CN108936662A - A kind of preparation method of the bitter gourd health food of auxiliary hyperglycemic - Google Patents
A kind of preparation method of the bitter gourd health food of auxiliary hyperglycemic Download PDFInfo
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- CN108936662A CN108936662A CN201810893240.7A CN201810893240A CN108936662A CN 108936662 A CN108936662 A CN 108936662A CN 201810893240 A CN201810893240 A CN 201810893240A CN 108936662 A CN108936662 A CN 108936662A
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- balsam pear
- mulberries
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The present invention provides a kind of preparation method of the bitter gourd health food of auxiliary hyperglycemic, rationally compounding is carried out by the way that the water of balsam pear alcohol extract and Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA is mentioned composition to be made, specifically include the component of following parts by weight: 60-70 parts of balsam pear alcohol extract, Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA water mention 30-40 parts of composition, be made of raw material Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA by the mass ratio of 30-35:20-25:5-8:5-8 wherein the water mentions composition.Present invention significantly reduces fasting blood sugar amounts, compared with the prior art, have effects that quite or more preferably auxiliary hyperglycemic, to produce synergistic effect.Simultaneously as raw material all has the features such as resourceful, widely distributed, cheap and easy to get, production process is relatively simple, and operating cost is relatively low, is more suitable for ordinary consumption group, and safety is good.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of balsam pear health-care food with auxiliary hyperglycemic
The preparation of product.
Background technique
Diabetes are a kind of incretion metabolism diseases, with the secondary fat of hyperglycemia and hyperglycemia, protein, water, electrolysis
The disorders such as matter are characterized, and typical performance is more drinks, more foods, diuresis and syntexis, are under the jurisdiction of " quenching one's thirst " scope of Chinese medicine.With existing
For diet and living-pattern preservation, illness rate rises year by year trend.At present clinically, hypoglycemic main ingredient is still west
Medicine, however there is more side effects in the treatment for Western medicine, study natural integration of drinking and medicinal herbs class raw material in this side of auxiliary hyperglycemic
The effect in face is the trend of modern development.
Balsam pear alias balsam pear, balsam pear etc., be Curcurbitaceae balsam pear platymiscium balsam pear (Momordica charantia L.)
Fruit, have it is clearing heat and detoxicating, nourish strong, improving eyesight and relieve fatigue and other effects, can also reduce blood glucose, antibacterial, antiviral and mention
High immunity, while being also common food and medicament dual-purpose (integration of drinking and medicinal herbs) class edible vegetable, there is resourceful, widely distributed, valence
Honest and clean the features such as being easy to get, great application value.But during being applied as health food, it was also found that since balsam pear has
Certain bitter taste, directly edible balsam pear, on the one hand, bitter substance therein may bring bad eat to some consumers
Experience, to affect the further application and development of its product；And on the other hand, after functional component content is relatively extracted
It is lower for extract, then need to add more balsam pear raw materials to reach same effect of lowering blood sugar, this further makes
At the exacerbation of product bitter taste.
Siraitia grosvenorii is the fruit of Curcurbitaceae perennial root liana Siraitia grosvenorii, belongs to the distinctive economy in China and medicine
With plant, containing a variety of active ingredients such as flavones, polysaccharide, sweet tea glycosides and polyphenol, modern pharmacological research is confirmed, with hypoglycemic etc.
Pharmacological action, active blood sugar-lowering substances mainly have the substances such as mogroside, grosvenor momordica flavonoid and momordica grosvenori polysaccharide.Mulberries
It is the ripening fruits of mulberry tree, it is one of the fruit of people's often feeding that sweet juice is mostly, bright with liver-kidney tonifying, fluid dryness, black hair
Mesh and other effects, while also having certain auxiliary hyperglycemic and other effects.Corn stigma as corn's by-products, rich in polysaccharide isoreactivity at
Point, there is hypoglycemic, lipid-loweringing and other effects, and its resource is huge, have many advantages, such as abundance, it is cheap, be easy to collect, but mesh
The preceding development and utilization to it are very limited, most of to be abandoned in vain, cause the wasting of resources.And STEVIA REBAUDIANA is composite family Eupatorium
The leaf of plant Stevia rebaudiana has and promotes the production of body fluid to quench thirst, is blood pressure lowering, hypoglycemic and other effects, can be used as natural sweet taste low in calories
Agent uses, and is one of the raw material of food and pharmaceutical industries.As it can be seen that above-mentioned Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA, are removed
Have effects that outside certain auxiliary hyperglycemic, raw material itself also has certain sweet taste, taste and sweet mouthfeel is easily connect by consumer
By.
