)粉碎：使用粉碎机将清洗后的全谷物粉碎成60-80目颗粒；
4)一次挤压膨化：将步骤3)得到的全谷物颗粒与葛根粉、火麻脱脂粉混合在一起得混合料，并使混合料含水分为25％，调整双螺旋杆挤压膨化机参数为螺杆转速250r/min，膨化温度140℃，对物料进行挤压膨化，然后在55℃的恒温箱中干燥3-4h，干燥粉碎；
5)二次挤压膨化：调质使一次挤压膨化后的物料水分含量为20％，进行二次挤压，工艺条件为：膨化温度140℃，螺杆转速250r/min，收集挤出物，57℃的恒温箱中干燥3-4h，粉碎后密封保存；
6)混合干粉：取黑芝麻粉、微量元素混合粉、鱼骨胶原蛋白肽粉、维生素混合粉、益生元加入到步骤5)制备的三种物质的混合粉中，再放入三维混合罐中进行混合；
7)向步骤6)得到的混合粉中加入麦芽糊精、木糖醇和益生菌微胶囊，混合均匀得成品。
实施例3、
一种预防骨质疏松的全谷物营养粉，按质量百分比计，包括如下组分：全谷物粉(全谷物包括2份小麦和1份玉米、1份燕麦、1份荞麦、1份小米)60％、火麻脱脂粉10％、葛根粉5％、黑芝麻粉5％、微量元素混合粉(按重量份包括钙45份，钾30份，磷13份，镁6份)1％、鱼骨胶原蛋白肽粉2％、维生素混合粉(按重量份包括维生素A0.12份，维生素C 65份，维生素D3 17份，维生素E 10份、维生素Bl 0.4份，维生素B20.3份，维生素B6 0.7份，维生素B120.002份，维生素K2粉2份、烟酸3份)1％，益生菌微胶囊(植物乳杆菌50份，长双歧杆菌40份，双歧杆菌30份，保加利亚乳杆菌17份)3％、益生元为(低聚果糖35份、菊粉7份、低聚半乳糖7份)5％、木糖醇5％、麦芽糊精3％。
上述的预防骨质疏松的全谷物营养粉的制备方法，包括如下步骤：
1)选料：优选颗粒饱满、无病害虫及机械损伤、无腐烂的全谷物；
2)清洗：将全谷物于清水中清洗5-10min，去掉残杂，沥水后于65-75℃烘干；
3)粉碎：使用粉碎机将清洗后的全谷物粉碎成60-80目颗粒；
4)一次挤压膨化：将步骤3)得到的全谷物颗粒与葛根粉、火麻脱脂粉混合在一起得混合料，并使混合料含水分为30％，调整双螺旋杆挤压膨化机参数为螺杆转速300r/min，膨化温度150℃，对物料进行挤压膨化，然后在55℃的恒温箱中干燥3-4h，干燥粉碎；
5)二次挤压膨化：调质使一次挤压膨化后的物料水分含量为25％，进行二次挤压，工艺条件为：膨化温度150℃，螺杆转速300r/min，收集挤出物，60℃的恒温箱中干燥3-4h，粉碎后密封保存；
6)混合干粉：取黑芝麻粉、微量元素混合粉、鱼骨胶原蛋白肽粉、维生素混合粉、益生元加入到步骤5)制备的三种物质的混合粉中，再放入三维混合罐中进行混合；
7)向步骤6)得到的混合粉中加入麦芽糊精、木糖醇和益生菌微胶囊，混合均匀得成品。
本次实验使用清洁级SD雌性大鼠48只，体质量180-220g，饲养条件为：25摄氏度，55％的湿度，12小时昼夜间期。大鼠随机分成6组，分别对应命名为正常组、模型组、补钙组(普通鼠粮加入135mg/kg碳酸钙，800U的D3/kg)、实施例1组、实施例2组和实施例3组。其中对照组：5只SD大鼠给予灌生理盐水8m1/kg·d；模型组、补钙鼠粮组、实施例1、2、3组：预饲养1周后，用维甲酸80mg/kg·d灌胃15d造模，检查骨密度确认骨质疏松造模成功后。按照分组连续喂养90天，试验结束前12h禁食，麻醉后取血液处死，完整的取出左侧股骨备用。将采集的血液放在37℃水浴锅中恒温20min，4℃冷藏过夜后离心(10min,4000r/min)，分离出血清，全自动生化分析仪测定血脂相关指标、血清钙、血清碱性磷酸酶、骨钙素含量；股骨剔除附着软组织和残肉，使用双能X线骨密度分析仪进行骨密度检测。
结果见下表：
表1 血清钙相关指标的比较
表2 血脂相关指标的比较
表3 大鼠股骨骨密度的比较
Claims (6)
1.一种预防骨质疏松的全谷物营养粉，其特征在于，按质量百分比计，包括如下组分：全谷物粉40-60％、火麻脱脂粉10-15％、葛根粉5-8％、黑芝麻粉5-10％、微量元素混合粉1-2％、鱼骨胶原蛋白肽粉2-3％、维生素混合粉1-2％、益生菌微胶囊3-5％、益生元3-5％、木糖醇5-8％、麦芽糊精3-5％。
