CN109010481A - 一种治疗皮肤病药物及制备方法和制剂 - Google Patents
一种治疗皮肤病药物及制备方法和制剂 Download PDFInfo
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- CN109010481A CN109010481A CN201811155721.4A CN201811155721A CN109010481A CN 109010481 A CN109010481 A CN 109010481A CN 201811155721 A CN201811155721 A CN 201811155721A CN 109010481 A CN109010481 A CN 109010481A
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- root skin
- tinea
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Abstract
本发明属于中药制备领域,具体公开了一种治疗皮肤病的药物及制备方法和制剂。治疗皮肤病的药物,它是由如下重量份数的原料制得:长叶冻绿50~150份,剪草25~75份,木鳖子根皮25~75份,银杏外种皮50~150份,银杏树根皮25~75份,蛇床子20~40份,五倍子20~40份,花椒10~30份。采用对皮肤癣症有确切功效的中药材组合,能根据临床需要制备成不同的外用制剂,使用方便。抗菌作用强,且能兼具用药舒爽,止干、止痒较快,能有效治疗皮炎、神经性皮炎、疥疮、痤疮、汗斑、手足癣、甲癣、花斑癣、体癣、股癣等皮肤病,同时对有病灶感染的糜烂性炎症,具有良好的收敛、止渗出、止痛、止痒效果,是一种较为理想的治疗皮炎、疥疮、癣疾等皮肤病的药物。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗皮肤病药物及制备方法和制剂。
背景技术
中医学认为,人体内有一些疾病可以通过皮肤反映出来,很多疾病是内脏疾病的外在表现,即皮肤发生的根本原因在于阴阳失调,血垢瘀阻、毒素累积所致。但,有些皮肤病则是因真菌、皮肤细菌感染等引起。总之,皮肤病是皮肤(包括毛发和甲)受到内外因素的影响后,其形态、结构和功能均发生变化,产生病理过程,并相应的产生各种临床先后表现。皮肤病也是严重影响人们健康的常见病症,常见的皮肤病有银屑病、湿疹、皮炎、神经性皮炎、寻常疣、过敏性红疹、疥疮、青春痘、手足癣、甲癣、花斑癣、体癣、股癣等,这些皮肤疾病经常困扰人们的幸福生活,困扰着人们的心灵和精神。精确完善的治疗能使人们充满对生活的热爱和自信。现有的中药治疗皮肤病,其配方均有单一型或局限性,或是药材组成配伍不合理,或因在加工或炮制的过程中对其有效成分提取不完整或者提取不合理、不到位,在一定程度上达不到深层治疗的效果,因而造成治疗不彻底容易复发。还有就现有的西药或中药在治疗皮肤病中不同程度的添加激素类或抗生素类药物,存在一定的毒副作用或容易产生抗体,还有部分药物达不到治疗和修复病变部位的目的,疗效局限不理想,治愈率低、反复发作,尤其是一些常见的如皮炎、神经性皮炎、痤疮、疥疮、汗斑、手足癣、甲癣、花斑癣、体癣、股癣等药效不明显,不仅能给患者造成精神压力和负担,同时还给患者增加经济负担。
发明内容
针对现有技术存在的不足,本发明提供了一种治疗皮肤病药物。
本发明还提供一种治疗皮肤病药物的制备方法。
制备一种有针对性的解决因各种细菌、真菌等造成的皮炎、神经性皮炎、疥疮、痤疮、手足癣、甲癣、花斑癣、体癣、股癣等在皮肤病防治中的应用。