If but above-mentioned raw materials be used alone, the taste of product is relatively simple, and the effect of lowering blood sugar of single component is not
Significantly.Although existing lot of documents discloses the Ricipe for health care food with auxiliary hyperglycemic in this regard, in the prior art,
For current overall technology situation, there are such as following problems in such health food:
(1) on health-care efficacy, although raw material multiplicity is selected to increasingly focus on the blood sugar reducing function individually played in its own, for
It is less with the research for reaching synergy that how rationally compounding is carried out between raw material, and experiments prove that more；Although existing
It is involved in technology and balsam pear is used to prepare assistant hypoglycemia healthcare food as raw material, also known corn stigma, Siraitia grosvenorii, mulberry
Shen, STEVIA REBAUDIANA etc. more or less have some Hyperglycemic health care effects, are also mostly common integration of drinking and medicinal herbs raw material, but it is each
When a raw material individually adds, blood sugar decreasing effect is not mostly significant.
(2) in edible quality, have effects that the balsam pear product of auxiliary hyperglycemic is also more on taste flavor on the market at present
Shortcomings, although such as balsam pear raw material itself have certain effect of lowering blood sugar, be used alone when effect performance more
It is limited, and since itself has the characteristics that bitter, exist and how to compound to realize the function of reducing blood sugar, again that can give full play to balsam pear
Avoid the problem that the above-mentioned technical assignment that may cause.
(3) in preparation method, balsam pear product on the market is mostly the form that balsam pear raw material is directly made to powdery, or multiple again
With being used for composition or convection drying is made Ilex Latifolia Thunb, balsam pear slice etc. and brews and drinks, do not extract pointedly its effectively at
Point and realize hypoglycemic application, while mostly preparation method using general processing step, and it is non-selected targetedly
Process conditions and parameter optimization.
Summary of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the purpose of the present invention is to provide one kind to have effects that auxiliary hyperglycemic
Health food and preparation method thereof, it is final to determine to extract hardship by the independent and combination experiment of a variety of integration of drinking and medicinal herbs raw materials
The balsam pear alcohol extract of melon effective component, collocation Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA water mention composition, it is wide that consumer is made
The food product forms of general receiving, such as taken in a manner of brewing and drinking, for auxiliary hyperglycemic effect, there is collaboration
Synergistic effect significantly reduces fasting blood sugar amount, compared with the prior art, has quite or more preferably auxiliary hyperglycemic function
Effect, and the homologous substance of natural medicine-food that raw material mostly uses cost more cheap, cost of manufacture is lower and safety is good.
Specifically, the present invention is achieved through the following technical solutions；
The purpose of the present invention is to provide a kind of preparation method of the bitter gourd health food of auxiliary hyperglycemic, and preparation method includes:
(1) pretreatment of raw material: taking balsam pear, Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA, pre-processes through raw material screening, cleaning etc.
Afterwards, it is crushed respectively；
(2) water proposes the preparation of composition: taking Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA mixing of the step (1) through crushing, mixture
Distilled water is added, impregnates, ultrasonic wave batch process is used when water extracts, extraction process is recycled with this；Fetch water extracting solution, through from
The heart crushes after taking supernatant, concentration, vacuum freeze drying, obtains water and mentions composition；
(3) preparation of balsam pear alcohol extract: taking balsam pear raw material of the step (1) through crushing, and dry after pretreatment, crushing, ethyl alcohol mentions
It takes, while carrying out ultrasonic wave batch process, extraction process is recycled with this；It filters to get filtrate, the paste that recycles ethyl alcohol and will obtain
Object carries out vacuum freeze drying, and balsam pear alcohol extract is obtained after crushing；
(4) Siraitia grosvenorii that takes step (2) to obtain, mulberries, corn stigma, STEVIA REBAUDIANA water mention composition and step (3) obtains
Balsam pear alcohol extract is made after mixing, packaging, sterilizing.