2.按照权利要求1所述的预防骨质疏松的全谷物营养粉，其特征在于，按重量份计，所述全谷物粉包括2份小麦和1份玉米、1份燕麦、1份荞麦、1份小米中的至少1种。
3.按照权利要求1所述的预防骨质疏松的全谷物营养粉，其特征在于，
所述微量元素混合粉按重量份数计，包括钙35-60份，钾21-40份，磷8-19份，镁2-9份；
所述维生素混合粉按重量份数计，包括维生素A 0.05-0.25份，维生素C 60-70份，维生素D3 15-20份，维生素E 5-15份、维生素Bl 0.1-0.6份，维生素B20.1-0.6份，维生素B6 0.2-1.2份，维生素B12 0.0005-0.004份，维生素K2粉0.5-2份、烟酸1-5份；
所述益生菌微胶囊内，按重量份数计，包括植物乳杆菌45-55份，长双歧杆菌35-45份，双歧杆菌25-35份，保加利亚乳杆菌15-20份；
所述益生元按重量份计，包括低聚果糖30-40份、菊粉5-10份、低聚半乳糖5-10份。
4.一种权利要求1所述的预防骨质疏松的全谷物营养粉的制备方法，其特征在于，包括如下步骤：
1)选料：优选颗粒饱满、无病害虫及机械损伤、无腐烂的全谷物；
2)清洗：将全谷物于清水中清洗5-10min，去掉残杂，沥水后于65-75℃烘干；
3)粉碎：使用粉碎机将清洗后的全谷物粉碎成60-80目颗粒；
4)一次挤压膨化：将步骤3)得到的全谷物颗粒与葛根粉、火麻脱脂粉混合在一起得混合料，并使混合料含水分为20-30％，调整双螺旋杆挤压膨化机参数为螺杆转速200-300r/min，膨化温度130-150℃，对物料进行挤压膨化，然后在55℃的恒温箱中干燥3-4h，干燥粉碎；
5)二次挤压膨化：调质使一次挤压膨化后的物料水分含量为15-25％，进行二次挤压，工艺条件为：膨化温度130-150℃，螺杆转速200-300r/min，收集挤出物，55-60℃的恒温箱中干燥3-4h，粉碎后密封保存；
6)混合干粉：取黑芝麻粉、微量元素混合粉、鱼骨胶原蛋白肽粉、维生混合粉、益生元加入到步骤5)制备的三种物质的混合粉中，再放入三维混合罐中进行混合；
7)向步骤6)得到的混合粉中加入麦芽糊精、木糖醇和益生菌微胶囊，混合均匀得成品。
5.按照权利要求4所述的预防骨质疏松的全谷物营养粉的制备方法，其特征在于，按重量份计，所述全谷物包括2份小麦和1份玉米、1份燕麦、1份荞麦、1份小米中的至少1种。
6.按照权利要求4所述的预防骨质疏松的全谷物营养粉的制备方法，其特征在于，所述微量元素混合粉按重量份数计，包括钙35-60份，钾21-40份，磷8-19份，镁2-9份；
所述维生素混合粉按重量份数计，包括维生素A 0.05-0.25份，维生素C 60-70份，维生素D3 15-20份，维生素E 5-15份、维生素Bl 0.1-0.6份，维生素B20.1-0.6份，维生素B6 0.2-1.2份，维生素B12 0.0005-0.004份，维生素K2粉0.5-2份、烟酸1-5份；
所述益生菌微胶囊内，按重量份数计，包括植物乳杆菌45-55份，长双歧杆菌35-45份，双歧杆菌25-35份，保加利亚乳杆菌15-20份；
所述益生元按重量份计，包括低聚果糖30-40份、菊粉5-10份、低聚半乳糖5-10份。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109998118A (zh) * | 2019-05-10 | 2019-07-12 | 雷件文 | 一种功能性营养早餐谷物食品 |
| CN110693035A (zh) * | 2019-11-01 | 2020-01-17 | 辽宁太爱肽生物工程技术有限公司 | 一种供骨质疏松人群食用的含肽组合物及应用 |
| CN113398241A (zh) * | 2020-12-31 | 2021-09-17 | 江中药业股份有限公司 | 一种骨肽组合物、骨肽片剂、制备方法及评价方法 |
