CN108669557A - Soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil - Google Patents
Soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil Download PDFInfo
- Publication number
- CN108669557A CN108669557A CN201810484509.6A CN201810484509A CN108669557A CN 108669557 A CN108669557 A CN 108669557A CN 201810484509 A CN201810484509 A CN 201810484509A CN 108669557 A CN108669557 A CN 108669557A
- Authority
- CN
- China
- Prior art keywords
- natural
- content
- tomato
- seed oil
- pumpkin seed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000007688 Lycopersicon esculentum Nutrition 0.000 title claims abstract description 75
- 239000008171 pumpkin seed oil Substances 0.000 title claims abstract description 47
- 239000007901 soft capsule Substances 0.000 title claims abstract description 30
- 239000002552 dosage form Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 240000003768 Solanum lycopersicum Species 0.000 title claims description 72
- 235000012661 lycopene Nutrition 0.000 claims abstract description 28
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims abstract description 25
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims abstract description 25
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims abstract description 25
- 229960004999 lycopene Drugs 0.000 claims abstract description 25
- 239000001751 lycopene Substances 0.000 claims abstract description 25
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims abstract description 25
- YVLPJIGOMTXXLP-UHFFFAOYSA-N 15-cis-phytoene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C YVLPJIGOMTXXLP-UHFFFAOYSA-N 0.000 claims description 20
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 19
- 239000004519 grease Substances 0.000 claims description 19
- 239000003921 oil Substances 0.000 claims description 15
- 235000019198 oils Nutrition 0.000 claims description 15
- 235000016709 nutrition Nutrition 0.000 claims description 12
- 241000196324 Embryophyta Species 0.000 claims description 11
- 239000004615 ingredient Substances 0.000 claims description 11
- YVLPJIGOMTXXLP-UUKUAVTLSA-N 15,15'-cis-Phytoene Natural products C(=C\C=C/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C YVLPJIGOMTXXLP-UUKUAVTLSA-N 0.000 claims description 10
- YVLPJIGOMTXXLP-BAHRDPFUSA-N 15Z-phytoene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)CCC=C(/C)CCC=C(C)C)C)C)C)C YVLPJIGOMTXXLP-BAHRDPFUSA-N 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 10
- 235000011765 phytoene Nutrition 0.000 claims description 10
- 229930182558 Sterol Natural products 0.000 claims description 9
- 150000003432 sterols Chemical class 0.000 claims description 9
- 235000003702 sterols Nutrition 0.000 claims description 9
- 229930003799 tocopherol Natural products 0.000 claims description 9
- 229960001295 tocopherol Drugs 0.000 claims description 9
- 239000011732 tocopherol Substances 0.000 claims description 9
- 235000010384 tocopherol Nutrition 0.000 claims description 9
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 9
- XKRFYHLGVUSROY-UHFFFAOYSA-N argon Substances [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 7
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- 229910052786 argon Inorganic materials 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 244000061458 Solanum melongena Species 0.000 claims description 4
- 235000002597 Solanum melongena Nutrition 0.000 claims description 4
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 4
- 241001076960 Argon Species 0.000 claims description 3
- 235000000832 Ayote Nutrition 0.000 claims description 3
- 235000009854 Cucurbita moschata Nutrition 0.000 claims description 3
- 240000001980 Cucurbita pepo Species 0.000 claims description 3
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 claims description 3
- 235000013876 argon Nutrition 0.000 claims description 3
- -1 argon Lycopenes Chemical class 0.000 claims description 3
- 235000015136 pumpkin Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims description 2
- 241000353135 Psenopsis anomala Species 0.000 claims 1
- 230000003647 oxidation Effects 0.000 abstract description 10
- 238000007254 oxidation reaction Methods 0.000 abstract description 10
- 150000002632 lipids Chemical class 0.000 abstract description 8
- 210000002966 serum Anatomy 0.000 abstract description 7
- 206010006187 Breast cancer Diseases 0.000 abstract description 5
- 208000026310 Breast neoplasm Diseases 0.000 abstract description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 201000005202 lung cancer Diseases 0.000 abstract description 5
- 208000020816 lung neoplasm Diseases 0.000 abstract description 5
- 230000019100 sperm motility Effects 0.000 abstract description 5
