CN108904696A - A kind of climbing groundsel eye refreshing drop and its preparation process - Google Patents

A kind of climbing groundsel eye refreshing drop and its preparation process Download PDF

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Publication number
CN108904696A
CN108904696A CN201810911706.1A CN201810911706A CN108904696A CN 108904696 A CN108904696 A CN 108904696A CN 201810911706 A CN201810911706 A CN 201810911706A CN 108904696 A CN108904696 A CN 108904696A
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parts
climbing groundsel
eye
distillation
minutes
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黄胜群
刘懿锋
黄峥榕
刘道权
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Guangzhou Baijitang Research Center Of Traditional Chinese Medicine
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Guangzhou Baijitang Research Center Of Traditional Chinese Medicine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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Abstract

The present invention relates to a kind of climbing groundsel eye refreshing drop and its preparation processes.It is formed in parts by weight, including：10-50 parts of climbing groundsel, 10-50 parts of wild chrysanthemum, 5-20 parts of dandelion, 5-20 parts of fructus lycii, 5-20 parts of kuh-seng, 5-20 parts of cassia seed, 1-10 parts of safflower, 1-10 parts of rhizoma polygonati, 5-20 parts of Radix Polygalae, 1-10 parts of Radix Glycyrrhizae.The present invention also provides a kind of preparation processes of climbing groundsel eye refreshing drop.Beneficial effect：The effect of the application has eye-candy visual function improving, clears liver and improve vision, and wind-dispelling is anti-inflammatory, promoting circulation of blood dredging collateral.The application can improve various eye illnesses and asthenopia, have the effect of visual impairment.Climbing groundsel is minerals positively charged in the natural alkaline soil plant of nature, and the climbing groundsel eye refreshing drop prepared by the application technique has powerful suction-operated to negatively charged all kinds of harmful substances, and is automatically repaired the impaired ability of skin.

Description

A kind of climbing groundsel eye refreshing drop and its preparation process
Technical field
The present invention relates to a kind of climbing groundsel eye refreshing drops, further relate to a kind of preparation process of climbing groundsel eye refreshing drop.
Background technique
Generated metabolin when eye fatigue is usually deposited in eye and the capillary of eye circumference.It accumulates over a long period, from It is excessive by base accumulation, periocular muscle flexibility decrease is caused, ciliary muscle functional deterioration can be made, regulating power decline closely occurs The symptoms such as visual impairment, ophthalmodynia, eye are swollen, the serious generation that will lead to various eye diseases.And old man itself also has one A little irreversible vision disorders, mainly since the aging of macula lutea plot structure sexually revises.Senile macular degeneration mostly occurs in 45 Year old or more, illness rate increases with the age and is increased, and is the important diseases of current the elderly's blinding.Laser therapy had once been once main Therapy is wanted, the disease therapeuticing medicine research is goed deep into recently as major pharmacy giant, first therapeutic agent, injection Verteporfin, anti-vegf therapeutic agent, recombinant humanized monoclonal antibody are come out one after another, and protein tyrosine kinase inhibitor exists In clinical test, market prospects be can not be ignored.It is taken on clinical treatment every the intravitreal injection of progress in 28 days, this greatly increases The pain and financial burden of patient are added, it is often more important that frequent drug administration by injection easily causes the generation of complication, such as vitreum Bleeding, detachment of retina, entophthamia, cataract etc..Eye metabolin can be removed, environment in eye is improved, restores ocular skin The elasticity of muscle improves blood circulation, is the most important thing for effectively preventing various eye disease occurrence and development.
Therefore, it is necessary to propose effective technical solution, solve the above problems.
Summary of the invention
The present invention in view of the above shortcomings of the prior art, provides one kind and has eye-candy visual function improving, clear liver and improve vision, and wind-dispelling is anti-inflammatory, The climbing groundsel eye refreshing drop and its preparation process of promoting circulation of blood dredging collateral effect.
The technical solution that the present invention solves above-mentioned technical problem is as follows：
A kind of climbing groundsel eye refreshing drop forms in parts by weight, including：10-50 parts of climbing groundsel, wild chrysanthemum 10-50 Part, 5-20 parts of dandelion, 5-20 parts of fructus lycii, 5-20 parts of kuh-seng, 5-20 parts of cassia seed, 1-10 parts of safflower, 1-10 parts of rhizoma polygonati, Radix Polygalae 5-20 parts, 1-10 parts of Radix Glycyrrhizae.
Preferably, it forms in parts by weight, including：30 parts of climbing groundsel, 30 parts of wild chrysanthemum, 15 parts of dandelion, Chinese holly 10 parts of Qi, 10 parts of kuh-seng, 10 parts of cassia seed, 5 parts of safflower, 5 parts of rhizoma polygonati, 10 parts of Radix Polygalae, 5 parts of Radix Glycyrrhizae.
The present invention also provides a kind of preparation processes of climbing groundsel eye refreshing drop, and specific step is as follows：
(1) it dries：After the component of climbing groundsel eye refreshing drop of any of claims 1 or 2 is selected, cleaned, then dry, The drying condition：Drying temperature is set as：40-62 degrees Celsius；Drying time is：35-60 minutes, the component dried is put Into being cooled in desinfection chamber, for use；
(2) it crushes：The component that step (1) has been dried is crushed, the pulverization conditions：Revolving speed is set as：5000- 7000 revs/min, smashing fineness is set as：40-120 mesh, grinding time：10-15 minutes, put the component that drying cools into system Pulverization process is carried out in medicine disintegrating apparatus, in the vibration sieving filter that the component crushed is put into 304 material of food-grade, into Row screening filtration treatment, filter sieve are set as 60-80 mesh, time：10-40 minutes, set vibrating screen as it is horizontal, vertical, Tilt three-D movement；
(3) add water high pressure：Filtered component will be sieved to put into distillation separator, suitable moisture is injected, added Heat, heating temperature are set as：100-120 degrees Celsius, air pressure is set as：0.1-0.5Mpa；
(4) high pressure distillation：Distill the temperature setting in separator at 100-120 degrees Celsius, air pressure in 0.2-0.5Mpa, into Horizontal high voltage distillation, distillation time were arranged at 10-30 minutes；
(5) recycling distillate bottling：The good distillate bottling encapsulation of high pressure distillation is placed, every bottle of capacity is arranged in 10- 15ml。
Preferably, step (1) described drying temperature is set as：51 degree.
Preferably, step (2) pulverization conditions：Revolving speed is set as：6000 revs/min, smashing fineness is set as：80 Mesh, grinding time：13 minutes.
Preferably, step (3) described heating temperature is set as 110 degrees Celsius, and air pressure is set as 0.3Mpa.
Preferably, at 110 degrees Celsius, air pressure carries out the temperature setting in step (4) the distillation separator in 0.4Mpa High pressure distillation, distillation time were arranged at 20 minutes.
Beneficial effect：
The effect of the application has eye-candy visual function improving, clears liver and improve vision, and wind-dispelling is anti-inflammatory, promoting circulation of blood dredging collateral.The application can improve various Eye illness and asthenopia, have the effect of visual impairment.
Climbing groundsel is minerals positively charged in the natural alkaline soil plant of nature, a thousand li prepared by the application technique Light eye refreshing drop has powerful suction-operated to negatively charged all kinds of harmful substances, and is automatically repaired what skin was damaged Ability.
Specific embodiment
