CN109219449B - 包含乙型肝炎病毒的表面抗原和核衣壳抗原的药用组合物 - Google Patents

包含乙型肝炎病毒的表面抗原和核衣壳抗原的药用组合物 Download PDF

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CN109219449B
CN109219449B CN201780033618.XA CN201780033618A CN109219449B CN 109219449 B CN109219449 B CN 109219449B CN 201780033618 A CN201780033618 A CN 201780033618A CN 109219449 B CN109219449 B CN 109219449B
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hbsag
antigen
hbcag
virus
mrna
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CN109219449A (zh
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J·C·阿吉拉尔鲁维多
Y·洛拜纳马托
E·伊格莱西亚斯佩雷斯
E·彭顿阿里亚斯
G·E·纪廉涅托
J·A·阿吉亚尔圣地亚哥
S·冈萨雷斯布兰科
J·巴尔德斯埃尔南德斯
M·巴斯克斯卡斯蒂略
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Centro de Ingenieria Genetica y Biotecnologia CIGB
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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CN201780033618.XA 2016-03-31 2017-03-14 包含乙型肝炎病毒的表面抗原和核衣壳抗原的药用组合物 Active CN109219449B (zh)

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Application Number Priority Date Filing Date Title
CU2016-0038 2016-03-31
CU2016000038A CU24454B1 (es) 2016-03-31 2017-03-14 Composición farmacéutica que comprende los antígenos de la superficie y de la nucleocápsida del virus de la hepatitis b
PCT/CU2017/050001 WO2017167317A1 (es) 2016-03-31 2017-03-14 Composición farmacéutica que comprende los antígenos de la superficie y de la nucleocápsida del virus de la hepatitis b

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CN109219449A CN109219449A (zh) 2019-01-15
CN109219449B true CN109219449B (zh) 2022-08-30

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CA (1) CA3017778A1 (enExample)
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Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
AU2020355020A1 (en) * 2019-09-23 2022-04-28 Ascendo Biotechnology, Inc. Biodegradable nanocomplex vaccines, methods for suppression of hepapitis B virus replication and hepapitis B virus surface antigen secretion
CU20200028A7 (es) 2020-04-20 2021-11-04 Ct Ingenieria Genetica Biotecnologia Nucleoproteína viral y formulaciones que la contienen
CN116218881B (zh) * 2022-10-21 2024-08-13 山东大学 一种治疗或者预防乙肝病毒的疫苗

Citations (2)

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CN1477972A (zh) * 2000-12-01 2004-02-25 �Ŵ����������＼������ 获得抗原性聚集物的方法及其在制剂中的用途
CN102665687A (zh) * 2009-09-29 2012-09-12 遗传工程与生物技术中心 用于细胞刺激随后进行治疗性免疫的乙肝病毒抗原制剂

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CU22290A1 (es) 1990-10-08 1995-01-31 Cigb Procedimiento para la obtencion de antigeno de superficie del virus de la hepatitis b de superior capacidad inmunoganica y su uso en un preparado vacunal
CU22871A1 (es) 1998-12-02 2003-10-21 Ct Ingenieria Genetica Biotech Formulaciones conteniendo partículas semejantes a virus como inmunopotenciadores por vía mucosal
CN1164331C (zh) * 2001-05-23 2004-09-01 中国人民解放军第二军医大学 一种人乙型肝炎核酸疫苗
CN110859961A (zh) * 2013-07-26 2020-03-06 复旦大学 病毒免疫治疗药物复合物在制备治疗hbv感染药物中的应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1477972A (zh) * 2000-12-01 2004-02-25 �Ŵ����������＼������ 获得抗原性聚集物的方法及其在制剂中的用途
CN102665687A (zh) * 2009-09-29 2012-09-12 遗传工程与生物技术中心 用于细胞刺激随后进行治疗性免疫的乙肝病毒抗原制剂

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A VLP Library of C-Terminally Truncated Hepatitis B Core Proteins: Correlation of RNA Encapsidation with a Th1/Th2 Switch in the Immune Responses of Mice;Irina Sominskaya等;《PLoS One》;20130923;第8卷(第9期);第1页摘要，图1-2,4-5 *
Comparison of the immune response induced in mice by five commercial vaccines based on recombinant HBsAg from different sources, implications on their therapeutic use;Yadira Lobaina等;《Biotecnología Aplicada》;20080101;第25卷(第4期);第325页摘要，第326页右栏第2段，第329页右栏第4-5段，第330页左栏第4段 *
Phase I clinical trial in healthy adults of a nasal vaccine candidate containing recombinant hepatitis B surface and core antigens;Arístides AguilarBetancourt等;《International Journal of Infectious Diseases》;20070124;第11卷(第5期);第394-401页 *
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EP3437654B1 (en) 2023-09-20
ZA201806325B (en) 2020-08-26
EA201892212A1 (ru) 2019-03-29
HK1259329A1 (zh) 2019-11-29
MY202118A (en) 2024-04-04
CU20160038A7 (es) 2017-11-07
JP2019510064A (ja) 2019-04-11
ES2965709T3 (es) 2024-04-16
AR108009A1 (es) 2018-07-04
AU2017243136B2 (en) 2022-02-17
CU24454B1 (es) 2019-11-04
UA128952C2 (uk) 2024-12-11
WO2017167317A1 (es) 2017-10-05
US20220193228A1 (en) 2022-06-23
EP3437654A1 (en) 2019-02-06
US20200297840A1 (en) 2020-09-24
TWI755383B (zh) 2022-02-21
US11491218B2 (en) 2022-11-08
CN109219449A (zh) 2019-01-15
KR20180125985A (ko) 2018-11-26
CA3017778A1 (en) 2017-10-05
US11759517B2 (en) 2023-09-19
JP6981992B2 (ja) 2021-12-17
AU2017243136A1 (en) 2018-10-11
TW201735945A (zh) 2017-10-16
MX2018011793A (es) 2018-12-17
BR112018069738A2 (pt) 2019-02-05

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