- 206010060862 Prostate cancer Diseases 0.000 abstract description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract description 4
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 239000008280 blood Substances 0.000 abstract description 4
- 208000029078 coronary artery disease Diseases 0.000 abstract description 4
- 230000036039 immunity Effects 0.000 abstract description 4
- 206010046766 uterine cancer Diseases 0.000 abstract description 4
- 230000004888 barrier function Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 230000000977 initiatory effect Effects 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 230000001151 other effect Effects 0.000 abstract description 3
- 230000036559 skin health Effects 0.000 abstract description 3
- 241000227653 Lycopersicon Species 0.000 abstract 3
- 102000007330 LDL Lipoproteins Human genes 0.000 description 10
- 108010007622 LDL Lipoproteins Proteins 0.000 description 10
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 5
- 102100038358 Prostate-specific antigen Human genes 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 230000004224 protection Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- OVSVTCFNLSGAMM-KGBODLQUSA-N cis-phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/C=C/C=C(C)/CCC=C(/C)CCC=C(C)C)C)C)C)C OVSVTCFNLSGAMM-KGBODLQUSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- OVSVTCFNLSGAMM-UZFNGAIXSA-N phytofluene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=C\C=C(/C)\C=C\C=C(C)CCC=C(C)CCC=C(C)C OVSVTCFNLSGAMM-UZFNGAIXSA-N 0.000 description 1
- 235000002677 phytofluene Nutrition 0.000 description 1
- ZYSFBWMZMDHGOJ-SGKBLAECSA-N phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)C=CC=C(/C)CCC=C(C)C)C)C)C)C ZYSFBWMZMDHGOJ-SGKBLAECSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- ZIUDAKDLOLDEGU-UHFFFAOYSA-N trans-Phytofluen Natural products CC(C)=CCCC(C)CCCC(C)CC=CC(C)=CC=CC=C(C)C=CCC(C)CCCC(C)CCC=C(C)C ZIUDAKDLOLDEGU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of soft capsule dosage forms and preparation method thereof containing natural tomato extract liquor pumpkin seed oil, including the red extract 220.0mg~250.0mg of natural tomato, pumpkin seed oil 200mg~230mg, the red extract content ratio of natural tomato is 48.89~55.56%, and pumpkin seed oil content ratio is 44.44%~51.11%.Optimum and the best natural nutrient that can faster assist the healthy defensive barrier of human body foundation, natural Lycopene is fat-soluble, the initiation potential of coronary heart disease is reduced if can inhibit serum lipids (Serum lipid) and LDL oxidation (LDL Oxidation) containing Lycopene in blood of human body, also there is the generation for improving the immunity of the human body, reducing disease, and for preventing prostate cancer, lung cancer, breast cancer, uterine cancer and improving sperm motility and concentration and other effects, have the effect of beneficial skin health.
Description
Technical field
The present invention relates to a kind of soft capsule dosage forms and preparation method thereof containing natural tomato extract liquor pumpkin seed oil, belong to
Food technology field.
Background technology
Present living standards of the people are greatly improved, but under the animation of high rhythm, are easy to cause human body
Health status declines, and mainly has：Illness rate caused by immunity degradation improves, and is susceptible to serum lipids and low-density lipoprotein
Coronary heart disease caused by oxidation, the cancers such as prostate cancer, lung cancer, breast cancer, uterine cancer, sperm motility and concentration decline, skin
Situations such as aging, and can quickly be aoxidized after common Lycopene is light-exposed and ingress of air, there is no for such healthy shape at present
State declines and the nutriment of exploitation, therefore can not be replenished in time when lacking nutrition.
Invention content
The present invention provides a kind of soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil, solutions
It has determined the above problem.
The present invention provides a kind of soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, including natural tomato are red
Extract 220.0mg~250.0mg, pumpkin seed oil 200mg~230mg, the red extract content ratio of natural tomato be 48.89~
55.56%, pumpkin seed oil content ratio is 44.44%~51.11%.
Further, in above-mentioned technical proposal, the nutritional ingredient difference in the red extract of natural tomato is as follows：
Natural Lycopene content is 13.2mg~15.75mg；
Natural hexahydro and Phytoene content are 2.2mg~2.5mg；
Natural tocopherol level is 3.344mg~3.8mg；
Natural bata-carotene content is 0.44mg~0.5mg；
Natural plants sterol content is 6.6mg~7.5mg；
Tomato oil and grease extracting content is 194.216mg~220.7mg.