The present invention relates to a kind of climbing groundsel eye refreshing drops, form in parts by weight, including：10-50 parts of climbing groundsel, open country 10-50 parts of chrysanthemum, 5-20 parts of dandelion, 5-20 parts of fructus lycii, 5-20 parts of kuh-seng, 5-20 parts of cassia seed, 1-10 parts of safflower, rhizoma polygonati 1- 10 parts, 5-20 parts of Radix Polygalae, 1-10 parts of Radix Glycyrrhizae.
The present invention relates to a kind of preparation process of climbing groundsel eye refreshing drop, process is：
The above Chinese medicine is carried out select-clean-dry-to crush-add water high pressure-high pressure distillation-recycling distillate Bottling.
Embodiment 1
A kind of climbing groundsel eye refreshing drop forms in parts by weight, including：Climbing groundsel 30g, wild chrysanthemum 30g, dandelion 15g, fructus lycii 10g, kuh-seng 10g, cassia seed 10g, safflower 5g, rhizoma polygonati 5g, Radix Polygalae 10g, Radix Glycyrrhizae 5g.
A kind of preparation process of climbing groundsel eye refreshing drop, specific step is as follows：
(1) it selects：Prepare the flat basket of screening, a non-staple foodstuff grade disposable glove, then prepare a food nappy, By 30 parts of climbing groundsel, 30 parts of wild chrysanthemum, 15 parts of dandelion, 10 parts of fructus lycii, 10 parts of kuh-seng, 10 parts of cassia seed, 5 parts of safflower, rhizoma polygonati 5 Part, 10 parts of Radix Polygalae, 5 parts of Radix Glycyrrhizae are gradually poured into one by one in the flat basket of screening, each gradually select putting into nappy, for use；
(2) it cleans:Prepare a bite iron pan, suitable water will be injected in pot, boil, cool, the boiling water cooled is poured into dish It in basin, is cleaned, prepares a Water tank, cleaned Chinese medicine is put into Water tank and is drained away the water, for use；
(3) it dries：Prepare a Chinese medicine dryer, the Chinese medicine to drain away the water is put into dryer, drying temperature setting For：51 degree, drying the period be：5 temperature sections, drying time are:35-60 minutes, the Chinese medicine dried is put into desinfection chamber It is cooled, for use；
(4) it crushes：Prepare a pharmacy disintegrating apparatus, revolving speed is set as：6000 revs/min, smashing fineness is set as： 80 mesh, grinding time：13 minutes, the Chinese medicine that drying cools is put into and carries out pulverization process in pharmacy disintegrating apparatus, will be crushed Chinese medicine put into the vibration sieving filter of 304 material of food-grade, carry out screening filtration treatment, filter sieve is set as 70 Mesh, time：25 minutes, vibrating screen was set as horizontal, vertical, inclination three-D movement；
(5) add water high pressure：Filtered Chinese medicine will be sieved to put into distillation separator, suitable moisture is injected, added Heat, heating temperature are set as:110 degrees Celsius, air pressure is set as 0.3Mpa；
(6) high pressure distillation：The temperature setting in separator is distilled at 110 degrees Celsius, and air pressure carries out high pressure steaming in 0.4Mpa It evaporates, distillation time was arranged at 20 minutes；
(7) recycling distillate bottling：The good distillate bottling encapsulation of high pressure distillation is placed, every bottle of capacity setting exists 13ml。
Embodiment 2
A kind of climbing groundsel eye refreshing drop forms in parts by weight, including：Climbing groundsel 10g, wild chrysanthemum 10g, dandelion 5g, fructus lycii 5g, kuh-seng 5g, cassia seed 5g, safflower 5g, rhizoma polygonati 1g, Radix Polygalae 5g, Radix Glycyrrhizae 1g.
Embodiment 3
A kind of climbing groundsel eye refreshing drop forms in parts by weight, including：Climbing groundsel 50g, wild chrysanthemum 50g, dandelion 10g, fructus lycii 20g, kuh-seng 20g, cassia seed 20g, safflower 10g, rhizoma polygonati 10g, Radix Polygalae 20g, Radix Glycyrrhizae 10g.
The effect of the application has eye-candy visual function improving, clears liver and improve vision, and wind-dispelling is anti-inflammatory, promoting circulation of blood dredging collateral.The application can improve various Eye illness and asthenopia, have the effect of visual impairment.
Climbing groundsel (Senecio scandens Buch.-Ham.ex D.Don) also known as nine inner bright, Herba Senecionis Scandentis, HERBA SENECIONIS SCANDENTIS, Bright stroke of eye, sweet vernal grass, Broomjutre Sida Herb, Kowloon light, nine ridge light.It is cold in nature for catananche, bitter, have it is clearing heat and detoxicating, it is bright Mesh, it is antipruritic and other effects.It is chiefly used in anemopyretic cold, red eye, swell pain, dysentery, skin eczema boil.
Climbing groundsel is minerals positively charged in the natural alkaline soil plant of nature, a thousand li prepared by the application technique Light eye refreshing drop has powerful suction-operated to negatively charged all kinds of harmful substances, and is automatically repaired what skin was damaged Ability.
In combination with modern transdermal drag delivery, product is non-stimulated to be contacted with eyes epidermis acupuncture point zero distance the application, make With direct, rapid, by target administration, Transdermal absorption makes eye respectively organize that contained natural drug essence can be absorbed rapidly, accelerates Ocular circulation promotes eye respectively to organize the absorption to nutriment.It removes the free radical that eye accumulates rapidly simultaneously, promotes Eye metabolism, full effect release the asthenopias symptoms such as dry, astringent, the eye distending pain of the eyes as caused by various eye disease, entirely Take good care of eye health in face.
The application climbing groundsel product can operate with eye drops, eyes are sprayed etc..
The present invention can be summarized with others without prejudice to the concrete form of spirit or essential characteristics of the invention.Therefore, nothing By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair Bright, claims indicate the scope of the present invention, and above-mentioned explanation does not point out the scope of the present invention, therefore, with this Any change in the comparable meaning and scope of claims of invention is all considered as including in claim of the invention In the range of book.

Claims (7)

1. a kind of climbing groundsel eye refreshing drop, which is characterized in that it is formed in parts by weight, including：10-50 parts of climbing groundsel, open country 10-50 parts of chrysanthemum, 5-20 parts of dandelion, 5-20 parts of fructus lycii, 5-20 parts of kuh-seng, 5-20 parts of cassia seed, 1-10 parts of safflower, rhizoma polygonati 1- 10 parts, 5-20 parts of Radix Polygalae, 1-10 parts of Radix Glycyrrhizae.
2. climbing groundsel eye refreshing drop as described in claim 1, which is characterized in that it is formed in parts by weight, including：A thousand li It is 30 parts of light, 30 parts of wild chrysanthemum, 15 parts of dandelion, 10 parts of fructus lycii, 10 parts of kuh-seng, 10 parts of cassia seed, 5 parts of safflower, 5 parts of rhizoma polygonati, remote 10 parts of will, 5 parts of Radix Glycyrrhizae.
3. a kind of preparation process of climbing groundsel eye refreshing drop, which is characterized in that specific step is as follows：
(1) it dries：After the component of climbing groundsel eye refreshing drop of any of claims 1 or 2 is selected, cleaned, then dry, it is described Drying condition：Drying temperature is set as：40-62 degrees Celsius；Drying time is：35-60 minutes, put the component dried into nothing Bacterium is cooled in room, for use；
(2) it crushes：The component that step (1) has been dried is crushed, the pulverization conditions：Revolving speed is set as：5000-7000 Rev/min, smashing fineness is set as：40-120 mesh, grinding time：10-15 minutes, put the component that drying cools into pharmacy powder Pulverization process is carried out in broken equipment, in the vibration sieving filter that the component crushed is put into 304 material of food-grade, is sieved Divide filtration treatment, filter sieve is set as 60-80 mesh, time：10-40 minutes, vibrating screen was set as horizontal, vertical, inclination Three-D movement；
(3) add water high pressure：Filtered component will be sieved to put into distillation separator, suitable moisture is injected, heated, added Hot temperature setting is：100-120 degrees Celsius, air pressure is set as：0.1-0.5Mpa；
(4) high pressure distillation：The temperature setting in separator is distilled at 100-120 degrees Celsius, and air pressure carries out high in 0.2-0.5Mpa Pressure distillation, distillation time were arranged at 10-30 minutes；
(5) recycling distillate bottling：The good distillate bottling encapsulation of high pressure distillation is placed, every bottle of capacity is arranged in 10-15ml.
4. preparation process as claimed in claim 3, which is characterized in that step (1) described drying temperature is set as：51 degree.
5. preparation process as claimed in claim 3, which is characterized in that step (2) described pulverization conditions：Revolving speed is set as： 6000 revs/min, smashing fineness is set as：80 mesh, grinding time：13 minutes.
6. preparation process as claimed in claim 3, which is characterized in that it is Celsius that step (3) described heating temperature is set as 110 Degree, air pressure are set as 0.3Mpa.
7. preparation process as claimed in claim 3, which is characterized in that the temperature setting in step (4) the distillation separator At 110 degrees Celsius, air pressure carries out high pressure distillation in 0.4Mpa, and distillation time was arranged at 20 minutes.
CN201810911706.1A 2018-08-10 2018-08-10 A kind of climbing groundsel eye refreshing drop and its preparation process Pending CN108904696A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112121103A (en) * 2020-09-28 2020-12-25 杭州市余杭区第五人民医院 Traditional Chinese medicine fumigation patch for preventing and controlling myopia of students and preparation method thereof
CN113069513A (en) * 2021-04-20 2021-07-06 华辰顺合农业科技(成都)有限公司 Eye-protecting liquid and preparation method thereof
EP3900714A4 (en) * 2018-12-18 2022-09-21 Santen Pharmaceutical Co., Ltd. Agent containing 4-phenylbutyrate, for preventing or treating presbyopia

Citations (3)

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