CN108721166B - Whitening composition, whitening and moisturizing essence containing kakakadu plum extract and preparation method of whitening and moisturizing essence - Google Patents

Whitening composition, whitening and moisturizing essence containing kakakadu plum extract and preparation method of whitening and moisturizing essence Download PDF

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CN108721166B
CN108721166B CN201810802776.3A CN201810802776A CN108721166B CN 108721166 B CN108721166 B CN 108721166B CN 201810802776 A CN201810802776 A CN 201810802776A CN 108721166 B CN108721166 B CN 108721166B
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whitening
extract
weight
moisturizing
stirring
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CN108721166A (en
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谢水林
孙娟娟
赵美贺
陈凤鸾
魏坤
王晓慧
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Guangzhou Rui Sen Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic

Abstract

The invention provides a whitening and moisturizing composition which comprises kakakadu plum extract and almond extract. The composition has good moisturizing effect and whitening effect. The whitening and moisturizing essence containing the kakakadu plum extract has the advantages of mild skin, high safety, small irritation, high stability and the like, and is superior to the existing whitening and moisturizing products.

Description

Whitening composition, whitening and moisturizing essence containing kakakadu plum extract and preparation method of whitening and moisturizing essence
Technical Field
The invention relates to a whitening and moisturizing composition, whitening and moisturizing essence containing kakadu plum extract and a preparation method thereof.
Background
In recent years, with the acceleration of people's life and work pace and the increase of environmental pollution, people face more and more skin problems, especially dark complexion, pigmentation and the like become common problems, and therefore whitening cosmetics become a hot spot in the field of skin care product development. Human skin color changes are caused by melanin. Melanin is produced in specific dendritic cell melanocytes located under or between the basal cells of the skin epidermis. Melanin is synthesized by a cascade of reactions triggered by tyrosinase.
The kakakadu plum (kakakadu plum), also known as prunus caprina, has the fruit with the highest vitamin C content, contains 3200-5000 mg vitamin C in the pulp of 100g enzyme, can increase the antioxidant defense mechanism of cells, can support, supplement or prevent the loss of cell antioxidants in skin cells, can inhibit the production of melanin in melanocytes, and can reduce or prevent oxidative damage of skin.
The almond is a dry seed of Prunus armeniaca L belonging to Rosaceae, contains abundant nutritional ingredients such as unsaturated fatty acid and protein, and has good nourishing effect on skin; the almond oil can inhibit tyrosinase activity and melanin synthesis, and has no influence on melanoma cell proliferation.
The existing whitening approaches mainly have the following aspects, 1, exfoliating, promoting the metabolism of keratin cells and accelerating the fading of color spots; 2. protecting against ultraviolet rays, and eliminating the stimulation effect on melanin formation; 3. an antioxidant, which inhibits the promoting effect of free radicals on melanin formation and maintains the dual functions of tyrosinase inhibitor activity; 4. anti-inflammatory allergy, eliminating inflammation, and promoting the formation of melanin by sensitizing factor; 5. inhibiting tyrosinase, polypeochrome tautomerase, DHICA oxidase activity; 6. abrogate the message-modulating effects of endothelin-endothelin antagonists; 7. activating skin cells, improving the self-protection capability of the skin and the like.
At present, skin whitening active substances on the market are mainly tyrosinase inhibitors, including arbutin, kojic acid, hydroquinone and the like, but the skin whitening active substances have some defects, such as unstable arbutin and easy oxidative discoloration; kojic acid has poor percutaneous absorption, and the components cannot exert the efficacy; hydroquinone is cytotoxic and is prone to cause skin irritation.
At present, some whitening products adopting chemicals as raw materials not only treat the symptoms but also do not treat the root causes, but also can generate some side effects, cause serious burden to the skin and have low safety. The whitening agents of the current skin care products mainly comprise hydroquinone, kojic acid, tartaric acid, arbutin, derivatives and the like, but the application of the whitening agents is limited due to the defects of strong cytotoxicity, poor skin permeability, weak stability, high price and the like.
The whitening cosmetic is a cosmetic which can inhibit the formation of melanin or act on each stage of melanin metabolic pathway to control and inhibit the production of melanin. Therefore, the search for effective melanin inhibiting components which are effective, have no toxic or side effect on human bodies and have small irritation becomes one of the keys for researching the formula of the whitening cosmetics.
