CN111329783B

CN111329783B - Composition for instantly brightening skin color and application thereof

Info

Publication number: CN111329783B
Application number: CN202010143442.7A
Authority: CN
Inventors: 陈衍玲; 王玉玲; 徐松堂; 范馨仪; 王琳琳; 崔仰杰; 郭学平
Original assignee: Bloomage Biotech Co Ltd; Shandong Bloomage Hyinc Biopharm Co Ltd
Current assignee: Bloomage Biotech Co Ltd
Priority date: 2020-03-04
Filing date: 2020-03-04
Publication date: 2022-08-19
Anticipated expiration: 2040-03-04
Also published as: CN111329783A

Abstract

The invention discloses a composition for instantly brightening skin color and application thereof, wherein the composition comprises the following components in parts by weight: 0.01-0.2 part of tetrahydrocurcumin, 100.01-0.1 part of coenzyme Q and 0.01-0.2 part of hyaluronic acid substances. According to the invention, the tetrahydrocurcumin, the coenzyme Q10 and the hyaluronic acid substances are compounded, the three substances are compounded synergistically to show outstanding effects of instant brightening and emergency skin care, the raw materials of the three ingredients are easy to obtain, the dosage of the three ingredients in the cosmetics is very low, and compared with an instant brightening product in the prior art, the instant brightening product has the advantages of few ingredient types, small addition amount in the cosmetics, low cost, outstanding instant brightening effect and the like, and is particularly suitable for the cosmetics of emergency skin care type.

Description

Composition for instantly brightening skin color and application thereof

Technical Field

The invention relates to a composition, in particular to a composition containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances and having an instant brightening, emergency caring and skin caring effect and application thereof, and belongs to the technical field of cosmetics.

Background

The modern society has large working pressure and intensity, the management of facial skin is not comprehensive, and most people have the condition of skin fatigue caused by overtime or staying up night, so that the skin problems of facial grease secretion exuberance, pore blockage and coarseness, acne, dark face, dark eye circles, dry lines, fine lines, even wrinkles and the like can occur. Therefore, people urgently need to relieve or solve the skin problems in time so that the skin can quickly restore the good complexion on the next day to meet the aesthetic requirements of work, study, life or self.

Tetrahydrocurcumin (THC) is a high-purity turmeric extract, can exert the ability of inhibiting tyrosinase at an extremely low concentration, has a whitening effect which is several times that of common whitening active ingredients such as arbutin, liquorice, vitamin C and the like, also has a unique biological protection effect, can provide double antioxidant protection for skin, and helps the skin to resist the invasion caused by ultraviolet rays, inflammation and the like. Safety tests show that the whitening cream has no any stimulation or sensitization side effect on human skin, and can safely and effectively play the natural whitening and skin brightening functions. Compared with the western medicine phenylbutazone, the THC can achieve the same effect by only half of dosage. Compared with curcumin and its analogues, THC has better curative effect on acute and subacute inflammation. THC has inhibitory effect on lipoxygenase, collagenase, and hyaluronidase, and can reduce skin inflammation including erythema, reduce wrinkle, keep skin elasticity, and resist aging. The tetrahydrocurcumin can improve skin texture and increase glossiness while whitening skin, so that the skin is healthy and bright in color.

Coenzyme Q10 is a fat-soluble quinone compound, also known as ubiquinone. Coenzyme Q10 is present in mitochondria in the highest amount (40% to 50%) in cells, plays an important role in the electron transport chain, is an important cofactor for cellular respiration and metabolism, and is an important coenzyme for ATP production. Coenzyme Q10 also has effects of resisting oxidation, scavenging free radicals, and stabilizing biological membrane. Coenzyme Q10 keeps cells in good health state, so that the body is full of vitality, vigorous and energetic. The biological activity of coenzyme Q10 is mainly derived from the redox characteristics of the quinone ring and the physicochemical properties of the side chain. It is a natural antioxidant and a cell metabolism promoter produced by cells themselves, has the functions of protecting and restoring the integrity of a biological membrane structure and stabilizing a membrane potential, is a nonspecific immunopotentiator of an organism, and therefore shows an excellent anti-fatigue effect.