Further, in above-mentioned technical proposal, the nutritional ingredient difference in the red extract of natural tomato is as follows：
Natural Lycopene content occupation ratio is 6%~6.3%；
Natural hexahydro and Phytoene content occupation ratio are 1%；
Natural tocopherol level occupation ratio is 1.52%；
Natural bata-carotene content occupation ratio is 0.2%；
Natural plants sterol content occupation ratio is 3%；
Tomato oil and grease extracting content occupation ratio is 87.98%~88.28%.
A kind of preparation method of the soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, the preparation method is that：
The preparation method is that：
1. predetermined weight part is pressed, natural Lycopene, six argons and eight argon Lycopenes, vitamin E, bata-carotene, plant is solid
Alcohol, tomato oil and grease extracting are added containing the mixing of the pumpkin grease of monounsaturated fatty acid and polybasic unsaturated fatty acid；
2. in the yellow light space of toilet, by emulsifying device, through 50~55 DEG C of stirring and emulsifyings；
3. being put into lighttight capsule or soft capsule.
The present invention has the beneficial effect that：
1. the present invention can inhibit serum lipids (Serum lipid) and LDL oxidation (LDL Oxidation)
And the initiation potential of coronary heart disease is reduced, also there is the generation for improving the immunity of the human body, reducing disease, and for preventing prostate
Cancer, lung cancer, breast cancer, uterine cancer and raising sperm motility and concentration and other effects；In addition, it also allow human body blood in do not allow most
Destruction easily is received, the pigment that fat is not injured by oxygen and tomato is allowed to be popular in blood can be protected instead, Skin Cell is by ultraviolet
The absorbable ultraviolet light of lycopene is destroyed in cell when line irradiates, it is thus possible to beneficial to the effect of skin health；
2. the capsule 's content range for being supplied to human nutrition to be helped with health maximum is optimum and can faster be assisted
Human body establishes the best natural nutrient of healthy defensive barrier；
3. preparation method of the present invention can avoid sunlight and air oxidation, with lighttight capsule or soft capsule dosage form
It presents so that reach ingredient protection, and be easy to edible quick with absorption.
Specific implementation mode
Following non-limiting embodiments can make those skilled in the art be more fully understood the present invention, but not with
Any mode limits the present invention.
A kind of soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil, including natural tomato are red
Extract 220.0mg~250.0mg, pumpkin seed oil 200mg~230mg, the red extract content ratio of natural tomato be 48.89~
55.56%, pumpkin seed oil content ratio is 44.44%~51.11%, and the nutritional ingredient in the red extract of the natural tomato point
It is not as follows：
Natural Lycopene content is 13.2mg~15.75mg, and occupation ratio is 6%~6.3%；
Natural hexahydro and Phytoene content are 2.2mg~2.5mg, occupation ratio 1%；
Natural tocopherol level is 3.344mg~3.8mg, occupation ratio 1.52%；
Natural bata-carotene content is 0.44mg~0.5mg, occupation ratio 0.2%；
Natural plants sterol content is 6.6mg~7.5mg, occupation ratio 3%；
Tomato oil and grease extracting content is 194.216mg~220.7mg, and occupation ratio is 87.98%~88.28%.
When natural tomato red extract content ratio increases to highest 250mg, pumpkin seed oil content ratio is then reduced to
200mg；Opposite, the red extract content ratio of natural tomato is reduced to minimum 220mg, pumpkin seed oil content ratio then to increase to
Highest 230mg, therefore the two collocation amount then goes to allocate with opposite way, and above-mentioned limited range is arranged in pairs or groups, then is to provide
To human nutrition and the maximum capsule 's content range helped of health.