The whitening component extracted from the plant has the characteristics of mild to skin, high safety, small irritation, stable performance and the like.
Disclosure of Invention
The invention aims to provide a whitening and moisturizing composition, and also provides whitening and moisturizing essence containing kakakadu plum extract and a preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that: a whitening and moisturizing composition comprises kakadu plum extract and almond extract. In the prior art, a single extract is generally adopted for moisturizing or whitening, but the effect is not as ideal as possible, and the inventor of the application finds that the whitening and moisturizing effects of the kakakadu plum extract and a small amount of almond extract are remarkably superior to those of a single extract by compounding the kadu plum extract and the small amount of almond extract through a large amount of researches.
Preferably, the weight ratio of the kakakadu plum extract to the almond extract is 4: 1-10: 1.
Preferably, the weight ratio of kakadu plum extract to almond extract is 7: 1. The kakadu plum extract and the almond extract are compounded according to the proportion, so that the whitening and moisturizing effects are the best.
The invention provides whitening and moisturizing essence containing kakakadu plum extract, which comprises the following components in parts by weight:
Figure BDA0001737484530000021
Figure BDA0001737484530000031
preferably, the whitening and moisturizing essence comprises the following components in parts by weight:
Figure BDA0001737484530000032
most preferably, the whitening and moisturizing essence comprises the following components in parts by weight:
Figure BDA0001737484530000033
preferably, the thickening agent comprises xanthan gum and macromolecular hyaluronic acid, and the weight ratio of the xanthan gum to the macromolecular hyaluronic acid is 1: 5-5: 1.
More preferably, the weight ratio of the xanthan gum to the macromolecular hyaluronic acid is 1: 1.
Preferably, the preservative comprises perilla leaf extract, forsythia suspense extract and betaine, and the weight ratio of the perilla leaf extract to the forsythia suspense extract to the betaine is as follows: and (3) fructus forsythiae extract: betaine is 0.1-2: 0.1-2: 0.1 to 2.
More preferably, the weight ratio of the perilla leaf extract to the forsythia suspense extract to the betaine is that the perilla leaf extract: and (3) fructus forsythiae extract: betaine ═ 1: 1: 1.
the invention provides a preparation method of the whitening and moisturizing essence containing kakadu plum extract, which comprises the following steps:
(1) mixing water and glycerol at 80-90 deg.C, adding 1, 3-butanediol and sodium hyaluronate under stirring, and stirring to mix well; cooling to 45-60 ℃, adding the thickening agent, and uniformly stirring to obtain a mixture A;
(2) adding the whitening and moisturizing composition into the mixture A, and stirring until the mixture is uniformly mixed to obtain a mixture B;
(3) and when the mixture B is cooled to the normal temperature, sequentially adding essence and preservative, and uniformly mixing to obtain the whitening and moisturizing essence.
The invention has the beneficial effects that:
(1) the invention provides a whitening and moisturizing composition which has a good moisturizing function and can play a whitening role.
(2) The whitening and moisturizing essence containing the kakakadu plum extract has the advantages of mild skin, high safety, small irritation, high stability and the like, and is superior to the existing whitening and moisturizing products.
Drawings
FIG. 1 is a graph showing the evaluation of permeability and absorbency in examples 1 to 3 of the present invention and a blank comparative example;
FIG. 2 is a graph showing the whitening and moisturizing effects of examples 1 to 3 and a blank comparative example according to the present invention;
FIG. 3 is a graph showing the evaluation of the effect of improving skin glossiness of examples 1 to 3 according to the present invention and a blank comparative example;
FIG. 4 is a graph showing the evaluation of skin elasticity effect of examples 1 to 3 of the present invention and a blank comparative example.
Detailed Description
Example 1
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 85 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly and sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate while stirring at the temperature of 80-90 ℃ and the stirring speed of 400-500r/min, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) Adding Kakadu plum extract 0.525 weight parts and semen Armeniacae amarum extract 0.075 weight parts into mixture A, stirring for 30min, and mixing to obtain mixed solution B.
(3) After the mixture B is cooled to the normal temperature, 0.0001 weight part of essence is added, the mixture is stirred for 20min at the speed of 400-500 r/min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 2
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 80 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly stirring at 80-90 ℃ and at a stirring speed of 400-500r/min, sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) Adding Kakadu plum extract 3.5 weight parts and almond extract 0.5 weight parts into mixture A, stirring for 30min, and mixing to obtain mixed solution B.