Preferably, the Siraitia grosvenorii through crushing, mulberries, corn stigma, STEVIA REBAUDIANA, according to the matter of 30-35:20-25:5-8:5-8
The mixing of amount ratio.
It is further preferred that the Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA water mention composition, press 35 by raw material:
The mass ratio of 23:7:5 mixes.
Preferably, in parts by weight, the Siraitia grosvenorii that takes step (2) to obtain, mulberries, corn stigma, STEVIA REBAUDIANA water mention
Obtain 60-70 parts of balsam pear alcohol extract of 30-40 parts of composition and step (3) are made after mixing, packaging, sterilizing.
It is further preferred that in the step (4), the Siraitia grosvenorii, mulberries, the corn stigma, STEVIA REBAUDIANA that take step (2) to obtain
Water mention 35 parts of composition and step (3) obtains 65 parts of balsam pear alcohol extract.
Preferably, the step (2) water proposes the preparation of composition: taking Siraitia grosvenorii, mulberries, jade of the step (1) through crushing
Rice palpus, STEVIA REBAUDIANA mixing, mixture are added distilled water according to the ratio of solid-liquid ratio 1:30-60(m/v), impregnate 30-60min, water
Ultrasonic wave batch process is used when extraction, the 5-10min per treatment under the conditions of 500-800W, 40-80 DEG C stands 5min, then
It is ultrasonically treated 5-10min, then stands 5min, extraction process 30-90min is recycled with this；Water intaking extracting solution, is centrifuged, takes supernatant
It is crushed after liquid, concentration, vacuum freeze drying, obtains water and mention composition；
It is further preferred that described step (2) water proposes the preparation of composition: taking Siraitia grosvenorii, corn of the step (1) through crushing
Palpus, STEVIA REBAUDIANA and mulberries mixing, mixture are added distilled water according to the ratio of solid-liquid ratio 1:50(m/v), impregnate 60min, and water mentions
Ultrasonic wave batch process is used when taking, the 10min per treatment under the conditions of 600W, 60 DEG C stands 5min, is then sonicated
10min, then 5min is stood, extraction process 90min is recycled with this；Water intaking extracting solution, is centrifuged, takes supernatant, concentration, vacuum cold
Freeze crushed after being dried, obtains water and mention composition.
Preferably, the preparation of the step (3) balsam pear alcohol extract: balsam pear raw material of the step (1) through crushing is taken, is located in advance
Concentration 50-90wt% ethyl alcohol is added according to the ratio of solid-liquid ratio 1:20-40(m/v) in dry after reason, crushing, and ethyl alcohol, which extracts, to be used
Ultrasonic wave batch process is carried out under the conditions of 200-400W, 30-50 DEG C, 1-5min per treatment stands 5min, is then sonicated
1-5min, then 5min is stood, extraction process 30-60min is recycled with this；It filters to get filtrate, the paste that recycles ethyl alcohol and will obtain
Object carries out vacuum freeze drying, and balsam pear alcohol extract is obtained after crushing；
It is further preferred that the preparation of described step (3) the balsam pear alcohol extract: balsam pear raw material of the step (1) through crushing is taken, through pre-
Concentration 80wt% ethyl alcohol is added according to the ratio of solid-liquid ratio 1:30(m/v) in dry after processing, crushing, and ethyl alcohol, which extracts, to be used
300W, ultrasonic wave batch process is carried out under the conditions of 40 DEG C, 5min per treatment stands 5min, is then sonicated 5min, then stand
5min recycles extraction process 60min with this；It filters to get filtrate, recycle ethyl alcohol and does the progress vacuum refrigeration of obtained paste
It is dry, balsam pear alcohol extract is obtained after crushing.
Compared with prior art, the present invention having the following beneficial effects:
(1) for the selection of raw material, of the invention one is big, and technical contribution point is, at present on the market have auxiliary drop
Taste existing for the bitter gourd health food of blood glucose effect is more bitter, on taste flavor more Shortcomings and can not large amounts of food ask
Balsam pear, corn stigma, Siraitia grosvenorii, mulberries, STEVIA REBAUDIANA these types raw material, are creatively reasonably combined by topic, and determine
To extract the balsam pear alcohol extract of balsam pear effective component, collocation Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA water mention composition.It is first
First, further enhance the edible experience of consumer, avoid product it is excessively bitter brought by influence, i.e., selection Siraitia grosvenorii, mulberries,
The combination of corn stigma, STEVIA REBAUDIANA, using sweet taste mouthfeel possessed by the composition, neutralizes while enhancing effect of lowering blood sugar
The bitter taste of Bitter Melon P.E, make the taste flavor of finally obtained product more it is soft it is agreeable to the taste, flavor is moderate.Secondly, for upper
The relatively limited defect of the performance of effect when material composition is used alone is stated, the reasonable combination of raw material is carried out, it is excellent to give full play to its
The feature of gesture complementation, further improves the effect of lowering blood sugar of product, and a combination thereof is made to have the function of synergy, compared to
The prior art has effects that quite or more preferably auxiliary hyperglycemic.Furthermore above-mentioned raw materials belong to the material of integration of drinking and medicinal herbs more, and
The features such as resourceful, widely distributed, cheap and easy to get is all had, production process is relatively simple, and operating cost is relatively low, is more suitable for
Ordinary consumption group, and safety is also better than and takes Western medicine drug.
(2) for being adapted to the optimization of technique, another technical contribution point of the invention is, according to raw material balsam pear, Siraitia grosvenorii,
Mulberries, corn stigma in STEVIA REBAUDIANA the characteristics of hypoglycemic effective component, are grasped accordingly by the extracting mode that alcohol extracting or water mention
Make, for raw material, the concentration of target effective ingredient greatly improves obtained extract, is playing concentration, purifying work
With while, but also consumer, which takes less product formulation, can obtain identical effect of lowering blood sugar.Meanwhile passing through ultrasound
Wave interval is extracted, and has the function of that collaboration promotes to extraction process, the cavitation etc. generated by ultrasound, after crushed
Balsam pear, Siraitia grosvenorii, mulberries, corn stigma, Stevia rebaudiana starting material, interior tissue is repeatedly subjected to compression and stretching action, in raw material
It is formd hole (cavitation bubble) in portion's tissue, recycles pressure difference to make cell wall rupture, so that functional component is preferably thin
Dissolution intracellular to substantially increase the dissolution recovery rate of functional component, and then passes through the phase of each raw material effect of lowering blood sugar ingredient
Interaction makes bitter gourd health food of the invention compared with the blood sugar decreasing effect of existing product, significantly improves.
(3) for application prospect, by comparative experimental data it can be confirmed that the fasting blood of bitter gourd health food of the invention
Sugared measured value reduction is statistically significant, and the experimental result for reducing fasting blood-glucose is positive, and has significant auxiliary hyperglycemic
Effect.Colleague, is used alone compared to each raw material and other combination matchings, formula of the invention also have synergistic work
With, and compared with the prior art, have effects that quite or more preferably auxiliary hyperglycemic, quantification effect have exceeded those skilled in the art
The expection of member.
Specific embodiment
Further illustrate that the present invention, following embodiment are the specific embodiment party of the present invention below by specific embodiment
Formula, but embodiments of the present invention are not limited by following embodiments.
Embodiment 1:
Water is made by the mass ratio of 35:23:7:5 in raw material Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA and mentions composition, is prepared
Method includes: (1) pretreatment of raw material: Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA are taken, after raw material screening, cleaning pretreatment,
It is crushed respectively；(2) water proposes the preparation of composition: Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA of the step (1) through crushing are taken,
It is mixed according to above-mentioned mass ratio, distilled water is added according to the ratio of solid-liquid ratio 1:50(m/v) in mixture, impregnates 60min, and water mentions
Ultrasonic wave batch process is used when taking, the 10min per treatment under the conditions of 600W, 60 DEG C stands 5min, is then sonicated
10min, then 5min is stood, extraction process 90min is recycled with this；Water intaking extracting solution, is centrifuged, takes supernatant, concentration, vacuum cold
Freeze crushed after being dried, obtains water and mention composition.
Embodiment 2:
By raw material Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA, water is made by the mass ratio of 30:25:7:8 and mentions composition, it is specific to make
Preparation Method is the same as embodiment 1.
Embodiment 3:
By raw material Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA, water is made by the mass ratio of 35:20:8:7 and mentions composition, it is specific to make
Preparation Method is the same as embodiment 1.
Comparative example A 1-13:
By raw material Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA, water is made by different mass ratioes and mentions composition (specifically with such as
Shown in table 1), it is specific that the preparation method is the same as that of Example 1.
Table 1
Embodiment 4-6 and comparative example B1-3:
A kind of preparation method of the bitter gourd health food of auxiliary hyperglycemic, preparation method include: (1) pretreatment of raw material: taking arhat
Fruit, mulberries, corn stigma and STEVIA REBAUDIANA are crushed respectively after raw material screening, cleaning pretreatment；(2) water proposes the system of composition
It is standby: by raw material corn stigma, Siraitia grosvenorii and mulberries by the mass ratio of 35:23:7:5 (i.e. using the formula of embodiment 1 and preparation side
Method) be made Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA water mention composition；The preparation of balsam pear alcohol extract: (3) balsam pear alcohol extract
Preparation: taking balsam pear raw material of the step through crushing, and dry after pretreatment, crushing is added according to the ratio of solid-liquid ratio 1:30(m/v)
Concentration 80wt% ethyl alcohol, ethyl alcohol are extracted using progress ultrasonic wave batch process under the conditions of 300W, 40 DEG C, 5min per treatment,
5min is stood, 5min is then sonicated, then stand 5min, extraction process 60min is recycled with this；It filters to get filtrate, recycles ethyl alcohol
And obtained paste is subjected to vacuum freeze drying, balsam pear alcohol extract is obtained after crushing；(4) in parts by weight, difference is taken
The balsam pear alcohol extract and Siraitia grosvenorii of ratio, mulberries, corn stigma, STEVIA REBAUDIANA water mention composition (specifically with such as table 2), through mixed
It closes, pack, be made after sterilizing.
Table 2
Experimental design:
Effect of lowering blood sugar possessed by health food of the invention is to test to confirm by reduction fasting blood-glucose below.
Materials and methods:
Experimental animal selection: the kunming mice (20 ± 2g) of 140 or more health is selected, 1 blank control group, 1 are set
Model control group, 1 positive drug control group and administration group (including 6 embodiment groups, 13 comparative example A's groups, 3 comparative example B
Group), every group of 10/5 mouse.
Reduce fasting blood-glucose experiment:
Mouse is selected to be grouped by the blood glucose level of fasting 3-5 hours, as blank control group.It is in addition to blank control group, remaining is small
Mouse fasting 24 hours, alloxan 100mg/kg intraperitoneal injection is given, continues to give feed feeding 5 days, rear fasting 3-5 after injection
Hour, blood glucose is surveyed, blood glucose value 10-25mmol/L is hyperglycemia model success animal.Select hyperglycemia model animal small by fasting 3-5
When blood glucose level grouping, wherein embodiment group/other stomach-filling of comparative example A's group/comparative example B component give accordingly be formulated it is tested
Sample, dosage 0.5g/kg, same volume gastric infusion, once a day；Model control group give the stomach-filling of same volume solvent to
Medicine, once a day；Positive drug control group, administration melbine, dosage 0.5g/kg, same volume gastric infusion, daily one
It is secondary.Successive administration 32 days.Off-test groups of animals fasting 4 hours, detects fasting blood-glucose.Measurement result is shown in Table 3.