Natural Lycopene (Lycopene), six argon eggplants contained in the natural tomato fruit of the desert kind of mediterranean are red
Plain (Phytofluene) and eight argon Lycopene (Phytopene) equal sizes than general Lycopersicon esculentum fruit Lycopene more than 3~5
Times, also most natural fat-soluble strong anti-oxidation and the by force ability of removing free radical, and the eggplant of the tamato fruit of general kind is red
Element, their oxidation resistance are again 3 times or more than being higher by 2~3 times with the bata-carotene of dosage, and higher than vitamin E, therefore
With Lycopene content the higher person than general tamato fruit as the fitness food formulation of the present invention, it is most suitable for selection
Human body can be assisted to establish the best natural nutrient of healthy defensive barrier preferably and faster, natural Lycopene is fat-soluble, if people
In body blood serum lipids (Serum lipid) and LDL oxidation (LDL Oxidation) are can inhibit containing Lycopene
And the initiation potential of coronary heart disease is reduced, also there is the generation for improving the immunity of the human body, reducing disease, and for preventing prostate
Cancer, lung cancer, breast cancer, uterine cancer and raising sperm motility and concentration and other effects；In addition, the present invention can allow in the blood of human body
Fat do not injured by oxygen, the present invention can absorb UV protection skin when Skin Cell is irradiated by ultraviolet light, therefore with benefit
The effect of skin health.
The embodiment of the technology of the present invention, simultaneously using the natural tomato fruit of the desert kind of mediterranean as main material
Natural tomato extract is then set as 220.0mg~250mg, pumpkin seed oil 230mg~200mg (contains by extraction in allotment
Amount setting is with extract at opposite direction), the red extract content ratio of natural tomato is 48.89%~55.56%, pumpkin seed oil
Content ratio is 51.11%~44.44% (content setting ratio is with extract at opposite direction), and the two ratio hybrid mode is
The red extract content ratio of natural tomato increases to highest 250mg, and pumpkin seed oil content ratio is then reduced to 200mg；Conversely, day
Right tomato red extract content ratio minimizes 220mg, and pumpkin seed oil content ratio then increases to highest 230mg, therefore two
Person's collocation amount then goes to allocate with opposite way.Natural tomato extract is then that Lycopene content is 13.2mg~15.75mg, is occupied
Ratio is 6%~6.3%；Hexahydro and Phytoene content are 2.2mg~2.5mg, occupation ratio 1%；Content of vitamin E
For 3.344mg~3.80mg, occupation ratio 1.52%；Bata-carotene content is 0.44mg~0.5mg, and occupation ratio is
0.2%；Phytosterol content be 6.6mg~7.5mg, occupation ratio be 3% and tomato oil and grease extracting content be 194.216mg~
220.7mg, (occupation ratio is 87.98%~88.28%).
As shown in the table：
Embodiment 1
A kind of soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, including the red extract of natural tomato
220.0mg, pumpkin seed oil 230mg, the red extract content ratio of natural tomato are 48.89%, and pumpkin seed oil content ratio is
51.11%, and the nutritional ingredient difference in the red extract of the natural tomato is as follows：
Natural Lycopene content is 13.2mg, occupation ratio 6%；
Natural hexahydro and Phytoene content are 2.2mg, occupation ratio 1%；
Natural tocopherol level is 3.344mg, occupation ratio 1.52%；
Natural bata-carotene content is 0.44mg, occupation ratio 0.2%；
Natural plants sterol content is 6.6mg, occupation ratio 3%；
Tomato oil and grease extracting content is 194.216mg, occupation ratio 88.28%.
40 sufferers are divided into two groups by clinical trial, and first group of 20 sufferer takes placebo, and second group of 20 sufferer is every
Day takes the soft capsule dosage form of the present invention containing natural tomato extract liquor pumpkin seed oil, continues 180 days, then takes each group
The average value of PSA such as following table：
PSA is the higher expression hypertrophy of the prostate of prostate specific antigen prostate specific antigen, PSA values
(BPH, that is, Benign prostatic hyperplasia) is more serious, and the placebo is the capsule that the present invention is not added,
It can be seen that the soft capsule dosage form of the present invention containing natural tomato extract liquor pumpkin seed oil is taken after 6 months, second group of trouble
Person's PSA numerical value that is averaged is reduced to 5.65 by 6.76, has apparent improvement to the symptom of controlled micturition difficulty.
Embodiment 2
A kind of soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, including the red extract of natural tomato
250.0mg, pumpkin seed oil 200mg, the red extract content ratio of natural tomato are 55.56%, and pumpkin seed oil content ratio is
44.44%%, and the nutritional ingredient difference in the red extract of the natural tomato is as follows：
Natural Lycopene content is 15.75mg, occupation ratio 6.3%；
Natural hexahydro and Phytoene content are 2.5mg, occupation ratio 1%；
Natural tocopherol level is 3.8mg, occupation ratio 1.52%；
Natural bata-carotene content is 0.5mg, occupation ratio 0.2%；
Natural plants sterol content is 7.5mg, occupation ratio 3%；
Tomato oil and grease extracting content is 219.95mg, occupation ratio 87.98%.
