CN109432402B - 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法 - Google Patents

通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法 Download PDF

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Publication number
CN109432402B
CN109432402B CN201811146540.5A CN201811146540A CN109432402B CN 109432402 B CN109432402 B CN 109432402B CN 201811146540 A CN201811146540 A CN 201811146540A CN 109432402 B CN109432402 B CN 109432402B
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lipocalin
lipocalin mutein
pharmaceutical composition
use according
human
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CN109432402A (zh
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安德里亚斯·霍尔鲍姆
劳伦·奥多利
贝弗莉·科勒
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Pieris Pharmaceuticals GmbH
Bristol Myers Squibb Co
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Pieris Pharmaceuticals GmbH
Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201811146540.5A 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法 Expired - Fee Related CN109432402B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161570018P 2011-12-13 2011-12-13
US61/570,018 2011-12-13
CN201280061754.7A CN103998053B9 (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法
PCT/EP2012/075146 WO2013087660A1 (en) 2011-12-13 2012-12-12 Methods for preventing or treating certain disorders by inhibiting binding of il-4 and/or il-13 to their respective receptors

Related Parent Applications (1)

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CN201280061754.7A Division CN103998053B9 (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法

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CN109432402A CN109432402A (zh) 2019-03-08
CN109432402B true CN109432402B (zh) 2022-04-29

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CN201811146540.5A Expired - Fee Related CN109432402B (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法
CN201280061754.7A Expired - Fee Related CN103998053B9 (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法

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US (6) US9572863B2 (enExample)
EP (3) EP3842058B1 (enExample)
JP (5) JP6163162B2 (enExample)
CN (2) CN109432402B (enExample)
AU (1) AU2012350660B2 (enExample)
CA (1) CA2858962C (enExample)
DK (2) DK2790719T3 (enExample)
ES (2) ES2863410T3 (enExample)
HU (2) HUE042720T2 (enExample)
PL (2) PL2790719T3 (enExample)
SG (2) SG11201402992SA (enExample)
TR (1) TR201901826T4 (enExample)
WO (1) WO2013087660A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201906295T4 (tr) * 2010-06-08 2019-05-21 Astrazeneca Ab IL-4 R alfaya bağlanan gözyaşı lipokalini muteinleri.
ES2863410T3 (es) * 2011-12-13 2021-10-11 Pieris Pharmaceuticals Gmbh Métodos para prevenir o tratar ciertos trastornos mediante la inhibición de la unión de IL-4 y/o IL-13 a sus respectivos receptores.
BR112016027024A2 (pt) 2014-05-22 2017-10-31 Pieris Pharmaceuticals Gmbh polipeptídeos de ligação específica e seus usos
EP3322433B1 (en) 2015-07-15 2023-05-31 Pieris Pharmaceuticals GmbH Novel proteins specific for lag-3
CN107474134B (zh) * 2016-06-08 2021-07-27 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
EP3571219A1 (en) 2017-01-18 2019-11-27 Pieris Pharmaceuticals GmbH Lipocalin muteins with binding affinity for lag-3
AU2018254542B2 (en) * 2017-04-21 2022-12-22 Elanco Us Inc. IL4/IL13 receptor molecule for veterinary use
CN111514292B (zh) * 2018-12-25 2023-06-20 江苏荃信生物医药股份有限公司 抗人白介素4受体α单克隆抗体的制药用途
AU2020253034A1 (en) * 2019-03-29 2021-08-19 Pieris Pharmaceuticals Gmbh Inhaled administration of lipocalin muteins
KR20210146934A (ko) * 2019-03-29 2021-12-06 아스트라제네카 에이비이 천식 치료를 위한 리포칼린 뮤테인
PE20240799A1 (es) 2020-12-18 2024-04-18 Astrazeneca Ab Formulacion de polvo seco de muteina de lipocalina para el tratamiento del asma
CN115414467B (zh) * 2022-10-14 2023-06-06 中国人民解放军陆军军医大学第二附属医院 载脂蛋白d在制备治疗脑出血药物中的用途

Citations (1)

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FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
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ES2863410T3 (es) * 2011-12-13 2021-10-11 Pieris Pharmaceuticals Gmbh Métodos para prevenir o tratar ciertos trastornos mediante la inhibición de la unión de IL-4 y/o IL-13 a sus respectivos receptores.

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JP2020164532A (ja) 2020-10-08
TR201901826T4 (tr) 2019-03-21
AU2012350660B2 (en) 2018-01-25
CA2858962A1 (en) 2013-06-20
JP6889201B2 (ja) 2021-06-18
HUE042720T2 (hu) 2019-07-29
US20190030121A1 (en) 2019-01-31
US20230021168A1 (en) 2023-01-19
DK2790719T3 (en) 2019-02-11
US10398754B2 (en) 2019-09-03
HUE054342T2 (hu) 2021-08-30
CN109432402A (zh) 2019-03-08
US9572863B2 (en) 2017-02-21
ES2710384T3 (es) 2019-04-24
JP2017149733A (ja) 2017-08-31
EP3453400A1 (en) 2019-03-13
EP2790719A1 (en) 2014-10-22
US20170112900A1 (en) 2017-04-27
EP3842058A1 (en) 2021-06-30
CN103998053A (zh) 2014-08-20
US20140357548A1 (en) 2014-12-04
AU2012350660A1 (en) 2014-07-03
CA2858962C (en) 2023-09-05
EP3453400B1 (en) 2021-01-20
JP2015505303A (ja) 2015-02-19
JP2022084854A (ja) 2022-06-07
SG10201604566QA (en) 2016-07-28
CN103998053B9 (zh) 2020-07-21
JP2019116499A (ja) 2019-07-18
WO2013087660A1 (en) 2013-06-20
US20210145934A1 (en) 2021-05-20
SG11201402992SA (en) 2014-07-30
US11382951B2 (en) 2022-07-12
US20200009223A1 (en) 2020-01-09
JP7441589B2 (ja) 2024-03-01
EP2790719B1 (en) 2018-11-21
JP6163162B2 (ja) 2017-07-12
EP3842058B1 (en) 2023-08-23
US10016483B2 (en) 2018-07-10
US10857202B2 (en) 2020-12-08
PL2790719T3 (pl) 2019-05-31
PL3453400T3 (pl) 2021-08-09
DK3453400T3 (da) 2021-04-06
ES2863410T3 (es) 2021-10-11
JP6725447B2 (ja) 2020-07-15
CN103998053B (zh) 2018-11-02

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