CN108938800A - 一种治疗皮肤病涂液膜 - Google Patents
一种治疗皮肤病涂液膜 Download PDFInfo
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- CN108938800A CN108938800A CN201811157437.0A CN201811157437A CN108938800A CN 108938800 A CN108938800 A CN 108938800A CN 201811157437 A CN201811157437 A CN 201811157437A CN 108938800 A CN108938800 A CN 108938800A
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- ethyl alcohol
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Abstract
本发明属于中药制剂领域，具体公开了一种治疗皮肤病涂液膜，它是由长叶冻绿100g，剪草50g，木鳖子根皮50g，银杏外种皮100g，银杏树根皮50g，蛇床子30g，五倍子30g，花椒20g，冰片5g和适量的乙醇制成。本发明一种治疗皮肤病涂液膜以杀灭各种细菌和真菌为主，并兼顾杀虫止痒，对有感染形成的渗出性皮炎、痤疮、神经性皮炎、疥疮、手足癣等有显著疗效。用药量小，且有较好的临床治疗效果，特别是因感染而形成的创面渗出，治疗使用方便，患者普遍乐意接受，药物价格较低，能够显现出本发明治疗皮肤病的涂液膜具有很好的应用前景。
Description
技术领域
本发明属于中药制剂领域，具体涉及一种治疗皮肤病涂液膜。
背景技术
中医学认为，人体内有一些疾病可以通过皮肤反映出来，很多疾病是内脏疾病的外在表现，即皮肤发生的根本原因在于阴阳失调，血垢瘀阻、毒素累积所致。但，有些皮肤病则是因真菌、皮肤细菌感染等引起。总之，皮肤病是皮肤（包括毛发和甲）受到内外因素的影响后，其形态、结构和功能均发生变化，产生病理过程，并相应的产生各种临床先后表现。皮肤病也是严重影响人们健康的常见病症，常见的皮肤病有银屑病、湿疹、皮炎、神经性皮炎、寻常疣、过敏性红疹、疥疮、青春痘、手足癣、甲癣、花斑癣、体癣、股癣等，这些皮肤疾病经常困扰人们的幸福生活，困扰着人们的心灵和精神。精确完善的治疗能使人们充满对生活的热爱和自信。现有的中药治疗皮肤病，其配方均有单一型或局限性，或是药材组成配伍不合理，或因在加工或炮制的过程中对其有效成分提取不完整或者提取不合理、不到位，在一定程度上达不到深层治疗的效果，因而造成治疗不彻底容易复发。还有就现有的西药或中药在治疗皮肤病中不同程度的添加激素类或抗生素类药物，存在一定的毒副作用或容易产生抗体，还有部分药物达不到治疗和修复病变部位的目的。就目前针对皮肤病常用的水剂、酊剂等疗效局限不理想，治愈率低、反复发作，尤其是一些常见的如有渗出液的皮炎、神经性皮炎、痤疮、手足癣等用药不便和药效不明显，不仅能给患者造成精神压力和负担，同时还给患者增加经济负担。
发明内容
针对现有技术存在的不足，本发明提供了一种治疗皮肤病涂液膜，制备一种有针对性的解决因各种细菌、真菌感染等造成的渗出性皮炎、神经性皮炎、痤疮、手足癣等的治疗问题的涂液膜。
为了实现上述目的，本发明具体采用了以下技术方案：
一种治疗皮肤病涂液膜，其特征在于，它是由长叶冻绿100g，剪草50g，木鳖子根皮50g，银杏外种皮100g，银杏树根皮50g，蛇床子30g，五倍子30g，花椒20g，冰片5g制成，具体步骤如下：取长叶冻绿、剪草、木鳖子根皮、花椒分别粉碎成24目粗粉，取蛇床子、五倍子分别碾碎，然后将药材粉混合，加入含量浓度为75％v/v乙醇回流提取2次，第一次加药材总重量5倍乙醇，提取2.5h，第二次加药材总重量3倍乙醇，提取1.5h，合并提取液，回收乙醇，浓缩至相当药材总重量的浓缩液，然后将浓缩液加入3倍量的纯净水稀释，得稀释液，将稀释液经120℃蒸汽处理35min后，放置1h，抽滤除去鞣质聚合物沉淀，然后蒸干溶剂得提取物，取适量含量浓度为70％v/v的乙醇将冰片溶解，再将提取物加入冰片乙醇溶液和适量的含量浓度为70％v/v乙醇，研磨均匀，使成比重为1.35-1.43的稠膏，备用，得A液；取银杏外种皮、银杏树根皮分别切成碎粒状，混合，用含量浓度为70％v/v的乙醇回流提取3次，第一次加药材总重量3倍乙醇，提取2h，第二次加药材总重量2倍乙醇，提取1h，第三次加药材总重量1倍乙醇，提取0.5h，合并三次提取液，置于0℃-2℃条件下冷藏24h后，抽滤，抽滤液回收乙醇，浓缩至比重为1.25-1.30，备用，得B液；将上述分别得到的A液和B液混合搅匀，并调至呈棕黑色糊状，密闭包装即得。
本发明方法制得的一种治疗皮肤病涂液膜作为治疗皮炎、神经性皮炎、痤疮、疥疮、手足癣等因感染而形成的渗出性炎症的用途。
长叶冻绿，为鼠李科鼠李属植物长叶冻绿Rhamnus crenatus Sieb. et Zucc.，以根入药。其根含蒽醌类化合物柯桠素（chrysarobin，C15H12O3）、大黄酚（chrysophanol，C15H10O4）等。性味苦、辛，平。具有清热利湿，杀虫止痒功能。外用治疥疮，顽癣，湿疹，脓胞疮。
剪草，为金粟兰科植物丝穗金粟兰Chloranthus fortunei（A.Gray）Solms-Lamb.的全草或根。性味辛、苦，性平。具有祛风活血，解毒消肿之功能。用于风湿痹痛，跌打损伤，疮疖癣疥，毒蛇咬伤。本发明采用的为剪草全草。
木鳖子根，为葫芦科苦瓜属植物木鳖子Momrolica cochinchinensis (Lour.)Spreng.的根。具有散结消肿，攻毒疗疮功能，适用于疮疡肿毒，乳痈，痔漏，干癣、秃疮。本发明采用的为其根皮。
银杏外种皮是银杏树种子（即银杏）硬壳外面的部分，俗称白果衣，银杏种子的皮分肉质的外种皮、骨质的中种皮和膜质的内种皮，本发明采用的银杏外种皮是银杏种子的肉质外种皮。科学家经研究发现外种皮含有大量的氢化白果酸、白果酚和白果醇，还含有银杏黄素、异银杏黄素和多糖类成分，还有微量的银杏内酯。其作用性质与环磷酰胺及地塞米松等相似。银杏外种皮的多糖类可增强细胞免疫功能，对体液免疫过程中B淋巴细胞的产生和抗体形成有作用。具文献报道，银杏外种皮中的醇类中间体，对22种临床常见致病性真菌的抑制有效率为81%；0.1%氢化白果酸抑制25种临床常见致病性真菌的有效率为92%。据报道，银杏酸有较强的杀菌和抑制作用，对于葡萄球菌、化脓性球菌、甚至对于其它真菌有抑制作用，用它治疗真菌感染的湿癣有显著的作用。对病毒引起的脓胞疮疹、扁平疣有较好的疗效。
银杏树根皮，据文献报道：银杏树根皮亦含有银杏、银杏叶、银杏外种皮的相同成分。银杏树根皮也含有白果内酯A、B、C、M（《全国中草药汇编》编写组，全国中药汇编，上册，1975年，9月，第1版，801页）。
