CN108883204A8 - 脂质微泡及其制备方法 - Google Patents
脂质微泡及其制备方法 Download PDFInfo
- Publication number
- CN108883204A8 CN108883204A8 CN201780021520.2A CN201780021520A CN108883204A8 CN 108883204 A8 CN108883204 A8 CN 108883204A8 CN 201780021520 A CN201780021520 A CN 201780021520A CN 108883204 A8 CN108883204 A8 CN 108883204A8
- Authority
- CN
- China
- Prior art keywords
- dspe
- lipid
- preparation
- transition temperature
- phase transition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002632 lipids Chemical class 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 2
- 230000007704 transition Effects 0.000 abstract 2
- LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 abstract 1
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 abstract 1
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 abstract 1
- -1 DSPE-PEG2000 Chemical compound 0.000 abstract 1
- 229920002560 Polyethylene Glycol 3000 Polymers 0.000 abstract 1
- 101001000212 Rattus norvegicus Decorin Proteins 0.000 abstract 1
- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 abstract 1
- FVJZSBGHRPJMMA-UHFFFAOYSA-N distearoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
本文公开了一种在生理学上可接受的液体载体中的充气微泡的悬浮液及其制备方法，该微泡包含相转变温度为约41℃的第一脂质如DPPC或DPPG、相转变温度为约55℃的第二脂质如DSPC或DSPG以及PEG化的DSPE如DSPE-PEG2000、DSPE-PEG3000或DSPE-PEG5000的脂质混合物。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410113519.4A CN117919456A (zh) | 2016-02-01 | 2017-02-01 | 脂质微泡及其制备方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662289588P | 2016-02-01 | 2016-02-01 | |
| US62/289,588 | 2016-02-01 | ||
| PCT/US2017/016094 WO2017136475A1 (en) | 2016-02-01 | 2017-02-01 | Lipid microbubbles and process of making thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410113519.4A Division CN117919456A (zh) | 2016-02-01 | 2017-02-01 | 脂质微泡及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108883204A CN108883204A (zh) | 2018-11-23 |
| CN108883204A8 true CN108883204A8 (zh) | 2018-12-28 |
Family
ID=59500026
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410113519.4A Pending CN117919456A (zh) | 2016-02-01 | 2017-02-01 | 脂质微泡及其制备方法 |
| CN201780021520.2A Pending CN108883204A (zh) | 2016-02-01 | 2017-02-01 | 脂质微泡及其制备方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410113519.4A Pending CN117919456A (zh) | 2016-02-01 | 2017-02-01 | 脂质微泡及其制备方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20190046667A1 (zh) |
| EP (1) | EP3411082B1 (zh) |
| JP (2) | JP2019503403A (zh) |
| CN (2) | CN117919456A (zh) |
| AU (1) | AU2017213791B2 (zh) |
| CA (1) | CA3013341C (zh) |
| ES (1) | ES2952104T3 (zh) |
| WO (1) | WO2017136475A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3808344A4 (en) * | 2018-06-01 | 2022-03-30 | Sogang University Research Foundation | NANOPARTICLE COMPOSITE HAVING IMPROVED ENDOCYTOSIS EFFICIENCY BY SURFACE MODIFICATION USING A LIPID AND METHOD FOR MAKING THE SAME |
| CN116056759A (zh) * | 2020-08-24 | 2023-05-02 | 叶秩光 | 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 |
| CN113521315A (zh) * | 2021-07-28 | 2021-10-22 | 深圳先进技术研究院 | 一种多模态微泡造影剂及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| DE602004029010D1 (de) * | 2003-02-04 | 2010-10-21 | Bracco Suisse Sa | Ultraschall kontrastmittel und verfahren zur erstellung |
| US20050025710A1 (en) * | 2003-07-29 | 2005-02-03 | Michel Schneider | Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging |
| EP1701745B1 (en) | 2003-12-22 | 2014-12-10 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
| CA2826960A1 (en) * | 2005-12-09 | 2007-06-14 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| WO2008028917A1 (en) | 2006-09-05 | 2008-03-13 | Bracco Research Sa | Gas-filled microvesicles with polymer-modified lipids |
| US10279053B2 (en) * | 2011-07-19 | 2019-05-07 | Nuvox Pharma Llc | Microbubble compositions, method of making same, and method using same |
| CN103212094B (zh) * | 2013-04-28 | 2014-10-22 | 重庆医科大学附属儿童医院 | 一种氧氟脂质微泡及其制备方法 |
| TWI552761B (zh) * | 2013-05-03 | 2016-10-11 | 博信生物科技股份有限公司 | 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置 |
| CN103394102B (zh) * | 2013-05-22 | 2018-08-07 | 博信生物科技股份有限公司 | 一种脂质微/奈米气泡、及其优化的制备方法及制备装置 |
-
2017
- 2017-02-01 EP EP17748096.9A patent/EP3411082B1/en active Active
- 2017-02-01 CA CA3013341A patent/CA3013341C/en active Active
- 2017-02-01 WO PCT/US2017/016094 patent/WO2017136475A1/en active Application Filing
- 2017-02-01 CN CN202410113519.4A patent/CN117919456A/zh active Pending
- 2017-02-01 AU AU2017213791A patent/AU2017213791B2/en active Active
- 2017-02-01 JP JP2018559676A patent/JP2019503403A/ja active Pending
- 2017-02-01 US US16/073,566 patent/US20190046667A1/en not_active Abandoned
- 2017-02-01 CN CN201780021520.2A patent/CN108883204A/zh active Pending
- 2017-02-01 ES ES17748096T patent/ES2952104T3/es active Active
-
2021
- 2021-10-26 JP JP2021174298A patent/JP7266081B2/ja active Active
-
2022
- 2022-06-01 US US17/830,165 patent/US12048752B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3013341C (en) | 2024-01-02 |
| US20220296733A1 (en) | 2022-09-22 |
| US20190046667A1 (en) | 2019-02-14 |
| US12048752B2 (en) | 2024-07-30 |
| EP3411082B1 (en) | 2023-06-21 |
| EP3411082A1 (en) | 2018-12-12 |
| JP2022020696A (ja) | 2022-02-01 |
| CN117919456A (zh) | 2024-04-26 |
| CA3013341A1 (en) | 2017-08-10 |
| AU2017213791B2 (en) | 2023-10-19 |
| JP7266081B2 (ja) | 2023-04-27 |
| WO2017136475A1 (en) | 2017-08-10 |
| ES2952104T3 (es) | 2023-10-27 |
| JP2019503403A (ja) | 2019-02-07 |
| AU2017213791A1 (en) | 2018-08-09 |
| CN108883204A (zh) | 2018-11-23 |
| EP3411082A4 (en) | 2019-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| CI02 | Correction of invention patent application |
Correction item: Second inventor Correct: Ding Qianyu False: Ding Jianyu Number: 47-02 Page: The title page Volume: 34 Correction item: Second inventor Correct: Ding Qianyu False: Ding Jianyu Number: 47-02 Volume: 34 |
|
| CI02 | Correction of invention patent application | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181123 |
|
| RJ01 | Rejection of invention patent application after publication |