为了实现上述目的,本发明具体采用了以下技术方案:
一种治疗皮肤病的药物,其特征它是由如下重量份数的原料制得:长叶冻绿50~150份,剪草25~75份,木鳖子根皮25~75份,银杏外种皮50~150份,银杏树根皮25~75份,蛇床子20~40份,五倍子20~40份,花椒10~30份。
优选地一种治疗皮肤病的药物,它是由如下重量份数的原料制得:长叶冻绿100份,剪草50份,木鳖子根皮50份,银杏外种皮100份,银杏树根皮50份,蛇床子30份,五倍子30份,花椒20份。
上述所述一种治疗皮肤病的药物的制备方法,步骤如下:
(1)先将长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、花椒分别烘干,粉碎成45目粉,另将蛇床子、五倍子分别捣碎成粉,然后按配方量称取长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、蛇床子、五倍子、花椒粉混合均匀;
(2)将步骤(1)混合均匀的药材原料粉置入渗漉器中,用5倍含量浓度为86%-90%v/v的乙醇浸60h后,按1ml·min-1的流速渗漉,直至流尽,收集渗漉液备用;
(3)将渗漉后的漉渣再加入药材原料总重量8倍量浓度含量为72%v/v的乙醇,加热回流提取3小时,过滤,得回流提取液;
(4)将步骤(3)所得回流提取液与步骤(2)所得备用渗漉液合并,回收乙醇,得流浸膏;
(5)将步骤(4)所得流浸膏置入真空干燥箱内,在温度不大于62℃条件下真空干燥至水分含量小于5%,经粉碎,即得治疗皮肤病的药物。将所得治疗皮肤病药物还含有药学可接受的辅料。
上述所述的辅料包括但不限于淀粉、糊精、β-环糊精;羧甲基纤维素、羧甲基纤维钠、羟丙甲基纤维素;黄原胶、西黄蓍胶、阿拉伯胶、白芨胶、桃胶、卡波姆;磷脂、胆固醇;凡士林、羊毛脂、豚脂、蜂蜡、鲸蜡、石蜡;海藻酸钠、滑石粉、石膏、聚氧乙烯失水山梨醇单油酸酯、聚氧乙烯蓖麻油、聚氧乙烯氢化蓖麻油、十四酸异丙酯、乙二醇单乙基醚、泊洛沙姆、硬脂酸、油酸乙酯、单硬脂酸甘油酯、硬脂酸甘油酯、十二烷基硫酸钠、十六醇、硬脂醇;麻油、豆油、棉子油、氧化植物油、蓖麻油、二甲基硅油、花生油;液体石蜡、油酸、三乙醇胺、乙二胺、磷酸盐、醋酸盐、氢氧化钠、磷酸二氢钾、磷酸二氢钠、尼泊金甲酯、尼泊金乙酯、苯扎溴铵、聚乙二醇-8-甘油辛酸/葵酸酯、中链脂肪酸甘油三酯、聚乙二醇辛基苯基醚;乙酸、丙二醇、丙三醇、聚乙二醇;二甲基亚砜、氮酮、蒸馏水、纯化水和去离子水中的一种或几种。
所述治疗皮肤病的药物为外用剂型,包括软膏剂、糊剂、水溶液剂、油溶液剂、甘油剂、胶体溶液剂、乳膏剂、微乳剂、凝胶剂、混悬剂、酊剂、散剂。
所述的凝胶剂包括微乳凝胶剂、纳米凝胶剂和脂质体凝胶剂。
本发明所述的皮肤病为包括皮炎、神经性皮炎、疥疮、痤疮、汗斑、手足癣、甲癣、花斑癣、体癣、股癣等皮肤病。
本发明的优点是:采用对皮肤癣症有确切功效的中药材组合,经渗漉和回流提取结合工艺,能有效提取其中药材的精华部分,使得用量小,质量可控,能根据临床需要制备成不同的外用制剂,且价格便宜,使用方便。抗菌作用强,且能兼具用药舒爽,止干、止痒较快,能有效治疗皮炎、神经性皮炎、疥疮、 痤疮、汗斑、手足癣、甲癣、花斑癣、体癣、股癣等皮肤病,同时对有病灶感染的糜烂性炎症,具有良好的收敛、止渗出、止痛、止痒效果,是一种较为理想的治疗皮炎、疥疮、癣疾等皮肤病的药物。
本发明方法制得的一种治疗皮肤病药物作为治疗皮炎、神经性皮炎、疥疮、 痤疮、汗斑、手足癣、甲癣、花斑癣、体癣、股癣中的应用。