40 51-59 Sui Dai Xie syndrome male patients are divided into two groups by clinical trial, and first group of 20 sufferer takes peace
Console agent, second group of 20 sufferer daily soft capsule dosage form of the present invention containing natural tomato extract liquor pumpkin seed oil,
Continue 30 days, then takes the average value of each group LDL and blood pressure such as following table：
LDL is low-density lipoprotein, and the placebo is the capsule that the present invention is not added, it can be seen that takes this hair
The bright soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil is after 1 month, and second group of patient is averaged low-density lipoprotein
16.1mg/dl is reduced in vain, blood pressure reduces 6.8mmHg, and the low-density lipoprotein and blood pressure of Dui Dai Xie syndrome patients have
Apparent improvement.
Embodiment 3
A kind of soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, including the red extract of natural tomato
230.0mg, pumpkin seed oil 220mg, the red extract content ratio of natural tomato are 51.11%, and pumpkin seed oil content ratio is
48.89%, and the nutritional ingredient difference in the red extract of the natural tomato is as follows：
Natural Lycopene content is 14mg, occupation ratio 6.09%；
Natural hexahydro and Phytoene content are 2.3mg, occupation ratio 1%；
Natural tocopherol level is 3.496mg, occupation ratio 1.52%；
Natural bata-carotene content is 0.46mg, occupation ratio 0.2%；
Natural plants sterol content is 6.9mg, occupation ratio 3%；
Tomato oil and grease extracting content is 202.844mg, occupation ratio 88.19%.
40 31-39 Sui low sperm activity male patients are divided into two groups by clinical trial, and first group of 20 sufferer is taken
Placebo, second group of 20 sufferer daily soft capsule of the present invention containing natural tomato extract liquor pumpkin seed oil
Type continues 365 days, then takes the average value such as following table of a grades of sperm ratios of each group：
A grades of sperms are quick straight line propulsion, and the great-hearted sperm of tool of linear motion, the placebo is not add
Enter the capsule of the present invention, it can be seen that take the soft capsule dosage form of the present invention containing natural tomato extract liquor pumpkin seed oil
After 1 year, second group of patient a grades of sperm ratios that are averaged improve 5.7%, have to the sperm motility of low sperm activity patient bright
Aobvious improvement.
Embodiment 4
A kind of soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, including the red extract of natural tomato
250.0mg, pumpkin seed oil 200mg, the red extract content ratio of natural tomato are 55.56%, and pumpkin seed oil content ratio is
44.44%%, and the nutritional ingredient difference in the red extract of the natural tomato is as follows：
Natural Lycopene content is 15mg, occupation ratio 6%；
Natural hexahydro and Phytoene content are 2.5mg, occupation ratio 1%；
Natural tocopherol level is 3.8mg, occupation ratio 1.52%；
Natural bata-carotene content is 0.5mg, occupation ratio 0.2%；
Natural plants sterol content is 7.5mg, occupation ratio 3%；
Tomato oil and grease extracting content is 220.7mg, occupation ratio 88.28%.
Embodiment 5
A kind of preparation method of the soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil of the present invention, natural eggplant is red
Vitamin E, bata-carotene, phytosterol, tomato oil and grease extracting, unsaturated lipid containing unit is added in element, six argons and eight argon Lycopenes
The pumpkin grease of fat acid and polybasic unsaturated fatty acid, in the yellow light space of toilet, by emulsifying device, through 50~55
DEG C stirring and emulsifying makes to mix for natural plant grease；And Lycopene meets light and easy tos produce light boundary (Photolysis), therefore
It avoids sunlight and ingress of air from aoxidizing (Oxidation), is presented with lighttight capsule or soft capsule dosage form.
Common Lycopene is eaten people's body absorption speed and is relatively delayed, therefore this natural tomato extract is by tomato oil and grease extracting group
At the pumpkin seed oil of addition unit containing volume and polybasic unsaturated fatty acid mixes for vegetative grease；And avoid sunlight and sky
Gas aoxidizes, and is presented with lighttight capsule or soft capsule dosage form so that reaches ingredient protection, and is easy to edible and absorbs quick.
