CN109503714A - 与c-Met结合的抗原结合蛋白 - Google Patents
与c-Met结合的抗原结合蛋白 Download PDFInfo
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- CN109503714A CN109503714A CN201811232378.9A CN201811232378A CN109503714A CN 109503714 A CN109503714 A CN 109503714A CN 201811232378 A CN201811232378 A CN 201811232378A CN 109503714 A CN109503714 A CN 109503714A
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| CN112592408A (zh) * | 2020-07-20 | 2021-04-02 | 北京鼎成肽源生物技术有限公司 | 一种靶向c-Met的单链抗体、嵌合抗原受体、重组载体、CAR-T细胞及应用 |
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| EP2863946A4 (en) | 2012-06-21 | 2016-04-13 | Sorrento Therapeutics Inc | ANTIGEN-BINDING PROTEINS THAT BIND TO C-MET |
| US20180280531A1 (en) * | 2014-12-08 | 2018-10-04 | Sorrento Therapeutics, Inc. | C-met antibody drug conjugate |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| WO2018129248A1 (en) * | 2017-01-06 | 2018-07-12 | The Regents Of The University Of California | Therapeutic anti-ige antibodies and methods and compositions thereof |
| IL268554B2 (en) * | 2017-02-08 | 2025-03-01 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| WO2018148447A1 (en) * | 2017-02-08 | 2018-08-16 | Adimab, Llc | Antibody heavy chain variable domains targeting the nkg2d receptor |
| CA3235295C (en) | 2017-02-20 | 2024-11-19 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
| US20200129633A1 (en) | 2017-06-06 | 2020-04-30 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising c-met antibody-drug conjugate and use thereof |
| US11884733B2 (en) | 2018-02-08 | 2024-01-30 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
| US12384847B2 (en) | 2018-02-08 | 2025-08-12 | Dragonfly Therapeutics, Inc. | Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen |
| US12215157B2 (en) | 2018-02-20 | 2025-02-04 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| MA53284A (fr) | 2018-08-08 | 2022-01-26 | Dragonfly Therapeutics Inc | Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| CA3118418A1 (en) * | 2018-11-16 | 2020-05-22 | R.G.C.C. Holdings AG | Novel c-met and tmx2 antibodies |
| US12168696B2 (en) * | 2018-11-16 | 2024-12-17 | Memorial Sloan Kettering Cancer Center | Antibodies to mucin-16 (MUC16), encoding polynucleotides and methods of treating MUC16-positive cancer |
| CN114340684B (zh) | 2019-09-16 | 2025-09-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
| TW202208428A (zh) | 2020-05-06 | 2022-03-01 | 美商蜻蜓醫療公司 | 結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質 |
| CA3202024A1 (en) * | 2020-12-14 | 2022-06-23 | Scott A. Smith | Human ige monoclonal antibodies to antibodies to alpha-gal (galactose-a-1,3-galactose) and uses therefor |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101379192A (zh) * | 2006-02-06 | 2009-03-04 | 梅思尔斯平移研究有限公司 | 治疗肿瘤的抗Met单克隆抗体及其片段和载体及相应产品 |
| CN101415730A (zh) * | 2006-03-30 | 2009-04-22 | 诺瓦提斯公司 | c-Met抗体的组合物和使用方法 |
| CN102216333A (zh) * | 2008-11-21 | 2011-10-12 | 伊莱利利公司 | c-Met抗体 |
| CN102227446A (zh) * | 2008-12-02 | 2011-10-26 | 皮埃尔法布雷医药公司 | 抗-cMET抗体 |
| CN102639564A (zh) * | 2009-08-21 | 2012-08-15 | 皮埃尔法布雷医药公司 | 抗-cmet抗体及其用于癌症的检测和诊断的用途 |
| CN103003307A (zh) * | 2010-03-10 | 2013-03-27 | 根马布股份公司 | 抗c-MEt的单克隆抗体 |
| CN103002916A (zh) * | 2010-06-01 | 2013-03-27 | 皮埃尔法布雷医药公司 | 新的抗-cMET抗体 |
| CN103030695A (zh) * | 2011-10-05 | 2013-04-10 | 三星电子株式会社 | 抗c-Met人源化抗体及含其的预防或治疗癌症用的药物组合物 |
| WO2012030842A8 (en) * | 2010-09-03 | 2013-04-18 | Academia Sinica | Anti-c-met antibody and methods of use thereof |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3817827A (en) | 1972-03-30 | 1974-06-18 | Scott Paper Co | Soft absorbent fibrous webs containing elastomeric bonding material and formed by creping and embossing |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6010902A (en) | 1988-04-04 | 2000-01-04 | Bristol-Meyers Squibb Company | Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| JP3051145B2 (ja) | 1990-08-28 | 2000-06-12 | 住友製薬株式会社 | 新規なポリエチレングリコール誘導体修飾ペプチド |
| US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
