CN109265541A - 流感中和药剂 - Google Patents

流感中和药剂 Download PDF

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Publication number
CN109265541A
CN109265541A CN201811019451.4A CN201811019451A CN109265541A CN 109265541 A CN109265541 A CN 109265541A CN 201811019451 A CN201811019451 A CN 201811019451A CN 109265541 A CN109265541 A CN 109265541A
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CN
China
Prior art keywords
antibody
influenza
seq
polypeptide
bonding agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811019451.4A
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English (en)
Chinese (zh)
Inventor
S·拉居拉姆
维斯瓦纳坦·萨西赛哈兰
文卡塔拉曼·桑达拉拉詹
拉姆·萨西赛哈兰
维迪亚·苏布拉马尼亚安
卡纳安·塔拉卡拉曼
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of CN109265541A publication Critical patent/CN109265541A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201811019451.4A 2012-05-10 2013-03-14 流感中和药剂 Pending CN109265541A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261645453P 2012-05-10 2012-05-10
US61/645,453 2012-05-10
CN201380024604.3A CN104507500A (zh) 2012-05-10 2013-03-14 流感中和药剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380024604.3A Division CN104507500A (zh) 2012-05-10 2013-03-14 流感中和药剂

Publications (1)

Publication Number Publication Date
CN109265541A true CN109265541A (zh) 2019-01-25

Family

ID=49548780

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201811019451.4A Pending CN109265541A (zh) 2012-05-10 2013-03-14 流感中和药剂
CN201380024604.3A Pending CN104507500A (zh) 2012-05-10 2013-03-14 流感中和药剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380024604.3A Pending CN104507500A (zh) 2012-05-10 2013-03-14 流感中和药剂

Country Status (14)

Country Link
US (4) US9683030B2 (https=)
EP (2) EP3492101A3 (https=)
JP (2) JP6431477B2 (https=)
KR (1) KR102122618B1 (https=)
CN (2) CN109265541A (https=)
AU (2) AU2013260123A1 (https=)
BR (1) BR112014027991A2 (https=)
CA (1) CA2871160C (https=)
CL (1) CL2014003052A1 (https=)
HK (1) HK1207970A1 (https=)
IL (1) IL235237A0 (https=)
MX (1) MX378749B (https=)
SG (2) SG10201807059QA (https=)
WO (1) WO2013169377A1 (https=)

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US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
HK1207970A1 (en) * 2012-05-10 2016-02-19 Massachusetts Institute Of Technology Agents for influenza neutralization
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
EA038407B1 (ru) 2015-02-05 2021-08-24 Янссен Вэксинс Энд Превеншн Б.В. Связывающие молекулы, направленные против гемагглютинина вируса гриппа, и пути их применения
AU2016261299B2 (en) * 2015-05-11 2019-12-05 Janssen Vaccines & Prevention B.V. Influenza virus neutralizing peptidomimetic compounds
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN109195629A (zh) 2016-02-24 2019-01-11 威特拉公司 流行性感冒抗体分子制剂
KR101887876B1 (ko) 2016-08-18 2018-08-13 한국과학기술연구원 H5형 조류독감 바이러스에 특이적으로 결합하는 핵산 압타머 및 이를 이용하는 h5형 조류독감 바이러스의 검출방법
CN113924147A (zh) 2019-03-25 2022-01-11 威特拉公司 用于治疗和预防流感的组合物和方法
CN115551885A (zh) 2019-12-11 2022-12-30 威特拉公司 用于治疗和预防流感的组合物和方法

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Also Published As

Publication number Publication date
AU2018202468B2 (en) 2020-04-16
EP3492101A3 (en) 2019-10-23
HK1207970A1 (en) 2016-02-19
CL2014003052A1 (es) 2015-06-26
WO2013169377A1 (en) 2013-11-14
EP3492101A2 (en) 2019-06-05
JP6431477B2 (ja) 2018-12-05
JP2015517492A (ja) 2015-06-22
IL235237A0 (en) 2014-12-31
MX2014013678A (es) 2015-02-04
SG10201807059QA (en) 2018-09-27
MX378749B (es) 2025-03-10
KR102122618B1 (ko) 2020-06-29
JP2018118991A (ja) 2018-08-02
US9683030B2 (en) 2017-06-20
BR112014027991A2 (pt) 2017-07-18
SG11201406769RA (en) 2014-11-27
US20190062407A1 (en) 2019-02-28
CA2871160A1 (en) 2013-11-14
EP2846833A1 (en) 2015-03-18
US20170306003A1 (en) 2017-10-26
US10538578B2 (en) 2020-01-21
US20200123234A1 (en) 2020-04-23
CN104507500A (zh) 2015-04-08
AU2018202468A1 (en) 2018-04-26
AU2013260123A1 (en) 2014-11-13
US9982037B2 (en) 2018-05-29
KR20150008180A (ko) 2015-01-21
EP2846833A4 (en) 2016-01-06
US20130302348A1 (en) 2013-11-14
CA2871160C (en) 2023-03-14
US10947300B2 (en) 2021-03-16

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Application publication date: 20190125