CN109152399A - 营养补充剂 - Google Patents
营养补充剂 Download PDFInfo
- Publication number
- CN109152399A CN109152399A CN201780025047.5A CN201780025047A CN109152399A CN 109152399 A CN109152399 A CN 109152399A CN 201780025047 A CN201780025047 A CN 201780025047A CN 109152399 A CN109152399 A CN 109152399A
- Authority
- CN
- China
- Prior art keywords
- pectin
- alginates
- active constituent
- sugar
- nutritional supplement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 44
- 229920001277 pectin Polymers 0.000 claims abstract description 75
- 239000001814 pectin Substances 0.000 claims abstract description 75
- 235000010987 pectin Nutrition 0.000 claims abstract description 73
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 72
- 229920000615 alginic acid Polymers 0.000 claims abstract description 72
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 45
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 44
- 235000000346 sugar Nutrition 0.000 claims abstract description 34
- 239000000470 constituent Substances 0.000 claims description 54
- 239000000203 mixture Substances 0.000 claims description 26
- 235000016709 nutrition Nutrition 0.000 claims description 26
- 239000007787 solid Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 21
- 150000001413 amino acids Chemical class 0.000 claims description 19
- 239000004615 ingredient Substances 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 235000011496 sports drink Nutrition 0.000 claims description 13
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 12
- 239000011707 mineral Chemical class 0.000 claims description 12
- 239000003792 electrolyte Substances 0.000 claims description 8
- 235000015897 energy drink Nutrition 0.000 claims description 6
- 235000013361 beverage Nutrition 0.000 claims description 5
- 210000004051 gastric juice Anatomy 0.000 abstract description 7
- 230000002496 gastric effect Effects 0.000 abstract description 5
- 210000002784 stomach Anatomy 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 5
- 239000000017 hydrogel Substances 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 238000013268 sustained release Methods 0.000 abstract description 2
- 239000012730 sustained-release form Substances 0.000 abstract description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 23
- 229930091371 Fructose Natural products 0.000 description 17
- 239000005715 Fructose Substances 0.000 description 17
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 17
- 239000008103 glucose Substances 0.000 description 16