蛇床子，为伞形科蛇床属植物蛇床Cnidium monnieri Cuss.的干燥成熟果实。性味辛、苦，温。具有燥湿祛风，杀虫止痒，温肾壮阳功能，适用于阴痒带下，湿疹瘙痒，湿痹腰痛，肾虚阳痿，宫冷不孕。
五倍子，学名Rhus chinensis Mill.，为同翅目蚜虫科的角倍蚜或倍蛋蚜雌虫寄生于漆树科植物“盐肤木”及其同属其他植物的嫩叶或叶柄，刺伤而生成一种囊状聚生物虫瘿，经烘焙干燥后所得。五倍子其性寒，味酸、涩，具有敛肺降火、涩肠止泻、敛汗止血、收湿敛疮等功效。用于肺虚止咳，便血痔血，痈肿疮毒，皮肤湿烂等症。
花椒，为芸香科花椒属植物青花椒Zanthoxylum schinifolium Sieb. et Zucc.及花椒Zanthoxylum bungeanum Maxim.的干燥成熟果皮。性味辛，温。具有温中止痛，杀虫止痒功能。适用于脘腹冷痛，呕吐，泄泻，虫积腹痛；外用于湿疹，阴痒。
冰片，为无色透明或白色半透明的片状松脆结晶；气清香，味辛，凉。本品在药剂中作为透皮促进剂，能增加透皮给药药物的透过率。
本发明的有益效果
本发明一种治疗皮肤病涂液膜用时将病灶病变渗出液擦去后，立即用圆形或扁形长条物蘸取涂液，均匀涂敷于创面成一薄层，4-5min后即成膜。
本发明一种治疗皮肤病涂液膜以杀灭各种细菌和真菌为主，并兼顾杀虫止痒，对有感染形成的渗出性皮炎、痤疮、神经性皮炎、疥疮、手足癣等有显著疗效。本发明涂液膜制品成膜迅速，且愈合后不留瘢痕；涂液膜可以代替纱布敷料裹伤，防止水浸湿纱布而使创面感染和长入纱布网眼中新生肉芽在揭下时撕裂出血进一步损伤创面组织大大减轻了患者的痛苦。本发明治疗皮肤病的涂液膜为纯中药配制，保持了天然的药物毒性小，疗效好的特点，疗效明确，由于本发明是将药物的提取成分制成一种外用涂液膜，制备方法简单，不用裱褙材料，且使用方便，将涂液膜涂于患处，待涂液膜涂布干燥后，在患处形成的膜具有一定的抗断裂性，可减少药物的流动性，将涂液膜涂于患处，形成薄膜后，使药物逐渐释放起到治疗作用，能够使所含药物均衡吸收产生疗效。从临床应用上看本发明涂液膜使用方便，用药量小，且有较好的临床治疗效果，特别是因感染而形成的创面渗出，治疗使用方便，患者普遍乐意接受，药物价格较低，能够显现出本发明治疗皮肤病的涂液膜具有很好的应用前景。
具体实施方式
实施例1
治疗皮肤病涂液膜的制备
（1）取长叶冻绿100g，剪草50g，木鳖子根皮50g，花椒20g分别粉碎成24目粗粉，取蛇床子30g、五倍子30g分别碾碎，然后将药材粉混合；
（2）向混合粉加入含量浓度为75％v/v乙醇1400g，回流提取2.5h，过滤，取提取液，将药渣再加入75％v/v乙醇840g，回流提取1.5h，过滤，取提取液，将二次回流提取液合并，回收乙醇，浓缩成280g浓缩液，然后将浓缩加入840g纯净水稀释，得稀释液，将稀释液经120℃蒸汽处理35min后，放置1h，抽滤，除去鞣质聚合物沉淀，然后蒸干溶剂，得提取物；
（3）先取适量含量浓度为70％v/v乙醇将5g冰片溶解，得冰片乙醇溶液，再将提取物加入冰片乙醇溶液和适量的70％v/v乙醇，研磨均匀，使成比重为1.35的稠膏，备用，得A液；
（4）取银杏外种皮100g、银杏树根皮50g，分别切成碎粒状，混合，加入含量浓度为70％v/v的乙醇450g，回流提取2h，滤取提取液，将药渣再加入含量浓度为70％v/v的乙醇300g，回流提取1h，滤取提取液，再将药渣加入含量浓度为70％v/v的乙醇150g，回流提取0.5h，滤取提取液，将三次提取液合并，置于0℃条件下冷藏24h后，抽滤，抽滤液回收乙醇，浓缩至比重为1.30，备用，得B液；
（5）将步骤（3）所得A液与步骤（4）所得B液混合搅匀，并调至呈棕黑色糊状，用玻璃瓶定量分装，密闭包装即得。
实施例2
治疗皮肤病涂液膜的制备
（1）取长叶冻绿100g，剪草50g，木鳖子根皮50g，花椒20g分别粉碎成24目粗粉，取蛇床子30g、五倍子30g分别碾碎，然后将药材粉混合；
（2）向混合粉加入含量浓度为75％v/v乙醇1400g，回流提取2.5h，过滤，取提取液，将药渣再加入75％v/v乙醇840g，回流提取1.5h，过滤，取提取液，将二次回流提取液合并，回收乙醇，浓缩成280g浓缩液，然后将浓缩加入840g纯净水稀释，得稀释液，将稀释液经120℃蒸汽处理35min后，放置1h，抽滤，除去鞣质聚合物沉淀，然后蒸干溶剂，得提取物；
（3）先取适量含量浓度为70％v/v乙醇将5g冰片溶解，得冰片乙醇溶液，再将提取物加入冰片乙醇溶液和适量的70％v/v乙醇，研磨均匀，使成比重为1.43的稠膏，备用，得A液；
（4）取银杏外种皮100g、银杏树根皮50g，分别切成碎粒状，混合，加入含量浓度为70％v/v的乙醇450g，回流提取2h，滤取提取液，将药渣再加入含量浓度为70％v/v的乙醇300g，回流提取1h，滤取提取液，再将药渣加入含量浓度为70％v/v的乙醇150g，回流提取0.5h，滤取提取液，将三次提取液合并，置于1℃条件下冷藏24h后，抽滤，抽滤液回收乙醇，浓缩至比重为1.25，备用，得B液；
（5）将步骤（3）所得A液与步骤（4）所得B液混合搅匀，并调至呈棕黑色糊状，用玻璃瓶定量分装，密闭包装即得。
实施例3
治疗皮肤病涂液膜的制备
（1）取长叶冻绿100g，剪草50g，木鳖子根皮50g，花椒20g分别粉碎成24目粗粉，取蛇床子30g、五倍子30g分别碾碎，然后将药材粉混合；
（2）向混合粉加入含量浓度为75％v/v乙醇1400g，回流提取2.5h，过滤，取提取液，将药渣再加入75％v/v乙醇840g，回流提取1.5h，过滤，取提取液，将二次回流提取液合并，回收乙醇，浓缩成280g浓缩液，然后将浓缩加入840g纯净水稀释，得稀释液，将稀释液经120℃蒸汽处理35min后，放置1h，抽滤，除去鞣质聚合物沉淀，然后蒸干溶剂，得提取物；
（3）先取适量含量浓度为70％v/v乙醇将5g冰片溶解，得冰片乙醇溶液，再将提取物加入冰片乙醇溶液和适量的70％v/v乙醇，研磨均匀，使成比重为1.39的稠膏，备用，得A液；
（4）取银杏外种皮100g、银杏树根皮50g，分别切成碎粒状，混合，加入含量浓度为70％v/v的乙醇450g，回流提取2h，滤取提取液，将药渣再加入含量浓度为70％v/v的乙醇300g，回流提取1h，滤取提取液，再将药渣加入含量浓度为70％v/v的乙醇150g，回流提取0.5h，滤取提取液，将三次提取液合并，置于2℃条件下冷藏24h后，抽滤，抽滤液回收乙醇，浓缩至比重为1.275，备用，得B液；
（5）将步骤（3）所得A液与步骤（4）所得B液混合搅匀，并调至呈棕黑色糊状，用玻璃瓶定量分装，密闭包装即得。
典型病例
翟某某，男，48岁，左小腿下部患有皮炎半年多，因感染，产生大面积渗出，将局部用生理盐水冲洗后，利用本发明涂液膜涂敷，每日早晚各涂一次，经治疗7天后，痊愈，随访半年，未见复发。
Claims (2)