长叶冻绿,为鼠李科鼠李属植物长叶冻绿Rhamnus crenatus Sieb. et Zucc.,以根入药。其根含蒽醌类化合物柯桠素(chrysarobin,C15H12O3)、大黄酚(chrysophanol,C15H10O4)等。性味苦、辛,平。具有清热利湿,杀虫止痒功能。外用治疥疮,顽癣,湿疹,脓胞疮。
剪草,为金粟兰科植物丝穗金粟兰Chloranthus fortunei(A.Gray)Solms-Lamb.的全草或根。性味辛、苦,性平。具有祛风活血,解毒消肿之功能。用于风湿痹痛,跌打损伤,疮疖癣疥,毒蛇咬伤。本发明采用的为剪草全草。
木鳖子根,为葫芦科苦瓜属植物木鳖子Momrolica cochinchinensis (Lour.)Spreng.的根。具有散结消肿,攻毒疗疮功能,适用于疮疡肿毒,乳痈,痔漏,干癣、秃疮。本发明采用的为其根皮。
银杏外种皮是银杏树种子(即银杏)硬壳外面的部分,俗称白果衣,银杏种子的皮分肉质的外种皮、骨质的中种皮和膜质的内种皮,本发明采用的银杏外种皮是银杏种子的肉质外种皮。科学家经研究发现外种皮含有大量的氢化白果酸、白果酚和白果醇,还含有银杏黄素、异银杏黄素和多糖类成分,还有微量的银杏内酯。其作用性质与环磷酰胺及地塞米松等相似。银杏外种皮的多糖类可增强细胞免疫功能,对体液免疫过程中B淋巴细胞的产生和抗体形成有作用。具文献报道,银杏外种皮中的醇类中间体,对22种临床常见致病性真菌的抑制有效率为81%;0.1%氢化白果酸抑制25种临床常见致病性真菌的有效率为92%。据报道,银杏酸有较强的杀菌和抑制作用,对于葡萄球菌、化脓性球菌、甚至对于其它真菌有抑制作用,用它治疗真菌感染的湿癣有显著的作用。对病毒引起的脓胞疮疹、扁平疣有较好的疗效。
银杏树根皮,据文献报道:银杏树根皮亦含有银杏、银杏叶、银杏外种皮的相同成分。银杏树根皮也含有白果内酯A、B、C、M(《全国中草药汇编》编写组,全国中药汇编,上册,1975年,9月,第1版,801页)。
蛇床子,为伞形科蛇床属植物蛇床Cnidium monnieri Cuss.的干燥成熟果实。性味辛、苦,温。具有燥湿祛风,杀虫止痒,温肾壮阳功能,适用于阴痒带下,湿疹瘙痒,湿痹腰痛,肾虚阳痿,宫冷不孕。
五倍子,学名Rhus chinensis Mill.,为同翅目蚜虫科的角倍蚜或倍蛋蚜雌虫寄生于漆树科植物“盐肤木”及其同属其他植物的嫩叶或叶柄,刺伤而生成一种囊状聚生物虫瘿,经烘焙干燥后所得。五倍子其性寒,味酸、涩,具有敛肺降火、涩肠止泻、敛汗止血、收湿敛疮等功效。用于肺虚止咳,便血痔血,痈肿疮毒,皮肤湿烂等症。
花椒,为芸香科花椒属植物青花椒Zanthoxylum schinifolium Sieb. et Zucc.及花椒Zanthoxylum bungeanum Maxim.的干燥成熟果皮。性味辛,温。具有温中止痛,杀虫止痒功能。适用于脘腹冷痛,呕吐,泄泻,虫积腹痛;外用于湿疹,阴痒。
具体实施方式
实施例1
治疗皮肤病药物的制备
(1)首先将长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、花椒分别烘干,粉碎成45目粉,另将蛇床子、五倍子分别捣碎成粉,然后称取长叶冻绿粉100g、剪草粉50g、木鳖子根皮粉50g、银杏外种皮粉100g、银杏树根皮粉50g、蛇床子粉30g、五倍子粉30g、花椒粉20g混合均匀;
(2)将混合均匀的药粉置入渗漉器中,加入含量浓度为88%v/v的乙醇2150g浸60h后,按1ml·min-1的流速渗漉,直至流尽,将收集渗漉液备用;
(3)将渗漉后的漉渣再加入含量浓度为72%v/v的乙醇3440g,加热回流提取3h,过滤,得回流提取液;
(4)将回流提取液与备用渗漉液合并,回收乙醇,得流浸膏;