The soft capsule dosage form of the present invention containing natural tomato extract liquor pumpkin seed oil is taken, patient can be reduced and put
Penetrating property treatment after damage, reduce patient receive radiation after damage, take for a long time the present invention, can reduce breast cancer, lung cancer,
The illness rate of liver cancer can reduce uv damage protection skin.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (4)
1. a kind of soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, it is characterised in that：Including the red extraction of natural tomato
Take object 220.0mg~250.0mg, pumpkin seed oil 200mg~230mg, the red extract content ratio of natural tomato is 48.89~
55.56%, pumpkin seed oil content ratio is 44.44%~51.11%.
2. the soft capsule dosage form according to claim 1 containing natural tomato extract liquor south s melon seeds oil, it is characterised in that：
Nutritional ingredient difference in the red extract of natural tomato is as follows：
Natural Lycopene content is 13.2mg~15.75mg；
Natural hexahydro and Phytoene content are 2.2mg~2.5mg；
Natural tocopherol level is 3.344mg~3.8mg；
Natural bata-carotene content is 0.44mg~0.5mg；
Natural plants sterol content is 6.6mg~7.5mg；
Tomato oil and grease extracting content is 194.216mg~220.7mg.
3. the soft capsule dosage form according to claim 1 containing natural tomato extract liquor pumpkin seed oil, it is characterised in that：Institute
The nutritional ingredient difference stated in the red extract of natural tomato is as follows：
Natural Lycopene content occupation ratio is 6%~6.3%；
Natural hexahydro and Phytoene content occupation ratio are 1%；
Natural tocopherol level occupation ratio is 1.52%；
Natural bata-carotene content occupation ratio is 0.2%；
Natural plants sterol content occupation ratio is 3%；
Tomato oil and grease extracting content occupation ratio is 87.98%~88.28%.
4. a kind of preparation method of the soft capsule dosage form containing natural tomato extract liquor pumpkin seed oil, it is characterised in that：For making
The standby soft capsule dosage form as described in claim 1 containing natural tomato extract liquor pumpkin seed oil, preparation method are：
1. press predetermined weight part, by natural Lycopene, six argons and eight argon Lycopenes, vitamin E, bata-carotene, phytosterol, kind
Eggplant oil and grease extracting is added containing the mixing of the pumpkin grease of monounsaturated fatty acid and polybasic unsaturated fatty acid；
2. in the yellow light space of toilet, by emulsifying device, through 50~55 DEG C of stirring and emulsifyings；
3. being put into lighttight capsule or soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810484509.6A CN108669557A (en) | 2018-05-20 | 2018-05-20 | Soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810484509.6A CN108669557A (en) | 2018-05-20 | 2018-05-20 | Soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108669557A true CN108669557A (en) | 2018-10-19 |
Family
ID=63805109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810484509.6A Pending CN108669557A (en) | 2018-05-20 | 2018-05-20 | Soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108669557A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352940A (en) * | 2000-11-11 | 2002-06-12 | 吉建军 | Licopin linoleate capsule |
| CN1650951A (en) * | 2004-12-09 | 2005-08-10 | 宁波健永生物科技有限公司 | Lycophyll mixture |
| CN100998573A (en) * | 2006-06-26 | 2007-07-18 | 宁波健永生物科技有限公司 | Effect and use of capusle prepared by blending multiple sola-red-agent |
| CN101496796A (en) * | 2008-01-29 | 2009-08-05 | 北京康必得药业有限公司 | Composite soft capsule of lycopene |
| CN101808626A (en) * | 2007-07-12 | 2010-08-18 | 利库德有限公司 | synergistic combinations for treating hypertension |
| CN101897441A (en) * | 2010-07-09 | 2010-12-01 | 晨光生物科技集团天津有限公司 | Soft capsule of lycopene |
| CN104473167A (en) * | 2014-12-22 | 2015-04-01 | 威海百合生物技术股份有限公司 | Health-care food for improving male prostatic diseases |
| CN107232594A (en) * | 2017-06-22 | 2017-10-10 | 利康行(北京)生物科技有限公司 | A kind of complex health care product of strengthen immunity |