1.一种治疗皮肤病涂液膜，其特征在于，它是由长叶冻绿100g，剪草50g，木鳖子根皮50g，银杏外种皮100g，银杏树根皮50g，蛇床子30g，五倍子30g，花椒20g，冰片5g制成，具体步骤如下：取长叶冻绿、剪草、木鳖子根皮、花椒分别粉碎成24目粗粉，取蛇床子、五倍子分别碾碎，然后将药材粉混合，加入含量浓度为75％v/v乙醇回流提取2次，第一次加药材总重量5倍乙醇，提取2.5h，第二次加药材总重量3倍乙醇，提取1.5h，合并提取液，回收乙醇，浓缩至相当药材总重量的浓缩液，然后将浓缩液加入3倍量的纯净水稀释，得稀释液，将稀释液经120℃蒸汽处理35min后，放置1h，抽滤除去鞣质聚合物沉淀，然后蒸干溶剂得提取物，取适量含量浓度为70％v/v的乙醇将冰片溶解，再将提取物加入冰片乙醇溶液和适量的含量浓度为70％v/v乙醇，研磨均匀，使成比重为1.35-1.43的稠膏，备用，得A液；取银杏外种皮、银杏树根皮分别切成碎粒状，混合，用含量浓度为70％v/v的乙醇回流提取3次，第一次加药材总重量3倍乙醇，提取2h，第二次加药材总重量2倍乙醇，提取1h，第三次加药材总重量1倍乙醇，提取0.5h，合并三次提取液，置于0℃-2℃条件下冷藏24h后，抽滤，抽滤液回收乙醇，浓缩至比重为1.25-1.30，备用，得B液；将上述分别得到的A液和B液混合搅匀，并调至呈棕黑色糊状，密闭包装即得。
2.根据权利要求1所述治疗皮肤病涂液膜作为治疗皮炎、神经性皮炎、痤疮、疥疮、手足癣等因感染而形成的渗出性炎症的用途。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110236264A (zh) * | 2019-07-04 | 2019-09-17 | 邳州市尕星医药技术服务有限公司 | 一种防治足癣的丝瓜络药物鞋垫 |
| CN110301717A (zh) * | 2019-07-04 | 2019-10-08 | 邳州市尕星医药技术服务有限公司 | 一种基于防治足癣的鞋垫 |
| CN110301716A (zh) * | 2019-07-04 | 2019-10-08 | 邳州市尕星医药技术服务有限公司 | 一种防治脚气的鞋垫 |
| CN110313682A (zh) * | 2019-07-04 | 2019-10-11 | 邳州市尕星医药技术服务有限公司 | 一种抗真菌除臭保健鞋垫 |
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| CN110236264A (zh) * | 2019-07-04 | 2019-09-17 | 邳州市尕星医药技术服务有限公司 | 一种防治足癣的丝瓜络药物鞋垫 |
| CN110301717A (zh) * | 2019-07-04 | 2019-10-08 | 邳州市尕星医药技术服务有限公司 | 一种基于防治足癣的鞋垫 |
| CN110301716A (zh) * | 2019-07-04 | 2019-10-08 | 邳州市尕星医药技术服务有限公司 | 一种防治脚气的鞋垫 |
| CN110313682A (zh) * | 2019-07-04 | 2019-10-11 | 邳州市尕星医药技术服务有限公司 | 一种抗真菌除臭保健鞋垫 |
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