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 13
- 229930006000 Sucrose Natural products 0.000 description 13
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 13
- 239000005720 sucrose Substances 0.000 description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 10
- 229920002774 Maltodextrin Polymers 0.000 description 10
- 239000005913 Maltodextrin Substances 0.000 description 10
- 229940035034 maltodextrin Drugs 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- 230000006607 hypermethylation Effects 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 229910019142 PO4 Inorganic materials 0.000 description 8
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 8
- 239000010452 phosphate Substances 0.000 description 8
- 239000011591 potassium Substances 0.000 description 8
- 229910052700 potassium Inorganic materials 0.000 description 8
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 7
- 229940072056 alginate Drugs 0.000 description 7
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 7
- 239000008121 dextrose Substances 0.000 description 7
- 235000021433 fructose syrup Nutrition 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 235000020357 syrup Nutrition 0.000 description 7
- 239000006188 syrup Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 6
- 241000207199 Citrus Species 0.000 description 6
- AEMOLEFTQBMNLQ-BZINKQHNSA-N D-Guluronic Acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@H]1O AEMOLEFTQBMNLQ-BZINKQHNSA-N 0.000 description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 6
- 229920002230 Pectic acid Polymers 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 229930003268 Vitamin C Natural products 0.000 description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 235000020971 citrus fruits Nutrition 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000013355 food flavoring agent Nutrition 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 229910052749 magnesium Inorganic materials 0.000 description 6
- 239000008371 vanilla flavor Substances 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 229940088594 vitamin Drugs 0.000 description 6
- 235000019154 vitamin C Nutrition 0.000 description 6
- 239000011718 vitamin C Substances 0.000 description 6
- 150000003722 vitamin derivatives Chemical class 0.000 description 6
- 239000011701 zinc Substances 0.000 description 6
- 229910052725 zinc Inorganic materials 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 5
- 239000000783 alginic acid Substances 0.000 description 5
