TWI755383B - 包括b型肝炎病毒之表面及核殼體抗原的藥學組成物 - Google Patents

包括b型肝炎病毒之表面及核殼體抗原的藥學組成物 Download PDF

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TWI755383B
TWI755383B TW106109533A TW106109533A TWI755383B TW I755383 B TWI755383 B TW I755383B TW 106109533 A TW106109533 A TW 106109533A TW 106109533 A TW106109533 A TW 106109533A TW I755383 B TWI755383 B TW I755383B
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antigen
hbsag
hbcag
hepatitis
mrna
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TW106109533A
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TW201735945A (zh
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胡力歐 C. 艾古拉魯必多
亞迪拉 洛巴納馬托
安立奎 伊格雷西亞佩瑞茲
艾杜亞多 派頓亞瑞斯
吉拉多 E. 古倫尼托
喬治 A. 艾奎亞山迪亞果
索尼亞 岡薩雷茲布朗可
喬治 瓦迪茲賀朗德茲
瑪瑞拉 瓦奎茲卡斯堤洛
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古巴商遺傳工程與生物技術中心
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    • A61K39/12—Viral antigens
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    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW106109533A 2016-03-31 2017-03-22 包括b型肝炎病毒之表面及核殼體抗原的藥學組成物 TWI755383B (zh)

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Application Number Priority Date Filing Date Title
CU2016-0038 2016-03-31
CU2016000038A CU24454B1 (es) 2016-03-31 2017-03-14 Composición farmacéutica que comprende los antígenos de la superficie y de la nucleocápsida del virus de la hepatitis b

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TW201735945A TW201735945A (zh) 2017-10-16
TWI755383B true TWI755383B (zh) 2022-02-21

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US (2) US11491218B2 (enExample)
EP (1) EP3437654B1 (enExample)
JP (1) JP6981992B2 (enExample)
KR (1) KR20180125985A (enExample)
CN (1) CN109219449B (enExample)
AR (1) AR108009A1 (enExample)
AU (1) AU2017243136B2 (enExample)
BR (1) BR112018069738A2 (enExample)
CA (1) CA3017778A1 (enExample)
CU (1) CU24454B1 (enExample)
EA (1) EA201892212A1 (enExample)
ES (1) ES2965709T3 (enExample)
MX (1) MX2018011793A (enExample)
MY (1) MY202118A (enExample)
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UA (1) UA128952C2 (enExample)
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AU2020355020A1 (en) * 2019-09-23 2022-04-28 Ascendo Biotechnology, Inc. Biodegradable nanocomplex vaccines, methods for suppression of hepapitis B virus replication and hepapitis B virus surface antigen secretion
CU20200028A7 (es) 2020-04-20 2021-11-04 Ct Ingenieria Genetica Biotecnologia Nucleoproteína viral y formulaciones que la contienen
CN116218881B (zh) * 2022-10-21 2024-08-13 山东大学 一种治疗或者预防乙肝病毒的疫苗

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1477972A (zh) * 2000-12-01 2004-02-25 �Ŵ����������＼������ 获得抗原性聚集物的方法及其在制剂中的用途

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Publication number Priority date Publication date Assignee Title
CU22290A1 (es) 1990-10-08 1995-01-31 Cigb Procedimiento para la obtencion de antigeno de superficie del virus de la hepatitis b de superior capacidad inmunoganica y su uso en un preparado vacunal
CU22871A1 (es) 1998-12-02 2003-10-21 Ct Ingenieria Genetica Biotech Formulaciones conteniendo partículas semejantes a virus como inmunopotenciadores por vía mucosal
CN1164331C (zh) * 2001-05-23 2004-09-01 中国人民解放军第二军医大学 一种人乙型肝炎核酸疫苗
CU23740A1 (es) 2009-09-29 2011-12-28 Ct Ingenieria Genetica Biotech Método de obtención de una formulación de antígenos del virus de la hepatitis b
CN110859961A (zh) * 2013-07-26 2020-03-06 复旦大学 病毒免疫治疗药物复合物在制备治疗hbv感染药物中的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1477972A (zh) * 2000-12-01 2004-02-25 �Ŵ����������＼������ 获得抗原性聚集物的方法及其在制剂中的用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Aristides Aguilar Betancourt et al: Phase I clinical trial in healthy adults of a nasalvaccine candidate containing recombinant hepatitis B surface and core antigens. International Journal of Infectious Diseases (2007) 11, 394—401; *
Tey, Beng Ti, et al., "Optimal conditions for hepatitis B core antigen production in shaked flask fermentation.",Biotechnology and Bioprocess Engineering, Vol.9, No.5, October, 2004, page 374-378. *

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Publication number Publication date
EP3437654B1 (en) 2023-09-20
ZA201806325B (en) 2020-08-26
EA201892212A1 (ru) 2019-03-29
HK1259329A1 (zh) 2019-11-29
MY202118A (en) 2024-04-04
CU20160038A7 (es) 2017-11-07
JP2019510064A (ja) 2019-04-11
ES2965709T3 (es) 2024-04-16
CN109219449B (zh) 2022-08-30
AR108009A1 (es) 2018-07-04
AU2017243136B2 (en) 2022-02-17
CU24454B1 (es) 2019-11-04
UA128952C2 (uk) 2024-12-11
WO2017167317A1 (es) 2017-10-05
US20220193228A1 (en) 2022-06-23
EP3437654A1 (en) 2019-02-06
US20200297840A1 (en) 2020-09-24
US11491218B2 (en) 2022-11-08
CN109219449A (zh) 2019-01-15
KR20180125985A (ko) 2018-11-26
CA3017778A1 (en) 2017-10-05
US11759517B2 (en) 2023-09-19
JP6981992B2 (ja) 2021-12-17
AU2017243136A1 (en) 2018-10-11
TW201735945A (zh) 2017-10-16
MX2018011793A (es) 2018-12-17
BR112018069738A2 (pt) 2019-02-05

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