CN109153641B - 伊文思蓝衍生物的化学偶联物及其作为放射治疗和成像剂的用途 - Google Patents

伊文思蓝衍生物的化学偶联物及其作为放射治疗和成像剂的用途 Download PDF

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CN109153641B
CN109153641B CN201780029003.XA CN201780029003A CN109153641B CN 109153641 B CN109153641 B CN 109153641B CN 201780029003 A CN201780029003 A CN 201780029003A CN 109153641 B CN109153641 B CN 109153641B
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CN109153641A (zh
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陈小元
欧里特·雅各布森·韦斯
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    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
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    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
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    • C09B29/00—Monoazo dyes prepared by diazotising and coupling
    • C09B29/24—Monoazo dyes prepared by diazotising and coupling from coupling components containing both hydroxyl and amino directing groups
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    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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CN201780029003.XA 2016-05-09 2017-05-09 伊文思蓝衍生物的化学偶联物及其作为放射治疗和成像剂的用途 Active CN109153641B (zh)

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US201662333427P 2016-05-09 2016-05-09
US62/333,427 2016-05-09
PCT/US2017/031696 WO2017196806A1 (en) 2016-05-09 2017-05-09 Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents

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US (1) US10696631B2 (https=)
EP (1) EP3455206B1 (https=)
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CN (1) CN109153641B (https=)
SG (1) SG11201809982RA (https=)
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SG11202002882VA (en) 2017-10-03 2020-04-29 The United States Of America As Represented By The Secretary Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents
AU2019225154B2 (en) * 2018-02-22 2024-10-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents for targeting prostate cancer
TWI745616B (zh) * 2018-09-10 2021-11-11 行政院原子能委員會核能研究所 放射線標誌長效型靶向性胜肽藥物及其生產方法
CN109485642A (zh) * 2018-11-21 2019-03-19 希施生物科技（上海）有限公司 一种制备伊文氏蓝衍生物的方法
WO2020160222A2 (en) 2019-01-30 2020-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Conjugates of bivalent evans blue dye derivatives and methods of use
US12357712B2 (en) * 2019-05-24 2025-07-15 Beijing Giluntide Pharmaceutical Co., Ltd. Targeted radiopharmaceutical for tumor and its use in the imaging-guided combination therapy of targeted radiotherapy and immunotherapy
CA3174082A1 (en) * 2020-03-04 2021-09-10 Nihon Medi-Physics Co., Ltd. Compound and radioactive labeling compound
MX2022013783A (es) * 2020-05-06 2023-04-19 Univ Cornell Compuestos tratanosticos que contienen cobre y metodos de uso.
CN114790193B (zh) * 2020-12-21 2024-05-10 苏州药明博锐生物科技有限公司 成纤维细胞活化蛋白抑制剂
CN114369084B (zh) * 2021-02-10 2023-02-03 烟台蓝纳成生物技术有限公司 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用
NZ803235A (en) 2021-02-10 2026-01-30 Yantai Lannacheng Biotechnology Co Ltd Truncated evans blue modified fibroblast activation protein inhibitor, preparation method therefor, and application thereof
CN113004371A (zh) 2021-03-01 2021-06-22 上海蓝纳成生物技术有限公司 一种长循环半衰期的前列腺特异性膜抗原靶向化合物及其制备方法和应用
CN114796532A (zh) * 2022-04-20 2022-07-29 北京先通国际医药科技股份有限公司 放射性标记的伊文思蓝衍生物药物水溶液及其用途
WO2023236778A1 (zh) * 2022-06-10 2023-12-14 北京大学 一种三功能化合物及其用途
CN115433261B (zh) * 2022-11-07 2023-01-13 烟台蓝纳成生物技术有限公司 一种rgd二聚体化合物及其制备方法和应用
CN115583989B (zh) * 2022-12-09 2023-02-28 烟台蓝纳成生物技术有限公司 一种靶向sstr2的化合物及其制备方法和应用
CN115611779A (zh) * 2022-12-21 2023-01-17 北京先通国际医药科技股份有限公司 一种放射性药物前体的中间体的制备方法及其用途
CN115838393B (zh) * 2023-02-16 2023-05-05 烟台蓝纳成生物技术有限公司 用于fapi合成的中间体及其制备方法和应用
CN115850367B (zh) * 2023-03-02 2023-05-23 北京先通国际医药科技股份有限公司 Psma抑制剂的纯化方法及其用途
CN115947775B (zh) * 2023-03-13 2023-06-09 北京先通国际医药科技股份有限公司 一种制备化合物（i）的方法和化合物（i）及其用途
KR20260009883A (ko) * 2023-05-24 2026-01-20 베이징 창핑 래보러토리 신규 삼관능 화합물 및 이의 용도

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JP6946342B2 (ja) 2021-10-06
EP3455206A4 (en) 2019-11-27
EP3455206B1 (en) 2020-11-04
US20190084931A1 (en) 2019-03-21
US10696631B2 (en) 2020-06-30
WO2017196806A1 (en) 2017-11-16
JP2019519491A (ja) 2019-07-11
CN109153641A (zh) 2019-01-04
EP3455206A1 (en) 2019-03-20
SG11201809982RA (en) 2018-12-28

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