| DE4118120A1 (de) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| ATE225801T1 (de) | 1992-07-13 | 2002-10-15 | Bionebraska Inc | Verfahren zur modifizierung rekombinanter polypeptide |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| JP3589665B2 (ja) | 1992-10-23 | 2004-11-17 | イミュネックス・コーポレーション | 可溶性オリゴマー蛋白質の調製法 |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US20020142374A1 (en) | 1998-08-17 | 2002-10-03 | Michael Gallo | Generation of modified molecules with increased serum half-lives |
| GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
| ES2367891T3 (es) | 2000-09-29 | 2011-11-10 | Schering Corporation | Interleucina-10 pegilada. |
| GB0025144D0 (en) | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
| CA2516236A1 (en) | 2003-02-13 | 2004-08-26 | Pharmacia Corporation | Antibodies to c-met for the treatment of cancers |
| US20040202995A1 (en) | 2003-04-09 | 2004-10-14 | Domantis | Nucleic acids, proteins, and screening methods |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| ME01803B (me) * | 2004-08-05 | 2010-12-31 | Genentech Inc | Humanizovani anti-cmet antagonisti |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| CN101300273B (zh) * | 2005-08-31 | 2013-05-22 | 安姆根有限公司 | Trail受体2多肽和抗体 |
| EP2975057A1 (en) | 2006-07-10 | 2016-01-20 | Fujita Health University | Novel anti-cd73 antibody |
| EP2014681A1 (en) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| EP2863946A4 (en) | 2012-06-21 | 2016-04-13 | Sorrento Therapeutics Inc | ANTIGEN-BINDING PROTEINS THAT BIND TO C-MET |
| HK1208236A1 (en) * | 2012-06-22 | 2016-02-26 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind ccr2 |
-
2013
- 2013-06-21 EP EP13806086.8A patent/EP2863946A4/en not_active Withdrawn
- 2013-06-21 CN CN201380043630.0A patent/CN105050618B/zh not_active Expired - Fee Related
- 2013-06-21 CA CA2877573A patent/CA2877573A1/en not_active Abandoned
- 2013-06-21 US US13/924,492 patent/US10377827B2/en active Active
- 2013-06-21 JP JP2015518628A patent/JP6429771B2/ja not_active Expired - Fee Related
- 2013-06-21 WO PCT/US2013/047190 patent/WO2013192594A2/en not_active Ceased
- 2013-06-21 CN CN201811232378.9A patent/CN109503714A/zh active Pending
- 2013-06-21 HK HK15108908.7A patent/HK1208181A1/xx unknown
-
2018
- 2018-07-06 JP JP2018128712A patent/JP2018184421A/ja not_active Withdrawn
-
2019
- 2019-06-25 US US16/451,511 patent/US11155628B2/en not_active Expired - Fee Related
-
2021
- 2021-09-22 US US17/482,140 patent/US20220002422A1/en not_active Abandoned
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101379192A (zh) * | 2006-02-06 | 2009-03-04 | 梅思尔斯平移研究有限公司 | 治疗肿瘤的抗Met单克隆抗体及其片段和载体及相应产品 |
| CN101415730A (zh) * | 2006-03-30 | 2009-04-22 | 诺瓦提斯公司 | c-Met抗体的组合物和使用方法 |
| CN102216333A (zh) * | 2008-11-21 | 2011-10-12 | 伊莱利利公司 | c-Met抗体 |
| CN102227446A (zh) * | 2008-12-02 | 2011-10-26 | 皮埃尔法布雷医药公司 | 抗-cMET抗体 |
| CN102639564A (zh) * | 2009-08-21 | 2012-08-15 | 皮埃尔法布雷医药公司 | 抗-cmet抗体及其用于癌症的检测和诊断的用途 |
| CN103003307A (zh) * | 2010-03-10 | 2013-03-27 | 根马布股份公司 | 抗c-MEt的单克隆抗体 |
| CN103002916A (zh) * | 2010-06-01 | 2013-03-27 | 皮埃尔法布雷医药公司 | 新的抗-cMET抗体 |
| WO2012030842A8 (en) * | 2010-09-03 | 2013-04-18 | Academia Sinica | Anti-c-met antibody and methods of use thereof |
| CN103030695A (zh) * | 2011-10-05 | 2013-04-10 | 三星电子株式会社 | 抗c-Met人源化抗体及含其的预防或治疗癌症用的药物组合物 |
Non-Patent Citations (1)
| Title |
|---|
| 万佳艺等: "人源天然 Fab 噬菌体抗体库的构建及抗 c-Met 抗体的筛选、鉴定", 《南京医科大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112592408A (zh) * | 2020-07-20 | 2021-04-02 | 北京鼎成肽源生物技术有限公司 | 一种靶向c-Met的单链抗体、嵌合抗原受体、重组载体、CAR-T细胞及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013192594A2 (en) | 2013-12-27 |
| JP6429771B2 (ja) | 2018-11-28 |
| US20190359719A1 (en) | 2019-11-28 |
| HK1208181A1 (en) | 2016-02-26 |
| US20170283501A1 (en) | 2017-10-05 |
| JP2018184421A (ja) | 2018-11-22 |
| US10377827B2 (en) | 2019-08-13 |
| EP2863946A2 (en) | 2015-04-29 |
| JP2015521627A (ja) | 2015-07-30 |
| WO2013192594A3 (en) | 2014-04-03 |
| CA2877573A1 (en) | 2013-12-27 |
| US11155628B2 (en) | 2021-10-26 |
| CN105050618B (zh) | 2018-11-16 |
| EP2863946A4 (en) | 2016-04-13 |
| CN105050618A (zh) | 2015-11-11 |
| US20220002422A1 (en) | 2022-01-06 |
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