CN109476632A - 四氢萘啶戊酰胺整联蛋白拮抗剂 - Google Patents

四氢萘啶戊酰胺整联蛋白拮抗剂 Download PDF

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Publication number
CN109476632A
CN109476632A CN201780042122.9A CN201780042122A CN109476632A CN 109476632 A CN109476632 A CN 109476632A CN 201780042122 A CN201780042122 A CN 201780042122A CN 109476632 A CN109476632 A CN 109476632A
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CN
China
Prior art keywords
compound
hydrocarbyl
patient
tetrahydro
amino
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Pending
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CN201780042122.9A
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English (en)
Chinese (zh)
Inventor
巴里·S·科勒
玛塔·菲利左拉
迈克尔·安德鲁·福利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xi Naishanyikan Medical College
Rockefeller University
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Xi Naishanyikan Medical College
Rockefeller University
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Application filed by Xi Naishanyikan Medical College, Rockefeller University filed Critical Xi Naishanyikan Medical College
Publication of CN109476632A publication Critical patent/CN109476632A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780042122.9A 2016-07-05 2017-07-05 四氢萘啶戊酰胺整联蛋白拮抗剂 Pending CN109476632A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662358330P 2016-07-05 2016-07-05
US62/358,330 2016-07-05
US201662374234P 2016-08-12 2016-08-12
US62/374,234 2016-08-12
PCT/US2017/040657 WO2018009501A1 (en) 2016-07-05 2017-07-05 Tetrahydronaphthyridinepentanamide integrin antagonists

Publications (1)

Publication Number Publication Date
CN109476632A true CN109476632A (zh) 2019-03-15

Family

ID=60912284

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780042122.9A Pending CN109476632A (zh) 2016-07-05 2017-07-05 四氢萘啶戊酰胺整联蛋白拮抗剂

Country Status (9)

Country Link
US (1) US11192889B2 (https=)
EP (1) EP3481814B1 (https=)
JP (1) JP2019524702A (https=)
KR (1) KR20190026001A (https=)
CN (1) CN109476632A (https=)
AU (1) AU2017292754B2 (https=)
CA (1) CA3029829A1 (https=)
MX (1) MX2019000043A (https=)
WO (1) WO2018009501A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024125634A1 (zh) * 2022-12-16 2024-06-20 西藏海思科制药有限公司 一种四氢萘啶类化合物及其在医药上的应用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3509590A4 (en) 2016-09-07 2020-12-02 Pliant Therapeutics, Inc. N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
MX394210B (es) 2017-02-28 2025-03-04 Morphic Therapeutic Inc INHIBIDORES DE INTEGRINA AVß6.
MA52117A (fr) 2017-02-28 2022-04-06 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
FI3761980T3 (fi) * 2018-03-07 2024-02-21 Pliant Therapeutics Inc Aminohappoyhdisteitä ja käyttömenetelmiä
TWI841573B (zh) 2018-06-27 2024-05-11 美商普萊恩醫療公司 具有未分支連接子之胺基酸化合物及使用方法
AU2019318538B2 (en) 2018-08-08 2025-02-06 The General Hospital Corporation Polypeptide integrin antagonists
WO2020047208A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
WO2020047239A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. INHIBITING αV β6 INTEGRIN
SI3844162T1 (sl) 2018-08-29 2025-06-30 Morphic Therapeutic, Inc. Zaviralci integrina alfa v beta6
TW202028179A (zh) 2018-10-08 2020-08-01 美商普萊恩醫療公司 胺基酸化合物及使用方法
CN114173803A (zh) * 2019-04-08 2022-03-11 普利安特治疗公司 氨基酸化合物的剂型和方案
TW202329973A (zh) * 2021-10-14 2023-08-01 美商普萊恩醫療公司 整合素抑制劑及其與其他藥劑併用之用途

Citations (8)

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Publication number Priority date Publication date Assignee Title
CN1284944A (zh) * 1997-12-17 2001-02-21 麦克公司 整联蛋白受体拮抗剂
US20030139398A1 (en) * 2001-04-09 2003-07-24 Hoekstra William J. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
US20040038963A1 (en) * 2000-07-26 2004-02-26 Jiabing Wang Alpha v integrin receptor antagonists
US20040225111A1 (en) * 2000-05-09 2004-11-11 Jacques Demassey Antagonist derivatives of the vitronectin receptor
CN1589145A (zh) * 1999-06-02 2005-03-02 麦克公司 αv整联蛋白受体拮抗剂
CN102481347A (zh) * 2009-07-24 2012-05-30 加州大学董事会 治疗和预防整合素αvβ5相关疾病的方法及组合物
CN105246889A (zh) * 2013-02-07 2016-01-13 赛弗卢尔生命科学公司 氟化整联蛋白拮抗剂
US20160130270A1 (en) * 2013-02-07 2016-05-12 Scifluor Life Sciences, Inc. Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048861A (en) * 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists
JP2003277340A (ja) * 2002-03-22 2003-10-02 Toray Ind Inc 接着分子阻害剤及び新規アミノ酸誘導体

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1284944A (zh) * 1997-12-17 2001-02-21 麦克公司 整联蛋白受体拮抗剂
CN1589145A (zh) * 1999-06-02 2005-03-02 麦克公司 αv整联蛋白受体拮抗剂
US20040225111A1 (en) * 2000-05-09 2004-11-11 Jacques Demassey Antagonist derivatives of the vitronectin receptor
US20040038963A1 (en) * 2000-07-26 2004-02-26 Jiabing Wang Alpha v integrin receptor antagonists
US20030139398A1 (en) * 2001-04-09 2003-07-24 Hoekstra William J. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
CN102481347A (zh) * 2009-07-24 2012-05-30 加州大学董事会 治疗和预防整合素αvβ5相关疾病的方法及组合物
CN105246889A (zh) * 2013-02-07 2016-01-13 赛弗卢尔生命科学公司 氟化整联蛋白拮抗剂
US20160130270A1 (en) * 2013-02-07 2016-05-12 Scifluor Life Sciences, Inc. Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DAVID B. WHITMAN等: "Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic,des-amide backbone", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
KAREN M. BRASHEAR等: "Non-Peptide αVβ3 Antagonists.Part 5: Identification of Potent RGD Mimetics Incorporating 2-Aryl β-Amino Acids as Aspartic Acid Replacements", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
PAUL J. COLEMAN等: "Non-Peptide αVβ3 Antagonists.Part4: Potent and Orally Bioavailable Chain-Shortened RGD Mimetics", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024125634A1 (zh) * 2022-12-16 2024-06-20 西藏海思科制药有限公司 一种四氢萘啶类化合物及其在医药上的应用

Also Published As

Publication number Publication date
KR20190026001A (ko) 2019-03-12
EP3481814A4 (en) 2019-12-04
EP3481814A1 (en) 2019-05-15
WO2018009501A1 (en) 2018-01-11
EP3481814B1 (en) 2022-04-27
CA3029829A1 (en) 2018-01-11
JP2019524702A (ja) 2019-09-05
AU2017292754A1 (en) 2019-01-24
AU2017292754B2 (en) 2021-06-17
US11192889B2 (en) 2021-12-07
MX2019000043A (es) 2019-07-04
US20200181138A1 (en) 2020-06-11

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Application publication date: 20190315

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