CN109260173A - 一种胸腺法新药物组合物及其制备方法 - Google Patents
一种胸腺法新药物组合物及其制备方法 Download PDFInfo
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- CN109260173A CN109260173A CN201811364532.8A CN201811364532A CN109260173A CN 109260173 A CN109260173 A CN 109260173A CN 201811364532 A CN201811364532 A CN 201811364532A CN 109260173 A CN109260173 A CN 109260173A
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- Prior art keywords
- thymalfasin
- sodium alginate
- pharmaceutical composition
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- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 230000005924 vaccine-induced immune response Effects 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2292—Thymosin; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
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Cited By (2)
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---|---|---|---|---|
CN111499819A (zh) * | 2020-05-06 | 2020-08-07 | 青岛中和聚氨酯材料有限公司 | 一种聚氨酯海绵材料及其制备方法 |
CN111714469A (zh) * | 2019-03-22 | 2020-09-29 | 苏州特瑞药业有限公司 | 一种胸腺法新制剂及其制备方法 |
Citations (4)
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US20030068381A1 (en) * | 2000-12-21 | 2003-04-10 | Celal Albayrak | Induced phase transition method for the production of microparticles containing hydrophilic active agents |
CN102106828A (zh) * | 2011-02-25 | 2011-06-29 | 深圳翰宇药业股份有限公司 | 一种胸腺法新缓释微球制剂及其制备方法 |
CN103961320A (zh) * | 2014-05-23 | 2014-08-06 | 深圳市健元医药科技有限公司 | 一种免疫调节剂多肽缓释微球制剂及其制备方法 |
CN104984327A (zh) * | 2015-06-15 | 2015-10-21 | 烟台海安药物研发有限公司 | 一种胸腺法新缓释微球制剂及其制备方法 |
-
2018
- 2018-11-15 CN CN201811364532.8A patent/CN109260173B/zh active Active
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US20030068381A1 (en) * | 2000-12-21 | 2003-04-10 | Celal Albayrak | Induced phase transition method for the production of microparticles containing hydrophilic active agents |
CN102106828A (zh) * | 2011-02-25 | 2011-06-29 | 深圳翰宇药业股份有限公司 | 一种胸腺法新缓释微球制剂及其制备方法 |
CN103961320A (zh) * | 2014-05-23 | 2014-08-06 | 深圳市健元医药科技有限公司 | 一种免疫调节剂多肽缓释微球制剂及其制备方法 |
CN104984327A (zh) * | 2015-06-15 | 2015-10-21 | 烟台海安药物研发有限公司 | 一种胸腺法新缓释微球制剂及其制备方法 |
Non-Patent Citations (1)
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杨柳青等: "快速膜乳化法制备胸腺法新长效缓释微球", 《过程工程学报》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111714469A (zh) * | 2019-03-22 | 2020-09-29 | 苏州特瑞药业有限公司 | 一种胸腺法新制剂及其制备方法 |
CN111714469B (zh) * | 2019-03-22 | 2023-10-03 | 苏州特瑞药业股份有限公司 | 一种胸腺法新制剂及其制备方法 |
CN111499819A (zh) * | 2020-05-06 | 2020-08-07 | 青岛中和聚氨酯材料有限公司 | 一种聚氨酯海绵材料及其制备方法 |
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