- 229960001126 alginic acid Drugs 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 238000005868 electrolysis reaction Methods 0.000 description 5
- 239000010318 polygalacturonic acid Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 4
- -1 alginic acid Salt Chemical class 0.000 description 4
- 150000004781 alginic acids Chemical class 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 238000004088 simulation Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 230000032050 esterification Effects 0.000 description 3
- 238000005886 esterification reaction Methods 0.000 description 3
- 230000011987 methylation Effects 0.000 description 3
- 238000007069 methylation reaction Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 241000195493 Cryptophyta Species 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 206010016766 flatulence Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 229920000945 Amylopectin Polymers 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
- AEMOLEFTQBMNLQ-DTEWXJGMSA-N D-Galacturonic acid Natural products O[C@@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-DTEWXJGMSA-N 0.000 description 1
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- PYMYPHUHKUWMLA-VPENINKCSA-N aldehydo-D-xylose Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-VPENINKCSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 1
- WQZGKKKJIJFFOK-BYIBVSMXSA-N alpha-L-gulose Chemical compound OC[C@@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-BYIBVSMXSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000000728 ammonium alginate Substances 0.000 description 1
- 235000010407 ammonium alginate Nutrition 0.000 description 1
- KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-RWOPYEJCSA-N beta-D-mannose Chemical compound OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-RWOPYEJCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 235000021074 carbohydrate intake Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940099563 lactobionic acid Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 229920005684 linear copolymer Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- 229920003175 pectinic acid Polymers 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000737 potassium alginate Substances 0.000 description 1
- 235000010408 potassium alginate Nutrition 0.000 description 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
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Abstract