(3) After the mixture B is cooled to the normal temperature, 0.0001 weight part of essence is added, the mixture is stirred for 20min at the speed of 400-500 r/min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 3
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 75 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly and sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate while stirring at the temperature of 80-90 ℃ and the stirring speed of 400-500r/min, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) Adding Kakadu plum extract 8.75 weight parts and almond extract 1.25 weight parts into mixture A, stirring for 30min, and mixing to obtain mixed solution B.
(3) After the mixture B is cooled to the normal temperature, 0.0001 weight part of essence is added, the mixture is stirred for 20min at the speed of 400-500 r/min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 4
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 80 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly stirring at 80-90 ℃ and at a stirring speed of 400-500r/min, sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) Adding Kakadu plum extract 3.64 weight parts and almond extract 0.36 weight parts into mixture A, stirring for 30min, and mixing to obtain mixed solution B.
(3) After the mixture B is cooled to the normal temperature, 0.0001 weight part of essence is added, the mixture is stirred for 20min at the speed of 400-500 r/min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 5
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 80 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly stirring at 80-90 ℃ and at a stirring speed of 400-500r/min, sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) Adding Kakadu plum extract 3.2 weight parts and almond extract 0.8 weight parts into mixture A, stirring for 30min, and mixing to obtain mixed solution B.
(3) After the mixture B is cooled to the normal temperature, 0.0001 weight part of essence is added, the mixture is stirred for 20min at the speed of 400-500 r/min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 6
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 80 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly stirring at 80-90 ℃ and at a stirring speed of 400-500r/min, sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) And sequentially adding 4 parts by weight of kakakadu plum extract into the mixture A, stirring for 30min, and uniformly mixing to obtain a mixed solution B.
(3) After the mixture B is cooled to the normal temperature, 0.0001 weight part of essence is added, the mixture is stirred for 20min at the speed of 400-500 r/min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 7
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 80 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly stirring at 80-90 ℃ and at a stirring speed of 400-500r/min, sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) And sequentially adding 4 parts by weight of almond extract into the mixture A, stirring for 30min, and uniformly mixing to obtain a mixed solution B.
(3) After the mixture B is cooled to the normal temperature, 0.0001 weight part of essence is added, the mixture is stirred for 20min at the speed of 400-500 r/min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 8
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 80 parts by weight of water and 3 parts by weight of glycerol into a stirring pot, starting stirring, slowly stirring at 80-90 ℃ and at a stirring speed of 400-500r/min, sequentially adding 6 parts by weight of 1, 3-butanediol and 2 parts by weight of sodium hyaluronate, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.1 weight part of xanthan gum and 0.1 weight part of macromolecular hyaluronic acid, stirring uniformly at 1800r/min to obtain a mixed solution A.
(2) Adding Kakadu plum extract 3.5 weight parts and almond extract 0.5 weight parts into mixture A, stirring for 30min, and mixing to obtain mixed solution B.
(3) When the mixture B is cooled to normal temperature, adding 0.00005 parts by weight of essence at a speed of 400-500r/min, and stirring for 20 min; sequentially adding 0.1 weight part of perilla leaf extract, 0.1 weight part of fructus forsythiae extract and 0.1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Example 9
A preparation method of whitening and moisturizing essence comprises the following specific steps:
(1) adding 80 parts by weight of water and 8 parts by weight of glycerol into a stirring pot, starting stirring, slowly stirring at 80-90 ℃ and at a stirring speed of 400-500r/min, sequentially adding 2 parts by weight of 1, 3-butanediol and 6 parts by weight of sodium hyaluronate, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.5 weight part of xanthan gum and 0.5 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) Adding Kakadu plum extract 3.5 weight parts and almond extract 0.5 weight parts into mixture A, stirring for 30min, and mixing to obtain mixed solution B.
(3) After the mixture B is cooled to normal temperature, adding 0.0002 part by weight of essence, stirring at 400-500r/min for 20 min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine, stirring at 500r/min for 30min to obtain the whitening and moisturizing essence.
