CN1087916A - 糖基化的细胞素 - Google Patents

糖基化的细胞素 Download PDF

Info

Publication number
CN1087916A
CN1087916A CN93117879A CN93117879A CN1087916A CN 1087916 A CN1087916 A CN 1087916A CN 93117879 A CN93117879 A CN 93117879A CN 93117879 A CN93117879 A CN 93117879A CN 1087916 A CN1087916 A CN 1087916A
Authority
CN
China
Prior art keywords
interferon
sugar
modified
cytokine
rabbit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93117879A
Other languages
English (en)
Chinese (zh)
Inventor
滨口直
佐藤纯
道券一浩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1087916A publication Critical patent/CN1087916A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN93117879A 1992-09-24 1993-09-23 糖基化的细胞素 Pending CN1087916A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25496292 1992-09-24
JP254962/92 1992-09-24
JP8892093 1993-04-15
JP088920/93 1993-04-15

Publications (1)

Publication Number Publication Date
CN1087916A true CN1087916A (zh) 1994-06-15

Family

ID=26430256

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93117879A Pending CN1087916A (zh) 1992-09-24 1993-09-23 糖基化的细胞素

Country Status (9)

Country Link
US (1) US5643564A (enExample)
EP (1) EP0589378B1 (enExample)
KR (1) KR940007058A (enExample)
CN (1) CN1087916A (enExample)
AT (1) ATE229981T1 (enExample)
CA (1) CA2106821A1 (enExample)
DE (1) DE69332576T2 (enExample)
PH (1) PH31582A (enExample)
TW (1) TW263437B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107029245A (zh) * 2011-03-02 2017-08-11 森苏林公司 囊泡组合物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0770195A (ja) * 1993-08-23 1995-03-14 Yutaka Mizushima 糖修飾インターフェロン
IL116730A0 (en) * 1995-01-13 1996-05-14 Amgen Inc Chemically modified interferon
US6214535B1 (en) * 1995-08-30 2001-04-10 Toray Industries, Inc. Method for testing cardiac myocarditis or cardiomyopathy
AUPP660698A0 (en) * 1998-10-21 1998-11-12 University Of Queensland, The A method of protein engineering
AR078117A1 (es) 2006-06-20 2011-10-19 Protech Pharma S A Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina
CA3069321A1 (en) 2017-07-11 2019-01-17 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
US20200181220A1 (en) 2017-08-03 2020-06-11 Synthorx, Inc. Cytokine conjugates for the treatment of proliferative and infectious diseases
US20200246467A1 (en) 2019-02-06 2020-08-06 Synthorx, Inc. Il-2 conjugates and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386026A (en) * 1981-04-20 1983-05-31 Merck & Co., Inc. Cell-specific glycopeptide ligands
US4609546A (en) * 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質,その製造法および中間体
JPS63152393A (ja) * 1986-07-03 1988-06-24 Takeda Chem Ind Ltd グリコシル誘導体
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
US5162503A (en) * 1987-05-19 1992-11-10 Hoffmann-La Roche, Inc. Purification of interleukin-2 by receptor-affinity chromatography
US4829690A (en) * 1987-06-26 1989-05-16 Andros Theodore A Credit card chain holder
JPH01102098A (ja) * 1987-10-14 1989-04-19 Toray Ind Inc 糖鎖修飾糖タンパク質
JPH01102099A (ja) * 1987-10-14 1989-04-19 Toray Ind Inc 生理活性を有する糖タンパク質
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
JPH03106900A (ja) * 1989-09-20 1991-05-07 Toray Ind Inc 糖鎖修飾ヒトインターフェロン集合体
JPH085914B2 (ja) * 1990-02-16 1996-01-24 株式会社ディ・ディ・エス研究所 グリコシル−蛋白誘導体
US5096816A (en) * 1990-06-05 1992-03-17 Cetus Corporation In vitro management of ammonia's effect on glycosylation of cell products through pH control
JPH0770195A (ja) * 1993-08-23 1995-03-14 Yutaka Mizushima 糖修飾インターフェロン

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107029245A (zh) * 2011-03-02 2017-08-11 森苏林公司 囊泡组合物

Also Published As

Publication number Publication date
US5643564A (en) 1997-07-01
DE69332576D1 (de) 2003-01-30
CA2106821A1 (en) 1994-03-25
EP0589378B1 (en) 2002-12-18
EP0589378A2 (en) 1994-03-30
TW263437B (enExample) 1995-11-21
PH31582A (en) 1998-11-03
DE69332576T2 (de) 2003-11-20
KR940007058A (ko) 1994-04-26
ATE229981T1 (de) 2003-01-15
EP0589378A3 (en) 1995-02-22

Similar Documents

Publication Publication Date Title
CN1309705A (zh) Il-2选择性激动剂和拮抗剂
JPH04506006A (ja) ヒトサイトカイン、インターロイキン―9
CN1165539A (zh) 肽及蛋白质的修饰
JPS6310800A (ja) 化学修飾蛋白質,その製造法および中間体
US5547931A (en) Methods of stimulatory thrombocytopoiesis using modified C-reactive protein
HK1079987A1 (zh) 使用细胞脱唾液酸决定簇和糖缀合物将细胞靶向组织和器官的方法和组合物
CN1145693C (zh) 作为趋化因子拮抗剂的氨基端截短的mcp-2
CN1313343A (zh) N-端化学修饰的蛋白质组合物及方法
CN1322759A (zh) 刺激巨核细胞生长和分化的组合物及方法
US5362490A (en) Human myelomonocyte interferon-gamma, and process for preparation and use thereof
CN1142940C (zh) 含有mpl配体的药物组合物
JP2016128475A (ja) インターロイキン−22のウイルス性肝炎の治療における応用
US4462985A (en) Delivery of biologically active components of heterologous species interferon isolates
CN1087916A (zh) 糖基化的细胞素
CN1142186A (zh) 用白介素-10激活外周血单核细胞的细胞溶解活性
CN1606568A (zh) 生物活性粒细胞集落刺激因子的纯化和/或分离方法
CN1604790A (zh) 通过施用组织因子途径抑制剂(tfpi)治疗严重性肺炎
US6242255B1 (en) Protein which induces interferon-gamma production by immunocompetent cell
CN1091746A (zh) 维出那亭衍生的合成肽和含有这些合成肽的药物组合物
EP0058192A1 (en) Delivery of biologically active components of heterologous species interferon isolates
CN1023295C (zh) 预防和治疗病毒感染的方法和组合物
CN100346823C (zh) 用于调节免疫反应的釉质基质蛋白组合物
CN1468123A (zh) 用于改变b细胞介导病理的方法和组合物
CN101039696A (zh) 给药人il-18治疗创伤的方法
CN1210559A (zh) rDSPAαI的产生方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication