CN108779106B - 用于制备哒嗪酮除草剂的中间体和用于制备它们的方法 - Google Patents
用于制备哒嗪酮除草剂的中间体和用于制备它们的方法 Download PDFInfo
- Publication number
- CN108779106B CN108779106B CN201680076619.8A CN201680076619A CN108779106B CN 108779106 B CN108779106 B CN 108779106B CN 201680076619 A CN201680076619 A CN 201680076619A CN 108779106 B CN108779106 B CN 108779106B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- cycloalkyl
- haloalkyl
- formula
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562247438P | 2015-10-28 | 2015-10-28 | |
| US62/247,438 | 2015-10-28 | ||
| PCT/US2016/058755 WO2017074988A1 (en) | 2015-10-28 | 2016-10-26 | Intermediates to prepare pyridazinone herbicides, and a process to prepare them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108779106A CN108779106A (zh) | 2018-11-09 |
| CN108779106B true CN108779106B (zh) | 2021-12-07 |
Family
ID=57227157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680076619.8A Expired - Fee Related CN108779106B (zh) | 2015-10-28 | 2016-10-26 | 用于制备哒嗪酮除草剂的中间体和用于制备它们的方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10913719B2 (enExample) |
| EP (1) | EP3368531B1 (enExample) |
| JP (1) | JP6782774B2 (enExample) |
| KR (1) | KR20180075574A (enExample) |
| CN (1) | CN108779106B (enExample) |
| AR (1) | AR106522A1 (enExample) |
| AU (1) | AU2016346207B2 (enExample) |
| BR (1) | BR112018008616B1 (enExample) |
| CA (1) | CA3003410A1 (enExample) |
| HU (1) | HUE049157T2 (enExample) |
| IL (1) | IL258765B (enExample) |
| MX (1) | MX388612B (enExample) |
| RU (1) | RU2743561C2 (enExample) |
| SG (1) | SG11201803134VA (enExample) |
| TW (1) | TWI739769B (enExample) |
| WO (1) | WO2017074988A1 (enExample) |
| ZA (1) | ZA201803362B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3137456T (pt) | 2014-04-29 | 2021-08-06 | Fmc Corp | Herbicidas de piridazinona |
| JP6905521B2 (ja) | 2015-10-28 | 2021-07-21 | エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ | 新規なピリダジノン除草剤 |
| HUE049157T2 (hu) | 2015-10-28 | 2020-09-28 | Fmc Corp | Intermedierek piridazinon herbicidek elõállítására és eljárás azok elõállítására |
| TWI785022B (zh) | 2017-03-28 | 2022-12-01 | 美商富曼西公司 | 新穎噠嗪酮類除草劑 |
| WO2019005484A1 (en) * | 2017-06-30 | 2019-01-03 | Fmc Corporation | 4- (3,4-DIHYDRONAPHTH-1-YL OR 2H-CHROMEN-4-YL) -5-HYDROXY-2H-PYRADIZIN-3-ONES AS HERBICIDES |
| PE20211219A1 (es) | 2018-09-27 | 2021-07-05 | Fmc Corp | Herbicidas de piridazinona e intermedios de piridazinona usados para preparar un herbicida |
| EP3856722A1 (en) | 2018-09-27 | 2021-08-04 | Fmc Corporation | Intermediates for preparing herbicidal pyridazinones |
| AU2020355992A1 (en) | 2019-09-25 | 2022-03-31 | Nippon Soda Co., Ltd. | Pyridazine compound and herbicide |
| UY39137A (es) | 2020-04-01 | 2021-10-29 | Fmc Corp | Atropisómeros de derivados de piridazinona como herbicidas |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040225125A1 (en) * | 2003-05-05 | 2004-11-11 | New York University | Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling |
| WO2011045271A1 (de) * | 2009-10-15 | 2011-04-21 | Bayer Cropscience Ag | Herbizid wirksame heterocyclylsubstituierte pyridazinone |
| WO2012091156A1 (en) * | 2010-12-27 | 2012-07-05 | Sumitomo Chemical Company, Limited | Pyridazinone compound and herbicide and noxious arthropod controlling agent comprising it |
| CN103180300A (zh) * | 2010-09-08 | 2013-06-26 | 住友化学株式会社 | 制备哒嗪酮化合物的方法和其中间体 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1221842B (de) | 1965-02-26 | 1966-07-28 | Basf Ag | Herbizide |
| WO2005007632A1 (en) | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| TWI375669B (en) * | 2006-03-17 | 2012-11-01 | Sumitomo Chemical Co | Pyridazinone compound and use thereof |
| EP2042491A1 (de) | 2007-09-14 | 2009-04-01 | Bayer CropScience AG | Pyridazine als Fungizide |
| CL2008002703A1 (es) | 2007-09-14 | 2009-11-20 | Sumitomo Chemical Co | Compuestos derivados de 1,4-dihidro-2h-piridazin-3-ona; composicion herbicida que comprende a dichos compuestos; metodo de control de malezas; uso de dichos compuestos para el control de malezas; y compuestos intermediarios. |
| CL2008003785A1 (es) | 2007-12-21 | 2009-10-09 | Du Pont | Compuestos derivados de piridazina; composiciones herbicidas que comprenden a dichos compuestos; y método para controlar el crecimiento de la vegetación indeseada. |