CN105596275B discloses a cosmetic matrix containing double-bacterium fermented soymilk extract and application thereof, the skin-care matrix of the invention has obvious instant brightening effect, each active component in the matrix can be degraded by skin and absorbed through skin, thereby providing nutrition for the skin and having long-acting wrinkle-removing effect; the skin-care matrix is used in cosmetics to bring the effects of brightening the product immediately, preserving moisture and enhancing skin elasticity. CN105902423A discloses a whitening mask composition for making skin color uniform and brightening skin color, the main materials of the invention include: 0.5-1% of nicotinamide, 1-3% of hops extract, 1-10% of papain aqueous solution, 0.5-5% of glabridin alcohol solution and 0.1-1% of chlorphenamine maleate, and has double effects of immediately brightening skin and fading color spots in a long-acting manner. CN109125189A discloses an inclusion essence capable of instantly brightening skin color and a preparation method thereof, and the invention utilizes a nano-encapsulation technology to prepare lipid-soluble active substances into lipid inclusion base particles, so that the stability and the biological activity of the active substances can be effectively improved, the transdermal efficiency of the active substances can be promoted, the irritation of the active substances can be effectively reduced, the bioavailability of the active substances to a human body can be improved, the activity of tyrosinase can be effectively inhibited, the pigmentation can be prevented, epidermal cells can be repaired, the effects of whitening and moisturizing can be achieved, and the skin can be brightly and white.

At present, the number of first-aid skin care products on the market is increased day by day, and the dressing appearance of the next day is obviously affected due to the problem of dark skin brought by staying up all night, so that the instant brightening is a large direction of the first-aid skin care products, and is favored by beauty lovers, and the market prospect is wide. Therefore, it is urgently required to develop a skin care composition effective for instantly lightening skin color. However, in the current research, no report that the synergistic effect of tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances is used for realizing the instant brightening and skin-care effect is found.

Disclosure of Invention

Aiming at the condition of the prior art, the composition for instantly brightening the skin color is simple in component, achieves a good effect of instantly brightening the skin color through the synergistic combination of tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances, is obvious in instantly brightening effect, can be used for skin emergency treatment, and is particularly suitable for skin care products for emergency treatment at night.

The invention provides a composition for instantly lightening skin color, wherein the instantly lightening means that: the skin color brightening effect is obvious, the skin can quickly absorb the effective components after the skin is used, the external appearance of the skin care effect is quick and obvious, and the effects of obviously improving the skin brightness and the color can be achieved within 9 hours. The composition for instantly brightening the skin color consists of tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances, and comprises the following components in parts by weight: 0.01-0.2 part of tetrahydrocurcumin, 100.01-0.1 part of coenzyme Q and 0.01-0.2 part of hyaluronic acid substances. The composition has obvious instant brightening effect, is particularly suitable for emergency care and is particularly suitable for emergency series cosmetics.

Preferably, when 0.01-0.15 part of tetrahydrocurcumin, 100.01-0.05 part of coenzyme Q and 0.05-0.15 part of hyaluronic acid substances, the synergistic effect of the tetrahydrocurcumin, the coenzyme Q and the hyaluronic acid substances is stronger, and the instant brightening and skin-care effect of the obtained composition is more obvious.

Further, in the composition, the hyaluronic acid-based substance is at least one of hyaluronic acid, a hyaluronic acid salt, a hyaluronic acid derivative, and a hyaluronic acid salt derivative. For example, the hyaluronic acid-based substance may be selected from one or more hyaluronic acid salts, one or more hyaluronic acid derivatives, one or more hyaluronic acid salt derivatives, two or more hyaluronic acid, a hyaluronic acid salt, a hyaluronic acid derivative, and a hyaluronic acid salt derivative, or a mixture of hyaluronic acid salts and hyaluronic acid salt derivatives. Preferably, the hyaluronic acid-based substance is at least one of a hyaluronic acid salt and a hyaluronic acid salt derivative, and more preferably at least one of a hyaluronic acid salt.