(5)将流浸膏置入真空干燥箱内,在温度不大于62℃条件下真空干燥至水分含量为3.5%,经粉碎,得浸膏粉。
实施例2
治疗皮肤病药物的制备
(1)首先将长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、花椒分别烘干,粉碎成45目粉,另将蛇床子、五倍子分别捣碎成粉,然后称取长叶冻绿粉150g、剪草粉75g、木鳖子根皮粉75g、银杏外种皮粉150g、银杏树根皮粉75g、蛇床子粉40g、五倍子粉40g、花椒粉30g,混合均匀;
(2)将混合均匀的药粉置入渗漉器中,加入含量浓度为90%v/v的乙醇3175g浸60h后,按1ml·min-1的流速渗漉,直至流尽,将收集渗漉液备用;
(3)将渗漉后的漉渣再加入含量浓度为72%v/v的乙醇5080g,加热回流提取3h,过滤,得回流提取液;
(4)将回流提取液与备用渗漉液合并,回收乙醇,得流浸膏;
(5)将流浸膏置入真空干燥箱内,在温度不大于62℃条件下真空干燥至水分含量为4.0%,经粉碎,得浸膏粉。
实施例3
治疗皮肤病药物的制备
(1)首先将长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、花椒分别烘干,粉碎成45目粉,另将蛇床子、五倍子分别捣碎成粉,然后称取长叶冻绿粉150g、剪草粉25g、木鳖子根皮粉25g、银杏外种皮粉150g、银杏树根皮粉25g、蛇床子粉20g、五倍子粉20g、花椒粉10g混合均匀;
(2)将混合均匀的药粉置入渗漉器中,加入含量浓度为88%v/v的乙醇2125g浸60h后,按1ml·min-1的流速渗漉,直至流尽,将收集渗漉液备用;
(3)将渗漉后的漉渣再加入含量浓度为72%v/v的乙醇3400g,加热回流提取3h,过滤,得回流提取液;
(4)将回流提取液与备用渗漉液合并,回收乙醇,得流浸膏;
(5)将流浸膏置入真空干燥箱内,在温度不大于62℃条件下真空干燥至水分含量为4.5%,经粉碎,得浸膏粉。
实施例4
治疗皮肤病药物的制备
(1)首先将长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、花椒分别烘干,粉碎成45目粉,另将蛇床子、五倍子分别捣碎成粉,然后称取长叶冻绿粉120g、剪草粉35g、木鳖子根皮粉45g、银杏外种皮粉130g、银杏树根皮粉60g、蛇床子粉25g、五倍子粉25g、花椒粉15g混合均匀;
(2)将混合均匀的药粉置入渗漉器中,加入含量浓度为88%v/v的乙醇2275g浸60h后,按1ml·min-1的流速渗漉,直至流尽,将收集渗漉液备用;
(3)将渗漉后的漉渣再加入含量浓度为72%v/v的乙醇3640g,加热回流提取3h,过滤,得回流提取液;
(4)将回流提取液与备用渗漉液合并,回收乙醇,得流浸膏;
(5)将流浸膏置入真空干燥箱内,在温度不大于62℃条件下真空干燥至水分含量为4.5%,经粉碎,得浸膏粉。
实施例5
制备软膏剂
(1)取实施例4得到的浸膏粉100g,单软膏900g;
(2)取单软膏置搪瓷缸中,在水浴上加热熔化后,加浸膏粉,时时搅拌,继续加热1小时,用两层纱布滤过,不断搅拌直至冷凝,得到软膏。
其中的单软膏,为本技术领域公知的配方,其制法为取蜂蜡330g,与花生油670g置蒸发皿中,在水浴上加热,融化后,不断搅拌至冷即得。其中的花生油也可以用麻油、棉子油、豆油代替。
采用本实施例制得的软膏治疗皮炎7例,用法采用局部涂药后,用纱布覆盖包扎,一日2次换药,5天治愈者2例,7天治愈者4例,其中1例用药7天明显好转,总有效率100%。
实施例6
制备水溶液剂:
(1)取实施例4得到的浸膏粉150g,尼泊金乙酯醇溶液10g,吐温-80 5g,蒸馏水加至1000g;
(2)取适量蒸馏水,加入尼泊金乙酯醇溶液和吐温80,搅拌溶解,再加入浸膏粉搅拌使溶解,然后添加蒸馏水至全量,得水剂。由于尼泊金乙酯在水中的溶解性差和溶解度低,先将尼泊金乙酯用95%v/v的乙醇制成重量比为10%的尼泊金乙酯醇溶液,使用时,采用在搅拌下缓慢加入,其溶解性较好。
采用上述制备的水剂,治疗脚癣12例,每日涂药3-5次,用药一周后,12例脚癣患者均全部治愈。
实施例7
制备甘油剂:
(1)取实施例2得到的浸膏粉8g,甘油92g;
(2)取浸膏粉加甘油搅匀,于水浴上加热溶解,得甘油剂。
采用上述制备的甘油剂,治疗6例面颊部和额部 痤疮、,6例病例均为女性,年龄18-24岁,局部涂布,每日3次,6例患者均在一周内治愈。
实施例8
制备酊剂:
(1)取实施例3得到的浸膏粉12g,丙三醇8g,75%v/v乙醇80g;
(2)取浸膏粉加丙三醇和乙醇充分搅拌使溶解均匀,得酊剂。
采用上述制备的酊剂,治疗甲癣10例,采用局部涂布,每日3-5次,7天为一疗程,其中一个疗程治愈者3例,6例2个疗程治愈,1例好转,有效率100%。
实施例9
制备散剂:
(1)取实施例2得到的浸膏粉35g,滑石粉25g,淀粉40g;
(2)将浸膏粉与淀粉分别研细混合,分次加入滑石粉,过五号筛,得散剂。
采用上述制得的散剂,治疗因皮炎感染成糜烂性创面。患者刘某某,女性,36岁,右小腿部患皮炎感染,局部形成糜烂性创面,局部敷用散剂,纱布包裹,每日换药2次,经治疗8天后痊愈;患者钱某,男性,42岁,右上臂内测,患皮炎感染,局部敷散剂,用纱布包裹,每日换药2次,6天后治愈,患者邢某某,男,39岁,左脚面部患皮炎,因在稻田地劳作感染,局部糜烂,用散剂外敷,用纱布包裹,每天换药3次,7天治愈。
实施例10
制备糊剂:
(1)取实施例3得到的浸膏粉25g,淀粉(细粉)25g,凡士林50g;
(2)将浸膏粉、淀粉混合后,分次加入熔化的凡士林,研匀,得糊剂。
采用上述糊剂,局部涂布,每日换药2次,治疗神经性皮炎4例,7天为一疗程,其中2例1个疗程治愈,1例10天治愈。
实施例11
制备乳膏剂:
(1)取实施例1得到的浸膏粉250g,乳膏基质Ⅰ750g;
(2)取浸膏细粉,以递加稀释法加基质研匀即得,得乳膏剂。
其中乳膏基质Ⅰ是公知的较为普遍采用的乳膏剂基质,质量和稳定性均较为理想,其成分和制法如下:
成分:
甲液:硬脂酸372g,凡士林400g,单硬脂酸甘油酯372g,尼泊金甲酯4g;乙液:平平加92g,甘油1000g,蒸馏水1760g;
制法:取甲、乙两液,分别在水浴上加热约90℃,然后将甲液缓缓加入乙液中,随加随搅拌(每分钟80转为宜)至冷凝即得,制得乳膏剂4000g。
实施例12
制备乳膏剂:
(1)取实施例2得到的浸膏粉200g,乳膏基质Ⅱ800g;
(2)取浸膏细粉置乳钵内充分研磨,以递加稀释法加基质Ⅱ沿同一方向边加边研磨,至基质加完研匀即得。
其中乳膏基质Ⅱ是公知的较为普遍采用的乳膏基质,质量较为稳定,其成分和制法如下:
成分:
甲液:硬脂酸500g,蓖麻油500g,液体石蜡500g,尼泊金乙酯4g;乙液:三乙醇胺40g,甘油200g,蒸馏水2256g;
制法:将甲、乙两液,分别在水浴上加热约80℃,然后将乙液缓缓加入甲液中,沿同一方向随加随搅拌至乳化完全,冷凝即得,制得乳膏剂4000g。
采用实施例11制得的乳膏剂,治疗痤疮68例,其中女性56例,男性12例,平均年龄21-29岁,采用局部涂药,早、中、晚一天三次,5天为一疗程,其中2个疗程治愈59例,治疗2个疗程明显好转7例,1例效果不佳改用其他方法治疗,1例停药后复发,总有效率98.64%。采用实施例12得到的乳膏剂,治疗疥疮34例,其中男性28例,女性6例,年龄8-34岁,采用局部涂药,一日3次,5天为1疗程,其中22例经一个疗程治愈,其他病例均在一个半至两个疗程治愈。