Blank comparative example:
preparation method of whitening and moisturizing essence
The method comprises the following specific steps:
(1) adding 85 parts by weight of water and 5 parts by weight of glycerol into a stirring pot, starting stirring, slowly and sequentially adding 4 parts by weight of 1, 3-butanediol and 4 parts by weight of sodium hyaluronate while stirring at the temperature of 80-90 ℃ and the stirring speed of 400-500r/min, stirring for 30min, and uniformly mixing; cooling to 45-60 ℃, adding 0.2 weight part of xanthan gum and 0.2 weight part of macromolecular hyaluronic acid, stirring evenly at 1800r/min to obtain a mixed solution A.
(2) After the mixture A is cooled to normal temperature, adding 0.0001 weight part of essence at a speed of 400-500r/min, and stirring for 20 min; sequentially adding 1 weight part of perilla leaf extract, 1 weight part of fructus forsythiae extract and 1 weight part of betaine 400-.
The formula of the whitening and moisturizing essence is shown in the following table 1.
TABLE 1 whitening and moisturizing essence formula (in parts by weight)
Figure BDA0001737484530000091
Figure BDA0001737484530000101
Product evaluation
First, product safety evaluation (human body skin patch spot experiment)
And (3) carrying out safety evaluation on the whitening and moisturizing essence prepared in the examples 1-3 and the blank comparative example.
The tested population is female, 60 people and between the ages of 25 and 50. The skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary entry standard of the subject. Randomly grouped into 4 groups of 15 people each.
Selecting a qualified spot tester, dripping 0.015-0.025 ml of a tested substance into the spot tester in a closed spot patch test mode, externally applying a special adhesive tape to the back of a tested person, removing the tested substance after 24 hours, observing skin reactions after 0.5, 6, 12, 24 and 48 hours after the tested substance is removed respectively, and recording results according to skin reaction grading standards in cosmetic hygiene standards.
The results of the patch test on the skin of a human body show that: through the patch test of the whitening and moisturizing essence of examples 1-3 and the comparative example, skin reactions of all groups of subjects are observed within 0.5 hour, 6 hours, 12 hours, 24 hours and 48 hours, wherein 0 case has adverse skin reactions, which indicates that the whitening and moisturizing essence prepared by the invention is safe to use.
Second, product efficacy evaluation
Trial evaluation was performed on the whitening and moisturizing essence liquids prepared in examples 1 to 3 and the blank comparative example.
The trial subjects are 100, and the age range is 20-50 years, wherein 75 female subjects and 25 male subjects are selected. The skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject. Subjects were randomized and evenly divided into 4 groups of 25 people each.
The subjects used the whitening and moisturizing essence liquids prepared in examples 1 to 3 and the blank comparative example respectively to observe and feel the use effect. After a subject cleans the face, a proper amount of the whitening and moisturizing essence is uniformly applied to the face, and is gently massaged until the skin absorbs the essence, the whitening and moisturizing essence is used once a day in the morning and at night, the use period is 28 days, and the result is recorded in detail.
Test evaluation results: the evaluation results of the permeability and absorbency effects of examples 1 to 3 and the blank comparative example are shown in FIG. 1; the whitening and moisturizing effects of examples 1-3 and the blank comparative example are evaluated as shown in fig. 2; the evaluation of the effect of improving skin gloss of examples 1 to 3 of the present invention and the blank comparative example is shown in FIG. 3; the evaluation of skin elasticity effect of examples 1 to 3 of the present invention and the blank comparative example is shown in fig. 4.
From the results, the kakadu plum extract and the almond extract are used, so that the essence has good whitening and moisturizing effects, can be well absorbed by skin, and improves the glossiness and elasticity of the skin. The skin evaluation effect was better as the contents of kakadu plum extract and almond extract were increased. When the total amount of the additives is 4 parts by weight and 10 parts by weight, the difference in effect is not significant, and the preferable amount of the additive of 4 parts by weight is the most preferable in view of cost.