Further, in the composition, the hyaluronic acid derivative is acetylated hyaluronic acid, thiolated hyaluronic acid and the like, and various hyaluronic acid derivatives have similar effects; the hyaluronate derivatives are acetylated hyaluronate, thiolated hyaluronate and the like, and the effects of various hyaluronate derivatives are similar; the hyaluronate comprises sodium salt, potassium salt, calcium salt, zinc salt or magnesium salt of hyaluronic acid, wherein the sodium salt of hyaluronic acid is commonly used, and the effect of each hyaluronate is similar; the hyaluronate in the hyaluronate derivative comprises sodium salt, potassium salt, calcium salt, zinc salt or magnesium salt of hyaluronic acid, and the sodium salt of hyaluronic acid is commonly used.

Further, in the above composition, the weight average molecular weight of the hyaluronic acid-based substance is 0.1 × 10 ⁶ Da-1.0×10 ⁶ Da, preferably 0.5X 10 ⁶ Da-0.7×10 ⁶ Da. Within this preferred molecular weight range, the resulting mixture has a better instant lightening effect.

The composition of the invention is simple to prepare, and the components are physically mixed. The composition has quick and good effects in whitening skin, improving skin brightness and color, and has instant brightening effect, and is especially suitable for emergency cosmetics.

Further, the invention also provides a cosmetic which contains the composition for instantly brightening the skin color.

Further, the cosmetic is preferably a type of immediate lightening, first aid skin care cosmetic.

Further, in the cosmetic, the content of tetrahydrocurcumin in the cosmetic is 0.01-0.2wt%, the content of coenzyme Q10 in the cosmetic is 0.01-0.1wt%, and the content of hyaluronic acid substances in the cosmetic is 0.01-0.2 wt%.

Further, in the above cosmetic, the content of tetrahydrocurcumin in the cosmetic is preferably 0.01 to 0.15wt%, the content of coenzyme Q10 in the cosmetic is preferably 0.01 to 0.05wt%, and the content of hyaluronic acid-like substance in the cosmetic is preferably 0.05 to 0.15 wt%.

Further, the whole instant skin color-lightening composition is contained in the cosmetic in an amount of 0.03 to 0.5wt%, preferably 0.07 to 0.35 wt%.

Further, the cosmetic may be a skin care product, and may also be a color cosmetic, the types of the skin care product may include a mask, a essence, a lotion, a cream, etc., and the types of the color cosmetic may include a foundation having a skin care effect, a pressed powder, a honey powder, a loose powder, a BB cream, a concealer, a makeup base, a sunscreen, a blush, a makeup fixing spray, etc.

Furthermore, the cosmetic can contain other effective components such as components with effects of moisturizing, whitening, brightening skin, tightening, removing wrinkle, removing speckle, resisting aging, resisting oxidation, etc. besides the composition for instantly brightening skin color. By compounding the components, the efficacy of the cosmetic can be improved.

Further, the cosmetic contains matrix components necessary for preparing different types of cosmetics so that the effective components can be uniformly mixed and applied to the skin, wherein the matrix comprises a solvent, an emulsifier, a thickener, a preservative and the like.

The invention provides a composition containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances for instantly brightening skin color, which is compounded synergistically to show outstanding effects of instantly brightening and emergency skin care, is easy to obtain raw materials of the three components, is low in dosage in cosmetics, has the advantages of few component types, small addition amount in the cosmetics, low cost, outstanding effect of instantly brightening and the like compared with the instant brightening products in the prior art, and is particularly suitable for emergency skin care type cosmetics.

Detailed Description

In order to better explain the technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples. It should be noted that the process parameters, process steps, etc. which are not described in detail in the present invention are performed according to the conventional technical means in the art.

In the examples described below, various hyaluronic acids were used and were obtained from Huaxi biological products, Inc.

Example 1

The composition for instantly brightening the skin color comprises the following components in parts by weight: 0.05 part of tetrahydrocurcumin, 100.02 parts of coenzyme Q and 0.1 part of sodium hyaluronate. Wherein the sodium hyaluronate has a weight average molecular weight of 0.6 × 10 ⁶ Da。

In preparation, the components are mixed to obtain the composition.