本发明提供了包含与果胶组合的藻酸盐的营养补充剂，当暴露于低pH的胃液时，该营养补充剂将在胃中形成水凝胶。水凝胶的形成将导致胃中糖和其他活性成分的延迟释放。营养补充剂可以包含高浓度的糖和复合碳水化合物，而没有引起不需要的胃肠道症状。
Description
发明背景
参与耐力项目的运动员需要维持相对高的工作率持续延长的时间段，这导致高出汗率和能量消耗。为了延迟疲劳的开始并优化延长的耐力表现，推荐运动员补偿流体和电解质损失，以及用来自碳水化合物的能量为身体供能(fuel)。
碳水化合物摄入已经被示出改进耐力能力和表现，并且建议运动员在耐力项目期间以每小时0.7g kg-1体重的速率(30g h-1-60g h-1)消耗碳水化合物(American Collegeof Sports Medicine.Med Sci Sports Exerc.2009,41:709-31)。对于参加超过2h的激烈(超级)耐力项目的运动员，可选择的当代推荐建议高达90g h-1的甚至更高的碳水化合物摄入率(Jeukendrup Eur J.Sport Sci 2008,.8:77-86)。
高碳水化合物摄入率与表现显著地正相关，但同时也与胃肠道症状，例如恶心和肠胃气胀的较高的分数相关(Pfeiffer Med Sci Sports Exerc 2012,44:344-351)。
因此，存在对含有碳水化合物的营养补充剂的需求，该营养补充剂允许高碳水化合物摄入而不引起不需要的胃肠道症状。
发明描述
本发明通过提供包含优选地与果胶组合的藻酸盐的营养补充剂来解决该问题，当暴露于低pH的胃液时，该营养补充剂将在胃中形成水凝胶。水凝胶的形成将导致胃中糖和其他活性成分的延迟释放。营养补充剂可以包含高浓度的糖和复合碳水化合物(complexcarbohydrate)，而不引起不需要的胃肠道症状。
根据本发明的营养补充剂的组合物被选择性地选择，以提供与在暴露于低pH的胃液时有效的胶凝组合的在消耗时的低粘度两者。
本发明的第一方面提供了液体营养补充剂，所述液体营养补充剂包含：
a)0.05wt％至2.0wt％藻酸盐
b)0.03wt％至1.5wt％果胶，和
c)5wt％至25wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种，
用于作为运动饮料或作为能量饮料使用。
更具体地，用于在运动之前、在运动期间和/或在运动之后提供用于能量的碳水化合物，避免胃肠道症状，例如肠胃气胀和恶心。
在一个优选的实施方案中，液体营养补充剂基本上由以下组成：
a)0.05wt％至2.0wt％藻酸盐
b)0.03wt％至1.5wt％果胶，和
c)5wt％至25wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
藻酸盐含量可以是0.05wt％至2.0wt％，例如0.2wt％至0.8wt％，优选地0.5wt％至0.7wt％或0.3wt％至0.6wt％。
藻酸盐优选地是高古洛糖醛酸(高G)藻酸盐。
果胶含量可以是0.03wt％至1.5wt％，例如0.05wt％至1.0wt％，优选地0.2wt％至0.4wt％或0.3wt％至0.5wt％。
果胶优选地是高酯/高甲基化(HE/HM)果胶。
糖含量可以是5wt％至25wt％，例如7wt％至18wt％。糖可以选自但不限于葡萄糖、果糖、蔗糖和异麦芽酮糖。
如果存在，葡萄糖与果糖的比率可以是从10:1至1:10，例如4:1至1:1，优选地2:1。
复合碳水化合物可以选自淀粉、麦芽糖糊精、葡萄糖糖浆和果糖糖浆。
复合碳水化合物的含量可以是0wt％至40wt％，例如4wt％至9wt％。
电解质可以选自钠、钾、锌和镁的氯化物、磷酸盐和柠檬酸盐。
任选地，营养补充剂可以包含维生素，例如维生素C。
任选地，营养补充剂可以包含调味剂，例如柑橘或香草香味。
在一个优选的实施方案中，液体营养补充剂包含：
a)0.05wt％至0.7wt％藻酸盐，
b)0.03wt％至0.5wt％果胶，和
c)7wt％至15wt％的活性成分，所述活性成分由4wt％至6wt％果糖、8wt％至12wt％麦芽糖糊精和0wt％至1wt％氯化钠组成。
在另一个优选的实施方案中，液体营养补充剂包含：
a)0.05wt％至0.6wt％藻酸盐，
b)0.03wt％至0.4wt％果胶，和
c)12wt％至18wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
根据本发明的第一方面的以运动饮料或能量饮料形式的液体营养补充剂意图以从100ml至500ml的体积，例如以从120ml至350ml的体积消耗。
本发明的第二方面提供了固体营养补充剂，所述固体营养补充剂包含：
a)0.2wt％至16wt％藻酸盐，
b)0.12wt％至12wt％果胶，和
c)75wt％至99wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
在一个实施方案中，固体营养补充剂可以基本上由以下组成：
a)0.2wt％至16wt％藻酸盐，
b)0.12wt％至12wt％果胶，和
c)75wt％至99wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
根据本发明的此第二方面的固体营养补充剂意图溶解在限定体积的水中，产生根据本发明的第一方面的用于作为运动饮料或作为能量饮料使用的液体营养补充剂。
固体营养补充剂可以包含1wt％至10wt％的结合至藻酸盐、果胶、碳水化合物或其他活性成分的水。
对于在溶解于加入的水中之后意图包含7wt％至18wt％的活性成分的营养补充剂，藻酸盐含量可以是0.2wt％至16wt％、0.6wt％至6wt％，例如1.0wt％至4wt％，更优选地1.5wt％至2.7wt％，并且果胶含量可以是0.12wt％至12wt％、0.4wt％至4wt％，例如0.8wt％至2.4wt％，更优选地1.0wt％至1.8wt％。
藻酸盐优选地是高古洛糖醛酸(高G)藻酸盐。