Oxygen radical absorption Capacity test
A 75mM phosphate buffer solution was prepared at pH 7.4. A39.9. mu.M stock solution of fluorescein sodium was prepared in 75mM phosphate buffer and stored at 4 ℃ in the dark. For testing, stock solutions of fluorescein sodium were diluted to 0.159 μ M in phosphate buffered saline at pH 7.4, 75mM, AAPH was adjusted to 38.25mM in phosphate buffered saline at pH 7.4, 75mM, and ready for use. mu.L of the sample solution to be tested (or 75mM phosphate buffer solution as a blank) and 75. mu.L of the sodium fluorescein working solution were added to a 96-well plate, and the mixture was incubated at 37 ℃ for 10 min. The reaction was started by adding 100. mu.L of AAPH, and the reaction was timed and read at 37 ℃ with an excitation wavelength of 485nm and an emission wavelength of 530nm (f)0) Read one time per minute (f)0、f1、...、f120) The total number of readings is 121 times (total reaction time 120min), and each reading is connected to a curve. The final volume of the reaction system was 200. mu.L. Each sample was provided with 3 duplicate wells. Trolox is used as a standard substance. AUC represents the area under the curve.
AUC＝0.5(f0+fn)+(f1+f2+f3+.....+fn-1)
NetAUC＝AUCSample (I)-AUCBlank space
Trolox concentration is proportional to its NetAUC, and a standard curve is plotted. The Trolox equivalent oxygen radical absorbance capacity of the sample was calculated.
(AAPH: azobisisobutyramidine hydrochloride; Trolox: 6-hydroxy-2, 5,7, 8-tetramethylchromane-2-carboxylic acid)
The results of the oxygen radical absorbance test are shown in table 2 below:
TABLE 2 oxygen radical absorbance capacity test results
Figure BDA0001737484530000111
Figure BDA0001737484530000121
From table 2 above, it can be seen that: according to the whitening and moisturizing essence disclosed by the invention, the kakadu plum extract and a small amount of almond extract are compounded, the whitening and moisturizing effects are obviously superior to those of a single extract, the whitening and moisturizing essence disclosed by the invention has better oxidation resistance, the promotion effect of free radicals on melanin formation is inhibited, the comprehensive cost and the whitening effect are considered, and the formula of the embodiment 2 is optimal.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (10)

1. A whitening and moisturizing composition, comprising kakakadu plum extract and almond extract; the weight ratio of the kakadu plum extract to the almond extract is 4: 1-7: 1.
2. The whitening and moisturizing composition of claim 1, wherein the kakakadu plum extract and the almond extract are present in a weight ratio of 7: 1.
3. The whitening and moisturizing essence containing kakadu plum extract is characterized by comprising the following components in parts by weight:
Figure FDA0002755534690000011
4. the whitening and moisturizing essence according to claim 3, which comprises the following components in parts by weight:
Figure FDA0002755534690000012
5. the whitening and moisturizing essence according to claim 4, which is characterized by comprising the following components in parts by weight:
Figure FDA0002755534690000021
6. the whitening and moisturizing essence according to claim 3, wherein the thickener comprises xanthan gum and macromolecular hyaluronic acid, and the weight ratio of the xanthan gum to the macromolecular hyaluronic acid is 1: 5-5: 1.
7. The whitening and moisturizing essence according to claim 6, wherein the weight ratio of xanthan gum to macromolecular hyaluronic acid is 1: 1.
8. The whitening and moisturizing essence according to claim 3, wherein the preservative comprises perilla leaf extract, forsythia suspensa extract and betaine, and the weight ratio of the perilla leaf extract to the forsythia suspensa extract to the betaine is as follows: and (3) fructus forsythiae extract: betaine is 0.1-2: 0.1-2: 0.1 to 2.
9. The whitening and moisturizing essence according to claim 8, wherein the weight ratio of the perilla leaf extract to the forsythia suspensa extract to the betaine is as follows: and (3) fructus forsythiae extract: betaine ═ 1: 1: 1.
10. a method for preparing the kakadu plum extract-containing whitening and moisturizing essence as claimed in any one of claims 3 to 9, comprising the steps of:
(1) mixing water and glycerol, adding 1, 3-butanediol and sodium hyaluronate under stirring at 80-90 deg.C, and stirring to mix well; cooling to 45-60 ℃, adding the thickening agent, and uniformly stirring to obtain a mixture A;
(2) adding the whitening and moisturizing composition as defined in any one of claims 1-2 into the mixture A, and stirring until the mixture is uniformly mixed to obtain a mixture B;
(3) and when the mixture B is cooled to the normal temperature, sequentially adding essence and preservative, and uniformly mixing to obtain the whitening and moisturizing essence.
CN201810802776.3A 2018-07-20 2018-07-20 Whitening composition, whitening and moisturizing essence containing kakakadu plum extract and preparation method of whitening and moisturizing essence Active CN108721166B (en)

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