Example 2

The composition for instantly brightening the skin color comprises the following components in parts by weight: 0.01 part of tetrahydrocurcumin, 100.05 parts of coenzyme Q and 0.15 part of sodium hyaluronate. Wherein the sodium hyaluronate has a weight average molecular weight of 0.6 × 10 ⁶ Da。

Example 3

The composition for instantly brightening the skin color comprises the following components in parts by weight: 0.15 part of tetrahydrocurcumin, 100.01 parts of coenzyme Q and 0.05 part of sodium hyaluronate. Wherein the sodium hyaluronate has a weight average molecular weight of 0.6 × 10 ⁶ Da。

Example 4

The composition for instantly brightening the skin color comprises the following components in parts by weight: 0.2 part of tetrahydrocurcumin, 100.01 parts of coenzyme Q and 0.01 part of sodium hyaluronate. Wherein the sodium hyaluronate has a weight average molecular weight of 0.6 × 10 ⁶ Da。

Example 5

The composition for instantly brightening the skin color comprises the following components in parts by weight: 0.01 part of tetrahydrocurcumin, 100.1 parts of coenzyme Q and 0.2 part of sodium hyaluronate. Wherein the sodium hyaluronate has a weight average molecular weight of 0.6 × 10 ⁶ Da。

Example 6

A composition for instantly lightening skin color, the formulation being the same as in example 1, except that: the weight average molecular weight of sodium hyaluronate is 0.5 × 10 ⁶ Da。

Example 7

A composition for instantly lightening skin color, the formulation being the same as in example 1, except that: sodium hyaluronate has a weight average molecular weight of 1.0X 10 ⁶ Da。

Example 8

A composition for instantly lightening skin color, the formulation being the same as in example 1, except that: the weight average molecular weight of sodium hyaluronate is 0.1 × 10 ⁶ Da。

Example 9

A composition for instantly lightening skin color, the formulation of which is the same as example 1, except thatThe method comprises the following steps: the hyaluronic acid is acetylated sodium hyaluronate with average molecular weight of 0.6 × 10 ⁶ Da。

Example 10

A composition for instantly lightening skin color, the formulation being the same as in example 1, except that: the hyaluronic acid is sodium thiolated hyaluronate with average molecular weight of 0.6 × 10 ⁶ Da。

Comparative example 1

A skin care composition comprises the following components in parts by weight: 0.05 part of tetrahydrocurcumin, 100 parts of coenzyme Q and 0.1 part of sodium hyaluronate. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Comparative example 2

A skin care composition comprises the following components in parts by weight: 0 part of tetrahydrocurcumin, 100.02 parts of coenzyme Q and 0.1 part of sodium hyaluronate. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Comparative example 3

A skin care composition comprises the following components in parts by weight: 0.05 part of tetrahydrocurcumin, 100.02 parts of coenzyme Q and 0 part of sodium hyaluronate.

Comparative example 4

A skin care composition comprises the following components in parts by weight: 0 part of tetrahydrocurcumin, 100 parts of coenzyme Q and 0.1 part of hyaluronic acid substances. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Comparative example 5

A skin care composition comprises the following components in parts by weight: 0.05 part of tetrahydrocurcumin, 100 parts of coenzyme Q and 0 part of hyaluronic acid substances.

Comparative example 6

A skin care composition comprises the following components in parts by weight: 0 part of tetrahydrocurcumin, 100.02 parts of coenzyme Q and 0 part of hyaluronic acid substances.

Comparative example 7

A skin care composition comprises the following components in parts by weight: 0.25 part of tetrahydrocurcumin and 100 parts of coenzyme Q.15 parts of sodium hyaluronate and 0.1 part of sodium hyaluronate. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Comparative example 8

A skin care composition comprises the following components in parts by weight: 0.25 part of tetrahydrocurcumin, 100.02 parts of coenzyme Q and 0.25 part of sodium hyaluronate. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Comparative example 9

A skin care composition comprises the following components in parts by weight: 0.05 part of tetrahydrocurcumin, 100.15 parts of coenzyme Q and 0.25 part of sodium hyaluronate. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Comparative example 10

Glabridin can effectively inhibit activity of multiple enzymes in melanin production process, and has effects of preventing pachylosis, resisting inflammation, resisting oxidation and resisting bacteria. Replacing tetrahydrocurcumin with glabridin to obtain the skin care composition consisting of the following components in parts by weight: 0.05 part of glabridin, 100.02 parts of coenzyme Q and 0.1 part of sodium hyaluronate. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Comparative example 11

Carnosine is a multifunctional active peptide, effectively quenches active oxygen free radicals, can complex heavy metals, and has other effects of detoxifying and detoxifying heavy metals and the like. Replacing coenzyme Q10 with carnosine to obtain a skin care composition consisting of the following components in parts by weight: 0.05 part of tetrahydrocurcumin, 0.02 part of carnosine and 0.1 part of sodium hyaluronate. Wherein the molecular weight of sodium hyaluronate is 0.6 × 10 ⁶ Da。

Application example 1

The compositions prepared by the above embodiments and comparative examples of the invention can be used in cosmetics, can be used as an effective component of cosmetics, and are particularly suitable for emergency skin care cosmetics. The types of the cosmetics include, but are not limited to, skin care products such as essence, lotion, cream and mask, and color cosmetics such as foundation make-up, pressed powder, honey powder, loose powder, BB cream, concealer, makeup base, sunscreen cream, blush, makeup fixing spray and the like with skin care effects. During preparation, the cosmetic not only contains the composition for instantly brightening skin color, containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances, but also comprises a matrix required for preparing various dosage forms, the matrix can be selected from the matrixes commonly used by different types of cosmetics according to the prior art, and the preparation method of the cosmetics is prepared according to the conventional method of the prior art.

Application example 2

In order to verify the excellent effect of the composition for instantly lightening skin color of the present invention comprising tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid-like substances, the compositions of the above examples and comparative examples were prepared as first aid creams staying up overnight by the following method:

TABLE 1 basic formula of first-aid cream for staying up all night

Table 2 contents of ingredients in the examples and comparative examples in first aid overnight cream

The preparation method of the first aid cream for staying up all over comprises the following steps:

(1) mixing and stirring the phase A raw materials uniformly;

(2) adding the phase B into the phase A, and uniformly mixing and stirring to obtain a mixed phase 1;

(3) pre-dispersing and uniformly mixing the phase C, adding the mixed phase 1, and uniformly mixing and stirring to obtain a mixed phase 2;

(4) and adding the phase D and the phase F into the mixed phase 2 according to actual conditions, uniformly stirring, and discharging to obtain the overnight first aid cream.

Experimental example 1 whitening Effect

1. Experimental reagent

Cell culture solution: 1640 culture medium containing 10% FBS;

NaOH lysate: preparing NaOH lysate with the concentration of 0.1mol/L by using 10 percent DMSO solution;

mao monkey extract solution: preparing 20 mu M of a mao monkey hormone solution by using a cell culture solution;

sample solution: preparing a glycerol solution from the compositions of examples 1 to 10 and comparative examples 1 to 11 and glycerol according to a mass ratio of 1:1, and then mixing the glycerol solution with a mao monkey extract solution to prepare a solution with the concentration of the compositions of examples and comparative examples being 8 wt%;

MTT working solution: MTT working solution with concentration of 5% is prepared by PBS, filtered and sterilized by a 0.22 mu m filter membrane, and stored in a refrigerator at 4 ℃. And (5) standby.

2. The experimental method comprises the following steps: b16 cells were plated at 1X 10 ⁵ Inoculating to 6-well plate at 37 deg.C and 5% CO ₂ Culturing for 24h under the condition. Adding sample solution, reacting for 72h, cracking cells with NaOH lysate, heating at 80 deg.C for 30min, and detecting absorbance with enzyme-labeling instrument. Meanwhile, cells with the same volume density are inoculated in a 96-well plate to serve as proliferation control, and the influence of each sample on the melanin level in a unit cell is examined. The results are shown in Table 3.

TABLE 3

Sample (I)	Melanin inhibition per cell (%)
		Example 1	83.19
Example 2	80.13
		Example 3	82.68
Example 4	80.17
		Example 5	79.95
Example 6	82.94
		Example 7	81.76
Example 8	82.10
		Example 9	83.11
Example 10	83.21
		Comparative example 1	67.74
Comparative example 2	60.32
		Comparative example 3	71.07
Comparative example 4	10.09
		Comparative example 5	26.68
Comparative example 6	20.45
		Comparative example 7	86.20
Comparative example 8	85.95
		Comparative example 9	84.17
Comparative example 10	63.44
		Comparative example 11	59.16