果胶优选地是高甲基化(HM)果胶。
糖含量可以是25wt％至95wt％，例如30wt％至75wt％。糖可以选自葡萄糖、果糖、蔗糖、异麦芽酮糖。
如果存在，葡萄糖与果糖的比率可以是从10:1至1:10，例如4:1至1:1，优选地2:1，只要不包含复合碳水化合物。
复合碳水化合物可以选自淀粉、麦芽糖糊精、干葡萄糖糖浆和干果糖糖浆。
复合碳水化合物的含量可以是0wt％至80wt％，例如30wt％至65wt％。
矿物盐可以选自钠、钾、钙、锌和镁的氯化物、磷酸盐和柠檬酸盐。
任选地，营养补充剂可以包含维生素，例如维生素C。
任选地，营养补充剂可以包含调味剂，例如柑橘或香草香味。
在一个优选的实施方案中，在溶解于加入的水中之后意图包含18wt％的活性成分的固体营养补充剂包含：
a)0.4wt％至4.5wt％藻酸盐，
b)0.4wt％至3.0wt％果胶，和
c)由55wt％至65wt％葡萄糖、35wt％至45wt％果糖和0.5wt％至3wt％氯化钠组成的活性成分。
在一个优选的实施方案中，在溶解于加入的水中之后意图包含12wt％的活性成分的固体营养补充剂包含：
a)0.7wt％至9.5wt％藻酸盐，
b)0.7wt％至6.8wt％果胶，和
c)由25wt％至50wt％异麦芽酮糖、40wt％至80wt％麦芽糖糊精和1wt％至4wt％氯化钠组成的活性成分。
本发明的第三方面提供了液体营养补充剂，所述液体营养补充剂包含：
a)0.05wt％至0.15wt％藻酸盐
b)0.03wt％至0.1wt％果胶，和
c)5wt％至25wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
在一个优选的实施方案中，液体营养补充剂基本上由以下组成：
a)0.05wt％至0.15wt％藻酸盐
b)0.03wt％至0.1wt％果胶，和
c)5wt％至25wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
藻酸盐含量可以是0.05wt％至0.15wt％，更优选地0.075wt％至0.12wt％。最优选地，藻酸盐含量为0.09wt％至0.11wt％。
藻酸盐优选地是高古洛糖醛酸(高G)藻酸盐。
果胶含量可以是0.03wt％至0.1wt％，更优选地0.05wt％至0.08wt％。
果胶优选地是高酯/高甲基化(HE/HM)果胶。
优选地，藻酸盐和果胶的总含量小于0.25wt％，更优选地小于0.20wt％。
糖含量可以是4wt％至25wt％，例如7wt％至18wt％。糖可以选自但不限于葡萄糖、果糖、蔗糖和异麦芽酮糖。
如果存在，葡萄糖与果糖的比率可以是从10:1至1:10，例如4:1至1:1，优选地2:1。
复合碳水化合物可以选自淀粉、麦芽糖糊精、葡萄糖糖浆和果糖糖浆。
复合碳水化合物的含量可以是0wt％至40wt％，例如4wt％至9wt％。
电解质可以选自钠、钾、锌和镁的氯化物、磷酸盐和柠檬酸盐。
任选地，营养补充剂可以包含维生素，例如维生素C。
任选地，营养补充剂可以包含调味剂，例如柑橘或香草香味。
根据本发明的第三方面的液体营养补充剂可以呈运动饮料的形式，所述运动饮料意图以从100ml至500ml的体积，例如以从120ml至350ml的体积消耗。
本发明的第四方面提供了固体营养补充剂，所述固体营养补充剂包含：
a)0.2wt％至2.0wt％藻酸盐，
b)0.12wt％至1.4wt％果胶，和
c)75wt％至99wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
在一个实施方案中，固体营养补充剂可以基本上由以下组成：
a)0.2wt％至2.0wt％藻酸盐，
b)0.12wt％至1.4wt％果胶，和
c)75wt％至99wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
固体营养补充剂可以包含1wt％至10wt％的结合至藻酸盐、果胶、碳水化合物或其他活性成分的水。
根据本发明的此第四方面的固体营养补充剂意图溶解在限定体积的水中，产生根据本发明的第三方面的液体营养补充剂。
藻酸盐优选地是高古洛糖醛酸(高G)藻酸盐。
果胶优选地是高甲基化(HM)果胶。
对于在溶解于加入的水中之后包含7wt％至15wt％的活性成分的营养补充剂，藻酸盐含量可以是0.3wt％至2wt％，例如0.5wt％至1.5wt％，更优选地0.7wt％至1.0wt％，并且果胶含量可以是0.2wt％至1.3wt％，例如0.3wt％至0.9wt％，更优选地0.4wt％至0.7wt％。
对于在溶解于加入的水中之后包含12wt％至18wt％的活性成分的营养补充剂，藻酸盐含量可以是0.25wt％至1.25wt％，例如0.3wt％至1.0wt％，更优选地0.45wt％至0.8wt％，并且固体制剂的果胶含量可以是0.15wt％至0.9wt％，例如0.2wt％至0.7wt％，更优选地0.25wt％至0.5wt％。
糖含量可以是25wt％至95wt％，例如30wt％至75wt％。糖可以选自葡萄糖、果糖、蔗糖、异麦芽酮糖。
如果存在，葡萄糖与果糖的比率可以是从10:1至1:10，例如4:1至1:1，优选地2:1，只要不包含复合碳水化合物。
复合碳水化合物可以选自淀粉、麦芽糖糊精、干葡萄糖糖浆和干果糖糖浆。
复合碳水化合物的含量可以是0wt％至80wt％，例如30wt％至65wt％。
矿物盐可以选自钠、钾、钙、锌和镁的氯化物、磷酸盐和柠檬酸盐。
任选地，营养补充剂可以包含维生素，例如维生素C。
任选地，营养补充剂可以包含调味剂，例如柑橘或香草香味。
在一个优选的实施方案中，在溶解于加入的水中之后意图包含18wt％的活性成分的固体营养补充剂包含：
a)0.25wt％至0.8wt％藻酸盐，
b)0.25wt％至0.5wt％果胶，和
c)由55wt％至65wt％葡萄糖、35wt％至45wt％果糖和0.5wt％至3wt％氯化钠组成的活性成分。