本发明应当说明的是,以上实施例仅用以说明本发明的技术方案的实施,而非对本发明的限制,不影响本发明的保护范围。
Claims (8)
1.一种治疗皮肤病的药物,其特征在于,它是由如下重量份数的原料制得:长叶冻绿50~150份,剪草25~75份,木鳖子根皮25~75份,银杏外种皮50~150份,银杏树根皮25~75份,蛇床子20~40份,五倍子20~40份,花椒10~30份。
2.根据权利要求1所述的一种治疗皮肤病的药物,其特征在于,它是由如下重量份数的原料制得:长叶冻绿100份,剪草50份,木鳖子根皮50份,银杏外种皮100份,银杏树根皮50份,蛇床子30份,五倍子30份,花椒20份。
3.根据权利要求1或2所述治疗皮肤病的药物制备方法,其特征在于,步骤如下:
(1)先将长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、花椒分别烘干,粉碎成45目粉,另将蛇床子、五倍子分别捣碎成粉,然后按配方量称取长叶冻绿、剪草、木鳖子根皮、银杏外种皮、银杏树根皮、蛇床子、五倍子、花椒粉混合均匀;
(2)将步骤(1)混合均匀的药材原料粉置入渗漉器中,用5倍含量浓度为86%-90%v/v的乙醇浸60h后,按1ml·min-1的流速渗漉,直至流尽,收集渗漉液备用;
(3)将渗漉后的漉渣再加入药材原料总重量8倍量浓度含量为72%v/v的乙醇,加热回流提取3小时,过滤,得回流提取液;
(4)将步骤(3)所得回流提取液与步骤(2)所得备用渗漉液合并,回收乙醇,得流浸膏;
(5)将步骤(4)所得流浸膏置入真空干燥箱内,在温度不大于62℃条件下真空干燥至水分含量小于5%,经粉碎,即得治疗皮肤病的药物。
4.根据权利要求1或2所述的一种治疗皮肤病的药物,其特征在于,治疗皮肤病药物还含有药学可接受的辅料。
5.根据权利要求4所述的一种治疗皮肤病的药物,其特征在于,所述的辅料选自淀粉、糊精、β-环糊精;羧甲基纤维素、羧甲基纤维钠、羟丙甲基纤维素;黄原胶、西黄蓍胶、阿拉伯胶、白芨胶、桃胶、卡波姆;磷脂、胆固醇;凡士林、羊毛脂、豚脂、蜂蜡、鲸蜡、石蜡;海藻酸钠、滑石粉、石膏、聚氧乙烯失水山梨醇单油酸酯、聚氧乙烯蓖麻油、聚氧乙烯氢化蓖麻油、十四酸异丙酯、乙二醇单乙基醚、泊洛沙姆、硬脂酸、油酸乙酯、单硬脂酸甘油酯、硬脂酸甘油酯、十二烷基硫酸钠、十六醇、硬脂醇;麻油、豆油、棉子油、氧化植物油、蓖麻油、二甲基硅油、花生油;液体石蜡、油酸、三乙醇胺、乙二胺、磷酸盐、醋酸盐、氢氧化钠、磷酸二氢钾、磷酸二氢钠、尼泊金甲酯、尼泊金乙酯、苯扎溴铵、聚乙二醇-8-甘油辛酸/葵酸酯、中链脂肪酸甘油三酯、聚乙二醇辛基苯基醚;乙酸、丙二醇、丙三醇、聚乙二醇;二甲基亚砜、氮酮、蒸馏水、纯化水和去离子水中的一种或几种。
6.根据权利要求4所述的一种治疗皮肤病的药物,其特征在于,所述的治疗皮肤病药物为外用剂型,包括软膏剂、糊剂、水溶液剂、油溶液剂、甘油剂、胶体溶液剂、乳膏剂、微乳剂、微乳凝胶剂、凝胶剂、混悬剂、酊剂、散剂。
7.根据权利要求6所述的一种治疗皮肤病的药物,其特征在于,所述的外用剂型为微乳凝胶剂、纳米凝胶剂和脂质体凝胶剂。
8.根据权利要求1或2所述的一种治疗皮肤病的药物,其特征在于,所述的皮肤病为皮炎、神经性皮炎、疥疮、痤疮、汗斑、手足癣、甲癣、花斑癣、体癣、股癣。
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