| GB0803494D0 (en) | 2008-02-26 | 2008-04-02 | Sterix Ltd | Compound |
| EP2328586A2 (en) | 2008-05-20 | 2011-06-08 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| GB201206598D0 (en) | 2012-04-13 | 2012-05-30 | Syngenta Ltd | Herbicidal compounds |
| WO2014031971A1 (en) | 2012-08-24 | 2014-02-27 | E. I. Du Pont De Nemours And Company | Herbicidal pyridazinones |
| EP3041470A4 (en) | 2013-09-04 | 2017-05-03 | Board Of Regents Of the University Of Texas System | Methods and compositions for selective and targeted cancer therapy |
| GB201317791D0 (en) | 2013-10-08 | 2013-11-20 | Syngenta Ltd | Herbicidal compounds |
| GB2519092A (en) | 2013-10-08 | 2015-04-15 | Syngenta Ltd | Herbicidal Compounds |
| PT3137456T (pt) * | 2014-04-29 | 2021-08-06 | Fmc Corp | Herbicidas de piridazinona |
| HUE049157T2 (hu) | 2015-10-28 | 2020-09-28 | Fmc Corp | Intermedierek piridazinon herbicidek elõállítására és eljárás azok elõállítására |
-
2016
- 2016-10-26 HU HUE16790849A patent/HUE049157T2/hu unknown
- 2016-10-26 BR BR112018008616-9A patent/BR112018008616B1/pt not_active IP Right Cessation
- 2016-10-26 KR KR1020187014511A patent/KR20180075574A/ko not_active Ceased
- 2016-10-26 RU RU2018119134A patent/RU2743561C2/ru active
- 2016-10-26 JP JP2018522082A patent/JP6782774B2/ja not_active Expired - Fee Related
- 2016-10-26 SG SG11201803134VA patent/SG11201803134VA/en unknown
- 2016-10-26 CA CA3003410A patent/CA3003410A1/en not_active Abandoned
- 2016-10-26 WO PCT/US2016/058755 patent/WO2017074988A1/en not_active Ceased
- 2016-10-26 EP EP16790849.0A patent/EP3368531B1/en not_active Not-in-force
- 2016-10-26 CN CN201680076619.8A patent/CN108779106B/zh not_active Expired - Fee Related
- 2016-10-26 AU AU2016346207A patent/AU2016346207B2/en not_active Ceased
- 2016-10-26 US US15/771,896 patent/US10913719B2/en not_active Expired - Fee Related
- 2016-10-26 MX MX2018005133A patent/MX388612B/es unknown
- 2016-10-27 TW TW105134762A patent/TWI739769B/zh not_active IP Right Cessation
- 2016-10-28 AR ARP160103306A patent/AR106522A1/es active IP Right Grant
-
2018
- 2018-04-17 IL IL258765A patent/IL258765B/en active IP Right Grant
- 2018-05-21 ZA ZA2018/03362A patent/ZA201803362B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040225125A1 (en) * | 2003-05-05 | 2004-11-11 | New York University | Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling |
| WO2011045271A1 (de) * | 2009-10-15 | 2011-04-21 | Bayer Cropscience Ag | Herbizid wirksame heterocyclylsubstituierte pyridazinone |
| CN103180300A (zh) * | 2010-09-08 | 2013-06-26 | 住友化学株式会社 | 制备哒嗪酮化合物的方法和其中间体 |
| WO2012091156A1 (en) * | 2010-12-27 | 2012-07-05 | Sumitomo Chemical Company, Limited | Pyridazinone compound and herbicide and noxious arthropod controlling agent comprising it |
Non-Patent Citations (1)
| Title |
|---|
| Pyridazines. Part XXIX: Synthesis and Platelet Aggregation Inhibition Activity of 5-Substituted-6-phenyl-3(2H)-pyridazinones.Novel Aspects of Their Biological Actions,;Eddy Sotelo, et al.,;《Bioorganic & Medicinal Chemistry》;20021231;第10卷;第2873-2882页, * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018119134A3 (enExample) | 2020-03-16 |
| CN108779106A (zh) | 2018-11-09 |
| IL258765B (en) | 2021-01-31 |
| MX2018005133A (es) | 2019-01-10 |
| IL258765A (en) | 2018-06-28 |
| EP3368531B1 (en) | 2020-01-15 |
| US20180312467A1 (en) | 2018-11-01 |
| SG11201803134VA (en) | 2018-05-30 |
| BR112018008616B1 (pt) | 2021-09-08 |
| US10913719B2 (en) | 2021-02-09 |
| RU2018119134A (ru) | 2019-11-28 |
| CA3003410A1 (en) | 2017-05-04 |
| TW201722917A (zh) | 2017-07-01 |
| WO2017074988A1 (en) | 2017-05-04 |
| TWI739769B (zh) | 2021-09-21 |
| AR106522A1 (es) | 2018-01-24 |
| JP2018533580A (ja) | 2018-11-15 |
| AU2016346207B2 (en) | 2020-06-04 |
| EP3368531A1 (en) | 2018-09-05 |
| MX388612B (es) | 2025-03-11 |
| AU2016346207A1 (en) | 2018-05-10 |
| RU2743561C2 (ru) | 2021-02-19 |
| BR112018008616A2 (pt) | 2019-11-26 |
| HUE049157T2 (hu) | 2020-09-28 |
| KR20180075574A (ko) | 2018-07-04 |
| ZA201803362B (en) | 2019-08-28 |
| JP6782774B2 (ja) | 2020-11-11 |
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| GR01 | Patent grant | ||
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20211207 |