| CN107259562A (en) * | 2017-05-27 | 2017-10-20 | 新疆红帆生物科技有限公司 | Tomato peel is the method that raw material produces health food soft capsule of lycopene |
-
2018
- 2018-05-20 CN CN201810484509.6A patent/CN108669557A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352940A (en) * | 2000-11-11 | 2002-06-12 | 吉建军 | Licopin linoleate capsule |
| CN1650951A (en) * | 2004-12-09 | 2005-08-10 | 宁波健永生物科技有限公司 | Lycophyll mixture |
| CN100998573A (en) * | 2006-06-26 | 2007-07-18 | 宁波健永生物科技有限公司 | Effect and use of capusle prepared by blending multiple sola-red-agent |
| CN101808626A (en) * | 2007-07-12 | 2010-08-18 | 利库德有限公司 | synergistic combinations for treating hypertension |
| CN101496796A (en) * | 2008-01-29 | 2009-08-05 | 北京康必得药业有限公司 | Composite soft capsule of lycopene |
| CN101897441A (en) * | 2010-07-09 | 2010-12-01 | 晨光生物科技集团天津有限公司 | Soft capsule of lycopene |
| CN104473167A (en) * | 2014-12-22 | 2015-04-01 | 威海百合生物技术股份有限公司 | Health-care food for improving male prostatic diseases |
| CN107259562A (en) * | 2017-05-27 | 2017-10-20 | 新疆红帆生物科技有限公司 | Tomato peel is the method that raw material produces health food soft capsule of lycopene |
| CN107232594A (en) * | 2017-06-22 | 2017-10-10 | 利康行(北京)生物科技有限公司 | A kind of complex health care product of strengthen immunity |
Non-Patent Citations (1)
| Title |
|---|
| 钱凤英: "《走向平衡 寻找属于自己的健康思维》", 31 October 2016 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102805266A (en) | Feed for improving digestive and immunologic ability of chicken | |
| CN102204595A (en) | Functional edible oil containing lycoypene | |
| Usunobun et al. | Phytochemical, trace and mineral composition of Vernonia amygdalina leaves | |
| CN103431392B (en) | Composite marine food for special dietary uses for diabetics | |
| CN103536574A (en) | Coenzyme Q10 soft capsule and preparation method thereof | |
| CN102178808A (en) | Medicine for adjunctively treating prostatic disease | |
| CN105232907A (en) | Beverage capable of invigorating kidney and strengthening Yang and making method thereof | |
| CN102688331A (en) | Novel Chinese medicine foot bath powder | |
| CN107007646A (en) | A kind of nutrition compound of assisting in preventing and treating cancer | |
| CN105663282B (en) | A kind of peony seed oil fat emulsion and preparation method thereof | |
| CN108669557A (en) | Soft capsule dosage form and preparation method thereof containing natural tomato extract liquor pumpkin seed oil | |
| CN109758542A (en) | Compound inulol fat emulsion formulation and preparation method and application with digestion promoting function | |
| CN106668060A (en) | Anti-cancer preparation containing sulforaphane and selenium and preparation method thereof | |
| CN105477100A (en) | Lucid ganoderma spore oil compound health care spray and preparation method | |
| CN104758451A (en) | Traditional Chinese medicine composite for treating gout | |
| CN109497563A (en) | Leucoderma tailored version clinical nutrition formula and preparation method thereof | |
| CN101549145B (en) | Nutrient fluid capable of being radio-resistant and reducing side reaction of radiation treatment | |
| CN104430720A (en) | Method for making functional biscuits through okra, fungus and algae plant mixtures | |
| CN107468737A (en) | A kind of mugwort mosquito repellant worm cream and usage food ointment chemical product physiotherapy ointment contain skin care | |
| CN106819223A (en) | A kind of health-care milk tea and preparation method thereof | |
| CN107006622A (en) | A kind of healthy edible oil and preparation method thereof | |
| KR20140086555A (en) | The drinking water containing spirulina | |
| Ravi et al. | Beneficial Effects of Medicinal Plants Used For the Management of Obesity-A Review | |
| CN102205010A (en) | Pharmaceutical composition with auxiliary function of reducing blood fat | |
| CN101091720A (en) | Health food with efficacy for preventing osteoporosis and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181019 |
|
| WD01 | Invention patent application deemed withdrawn after publication |