CN109106944B - 一种预防和治疗骨关节炎的组合物及其应用 - Google Patents
一种预防和治疗骨关节炎的组合物及其应用 Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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Abstract
Description
服用前 | 2周 | 4周 | 8周 | |
实施例1 | 6.4±0.47 | 5.9±0.22<sup>a</sup> | 5.5±0.45<sup>b</sup> | 5.3±0.71<sup>c</sup> |
实施例2 | 6.6±0.31 | 6.4±0.25 | 6.3±0.41 | 6.0±0.37 |
实施例3 | 6.5±0.41 | 5.8±0.33<sup>A</sup> | 5.0±0.43<sup>B</sup> | 4.7±0.49<sup>C</sup> |
实施例4 | 6.8±0.27 | 5.7±0.41<sup>d</sup> | 4.9±0.47<sup>e</sup> | 4.8±0.87<sup>f</sup> |
实施例5 | 6.9±0.47 | 5.9±0.53<sup>D</sup> | 5.7±0.36<sup>E</sup> | 5.0±0.79<sup>F</sup> |
实施例6 | 6.6±0.83 | 5.7±0.47<sup>M</sup> | 4.9±0.85<sup>N</sup> | 4.6±0.98<sup>P</sup> |
实施例7 | 6.8±0.53 | 5.9±0.53<sup>D</sup> | 4.6±0.36<sup>E</sup> | 4.0±0.79<sup>F</sup> |
实施例8 | 6.8±0.88 | 5.7±0.47<sup>M</sup> | 4.5±0.85<sup>N</sup> | 4.1±0.98<sup>P</sup> |
对比例1 | 6.7±0.41 | 6.7±0.47 | 6.6±0.31 | 6.7±0.49 |
对比例2 | 6.8±0.34 | 6.8±0.45 | 6.6±0.72 | 6.8±0.93 |
对比例3 | 6.8±0.47 | 6.3±0.11<sup>a</sup> | 6.3±0.47<sup>a</sup> | 6.2±0.42<sup>a</sup> |
对比例4 | 6.4±0.21 | 6.0±0.39<sup>A</sup> | 5.9±0.11<sup>B</sup> | 5.9±0.23<sup>C</sup> |
对比例5 | 6.6±0.42 | 6.4±0.34 | 6.4±0.15 | 6.5±0.56 |
对比例6 | 6.6±0.47 | 6.5±0.76 | 6.5±0.89 | 6.4±0.54 |
对比例7 | 6.7±0.32 | 6.7±0.47 | 6.6±0.67 | 6.5±0.11 |
对比例8 | 6.5±0.89 | 6.5±0.47 | 6.4±0.61 | 6.3±0.43<sup>A</sup> |
Claims (14)
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CN111481658B (zh) * | 2020-04-29 | 2022-07-12 | 完美(广东)日用品有限公司 | 一种促进损伤关节软骨组织再生的组合物 |
CN112219958A (zh) * | 2020-07-08 | 2021-01-15 | 许昌神飞航天生物科技有限公司 | 一种针对骨关节调养的宇航级固体饮品 |
CN112675295A (zh) * | 2020-12-10 | 2021-04-20 | 浙江蓝美生物技术有限公司 | 一种可预防与改善骨关节炎症的蓝莓粉复方固体制剂及其制备方法和应用 |
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WO2022226731A1 (zh) * | 2021-04-26 | 2022-11-03 | 北京盛美诺生物技术有限公司 | 胶原蛋白产品或软骨中非变性ii型胶原蛋白定量检测的前处理方法及应用 |
WO2023150113A1 (en) * | 2022-02-02 | 2023-08-10 | Lonza Greenwood Llc | Fast acting joint health composition and use thereof |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103622013A (zh) * | 2013-11-21 | 2014-03-12 | 青岛贝尔特生物科技有限公司 | 一种供关节炎患者食用含骨胶原肽的食品配方 |
CN104645319A (zh) * | 2013-11-21 | 2015-05-27 | 杨明义 | 一种胶原蛋白口服制剂 |
CN106620659A (zh) * | 2016-12-19 | 2017-05-10 | 江苏红瑞制药有限公司 | 一种有助于骨健康的食品组合物 |
CN107126554A (zh) * | 2017-04-27 | 2017-09-05 | 北京市永康年健康科技有限责任公司 | 一种胶原蛋白制品及其制备方法和应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103622013A (zh) * | 2013-11-21 | 2014-03-12 | 青岛贝尔特生物科技有限公司 | 一种供关节炎患者食用含骨胶原肽的食品配方 |
CN104645319A (zh) * | 2013-11-21 | 2015-05-27 | 杨明义 | 一种胶原蛋白口服制剂 |
CN106620659A (zh) * | 2016-12-19 | 2017-05-10 | 江苏红瑞制药有限公司 | 一种有助于骨健康的食品组合物 |
CN107126554A (zh) * | 2017-04-27 | 2017-09-05 | 北京市永康年健康科技有限责任公司 | 一种胶原蛋白制品及其制备方法和应用 |
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