CN1094058A - 缓激肽拮抗剂 - Google Patents

缓激肽拮抗剂 Download PDF

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Publication number
CN1094058A
CN1094058A CN93114484A CN93114484A CN1094058A CN 1094058 A CN1094058 A CN 1094058A CN 93114484 A CN93114484 A CN 93114484A CN 93114484 A CN93114484 A CN 93114484A CN 1094058 A CN1094058 A CN 1094058A
Authority
CN
China
Prior art keywords
dipolymer
heterogeneous
group
bka
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93114484A
Other languages
English (en)
Chinese (zh)
Inventor
J·C·彻奥尼斯
J·K·博劳德格特
V·S·古德佛楼
M·V·马拉瑟
L·W·思普鲁斯
E·T·瓦雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortech Inc
Original Assignee
Cortech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortech Inc filed Critical Cortech Inc
Publication of CN1094058A publication Critical patent/CN1094058A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN93114484A 1992-11-10 1993-11-10 缓激肽拮抗剂 Pending CN1094058A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97400092A 1992-11-10 1992-11-10
US07/974,000 1992-11-10

Publications (1)

Publication Number Publication Date
CN1094058A true CN1094058A (zh) 1994-10-26

Family

ID=25521455

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93114484A Pending CN1094058A (zh) 1992-11-10 1993-11-10 缓激肽拮抗剂

Country Status (11)

Country Link
EP (1) EP0671941A4 (es)
JP (1) JPH08503460A (es)
CN (1) CN1094058A (es)
AU (1) AU5410994A (es)
CA (1) CA2147869A1 (es)
IL (1) IL107400A0 (es)
MX (1) MX9306988A (es)
NZ (1) NZ257477A (es)
PL (1) PL304654A1 (es)
WO (1) WO1994011021A1 (es)
ZA (1) ZA938014B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3843456B2 (ja) * 1993-07-23 2006-11-08 東レ株式会社 モルヒナン誘導体および医薬用途
AU6044496A (en) * 1995-06-05 1996-12-24 Cortech, Inc. Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activity
JP4067117B2 (ja) * 1995-06-09 2008-03-26 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 選択性スロンビン抑制剤としてのブラジキニン同族体
FR2739553B1 (fr) * 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19642289A1 (de) 1996-10-14 1998-04-16 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
US6982249B1 (en) 1997-04-23 2006-01-03 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
US6359111B1 (en) * 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
EP2080511A3 (en) * 2000-08-22 2009-09-30 Shire LLC Active agent delivery systems and methods for protecting and administering active agents
WO2003020200A2 (en) 2000-11-16 2003-03-13 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
ES2373641T3 (es) * 2000-11-16 2012-02-07 Shire Llc Un nuevo compuesto farmacéutico y métodos para fabricarlo y usarlo.
AU2001297565B2 (en) * 2000-11-16 2008-06-05 Takeda Pharmaceutical Company Limited A novel pharmaceutical compound and methods of making and using same
US7338939B2 (en) 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US7375082B2 (en) 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US7700561B2 (en) 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
CA2477004C (en) 2002-02-22 2011-05-10 Thomas Piccariello Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
AR040956A1 (es) 2002-07-31 2005-04-27 Schering Ag Nuevos conjugados de efectores, procedimientos para su preparacion y su uso farmaceutico
JP2006505627A (ja) * 2002-07-31 2006-02-16 シエーリング アクチエンゲゼルシャフト 新規エフェクター接合体、それらの生成方法及びそれらの医薬使用
NZ546226A (en) 2003-09-30 2009-03-31 Shire Llc Oxycodone conjugates for prevention of overdose or abuse
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894443A (en) * 1984-02-08 1990-01-16 Cetus Corporation Toxin conjugates
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
EP0586613A4 (en) * 1991-04-01 1994-08-24 Cortech Inc Bradykinin antagonists
SE9101472D0 (sv) * 1991-05-15 1991-05-15 Trion Forskning & Utveckling Galanin antagonist

Also Published As

Publication number Publication date
EP0671941A4 (en) 1996-05-29
CA2147869A1 (en) 1994-05-26
NZ257477A (en) 1996-07-26
IL107400A0 (en) 1994-01-25
AU5410994A (en) 1994-06-08
MX9306988A (es) 1995-01-31
WO1994011021A1 (en) 1994-05-26
ZA938014B (en) 1994-07-11
JPH08503460A (ja) 1996-04-16
PL304654A1 (en) 1995-01-09
EP0671941A1 (en) 1995-09-20

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication