CN108835636A - A kind of hawthorn health food of auxiliary hyperglycemic - Google Patents
A kind of hawthorn health food of auxiliary hyperglycemic Download PDFInfo
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- CN108835636A CN108835636A CN201810782182.0A CN201810782182A CN108835636A CN 108835636 A CN108835636 A CN 108835636A CN 201810782182 A CN201810782182 A CN 201810782182A CN 108835636 A CN108835636 A CN 108835636A
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- water
- hawthorn
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- fructus lycii
- corn stigma
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- 235000013204 Crataegus X haemacarpa Nutrition 0.000 title claims abstract description 50
- 235000009685 Crataegus X maligna Nutrition 0.000 title claims abstract description 50
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 title claims abstract description 50
- 235000009486 Crataegus bullatus Nutrition 0.000 title claims abstract description 50
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 title claims abstract description 50
- 235000009682 Crataegus limnophila Nutrition 0.000 title claims abstract description 50
- 235000004423 Crataegus monogyna Nutrition 0.000 title claims abstract description 50
- 235000002313 Crataegus paludosa Nutrition 0.000 title claims abstract description 50
- 235000009840 Crataegus x incaedua Nutrition 0.000 title claims abstract description 50
- 230000003345 hyperglycaemic effect Effects 0.000 title claims abstract description 29
- 235000013402 health food Nutrition 0.000 title claims abstract description 21
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 47
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- 239000002994 raw material Substances 0.000 claims abstract description 41
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- 239000000284 extract Substances 0.000 claims abstract description 29
- 244000185386 Thladiantha grosvenorii Species 0.000 claims description 35
- 235000019441 ethanol Nutrition 0.000 claims description 30
- 238000002360 preparation method Methods 0.000 claims description 21
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 201000001421 hyperglycemia Diseases 0.000 description 5
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 4
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- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
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- 150000002338 glycosides Chemical class 0.000 description 1
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
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- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
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- 150000002596 lactones Chemical class 0.000 description 1
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- 239000011707 mineral Substances 0.000 description 1
- 229930189775 mogroside Natural products 0.000 description 1
- -1 multivitamin Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
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- Food Science & Technology (AREA)
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Abstract
The present invention provides a kind of hawthorn health food of auxiliary hyperglycemic, by mentioning composition and carrying out rationally compounding and be made the water of hawthorn alcohol extract and corn stigma, Siraitia grosvenorii, fructus lycii, specifically includes the component of following parts by weight：50-100 parts of hawthorn alcohol extract, corn stigma, Siraitia grosvenorii, fructus lycii water mention 10-50 parts of composition, wherein the water mentions composition by raw material corn stigma, Siraitia grosvenorii and fructus lycii by 20-30：5-10：The mass ratio of 5-10 is made.Present invention significantly reduces fasting blood sugar amounts, compared with the prior art, have effects that quite or more preferably auxiliary hyperglycemic, to produce synergistic effect.Simultaneously as raw material belongs to the material of integration of drinking and medicinal herbs, the features such as resourceful, widely distributed, cheap and easy to get is all had, production process is relatively simple, and operating cost is relatively low, is more suitable for ordinary consumption group, and safety is good.
Description
The invention belongs to technical field of health care food, and in particular to a kind of hawthorn health care food with auxiliary hyperglycemic
Product.
Background technique
Diabetes are a kind of incretion metabolism diseases, with the secondary fat of hyperglycemia and hyperglycemia, protein, water, electrolysis
The disorders such as matter are characterized, and typical performance is more drinks, more foods, diuresis and syntexis, are under the jurisdiction of " quenching one's thirst " scope of Chinese medicine.With existing
For diet and living-pattern preservation, illness rate rises year by year trend.At present clinically, hypoglycemic main ingredient is still west
Medicine, however there is more side effects in the treatment for Western medicine, study natural integration of drinking and medicinal herbs class raw material in this side of auxiliary hyperglycemic
The effect in face is the trend of modern development.
Hawthorn is the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn or hawthorn, sweet in flavor sour, warm-natured, through modern pharmacological research
Show its containing the organic acids such as multivitamin, hawthorn acid, also containing flavonoids, lactone, carbohydrate, protein, fat and calcium, phosphorus,
The minerals such as iron have the effects that lowering blood pressure and blood fat, hypoglycemic, while being also that the Ministry of Public Health is approved as food and medicament dual-purpose（Medicine food is same
Source）Plant has the features such as resourceful, widely distributed, cheap and easy to get, great application value.But it is eaten as health care
, it was also found that taste is sourer, direct edible haw due to containing a variety of Determination of Organic Acids such as hawthorn acid during product are applied,
On the one hand, may some consumers be brought with bad edible experience, to affect its further application；And another party
Face, it is lower for the extract after functional component content is relatively extracted, it is then needed to reach same effect of lowering blood sugar
More haw raw materials are added, this further causes the exacerbation of product tart flavour.
Corn stigma is rich in polysaccharide isoreactivity ingredient as corn's by-products, has hypoglycemic, lipid-loweringing and other effects, and its resource
It is huge, have many advantages, such as abundance, it is cheap, be easy to collect, but it is very limited to its development and utilization at present, it is most of
It is abandoned in vain, causes the wasting of resources.Siraitia grosvenorii is the fruit of Curcurbitaceae perennial root liana Siraitia grosvenorii, is belonged to
The distinctive economy in China and medicinal plant contain a variety of active ingredients such as flavones, polysaccharide, sweet tea glycosides and polyphenol, modern pharmacological research
It confirms, waits pharmacological actions with hypoglycemic, active blood sugar-lowering substances mainly have mogroside, grosvenor momordica flavonoid and sieve
The substances such as Chinese fruit polysaccharide.And fructus lycii is classified as common flavour of a drug in a variety of tonic recipes, there is long clinical application history,
Middle polysaccharides is one of effective component of fructus lycii, can effectively inhibit the activity of alpha-glucosidase, has certain drop
Sugared effect.At the same time, above-mentioned corn stigma, Siraitia grosvenorii and fructus lycii, other than with effect of lowering blood sugar, raw material itself is also
With certain sweet taste, taste and sweet mouthfeel is easily received by consumer.
If but above-mentioned raw materials be used alone, the taste of product is relatively simple, and the effect of lowering blood sugar of single component is not
Significantly.Although existing lot of documents discloses the Ricipe for health care food with auxiliary hyperglycemic in this regard, in the prior art,
For current overall technology situation, there are such as following problems in such health food：（1）On health-care efficacy, although selecting former
Material multiplicity but the blood sugar reducing function individually played in its own is increasingly focused on, for how to carry out rationally compounding to reach between raw material
It is less to synergistic research, and experiments prove that more；Use hawthorn as original although being involved in the prior art
Material prepares assistant hypoglycemia healthcare food, and also known corn stigma, Siraitia grosvenorii, fructus lycii etc. all have certain Hyperglycemic health care function
When imitating, be also common integration of drinking and medicinal herbs raw material, but its each raw material individually being added, blood sugar decreasing effect is not mostly significant.
（2）In edible quality, have effects that the haw products of auxiliary hyperglycemic also more Shortcomings on taste flavor on the market at present,
Although such as haw raw material itself have certain effect of lowering blood sugar, be used alone when effect performance it is relatively limited, and by
Have the characteristics that in itself sour, if relatively large edible, the taste flavor of peracid may be not suitable with because of some consumers
And the application of its product is influenced, meanwhile, a large amount of feed hawthorn also result in gastric acid secretion and increase, and it is anti-to aggravate gastric ulcer, stomach oesophagus
Stream etc. symptoms, thus exist how to compound with realize can give full play to hawthorn function of reducing blood sugar, avoid above-mentioned may cause again
The problem of technical assignment.（3）In preparation method, haw products on the market are mostly that hawthorn powder directly is made in haw raw material
Form, or be made after hawthorn powder to compound again and be used for composition, its effective component is not extracted pointedly and is realized hypoglycemic
Using, while preparation method is using general processing step mostly, and non-selected targeted process conditions and parameter
Optimization.（4）In addition, the integration of drinking and medicinal herbs material known in the state of the art with blood sugar decreasing effect be also it is varied, many kinds of,
Combined sorting is removed one by one, it is clear that is to need to pay creative labor.
Summary of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the purpose of the present invention is to provide one kind to have effects that auxiliary hyperglycemic
Health food, it is final to determine to extract hawthorn effective component by the independent and combination experiment of a variety of integration of drinking and medicinal herbs raw materials
Hawthorn alcohol extract, collocation corn stigma, Siraitia grosvenorii, fructus lycii water mention composition, the food product that consumer accepts extensively is made
Form, such as taken in a manner of brewing and drinking, for auxiliary hyperglycemic effect, there is synergistic function, it is significant to drop
Low fasting blood sugar amount has effects that quite or more preferably auxiliary hyperglycemic, and raw material is all made of into compared with the prior art
This more cheap homologous substance of natural medicine-food, cost of manufacture is lower and safety is good.
Specifically, the present invention is achieved through the following technical solutions；
The purpose of the present invention is to provide a kind of hawthorn health food of auxiliary hyperglycemic, the component including following parts by weight：
50-100 parts of hawthorn alcohol extract, corn stigma, Siraitia grosvenorii, fructus lycii water mention 10-50 parts of composition.
Preferably, the corn stigma, Siraitia grosvenorii, fructus lycii water mention composition, by raw material corn stigma, Siraitia grosvenorii and Chinese holly
Matrimony vine presses 20-30：5-10：The mass ratio of 5-10 is made.
It is further preferred that the water of the corn stigma, Siraitia grosvenorii, fructus lycii mentions composition, by raw material corn stigma, arhat
Fruit and fructus lycii press 25：10：5 mass ratio is made.
It is further preferred that the hawthorn health food of the auxiliary hyperglycemic includes the component of following parts by weight：Uvaol
70 parts of extract, corn stigma, Siraitia grosvenorii, fructus lycii water mention 30 parts of composition.
Preferably, wherein corn stigma, Siraitia grosvenorii, fructus lycii water propose the preparation method of composition and include：（1）At raw material
Reason：Corn stigma, Siraitia grosvenorii and fructus lycii are taken, is mixed after pretreatment, coarse crushing is carried out；（2）Water proposes processing：By step（1）Through
Appropriate distilled water immersion is added in the mixture of coarse crushing, reheats progress water and mentions, extracts and use Sonication assisted treatment；（3）Water
Propose the preparation of composition：Take step（2）Aqueous extracts, be centrifuged, take supernatant, concentration, vacuum freeze drying after crush, obtain water
Mention composition.
It is further preferred that wherein corn stigma, Siraitia grosvenorii, fructus lycii water propose the preparation method of composition and include：（1）It is former
Material processing：Corn stigma, Siraitia grosvenorii and fructus lycii are taken, is mixed after pretreatment, coarse crushing is carried out；（2）Water proposes processing：By step
（1）Mixture through coarse crushing is according to solid-liquid ratio 1：10-50（m/v）Ratio be added distilled water, impregnate 10-60min, then
It carries out water under the conditions of 60-100 DEG C to mention, extraction time 30-60min is extracted and used 200-800W Sonication assisted treatment；（3）Water
Propose the preparation of composition：Take step（2）Aqueous extracts, be centrifuged, take supernatant, concentration, vacuum freeze drying after crush, obtain water
Mention composition.
Preferably, wherein the preparation method of hawthorn alcohol extract includes：Haw raw material is taken, dry after pretreatment, crushing adds
Enter ethanol in proper amount to extract, extracts and use Sonication assisted treatment, filter to get filtrate, the paste that recycles ethyl alcohol and will obtain
Vacuum freeze drying is carried out, hawthorn alcohol extract is obtained after crushing.
It is further preferred that wherein the preparation method of hawthorn alcohol extract includes：Haw raw material is taken, dry after pretreatment,
It crushes, according to solid-liquid ratio 1：5-30（m/v）Ratio be added concentration 50-90wt% ethyl alcohol, ethyl alcohol is carried out under the conditions of 30-50 DEG C
30-60min is extracted, extracts and uses 200-500W Sonication assisted treatment, filter to get filtrate, the paste that recycles ethyl alcohol and will obtain
Object carries out vacuum freeze drying, and hawthorn alcohol extract is obtained after crushing.
Compared with prior art, the present invention having the advantages that：
（1）Selection for raw material, of the invention one is big, and technical contribution point is, at present on the market have auxiliary drop
Taste existing for the hawthorn health food of blood glucose effect is sourer, on taste flavor more Shortcomings and can not large amounts of food ask
Hawthorn, corn stigma, Siraitia grosvenorii, fructus lycii these types integration of drinking and medicinal herbs raw material, are creatively reasonably combined by topic, and really
The fixed hawthorn alcohol extract to extract hawthorn effective component, collocation corn stigma, Siraitia grosvenorii, fructus lycii water mention composition.Firstly, into
One step enhances the edible experience of consumer, avoids the brought influence of product peracid, i.e. selection corn stigma, Siraitia grosvenorii and Chinese holly
The combination of matrimony vine, using sweet taste mouthfeel possessed by the composition, neutralizes haw thorn extract while enhancing effect of lowering blood sugar
Tart flavour, keep the taste flavor of finally obtained product more soft, sour and sweet palatability, flavor are moderate.Secondly, being directed to above-mentioned raw materials
The relatively limited defect of the performance of effect, carries out the reasonable combination of raw material, gives full play to its mutual supplement with each other's advantages when ingredient is used alone
The characteristics of, the effect of lowering blood sugar of product is further improved, and a combination thereof is made to have the function of synergy, compared to existing skill
Art has effects that quite or more preferably auxiliary hyperglycemic.Furthermore above-mentioned raw materials belong to the material of integration of drinking and medicinal herbs, and all have
The features such as resourceful, widely distributed, cheap and easy to get, production process is relatively simple, and operating cost is relatively low, is more suitable for commonly disappearing
Take group, and safety is also better than and takes Western medicine drug.
（2）For being adapted to the optimization of technique, another technical contribution point of the invention is, according to raw material corn stigma, arhat
In fruit, fructus lycii the characteristics of hypoglycemic effective component, is operated, obtained accordingly by the extracting mode that alcohol extracting or water mention
For raw material, the concentration of target effective ingredient greatly improves extract, while playing concentration, purification,
But also consumer, which takes less product formulation, can obtain identical effect of lowering blood sugar.Meanwhile it being mentioned by ultrasonic wave auxiliary
It takes, has the function of that collaboration promotes to extraction process, the cavitation etc. generated by ultrasound, hawthorn after crushing, jade
Rice palpus, Siraitia grosvenorii, fructus lycii raw material, interior tissue are repeatedly subjected to compression and stretching action, are formed in raw material interior tissue
Hole（Cavitation bubble）, recycle pressure difference to make cell wall rupture, so that functional component preferably dissolves out into the cell, thus
The dissolution recovery rate of functional component is substantially increased, and then by the interaction of each raw material effect of lowering blood sugar ingredient, makes this hair
Bright hawthorn health food is significantly improved compared with the blood sugar decreasing effect of existing product.
（3）For application prospect, by comparative experimental data it can be confirmed that the fasting blood of hawthorn health food of the invention
Sugared measured value reduction is statistically significant, and the experimental result for reducing fasting blood-glucose is positive, and has significant auxiliary hyperglycemic
Effect.Colleague, is used alone compared to each raw material and other combination matchings, formula of the invention also have synergistic work
With, and compared with the prior art, have effects that quite or more preferably auxiliary hyperglycemic, quantification effect have exceeded those skilled in the art
The expection of member.
Specific embodiment
Further illustrate that the present invention, following embodiment are the specific embodiment party of the present invention below by specific embodiment
Formula, but embodiments of the present invention are not limited by following embodiments.
Embodiment 1：
Raw material corn stigma, Siraitia grosvenorii and fructus lycii are pressed 30：5：5 mass ratio is made water and mentions composition, and preparation method includes：
（1）Feedstock processing：Corn stigma, Siraitia grosvenorii and fructus lycii are taken, is mixed after pretreatment, coarse crushing is carried out；（2）Water proposes processing：It will
Step（1）Mixture through coarse crushing is according to solid-liquid ratio 1：30（m/v）Ratio distilled water is added, 60min is impregnated, then at 90 DEG C
Under the conditions of carry out water mention, extraction time 60min, extract use 600W Sonication assisted treatment；（3）Water proposes the preparation of composition：
Take step（2）Aqueous extracts, be centrifuged, take supernatant, concentration, vacuum freeze drying after crush, obtain water and mention composition.
Embodiment 2：
Raw material corn stigma, Siraitia grosvenorii and fructus lycii are pressed 25：10：5 mass ratio is made water and mentions composition, and specific preparation method is same
Embodiment 1.
Embodiment 3：
Raw material corn stigma, Siraitia grosvenorii and fructus lycii are pressed 20：10：10 mass ratio is made water and proposes composition, specific preparation method
With embodiment 1.
Comparative example A 1-6：
Water is made by different mass ratioes in raw material corn stigma, Siraitia grosvenorii and fructus lycii and mentions composition（Specifically match such as 1 institute of table
Show）It is, specific that the preparation method is the same as that of Example 1.
Table 1
Embodiment 4-6 and comparative example B1-3：
A kind of hawthorn health food of auxiliary hyperglycemic takes the hawthorn alcohol extract and corn stigma, Siraitia grosvenorii, fructus lycii of different proportion
Water mention composition（Specifically match such as table 2）；Raw material corn stigma, Siraitia grosvenorii and fructus lycii are wherein pressed 25：10：5 mass ratio
（Use the formula and preparation method of embodiment 2）Be made corn stigma, Siraitia grosvenorii, fructus lycii water mention composition；Hawthorn alcohol extracting
The preparation method of object includes：Haw raw material is taken, dry after pretreatment, crushing, according to solid-liquid ratio 1：20（m/v）Ratio be added
Concentration 80wt% ethyl alcohol carries out ethyl alcohol under the conditions of 50 DEG C and extracts 60min, extracts and uses 400W Sonication assisted treatment, filtering
Filtrate is obtained, ethyl alcohol is recycled and obtained paste is simultaneously subjected to vacuum freeze drying, hawthorn alcohol extract is obtained after crushing.
Table 2
Experimental design：
Effect of lowering blood sugar possessed by health food of the invention is real by reduction fasting blood-glucose real example below.
, materials and methods：
Experimental animal selection：Select the kunming mice of 100 or more health（20±2g）, 1 blank control group, 1 are set
Model control group, 1 positive drug control group and administration group（Including 6 embodiment groups, 6 comparative example A's groups, 3 comparative example B
Group）, every group of 10/5 mouse.
, reduce fasting blood-glucose experiment：
Mouse is selected to be grouped by the blood glucose level of fasting 3-5 hours, as blank control group.It is in addition to blank control group, remaining is small
Mouse fasting 24 hours, alloxan 100mg/kg intraperitoneal injection is given, continues to give feed feeding 5 days, rear fasting 3-5 after injection
Hour, blood glucose is surveyed, blood glucose value 10-25mmol/L is hyperglycemia model success animal.Select hyperglycemia model animal small by fasting 3-5
When blood glucose level grouping, wherein embodiment group/other stomach-filling of comparative example A's group/comparative example B component give accordingly be formulated it is tested
Sample, dosage 0.5g/kg, same volume gastric infusion, once a day；Model control group give the stomach-filling of same volume solvent to
Medicine, once a day；Positive drug control group, administration melbine, dosage 0.5g/kg, same volume gastric infusion, daily one
It is secondary.Successive administration 32 days.Off-test groups of animals fasting 4 hours, detects fasting blood-glucose.Measurement result is shown in Table 3.
, experimental result
Embodiment is compared verifying with control group, comparative example.The results are shown in Table 3：
Table 3
The diabetogenic mechanism of alloxan be a species specific beta Cell of islet toxic agent, damage just to the property of can choose
The beta Cell of islet of normal mouse, makes hypoinsulinism in body, so that blood glucose be made continually and steadily to increase and lead to diabetes.
Therefore, in fasting blood sugar it can be seen from the measurement result of the fasting blood sugar of table 3, compared to the model that dosage is not added
Control group, the embodiment and comparative example for adding various dose formula all have lower fasting blood sugar, show that it is phonetic to four oxygen
Pyridine causes mouse hyperglycemia to have significant hypoglycemic effect, and implies that it may have protective effect to insulin β cell, can improve pancreas islet
Plain hyposecretion can promote insulin β cells secrete insulin and hypoglycemic.
But the quantification effect of different formulations is different, wherein the blood sugar decreasing effect and positive controls of 1-6 of the embodiment of the present invention
Quite or more preferably, and comparative example A/B effect is worse compared with positive controls for the effect of generation（Wherein except that comparative example B2,
Because its formula is same as Example 2）, while auxiliary hyperglycemic effect of embodiment 4-6 is also better than embodiment 1-3 on the whole,
Illustrate to mention composition as the water of material matching using corn stigma, Siraitia grosvenorii and fructus lycii three and the water mentions composition and hawthorn
The compounding of alcohol extract has the function of synergy, is not the effect of simple superposition, such as to show in its re-quantization data
It writes and is better than comparative example, for another example ratio is different from above-described embodiment group the composition type of raw material is identical, reaches
Actual effect may also have significant difference（Such as comparative example B3）.
In summary experimental result, by the variance analysis of data, the fasting blood-glucose of hawthorn health food of the invention is real
Measured value reduction is statistically significant, can determine that the experimental result of above-described embodiment group reduction fasting blood-glucose is positive, has significant
The effect of auxiliary hyperglycemic；And association is produced compared to the exclusive use of each raw material and other combination matchings, formula of the invention
With the effect of synergy, the effect of the auxiliary hyperglycemic reached, the expection of those skilled in the art is also had exceeded.
Claims (8)
1. a kind of hawthorn health food of auxiliary hyperglycemic, which is characterized in that the component including following parts by weight：Hawthorn alcohol extracting
50-100 parts of object, corn stigma, Siraitia grosvenorii, fructus lycii water mention 10-50 parts of composition.
2. the hawthorn health food of auxiliary hyperglycemic according to claim 1, which is characterized in that the corn stigma, sieve
Chinese fruit, fructus lycii water mention composition, by raw material corn stigma, Siraitia grosvenorii and fructus lycii press 20-30：5-10：The mass ratio of 5-10
It is made.
3. the hawthorn health food of auxiliary hyperglycemic according to claim 2, which is characterized in that the corn stigma, sieve
Chinese fruit, fructus lycii water mention composition, by raw material corn stigma, Siraitia grosvenorii and fructus lycii press 25：10：5 mass ratio is made.
4. the hawthorn health food of auxiliary hyperglycemic according to claim 3, which is characterized in that including following parts by weight
Component：70 parts of hawthorn alcohol extract, corn stigma, Siraitia grosvenorii, fructus lycii water mention 30 parts of composition.
5. the hawthorn health food of auxiliary hyperglycemic described in any one of -4 according to claim 1, which is characterized in that corn
Palpus, Siraitia grosvenorii, fructus lycii water propose the preparation method of composition and include：（1）Feedstock processing：Take corn stigma, Siraitia grosvenorii and fructus lycii
Son mixes after pretreatment, carries out coarse crushing；（2）Water proposes processing：By step（1）Appropriate steam is added in mixture through coarse crushing
Distilled water is impregnated, and is reheated progress water and is mentioned, extracts and use Sonication assisted treatment；（3）Water proposes the preparation of composition：Take step（2）
Aqueous extracts, be centrifuged, take supernatant, concentration, vacuum freeze drying after crush, obtain water and mention composition.
6. the hawthorn health food of auxiliary hyperglycemic according to claim 5, which is characterized in that corn stigma, Siraitia grosvenorii, Chinese holly
The preparation method that the water of matrimony vine mentions composition includes：（1）Feedstock processing：Corn stigma, Siraitia grosvenorii and fructus lycii are taken, after pretreatment
Mixing carries out coarse crushing；（2）Water proposes processing：By step（1）Mixture through coarse crushing is according to solid-liquid ratio 1：10-50（m/v）'s
Distilled water is added in ratio, impregnates 10-60min, then carries out water under the conditions of 60-100 DEG C and mention, and extraction time 30-60min is extracted
Using 200-800W Sonication assisted treatment；（3）Water proposes the preparation of composition：Take step（2）Aqueous extracts, be centrifuged, taken on
It is crushed after clear liquid, concentration, vacuum freeze drying, obtains water and mention composition.
7. the hawthorn health food of auxiliary hyperglycemic described in any one of -4 according to claim 1, which is characterized in that uvaol
The preparation method of extract includes：Haw raw material is taken, dry after pretreatment, crushing is added ethanol in proper amount and extracts, and extraction is adopted
It with Sonication assisted treatment, filters to get filtrate, recycle ethyl alcohol and obtained paste is subjected to vacuum freeze drying, after crushing
Hawthorn alcohol extract.
8. the hawthorn health food of auxiliary hyperglycemic according to claim 7, which is characterized in that the preparation of hawthorn alcohol extract
Method includes：Haw raw material is taken, dry after pretreatment, crushing, according to solid-liquid ratio 1：5-30（m/v）Ratio be added concentration
50-90wt% ethyl alcohol is carried out ethyl alcohol under the conditions of 30-50 DEG C and extracts 30-60min, extracted and assisted using 200-500W ultrasonic wave
Processing, filters to get filtrate, and recycles ethyl alcohol and obtained paste is carried out vacuum freeze drying, hawthorn alcohol extract is obtained after crushing.
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