CN109475109B - 用于使用多个引导rna来破坏免疫耐受性的方法 - Google Patents

用于使用多个引导rna来破坏免疫耐受性的方法 Download PDF

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CN109475109B
CN109475109B CN201780044071.3A CN201780044071A CN109475109B CN 109475109 B CN109475109 B CN 109475109B CN 201780044071 A CN201780044071 A CN 201780044071A CN 109475109 B CN109475109 B CN 109475109B
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mouse
sequence
human
guide rna
target
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CN109475109A (zh
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维拉·沃罗宁那
林恩·麦克唐纳
马林·普里塞特
卡曼·维纳斯·莱
阿肖克·巴迪斯
安德鲁·J.·莫菲
古斯塔沃·德罗格特
大卫·佛伦杜威
布莱恩·扎姆布罗维兹
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Regeneron Pharmaceuticals Inc
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US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
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CA3176380A1 (en) 2014-11-21 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modification using paired guide rnas
US12043852B2 (en) 2015-10-23 2024-07-23 President And Fellows Of Harvard College Evolved Cas9 proteins for gene editing
WO2017201476A1 (en) 2016-05-20 2017-11-23 Regeneron Pharmaceuticals, Inc. Methods for breaking immunological tolerance using multiple guide rnas
KR20250103795A (ko) 2016-08-03 2025-07-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
CN109804066A (zh) 2016-08-09 2019-05-24 哈佛大学的校长及成员们 可编程cas9-重组酶融合蛋白及其用途
JP6958917B2 (ja) * 2016-08-10 2021-11-02 国立大学法人 東京医科歯科大学 遺伝子ノックイン細胞の作製方法
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WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
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