在一个优选的实施方案中，在溶解于加入的水中之后意图包含12wt％的活性成分的固体营养补充剂包含：
a)0.4wt％至1.3wt％藻酸盐，
b)0.4wt％至0.9wt％果胶，和
c)由25wt％至50wt％异麦芽酮糖、40wt％至80wt％麦芽糖糊精和1wt％至4wt％氯化钠组成的活性成分。
本发明的第五方面提供了液体营养补充剂，所述液体营养补充剂包含：
a)0.1wt％至3.5wt％藻酸盐，和
b)10wt％至25wt％活性成分，其中活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
在一个优选的实施方案中，液体营养补充剂基本上由以下组成：
a)0.1wt％至3.5wt％藻酸盐，和
b)10wt％至25wt％活性成分，其中活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
藻酸盐含量可以是0.1wt％至3.5wt％，例如0.2wt％至0.8wt％，优选地0.3wt％至0.7wt％或0.5wt％至0.6wt％。
藻酸盐优选地是高古洛糖醛酸(高G)藻酸盐。
糖含量可以是5wt％至25wt％，优选地7wt％至18wt％，这可以提供意图以从100ml至500ml的体积，例如以从120ml至350ml的体积消耗的运动饮料。
糖可以选自但不限于葡萄糖、果糖、蔗糖和异麦芽酮糖。
如果存在，葡萄糖与果糖的比率可以是从10:1至1:10，例如4:1至1:1，优选地2:1。
复合碳水化合物可以选自淀粉、麦芽糖糊精、葡萄糖糖浆和果糖糖浆。
复合碳水化合物的含量可以是0wt％至25wt％，例如4wt％至9wt％。
电解质可以选自钠、钾、钙、锌和镁的氯化物、磷酸盐和柠檬酸盐。
任选地，营养补充剂可以包含维生素，例如维生素C。
任选地，营养补充剂可以包含调味剂，例如柑橘或香草香味。
本发明的第六方面提供了固体营养补充剂，所述固体营养补充剂包含：
a)0.5wt％至25wt％藻酸盐，和
b)75wt％至99wt％活性成分，其中活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
在一个实施方案中，固体营养补充剂可以基本上由以下组成：
a)0.5wt％至25wt％藻酸盐，和
b)75wt％至99wt％活性成分，其中活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
固体营养补充剂可以包含1wt％至10wt％的结合至藻酸盐、果胶、碳水化合物或其他活性成分的水。
根据本发明的此第六方面的固体营养补充剂意图溶解在限定体积的水中，产生根据本发明的第五方面的液体营养补充剂。
藻酸盐含量可以是0.5wt％至25wt％，例如1.0wt％至15wt％。
藻酸盐优选地是高古洛糖醛酸(高G)藻酸盐。
糖含量可以是75wt％至25wt％，优选地7wt％至18wt％，这可以提供意图以从100ml至500ml的体积，例如以从120ml至350ml的体积消耗的运动饮料。
糖可以选自但不限于葡萄糖、果糖、蔗糖和异麦芽酮糖。
如果存在，葡萄糖与果糖的比率可以是从10:1至1:10，例如4:1至1:1，优选地2:1。
复合碳水化合物可以选自淀粉、麦芽糖糊精、葡萄糖糖浆和果糖糖浆。
复合碳水化合物的含量可以是0wt％至25wt％，例如4wt％至9wt％。
矿物盐可以选自钠、钾、钙、锌和镁的氯化物、磷酸盐和柠檬酸盐。
任选地，营养补充剂可以包含维生素，例如维生素C。
任选地，营养补充剂可以包含调味剂，例如柑橘或香草香味。
本发明的另一个方面提供了根据本发明的营养补充剂作为运动饮料、能量饮料、饮料或食品产品的用途。
本发明的另一个方面提供了根据本发明的营养补充剂在制造运动饮料、能量饮料、饮料或食品产品中的用途。
附图说明
图1.在三个实验中重复的在模拟的胃液(SGF)中蔗糖从一种制剂的释放。在实验开始之后，平均值和标准偏差相对于时间被绘制。(-O-)。制剂由12wt％蔗糖、0.4wt％藻酸盐和0.6wt％HM-果胶组成。作为参照，相当于100％释放，制剂与自来水混合(---)。
图2.在模拟的胃液(SGF)中蔗糖从四种不同的制剂的释放。在SGF中测量的BRIX浓度作为参照溶液的BRIX浓度的百分比给出。
实验I：0.2wt％藻酸盐、0.3wt％果胶(··○··)
实验II：0.1wt％藻酸盐、0.15wt％果胶(--Δ--)
实验III：0.125wt％藻酸盐、0.375wt％果胶(--■--)
实验IV：0.4wt％藻酸盐、0.6wt％果胶(··X··)
图3.在实验开始之后，相对于时间绘制的在模拟的胃液(SGF)中蔗糖从一种制剂的释放。(-●-)。制剂由12wt％蔗糖、0.18wt％藻酸盐+HM-果胶组成。作为参照，相当于100％释放，制剂与自来水混合(-▲-)。
发明详述
在消化后，当暴露于低pH的胃液时，包含果胶和藻酸盐的液体营养补充剂将在胃中形成凝胶。凝胶形成将导致胃中糖的缓慢释放(图1、图2和图3)，避免不需要的胃肠道症状。
果胶
果胶，也被称为果胶多糖，是一种包含在陆生植物的细胞壁中的结构性杂多糖，并且富含半乳糖醛酸。已经在果胶组内识别和表征了若干种不同的多糖。同聚半乳糖醛酸(homogalacturonan)是α-(1-4)-连接的D-半乳糖醛酸的线性链。鼠李半乳糖醛酸聚糖(rhamnogalacturonan)I果胶(RG-I)包含重复二糖的骨架：→4)-α-D-半乳糖醛酸-(1,2)-α-L-鼠李糖-(1→。从许多鼠李糖残基中，分叉出(branch off)多种中性糖的侧链。中性糖主要是D-半乳糖、L-阿拉伯糖和D-木糖，其中中性糖的类型和比率随果胶的来源变化。果胶的另一种结构类型是鼠李半乳糖醛酸聚糖II(RG-II)，这是一种不太常见的、复杂的、高度支化的多糖。鼠李半乳糖醛酸聚糖II可以被分类在被取代的聚半乳糖醛酸的组内，因为鼠李半乳糖醛酸聚糖II骨架由D-半乳糖醛酸单元排他地制成。