Experimental result
Embodiment is compared verifying with control group, comparative example.The results are shown in Table 3:
Table 3
| Quantity | Dosage (g/kg) | Fasting blood sugar (mmol/L) | |
| Blank control group | 10 | — | 5.68±0.36 |
| Model control group | 10 | — | 16.71±1.96 |
| Positive drug control group | 10 | 0.5 | 8.41±0.91 |
| Embodiment 1 | 5 | 0.5 | 8.70±1.36 |
| Embodiment 2 | 5 | 0.5 | 8.89±0.78 |
| Embodiment 3 | 5 | 0.5 | 8.95±1.02 |
| Embodiment 4 | 5 | 0.5 | 8.23±0.83 |
| Embodiment 5 | 5 | 0.5 | 8.02±0.44 |
| Embodiment 6 | 5 | 0.5 | 8.11±0.41 |
| Comparative example A 1 | 5 | 0.5 | 12.98±0.99 |
| Comparative example A 2 | 5 | 0.5 | 13.45±1.03 |
| Comparative example A 3 | 5 | 0.5 | 13.20±0.91 |
| Comparative example A 4 | 5 | 0.5 | 13.14±1.28 |
| Comparative example A 5 | 5 | 0.5 | 11.36±1.43 |
| Comparative example A 6 | 5 | 0.5 | 11.50±0.56 |
| Comparative example A 7 | 5 | 0.5 | 12.10±1.38 |
| Comparative example A 8 | 5 | 0.5 | 11.10±0.86 |
| Comparative example A 9 | 5 | 0.5 | 12.21±0.84 |
| Comparative example A 10 | 5 | 0.5 | 13.00±1.07 |
| Comparative example A 11 | 5 | 0.5 | 11.01±1.39 |
| Comparative example A 12 | 5 | 0.5 | 11.07±1.18 |
| Comparative example A 13 | 5 | 0.5 | 10.95±1.20 |
| Comparative example B1 | 5 | 0.5 | 10.32±1.20 |
| Comparative example B2 | 5 | 0.5 | 8.70±1.36 |
| Comparative example B3 | 5 | 0.5 | 9.59±1.05 |
The diabetogenic mechanism of alloxan be a species specific beta Cell of islet toxic agent, damage just to the property of can choose
The beta Cell of islet of normal mouse, makes hypoinsulinism in body, so that blood glucose be made continually and steadily to increase and lead to diabetes.
Therefore, in fasting blood sugar it can be seen from the measurement result of the fasting blood sugar of table 3, compared to the model that dosage is not added
Control group, the embodiment and comparative example for adding various dose formula all have lower fasting blood sugar, show that it is phonetic to four oxygen
Pyridine causes mouse hyperglycemia to have significant hypoglycemic effect, and implies that it may have protective effect to insulin β cell, can improve pancreas islet
Plain hyposecretion can promote insulin β cells secrete insulin and hypoglycemic.
But the quantification effect of different formulations is different, wherein the blood sugar decreasing effect and positive controls of 1-6 of the embodiment of the present invention
The effect of generation quite or more preferably, and comparative example A/B effect it is worse compared with positive controls (wherein except that comparative example B2,
Because its formula is same as Example 1), while auxiliary hyperglycemic effect of embodiment 4-6 is also better than embodiment 1-3 on the whole,
Illustrate to mention composition using Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA as the water of material matching and the water mention composition with
The compounding of balsam pear alcohol extract, has certain synergistic effect, is not the effect of simple superposition, such as it is on quantized data
It is significantly better than comparative example, for another example ratio is different from above-described embodiment group the composition type of raw material is identical, reaches
To actual effect may also have significant difference (such as comparative example B3).
In summary experimental result, by the variance analysis of data, the fasting blood-glucose of bitter gourd health food of the invention is real
Measured value reduction is statistically significant, can determine that the experimental result of above-described embodiment group reduction fasting blood-glucose is positive, has significant
The effect of auxiliary hyperglycemic；And association is produced compared to the exclusive use of each raw material and other combination matchings, formula of the invention
With the effect of synergy, the effect of the auxiliary hyperglycemic reached, the expection of those skilled in the art is also had exceeded.
Claims (5)
1. a kind of preparation method of the bitter gourd health food of auxiliary hyperglycemic, which is characterized in that preparation method includes:
(1) pretreatment of raw material: taking balsam pear, Siraitia grosvenorii, mulberries, corn stigma and STEVIA REBAUDIANA, pre-processes through raw material screening, cleaning etc.
Afterwards, it is crushed respectively；
(2) water proposes the preparation of composition: Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA of the step (1) through crushing are taken, according to 30-35:
The mass ratio of 20-25:5-8:5-8 mixes, and distilled water is added according to the ratio of solid-liquid ratio 1:30-60(m/v) in mixture, impregnates
30-60min, using ultrasonic wave batch process when water extracts, the 5-10min per treatment under the conditions of 500-800W, 40-80 DEG C,
5min is stood, 5-10min is then sonicated, then stand 5min, extraction process 30-90min is recycled with this；Water intaking extracting solution, warp
Be centrifuged, take supernatant, concentration, vacuum freeze drying after crush, obtain water and mention composition；
(3) preparation of balsam pear alcohol extract: taking balsam pear raw material of the step (1) through crushing, dry after pretreatment, crushing, according to material
Liquor ratio 1:20-40(m/v) ratio concentration 50-90wt% ethyl alcohol is added, ethyl alcohol is extracted using in 200-400W, 30-50 DEG C of items
Ultrasonic wave batch process is carried out under part, 1-5min per treatment stands 5min, is then sonicated 1-5min, then stand 5min, with
This circulation extraction process 30-60min；It filters to get filtrate, recycle ethyl alcohol and obtained paste is subjected to vacuum freeze drying, powder
Balsam pear alcohol extract is obtained after broken；
(4) in parts by weight, the Siraitia grosvenorii that takes step (2) to obtain, mulberries, corn stigma, STEVIA REBAUDIANA water mention composition 30-
Obtain 60-70 parts of balsam pear alcohol extract of 40 parts and step (3), are made after mixing, packaging, sterilizing.
2. the preparation method of the bitter gourd health food of auxiliary hyperglycemic according to claim 1, which is characterized in that described
Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA water mention composition, by raw material Siraitia grosvenorii, mulberries, corn stigma, STEVIA REBAUDIANA press 35:23:
The mass ratio of 7:5 is made.
3. the preparation method of the bitter gourd health food of auxiliary hyperglycemic according to claim 2, which is characterized in that described
In step (4), the Siraitia grosvenorii that takes step (2) to obtain, mulberries, corn stigma, STEVIA REBAUDIANA water propose 35 parts of composition and step
(3) 65 parts of the balsam pear alcohol extract obtained.
4. the preparation method of the bitter gourd health food of auxiliary hyperglycemic according to claim 1 to 3, which is characterized in that described
The step of (2) water propose the preparation of composition: Siraitia grosvenorii, corn stigma, STEVIA REBAUDIANA and the mulberries mixing for taking step (1) through crushing mix
It closes object and distilled water is added according to the ratio of solid-liquid ratio 1:50(m/v), impregnate 60min, ultrasonic wave batch process is used when water extracts,
The 10min per treatment under the conditions of 600W, 60 DEG C is stood 5min, is then sonicated 10min, then stand 5min, is recycled and mentioned with this
Take processing 90min；Fetch water extracting solution, be centrifuged, take supernatant, concentration, vacuum freeze drying after crush, obtain water and mention composition.
5. the preparation method of the bitter gourd health food of auxiliary hyperglycemic described in -4 according to claim 1, which is characterized in that described
The step of (3) balsam pear alcohol extract preparation: take balsam pear raw material of the step (1) through crushing, it is dry after pretreatment, crush, according to
Solid-liquid ratio 1:30(m/v) ratio be added concentration 80wt% ethyl alcohol, ethyl alcohol extract using under the conditions of 300W, 40 DEG C carry out ultrasound
Wave batch process, 5min per treatment stand 5min, are then sonicated 5min, then stand 5min, recycle extraction process with this
60min；It filters to get filtrate, recycle ethyl alcohol and obtained paste is subjected to vacuum freeze drying, balsam pear alcohol extract is obtained after crushing.
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