From the data analysis of examples 1-3 and examples 4-5, it can be seen that the whitening effect of the preferred ratio of the instant lightening composition containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances is superior to the non-preferred ratio in the present consideration; from the data analysis of examples 1 and 6 to 8, it is found that in the skin color-lightening composition containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid-based substance, the molecular weight of the hyaluronic acid-based substance is 0.5 × 10 ⁶ Da-0.7×10 ⁶ Da is optimal from the cost point of view (generally, the smaller the molecular weight, the higher the cost is), and the skin feel in the molecular weight range is also better; from the data analysis of example 1 and examples 9 to 10, it is known that the variety of hyaluronic acid-based substances has little influence on the whitening effect in the instant skin lightening composition containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid-based substances.

The data analysis of the example 1 and the comparative examples 1 to 6 shows that the tetrahydrocurcumin, the coenzyme Q10 and the hyaluronic acid substances have obvious synergistic effect on the whitening effect; as can be seen from the data analysis of example 1 and comparative examples 7 to 9, in the instant skin color-improving composition containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances, when the contents of the tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances are all greatly increased, the improvement effect of the composition on the skin whitening effect is not obvious, but the cost is obviously increased; as can be seen from the comparative analysis between example 1 and comparative examples 10 and 11, in the instant skin color brightening composition containing tetrahydrocurcumin, coenzyme Q10 and hyaluronic acid substances, if the tetrahydrocurcumin and coenzyme Q10 are replaced by glabridin and carnosine which are commonly used as raw materials in the market at the same concentration, the effect is obviously deteriorated, and the whitening synergistic effect of the composition is better under the same content.

Experimental example 2 skin color and gloss experiment

Experimental samples: the first aid cream prepared in example 2 was applied overnight containing the compositions of the different examples and comparative examples.

Control sample: the same formula as the first aid cream of application example 2 except that the composition of any of the examples and comparative examples is not contained therein, can also be called blank first aid cream.

The instrument equipment comprises: VISIA CR (usa).

The experimental method comprises the following steps: the half-face control mode was used, the right face was treated with the overnight first aid cream containing the composition of example or comparative example, the left face was treated with the blank overnight first aid cream containing no composition of example or comparative example, the cream was applied once before sleep, and the left and right sides of the face were photographed by VISIA CR before use (about 5 am on the next day) and after use for 9h (about 9 am on the next day) and 16h (about 4 pm on the next day), and the change in skin color and gloss of the whole face was analyzed.

Subject: 20 late-sleeping overnight-staying nights with a sleeping time of about 24 o' clock or later are selected, the ages are 25-35 years old, and all women are women. The subjects were not pox-free and also had no visible redness of the skin.

Because of the limited selection of human subjects and the difficulty of experimental development, 4 samples representative of example 2 were selected for testing, respectively, as the overnight first aid cream containing example 1, the overnight first aid cream containing comparative example 8, the overnight first aid cream containing comparative example 10, and the overnight first aid cream containing comparative example 11. At the time of the experiment, each subject was asked to sleep at the earliest 23 nights, with 5 subjects using the overnight first aid cream of example 1, 5 subjects using the overnight first aid cream of comparative example 8, 5 subjects using the overnight first aid cream of comparative example 10, and 5 subjects using the overnight first aid cream of comparative example 11, the experimental procedures being as described previously.

After the experiment was completed, the relative values of the skin color Lab value and the gloss measurement value of each subject were calculated, and then the average relative value of the relative values of the same group of the testers was calculated. Wherein, the higher average relative value of the skin color L value represents the whitening of the skin color, the higher average relative value of the a value represents the reddish skin color, and the higher average relative value of the b value represents the yellowish skin color. Higher average relative value of gloss represents increased gloss.

Relative values are measured n hours after use/before use (n is 9, 16).

Average relative value is the sum of relative values of the same group/5.

The experimental results are shown in tables 4 and 5 below. In tables 4 and 5, T0 represents the average relative value before use, T1 represents the average relative value after 9h, and T2 represents the average relative value after 16 h.

