CN109562385A - 用于样品分析与处理的快速热循环 - Google Patents

用于样品分析与处理的快速热循环 Download PDF

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Publication number
CN109562385A
CN109562385A CN201780033573.6A CN201780033573A CN109562385A CN 109562385 A CN109562385 A CN 109562385A CN 201780033573 A CN201780033573 A CN 201780033573A CN 109562385 A CN109562385 A CN 109562385A
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China
Prior art keywords
bath
reactor
temperature
baths
nucleic acid
Prior art date
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Pending
Application number
CN201780033573.6A
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English (en)
Chinese (zh)
Inventor
龚海庆
文燕
曾旭东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Star Array Pte Ltd
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Star Array Pte Ltd
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Filing date
Publication date
Application filed by Star Array Pte Ltd filed Critical Star Array Pte Ltd
Priority claimed from PCT/SG2017/050285 external-priority patent/WO2017213586A1/en
Publication of CN109562385A publication Critical patent/CN109562385A/zh
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B01L7/5255—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones by moving sample containers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
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    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L9/065—Test-tube stands; Test-tube holders specially adapted for capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K5/00—Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
    • C09K5/08—Materials not undergoing a change of physical state when used
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
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    • G01N2035/00346—Heating or cooling arrangements
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    • G01N2035/00366—Several different temperatures used
    • G—PHYSICS
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    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
    • G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
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    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Thermal Sciences (AREA)
  • Optics & Photonics (AREA)
  • Combustion & Propulsion (AREA)
  • Biomedical Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201780033573.6A 2016-06-10 2017-06-06 用于样品分析与处理的快速热循环 Pending CN109562385A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662348155P 2016-06-10 2016-06-10
US62/348,155 2016-06-10
SG10201700260X 2017-01-12
SG10201700260XA SG10201700260XA (en) 2016-06-10 2017-01-12 Rapid thermal cycling for sample analyses and processing
PCT/SG2017/050285 WO2017213586A1 (en) 2016-06-10 2017-06-06 Rapid thermal cycling for sample analyses and processing

Publications (1)

Publication Number Publication Date
CN109562385A true CN109562385A (zh) 2019-04-02

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Family Applications (6)

Application Number Title Priority Date Filing Date
CN201780033573.6A Pending CN109562385A (zh) 2016-06-10 2017-06-06 用于样品分析与处理的快速热循环
CN201780033364.1A Active CN109641212B (zh) 2016-06-10 2017-06-07 用于样品分析与处理的快速热循环
CN201780033562.8A Active CN109562384B (zh) 2016-06-10 2017-06-09 用于样品分析与处理的快速热循环
CN201780033519.1A Pending CN109562383A (zh) 2016-06-10 2017-06-09 用于样品分析与处理的快速热循环
CN201911173391.6A Pending CN111220448A (zh) 2016-06-10 2019-11-26 用于样品分析与处理的快速热循环
CN201922065032.0U Active CN213337028U (zh) 2016-06-10 2019-11-26 一种根据热曲线为核酸来进行热处理的仪器

Family Applications After (5)

Application Number Title Priority Date Filing Date
CN201780033364.1A Active CN109641212B (zh) 2016-06-10 2017-06-07 用于样品分析与处理的快速热循环
CN201780033562.8A Active CN109562384B (zh) 2016-06-10 2017-06-09 用于样品分析与处理的快速热循环
CN201780033519.1A Pending CN109562383A (zh) 2016-06-10 2017-06-09 用于样品分析与处理的快速热循环
CN201911173391.6A Pending CN111220448A (zh) 2016-06-10 2019-11-26 用于样品分析与处理的快速热循环
CN201922065032.0U Active CN213337028U (zh) 2016-06-10 2019-11-26 一种根据热曲线为核酸来进行热处理的仪器

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US (6) US20200282401A1 (enExample)
EP (1) EP3656475A1 (enExample)
JP (2) JP6797205B2 (enExample)
CN (6) CN109562385A (enExample)
AU (2) AU2017277331B2 (enExample)
SG (2) SG10201700260XA (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10524980B2 (en) * 2016-09-13 2020-01-07 Vanrx Pharmasystems, Inc. Apparatus and method for aseptically filling pharmaceutical containers with a pharmaceutical fluid using rotary stage
SG10201700260XA (en) * 2016-06-10 2018-01-30 Star Array Pte Ltd Rapid thermal cycling for sample analyses and processing
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