| CN113575965A (zh) * | 2021-08-10 | 2021-11-02 | 广东聚谷来健康食品有限公司 | 一种益生菌活菌即食谷物制品及其制作方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496576A (zh) * | 2008-01-28 | 2009-08-05 | 中国食品发酵工业研究院 | 一种供骨伤患者食用含短肽的特殊膳食用食品配方 |
| CN103652567A (zh) * | 2012-09-20 | 2014-03-26 | 劲家庄(惠州)健康食品有限公司 | 什锦全谷物功能营养方便食品 |
| CN104187632A (zh) * | 2014-08-13 | 2014-12-10 | 胡安然 | 骨质疏松全营养配方食品 |
| CN104839664A (zh) * | 2015-04-10 | 2015-08-19 | 劲膳美生物科技股份有限公司 | 骨质疏松医学配方食品 |
| CN105145846A (zh) * | 2015-10-27 | 2015-12-16 | 江西美庐乳业集团有限公司 | 一种提高骨密度，改善骨质疏松的营养包 |
| CN108354147A (zh) * | 2018-01-25 | 2018-08-03 | 广东省农业科学院蚕业与农产品加工研究所 | 一种具有肠道菌群调节作用的全谷物龙眼营养餐粉及其制备方法 |
| CN108783467A (zh) * | 2018-06-04 | 2018-11-13 | 中食月太(北京)健康科技有限公司 | 改善骨质疏松和增加骨密度的组合物及其制备方法 |
-
2018
- 2018-12-04 CN CN201811471751.6A patent/CN109601861A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496576A (zh) * | 2008-01-28 | 2009-08-05 | 中国食品发酵工业研究院 | 一种供骨伤患者食用含短肽的特殊膳食用食品配方 |
| CN103652567A (zh) * | 2012-09-20 | 2014-03-26 | 劲家庄(惠州)健康食品有限公司 | 什锦全谷物功能营养方便食品 |
| CN104187632A (zh) * | 2014-08-13 | 2014-12-10 | 胡安然 | 骨质疏松全营养配方食品 |
| CN104839664A (zh) * | 2015-04-10 | 2015-08-19 | 劲膳美生物科技股份有限公司 | 骨质疏松医学配方食品 |
| CN105145846A (zh) * | 2015-10-27 | 2015-12-16 | 江西美庐乳业集团有限公司 | 一种提高骨密度，改善骨质疏松的营养包 |
| CN108354147A (zh) * | 2018-01-25 | 2018-08-03 | 广东省农业科学院蚕业与农产品加工研究所 | 一种具有肠道菌群调节作用的全谷物龙眼营养餐粉及其制备方法 |
| CN108783467A (zh) * | 2018-06-04 | 2018-11-13 | 中食月太(北京)健康科技有限公司 | 改善骨质疏松和增加骨密度的组合物及其制备方法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109998118A (zh) * | 2019-05-10 | 2019-07-12 | 雷件文 | 一种功能性营养早餐谷物食品 |
| CN110693035A (zh) * | 2019-11-01 | 2020-01-17 | 辽宁太爱肽生物工程技术有限公司 | 一种供骨质疏松人群食用的含肽组合物及应用 |
| CN113398241A (zh) * | 2020-12-31 | 2021-09-17 | 江中药业股份有限公司 | 一种骨肽组合物、骨肽片剂、制备方法及评价方法 |
| CN113575965A (zh) * | 2021-08-10 | 2021-11-02 | 广东聚谷来健康食品有限公司 | 一种益生菌活菌即食谷物制品及其制作方法 |
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