TABLE 4 skin color Change

TABLE 5 changes in skin gloss

From the data analysis in Table 4, it can be seen that the average relative L value of the skin color of the subjects increased with the compositions of example 1 and comparative example 8, the average relative L value of the composition of comparative example 8 was higher than that of example 1, and the average relative L value of the subjects decreased with the compositions of comparative examples 10 and 11. The average relative values of the a-value and the b-value using the compositions of example 1 and comparative example 8 were both reduced to a greater extent than using the compositions of comparative examples 10 and 11. From the consideration of use effect and cost, the composition of the embodiment 1 has better instant brightening effect and lower cost, and is suitable for industrial application.

From the data analysis of table 5, it can be seen that the skin color has an improvement effect using the compositions of example 1, comparative example 8, comparative example 10 and comparative example 11, and the composition of comparative example 8 has the best improvement effect, and secondly, the composition of example 1, and the composition of example 1 is more suitable for industrial application in view of cost and effect.

Claims

1. The composition for instantly brightening the skin color is characterized by comprising the following components in parts by weight: 0.01-0.2 part of tetrahydrocurcumin, 100.01-0.1 part of coenzyme Q and 0.01-0.2 part of hyaluronic acid substances; the hyaluronic acid substance is at least one of hyaluronate and hyaluronate derivative, and has a weight average molecular weight of 0.1 × 10 ⁶ Da-1.0×10 ⁶ Da。

2. The composition according to claim 1, which is characterized by consisting of the following components in parts by weight: 0.01-0.15 part of tetrahydrocurcumin, 100.01-0.05 part of coenzyme Q and 0.05-0.15 part of hyaluronic acid substances.

3. The composition according to claim 1 or 2, characterized in that: the hyaluronic acid substance is at least one of hyaluronic acid, a hyaluronic acid salt, a hyaluronic acid derivative and a hyaluronic acid salt derivative.

4. The composition as set forth in claim 3, wherein: the hyaluronic acid derivative comprises acetylated hyaluronic acid or thiolated hyaluronic acid; the hyaluronate derivative comprises acetylated hyaluronate or thiolated hyaluronate; the hyaluronate comprises sodium salt, potassium salt, calcium salt, zinc salt or magnesium salt of hyaluronic acid; the hyaluronate in the hyaluronate derivative comprises sodium salt, potassium salt, calcium salt, zinc salt or magnesium salt of hyaluronic acid.

5. The composition as set forth in claim 4, wherein: the hyaluronate is sodium salt of hyaluronic acid, and the hyaluronate in the hyaluronate derivatives is sodium salt of hyaluronic acid.

6. The composition as set forth in claim 1, wherein: the hyaluronic acid substance has a weight average molecular weight of 0.5 × 10 ⁶ Da-0.7×10 ⁶ Da。

7. A cosmetic characterized by: an instant skin lightening composition comprising any one of claims 1 to 6.

8. The cosmetic as set forth in claim 7, wherein: the cosmetic is first-aid cosmetic.

9. The cosmetic as set forth in claim 7, wherein: the content of tetrahydrocurcumin in cosmetic is 0.01-0.2wt%, the content of coenzyme Q10 in cosmetic is 0.01-0.1wt%, and the content of hyaluronic acid substances in cosmetic is 0.01-0.2 wt%.

10. The cosmetic as set forth in claim 7, wherein: the content of tetrahydrocurcumin in cosmetic is 0.01-0.15wt%, the content of coenzyme Q10 in cosmetic is 0.01-0.05wt%, and the content of hyaluronic acid substances in cosmetic is 0.05-0.15 wt%.

11. The cosmetic as set forth in claim 7, wherein: the total content of the composition for instantly lightening skin color in the cosmetic is 0.03-0.5 wt%.

12. The cosmetic as set forth in claim 11, wherein: the total content of the composition for instantly lightening the skin color in the cosmetics is 0.07-0.35 wt%.

13. The cosmetic according to any one of claims 7 to 12, wherein: the cosmetic is a skin care product or a color cosmetic, the skin care product comprises essence, emulsion, cream or a facial mask, and the color cosmetic comprises foundation with skin care effect, honey powder, sunscreen cream, blush or makeup fixing spray.

14. The cosmetic as set forth in claim 13, wherein: the color cosmetics are pressed powder, loose powder or makeup base.

15. The cosmetic as set forth in claim 13, wherein: the color cosmetic is BB cream.

16. The cosmetic as set forth in claim 13, wherein: the color cosmetic is concealer.