分离的果胶具有典型地60g/mol-150,000g/mol的分子量，随来源和提取条件变化。
同聚半乳糖醛酸的羧基基团本质上被甲基基团高度酯化(典型地～70％)。甲基化的羧基基团和非甲基化的羧基基团之间的比率，或者甲基化的程度(DM)取决于植物的成熟度及其他方面。在同聚半乳糖醛酸从植物中被提取后，DM常规地变化，在酸性条件下经由在甲醇中分散而增加或经由酸处理、碱处理或酶处理降低。酯化的半乳糖醛酸与非酯化的半乳糖醛酸的比率决定了果胶的胶凝行为。具有高甲酯程度(>50％)的果胶被表示为高甲氧基果胶(HM果胶)或高酯果胶(HE果胶)，并且具有低甲氧基含量(<50％)的果胶被表示为低甲氧基果胶(LM果胶)或低酯果胶(LE果胶)。
非酯化的半乳糖醛酸单元可以是游离酸(羧基基团)或与钠、钾或钙的盐。部分地酯化的果胶的盐被称为果胶酯酸盐，如果酯化的程度低于5％，则盐被称为果胶酸盐，不溶性酸形式的果胶酸。根据本发明，可以使用所有形式的果胶，包括HM-果胶、LM-果胶和酰胺化的LM-果胶。优选的果胶是HM-果胶。
藻酸盐
藻酸盐，也被称为藻胶(algin)或藻酸(alginic acid)，是一种广泛地分布在褐藻的细胞壁中的阴离子多糖。藻酸(alginate acid)是一种线性共聚物，具有分别以不同的顺序或嵌段共价连接在一起的(1-4)连接的β-D-甘露糖醛(M)及其C-5差向异构体α-L-古洛糖醛酸(G)残基的均聚物嵌段。单体可以出现在连续的G残基(G-嵌段)、连续的M残基(M-嵌段)或交替的M残基和G残基(MG-嵌段)的均聚物嵌段中。根据本发明，可以使用所有形式的藻酸盐，包括高G藻酸盐(>50％G)和高M藻酸盐(>50％M)。优选的藻酸盐是高G藻酸盐。抗衡离子可以是例如钠(藻酸钠)、钾(藻酸钾)、铵(藻酸铵)或其他合适的单价阳离子、或其混合物。
糖
根据本发明可以使用的糖是但不限于单糖如葡萄糖、果糖、半乳糖，二糖如乳糖、麦芽糖、蔗糖、乳果糖、海藻糖、纤维二糖。
复合碳水化合物
根据本发明可以使用的复合碳水化合物是但不限于淀粉如直链淀粉和支链淀粉的组分、麦芽糖糊精、葡萄糖糖浆和果糖糖浆。
实施例
材料和方法
实验1.将葡萄糖(12g)、果糖(6g)、藻酸盐(0.4g)和果胶(0.6g)与水(总重量100g)在小瓶中通过摇动混合。在至少1min之后，将15ml的混合物倒入在60ml圆柱形容器(内径26mm，长度120mm)中的40ml的模拟的胃液(SGF)中，缓慢地旋转该圆柱形容器(16rpm)。在0.5min、1min、2min、3min、6min、9min、12min、15min、18min和21min采集SGF的样品(0.20ml)。作为参照，使用包含所有成分(包括SGF)，但排除藻酸盐和果胶的水溶液。光密度和相应的BRIX浓度通过AT AGO PAL-3折射计测量。
实验2.与实验1相同，但仅用0.18g藻酸盐+果胶。
结果
制剂与SGF接触形成凝胶。
使用包含0.4wt％藻酸盐和0.6wt％果胶的制剂，在21min之后SGF中的游离蔗糖浓度小于参照的50％(图1)。释放的速率取决于胶凝剂藻酸盐和果胶的量。(图2和图3)。
Claims (9)
1.一种液体营养补充剂，包含：
a)0.05wt％至2.0wt％藻酸盐
b)0.03wt％至1.5wt％果胶，和
c)5wt％至25wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种，
用于作为运动饮料或作为能量饮料使用。
2.一种固体营养补充剂，包含：
a)0.2wt％至16wt％藻酸盐，
b)0.12wt％至12wt％果胶，和
c)75wt％至95wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
3.根据权利要求2所述的固体营养补充剂，意图溶解在水中用于作为运动饮料或能量饮料使用。
4.一种液体营养补充剂，包含：
a)0.05wt％至0.15wt％藻酸盐
b)0.03wt％至0.1wt％果胶，和
c)5wt％至25wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
5.一种固体营养补充剂，包含：
a)0.2wt％至2.0wt％藻酸盐，
b)0.12wt％至1.4wt％果胶，和
c)75wt％至99wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
6.根据权利要求5所述的固体营养补充剂，意图溶解在水中用于作为运动饮料或能量饮料使用。
7.一种液体营养补充剂，包含：
a)0.1wt％至3.5wt％藻酸盐，和
b)10wt％至25wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、电解质和氨基酸组成的成分中的一种或更多种。
8.一种固体营养补充剂，包含：
a)0.5wt％至25wt％藻酸盐，和
b)75wt％至99wt％活性成分，其中所述活性成分选自由糖、复合碳水化合物、矿物盐和氨基酸组成的成分中的一种或更多种。
9.根据权利要求8所述的固体营养补充剂，意图溶解在水中用于作为运动饮料或能量饮料使用。
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| SE1630098 | 2016-04-29 | ||
| SE1630098-0 | 2016-04-29 | ||
| SE1730056-7 | 2017-03-03 | ||
| SE1730056 | 2017-03-03 | ||
| PCT/EP2017/060261 WO2017186940A1 (en) | 2016-04-29 | 2017-04-28 | Nutritional supplements |
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